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Ch. 48 Lecture 48_Nervous_System
Ch. 48 Lecture 48_Nervous_System

... • Graded potentials are changes in polarization where the magnitude of the change varies with the strength of the stimulus • These are not the nerve signals that travel along axons, but they do have an effect on the generation of nerve signals ...
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... and lasts only a few milliseconds: • Depolarization phase – membrane potential rises toward zero and then becomes positive briefly ...
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... If there is a positive potential difference between the endolymph and the inside of the hair cells, electrical currents will tend to flow (A) into the hair cells (B) out of the hair cells (C) into the stria vascularis (D) across Reissner’s membrane ...
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... Ion channel closes ...
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... 4. Neuron structure varies, and they are classified according to the number of processes extending from the stroma. (Fig. 12.5) a. Multipolar neurons are those with one axon and multiple dendrites; they are the most common type. b. Bipolar neurons have one axon and one dendrite; examples include olf ...
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... presynaptic terminal by monoamine oxidase (MAO). 3. The neurotransmitter diffuses out of the synaptic cleft. D. Receptor molecules in synapses 1. Receptors for neurotransmitters are specific. 2. A neurotransmitter can bind to several different receptor types a. Therefore a neurotransmitter can be st ...
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June 14_Neuroanatomy & Audition

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... and can reduce dynamical entropy production by orders of magnitude. Very “crisp” action potential generators can even lead to a temporally irregular circuit dynamics that is not chaotic but stable. This phenomenon can be understood from the bandwidth of population encoding in an ensemble of uncouple ...
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... linearly with increasing drive. However, if this balance does not exist, for example by only increasing the presynaptic excitatory rate, the corresponding increase in conductance leads to a sub-linear depolarization with the drive. (ii) Increase of the voltage variance: It was recently suggested th ...
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... by another neuron or the environment  Action potential - When an impulse is sent the charge reverses inside the cell – it becomes positive  Threshold – the amount of stimulus required to activate the neuron ...
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... • Voltage-gated calcium channels are heteromultimers composed of an α1 subunit and three auxiliary subunits, 2-δ, β and γ. The α1 subunit forms the ion pore and possesses gating functions and, in some cases, drug binding sites. Ten α1 subunits have been identified, which, in turn, are associated wit ...
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... Two types of ion channels regulated by receptors and drugs. A. Diagram of a voltage-activated Na+ channel with the pore in the open and closed state. The pore-forming P loops are shown in blue, angled into the pore to form the selectivity filter. The S4 helices forming the voltage sensor are shown i ...
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... Two types of ion channels regulated by receptors and drugs. A. Diagram of a voltage-activated Na+ channel with the pore in the open and closed state. The pore-forming P loops are shown in blue, angled into the pore to form the selectivity filter. The S4 helices forming the voltage sensor are shown i ...
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... muscle cells, and endocrine cells, • is generated by special types of voltage-gated ion channels embedded in a cell's plasma membrane. ...
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Action potential



In physiology, an action potential is a short-lasting event in which the electrical membrane potential of a cell rapidly rises and falls, following a consistent trajectory. Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, and endocrine cells, as well as in some plant cells. In neurons, they play a central role in cell-to-cell communication. In other types of cells, their main function is to activate intracellular processes. In muscle cells, for example, an action potential is the first step in the chain of events leading to contraction. In beta cells of the pancreas, they provoke release of insulin. Action potentials in neurons are also known as ""nerve impulses"" or ""spikes"", and the temporal sequence of action potentials generated by a neuron is called its ""spike train"". A neuron that emits an action potential is often said to ""fire"".Action potentials are generated by special types of voltage-gated ion channels embedded in a cell's plasma membrane. These channels are shut when the membrane potential is near the resting potential of the cell, but they rapidly begin to open if the membrane potential increases to a precisely defined threshold value. When the channels open (in response to depolarization in transmembrane voltage), they allow an inward flow of sodium ions, which changes the electrochemical gradient, which in turn produces a further rise in the membrane potential. This then causes more channels to open, producing a greater electric current across the cell membrane, and so on. The process proceeds explosively until all of the available ion channels are open, resulting in a large upswing in the membrane potential. The rapid influx of sodium ions causes the polarity of the plasma membrane to reverse, and the ion channels then rapidly inactivate. As the sodium channels close, sodium ions can no longer enter the neuron, and then they are actively transported back out of the plasma membrane. Potassium channels are then activated, and there is an outward current of potassium ions, returning the electrochemical gradient to the resting state. After an action potential has occurred, there is a transient negative shift, called the afterhyperpolarization or refractory period, due to additional potassium currents. This mechanism prevents an action potential from traveling back the way it just came.In animal cells, there are two primary types of action potentials. One type is generated by voltage-gated sodium channels, the other by voltage-gated calcium channels. Sodium-based action potentials usually last for under one millisecond, whereas calcium-based action potentials may last for 100 milliseconds or longer. In some types of neurons, slow calcium spikes provide the driving force for a long burst of rapidly emitted sodium spikes. In cardiac muscle cells, on the other hand, an initial fast sodium spike provides a ""primer"" to provoke the rapid onset of a calcium spike, which then produces muscle contraction.
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