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... provide contemporary examples of how P-V analysis is providing unique insights into molecular physiology. A Bit of History The first studies regarding ventricular P-V relations were reported from frog ventricle and date to the late 19th century with the work of Otto Frank (7). However, it was the se ...
Reciprocal of Wall Thickness
Reciprocal of Wall Thickness

... progressively as ventricular size increases without this change necessarily indicating a change in contractile state. In this respect, an index of contractile function that is independent of ventricular size would have an obvious advantage. The exponential constant (k) of the end-systolic relation b ...
The Alternation Atrial Flutter and Atrial Fibrillation* `
The Alternation Atrial Flutter and Atrial Fibrillation* `

... with a history of embolization and only three of 17 in the postoperative ...
Noninvasive reconstruction of cardiac electrical activity: update on
Noninvasive reconstruction of cardiac electrical activity: update on

... team) [15], myocardial activation imaging [22], electrocardiographic mapping [36], inverse solution mapping [16], noninvasive imaging of cardiac electrophysiology [37], three-dimensional cardiac activation imaging (3-DCAI) [38], or similar terminology. We will refer to this full range of techniques ...
Structural Remodeling of Cardiac Myocytes in Patients
Structural Remodeling of Cardiac Myocytes in Patients

... would exacerbate the problem of tissue hypoxia characteristic of this disease. Conversely, series addition of contractile units (e.g., increased cell length) may not adversely affect diffusion distance if such a change were associated with a parallel increase in capillary length. An increase in cell ...
Antitachycardia Pacing for Ventricular Tachycardia
Antitachycardia Pacing for Ventricular Tachycardia

... dilated cardiomyopathy were studied by intraoperative mapping just prior to explantation among patients undergoing cardiac transplantation by Pogwizd et al.21 Zones of functional conduction delay and block were demonstrated in the epicardium and less often, in the midmyocardium and endocardium. Exte ...
Isolated Ventricular Systolic Interaction During
Isolated Ventricular Systolic Interaction During

... The volume and pressure of one ventricle have been demonstrated to modulate the volume and pressure in the contralateral chamber during systole and diastole. To quantitate the isolated systolic effects of left ventricular (LV) pressure on right ventricular (RV) mechanics, we rapidly withdrew blood f ...
Management of New Detected Atrial Fibrillation
Management of New Detected Atrial Fibrillation

... who were at least 65 years of age or who had at least 1 risk factor for stroke or death, such as hypertension, diabetes, previous stroke, or poor ventricular function, were followed for a mean of 3.5 years. Slightly more than one third of the patients were enrolled after their first episode of atria ...
2.4. Assessment of intrinsic contractility. Referring to figure 2.2
2.4. Assessment of intrinsic contractility. Referring to figure 2.2

... ejecting beat by using pressure values recorded before maximal first derivative of pressure development over time (dP/dt) and after minimal dP/dt. Right : this maximal vetricular pressure of isovolumic beats (Pmax) value is drawn on the pressurevolume diagram. The ESPVR line is drawn from Pmax down ...
1 Cardiac Electrical Activity
1 Cardiac Electrical Activity

... produce enough voltage to be recorded on the body surface. Clinical electrocardiography is made possible by the activation of large groups of atrial and ventricular myocardial cells, whose numbers are of sufficient magnitude for their electrical activity to be recorded on the body surface. Myocardia ...
Assessment of QT and JT Intervals in Patients With Left Bundle
Assessment of QT and JT Intervals in Patients With Left Bundle

... increases in depolarization duration and not in repolarization. Objectives: In this study, we aimed to apply corrected JT interval (JTc) as an appropriate measure of ventricular repolarization for predicting QTc in a formula. Patients and Methods: The study population consisted of 101 patients with ...
Ann Intern Med. 2003
Ann Intern Med. 2003

... who were at least 65 years of age or who had at least 1 risk factor for stroke or death, such as hypertension, diabetes, previous stroke, or poor ventricular function, were followed for a mean of 3.5 years. Slightly more than one third of the patients were enrolled after their first episode of atria ...
Localization of the Site of Ventricular Preexcitation with
Localization of the Site of Ventricular Preexcitation with

... retrogradely. However, pathway locations were confirmed in all patients by one or more of the following: measurement of local activation times at multiple atrial sites with catheters during orthodromic reciprocating tachycardia or ventricular pacing; determination of ventricular and atrial epicardia ...
serious arrhythmia induced by terfenadine
serious arrhythmia induced by terfenadine

... concentrations of terfenadine (0.02 to O.IJ..Lmol/L) and that these elevated concentrations are closely associated with prolongation of the QT interval.6.10-12 ...
EXPERIMENTAL & CLINICAL CARDIOLOGY
EXPERIMENTAL & CLINICAL CARDIOLOGY

