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Nervous System
Nervous System

... Chemical that is released into the synaptic cleft from axon terminal of a sending neuron, crosses a synapse, and binds to appropriate receptor sites on dendrites or cell body Neurotransmitter molecules diffuse across synaptic cleft where they can bind with receptor sites on postsynaptic end to influ ...
Neuron Function notes
Neuron Function notes

... inhibition – synapses at cell body and dendrite may involve TENS of THOUSANDS of other neurons – if more excitatory ...
Bio 17 – Nervous & Endocrine Systems
Bio 17 – Nervous & Endocrine Systems

... low levels; important for sleep and low levels assoc with depression Runner’s High = DECREASED GABA ...
Objectives: The student shall know the facts, understand the
Objectives: The student shall know the facts, understand the

... Vesicular transport; endocytosis and exocytosis Components of electrochemical (passive) driving force for membrane movement Factors that determine the ion distribution and resting membrane potential of neurons and the relative contribution of each EXCITABILITY & ACTION POTENTIALS Components of neuro ...
Developer Notes
Developer Notes

... Different types of neurons respond to different stimuli. A stimulus is anything that generates a nerve response. For example, light is a stimulus that generates a response in specific neurons called photoreceptors (rods & cones). Neurons are peculiar looking cells with a main cell body and a long ta ...
The Nervous System
The Nervous System

... Long-lived ...
05 Bioelectrical phenomena in nervous cells
05 Bioelectrical phenomena in nervous cells

... Forces that determine ionic movement Electrostatic forces Opposite charges attract Identical charges repel Concentration forces Diffusion – movement of ions through semipermeable membrane Osmosis – movement of water from region of high concentration to low ...
Lecture 12 revised 3/2010 How do synapses influence whether or
Lecture 12 revised 3/2010 How do synapses influence whether or

... EPSP- excitatory postsynaptic potential- incr probability of an A.P. IPSP- inhibitory postsynaptic potential- decr probability of an A.P. The factor determining whether a transmitter causes one or the other: type of channel(s) in postsynaptic membrane. But what property of the channel(s)? the ion(s) ...
PART 1: TRUE OR FALSE (1 point each)
PART 1: TRUE OR FALSE (1 point each)

... b. More complex functions are localized to more anterior regions of the neuraxis. c. Pathways cross the midline. d. A and B only are themes of brain organization exemplified by the voluntary motor control systems. e. All of the above are themes of brain organization exemplified by the voluntary moto ...
Chapter 11 Marieb
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... 3. Calcium influx stimulates exocytosis of vesicles containing neurotransmitter. This mechanism is not clear. 4. Neurotransmitter is released into the synaptic cleft and diffuses across cleft 5. Neurotransmitter binds to receptors on postsynaptic cell. GRADED POTENTIAL is a short-lived change in mem ...
Figure 8-9
Figure 8-9

... because h-gates will have to be reset before they sodium channels can reopen and initiate a new action potential. This period is called the refractory period and can be divided into: • The absolute refractory period when h-gates are shut and you cannot trigger a new AP until they are open. • The rel ...
Electrophysiology - University of Nevada, Las Vegas
Electrophysiology - University of Nevada, Las Vegas

... Threshold is 10-15 mV depolarized (ie. –55 to –60 mV) All or none response – Once membrane reaches threshold, amplitude is independent of strength of initiating stimulus – Action potential cannot be summed ...
Open Document - Clinton Community College
Open Document - Clinton Community College

... Neuron at rest: ◦ Slightly negative charge ◦ Contains ions flowing back and forth ...
Sensory function
Sensory function

... an equal buildup of positively charged ions, mainly sodium ions (Na+), in the interstitial fluid just outside the membrane. ...
The Nervous System
The Nervous System

... • Neurons transmit signals down axons by altering the flow of sodium and potassium ions across their membranes in response to chemical signals. The resulting imbalance of electrical charges inside vs. outside the axon creates an electrical voltage potential (an “action potential”) that is propagated ...
Biology 2401 Anatomy and Physiology I notes
Biology 2401 Anatomy and Physiology I notes

... Cell structures that are important: Fig 9.11-9.13 - pumps are plasma membrane proteins that force ions across the membrane against their concentration gradient and require ATP energy - specific (one type ion) (examples are Na+ / K+ pump and Ca++ pump) - channels are plasma membranes proteins that ar ...
Biopsychology 2012 – sec 002
Biopsychology 2012 – sec 002

... - IPSP: inhibitory post-synaptic potentials (potassium goes out, or chloride goes in – makes action potential less likely to be produced); 4. EPSPs and IPSPs are graded potentials, not action potentials; 5. Graded potentials travel passively and very fast toward the cell body; 6. Graded potentials a ...
WHAT PARTS DO YOU KNOW THAT ARE IN THE NERVOUS SYSTEM?
WHAT PARTS DO YOU KNOW THAT ARE IN THE NERVOUS SYSTEM?