... Ischemia of hypertrophied left ventricle in athlete’s heart is prevented by an increase in myocardial mitochondrial number, by normal activity of ATP-ase and by changes at the microcapillary level [16]. The most important problem is to distinguish athlete’s heart from hypertrophic cardiomyopathy [7] ...
Chapter07_Detailed_Answers
Chapter07_Detailed_Answers

... c: Intraventricular conduction defect causes the QRS complexes to appear abnormal. It is usually due to right or left bundle branch block. ...
CARDiAC RHYTHMS AND ARRHYTHMiAS
CARDiAC RHYTHMS AND ARRHYTHMiAS

... No treatment is indicated if the condition is transient. Remove or treat the cause. With hydrops, ST can be associated with cardiovascular collapse; the infant should be assessed closely and treated as for shock. Complications With any tachycardia, the ventricles do not have sufficient time to fill ...
ECG INTRODUCTION (Lecture 1)
ECG INTRODUCTION (Lecture 1)

... In leads with an “overall” positive QRS complex that is the positive deflection is larger than the negative deflection, the T wave also tends to be positive above the isoelectric line, while in leads with an overall negative QRS complex the T waves tend also to be negative, inverted below the isoele ...
Left Ventricular Hypertrophy Is a Common Echocardiographic
Left Ventricular Hypertrophy Is a Common Echocardiographic

... sulted in a twofold greater risk of sudden death compared to those without LVH. The adverse cardiac consequences from LVH are likely ultimately related to coronary ischemia, with increased muscle mass that is inadequately perfused, and which may compress endocardial capillaries.5,8,9 LVH may also ca ...
Effect of Acutely Increased Right Ventricular Afterload on Work
Effect of Acutely Increased Right Ventricular Afterload on Work

... pressure waveforms from cardiac cycles with similar left ventricular end-diastolic volumes during vena caval and pulmonary arterial occlusions are shown in Figure 1. Left ventricular pressurevolume loops obtained in the same study during the two occlusion states are shown in Figures 2A and 2B. In pa ...
reperfusion dysrhythmia - McGraw Hill Higher Education
reperfusion dysrhythmia - McGraw Hill Higher Education

... • Patients with myocardial ischemia, treatment of frequent PVCs includes: – administration of oxygen and placement of an IV line – identifying and correcting the underlying factor causing the PVCs • in some settings, administering lidocaine or other antidysrhythmics (e.g., amiodarone) by IV push and ...
Camera-Ready Format
Camera-Ready Format

... investigations have correlated ECG patterns and algorithms for detecting the localization of the AP [11]–[16]. Some study has been focused on the localization, realized through three-dimensional (3D)-heart reconstruction by the inverse solution of the ECG [17]–[22]. Several approaches have been expl ...
ECG Interpretation for the Veterinary Technician
ECG Interpretation for the Veterinary Technician

... directly on skin and wet with electrode gel or alcohol. Ideally the electrodes are placed distal to the elbows and hock, and under rather than over the chest wall, which will remove any baseline artifact from movement of the chest. Attempt to keep the patient calm and immobilized to prevent motion a ...
Temporary Pacemakers - University of California, San Diego
Temporary Pacemakers - University of California, San Diego

... Pacemaker not sensitive enough to patient’s intrinsic electrical activity (mV)  Insufficient myocardial voltage  Dislodged, loose, fibrotic, or fractured electrode  Electrolyte abnormalities  Low battery  Malfunction of pacemaker or bridging cable ...
Temporary Pacemakers-2hr
Temporary Pacemakers-2hr

... Pacemaker not sensitive enough to patient’s intrinsic electrical activity (mV)  Insufficient myocardial voltage  Dislodged, loose, fibrotic, or fractured electrode  Electrolyte abnormalities  Low battery  Malfunction of pacemaker or bridging cable ...
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Ventricular fibrillation



Ventricular fibrillation (V-fib or VF) is a condition in which there is uncoordinated contraction of the cardiac muscle of the ventricles in the heart, making them quiver rather than contract properly. Ventricular fibrillation is the most commonly identified arrhythmia in cardiac arrest patients. While there is some activity, the lay person is usually unable to detect it by palpating (feeling) the major pulse points of the carotid and femoral arteries. Such an arrhythmia is only confirmed by electrocardiography. Ventricular fibrillation is a medical emergency that requires prompt Advanced Life Support interventions. If this arrhythmia continues for more than a few seconds, it will likely degenerate further into asystole (""flatline""). This condition results in cardiogenic shock and cessation of effective blood circulation. As a consequence, sudden cardiac death (SCD) will result in a matter of minutes. If the patient is not revived after a sufficient period (within roughly 5 minutes at room temperature), the patient could sustain irreversible brain damage and possibly become brain-dead, due to the effects of cerebral hypoxia. On the other hand, death often occurs if sinus rhythm is not restored within 90 seconds of the onset of VF, especially if it has degenerated further into asystole.
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