... synapse. The action potential will NOT move across the synapse. 2. Vesicles with neurotransmitters move toward the membrane 3. Chemicals are released into the synaptic cleft and diffuse toward the next cell’s plasma membrane 4. The chemicals open up the transport proteins and allow the signal to pas ...
K - Cloudfront.net
K - Cloudfront.net

... – Sodium and potassium ions used for nerve impulses in the brain – Iron, found in hemoglobin, in the blood cells (this is what makes it red in color) ...
Sending Signals Notes
Sending Signals Notes

... membrane of the adjacent nerve cell, it changes the permeability of that membrane. • As a result, Na+ ions diffuse through the membrane into the cell. • If enough neurotransmitter is released by the axon terminal, so many Na+ ions diffuse into the neuron that the neuron becomes DEPOLARIZED. ...
Lecture 4 revised 1/10 How do neurons transmit information over
Lecture 4 revised 1/10 How do neurons transmit information over

... capacitative current due to passive membrane properties- charging of membrane to new voltage), whereas depolarization gives a transient inward current then a delayed outward current (in/out are w/ respect to inside/outside of cell). Thus, depolarization caused a voltage-dependent change in membrane ...
Membrane potential (mV)
Membrane potential (mV)

... active area to threshold New adjacent returning to by local inactive area current resting into which flow; now potential; no depolarization longer active active at is spreading; because of peak of will soon reach Remainder of axon still action refractory threshold at resting potential potential peri ...
Electricity within the body
Electricity within the body

... is an electrical potential difference.  This due to the presence of more negative ions on the inside of the membrane than the outside , the neuron said to be polarized .  The inside of the cell is typically 60 -90 mv more negative than outside. ...
Exam 3B key
Exam 3B key

... structure accounts for this change in ion channel permeability? (1 pt, 2 pts total for question 11) - the permeability to Na+ is increasing enormously, This increase in permeability is due to the opening of the activation gate of the Na+ channel 12. Why specifically does the rapid upwards sweep in m ...
Structures and Functions Lecture 2
Structures and Functions Lecture 2

... • ECF has higher concentration of Na+ than ICF • ICF has higher concentration of K+ than ECF • K+ plays most important role in membrane potential ...
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Action potential



In physiology, an action potential is a short-lasting event in which the electrical membrane potential of a cell rapidly rises and falls, following a consistent trajectory. Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, and endocrine cells, as well as in some plant cells. In neurons, they play a central role in cell-to-cell communication. In other types of cells, their main function is to activate intracellular processes. In muscle cells, for example, an action potential is the first step in the chain of events leading to contraction. In beta cells of the pancreas, they provoke release of insulin. Action potentials in neurons are also known as ""nerve impulses"" or ""spikes"", and the temporal sequence of action potentials generated by a neuron is called its ""spike train"". A neuron that emits an action potential is often said to ""fire"".Action potentials are generated by special types of voltage-gated ion channels embedded in a cell's plasma membrane. These channels are shut when the membrane potential is near the resting potential of the cell, but they rapidly begin to open if the membrane potential increases to a precisely defined threshold value. When the channels open (in response to depolarization in transmembrane voltage), they allow an inward flow of sodium ions, which changes the electrochemical gradient, which in turn produces a further rise in the membrane potential. This then causes more channels to open, producing a greater electric current across the cell membrane, and so on. The process proceeds explosively until all of the available ion channels are open, resulting in a large upswing in the membrane potential. The rapid influx of sodium ions causes the polarity of the plasma membrane to reverse, and the ion channels then rapidly inactivate. As the sodium channels close, sodium ions can no longer enter the neuron, and then they are actively transported back out of the plasma membrane. Potassium channels are then activated, and there is an outward current of potassium ions, returning the electrochemical gradient to the resting state. After an action potential has occurred, there is a transient negative shift, called the afterhyperpolarization or refractory period, due to additional potassium currents. This mechanism prevents an action potential from traveling back the way it just came.In animal cells, there are two primary types of action potentials. One type is generated by voltage-gated sodium channels, the other by voltage-gated calcium channels. Sodium-based action potentials usually last for under one millisecond, whereas calcium-based action potentials may last for 100 milliseconds or longer. In some types of neurons, slow calcium spikes provide the driving force for a long burst of rapidly emitted sodium spikes. In cardiac muscle cells, on the other hand, an initial fast sodium spike provides a ""primer"" to provoke the rapid onset of a calcium spike, which then produces muscle contraction.
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