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Chapter 3: Cellular Form and Function
Chapter 3: Cellular Form and Function

... Principles of Modern Cell Theory • All organisms composed of cells and cell products. • A cell is the simplest structural and functional unit of life. There are no smaller subdivisions of a cell or organism that, in themselves, are alive. • An organism’s structure and all of its functions are ultima ...
Stochastic fluctuations of the synaptic function
Stochastic fluctuations of the synaptic function

... synapses produced quantal Excitatory PostSynaptic Currents (EPSCs) with peak amplitudes having a 5-65 pA range. The histogram of the peak amplitudes showed a long right tail. If the variability of the postsynaptic response observed in hippocampal neurons should be extended to all the neurons of brai ...
Gene7-26
Gene7-26

... (including engrailed). A similar pathway is found in vertebrate cells (components named in blue). ...
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... membrane with numerous folds (cristae) ...
Detergent-resistant membranes and the protein
Detergent-resistant membranes and the protein

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The Cell Membrane

...  Fatty acid tails ...
axonal terminals
axonal terminals

... reached. ...
The Neuron - Austin Community College
The Neuron - Austin Community College

... At rest all voltage-gated Na+ channels are closed and RMP is -70 mV, a stimulus (triggering event) opens some voltage-gated Na+ channels. Na+ diffuses into cell down its concentration gradient and entry decreases membrane potential, causing more Na+ channels to be activated. If depolarization reache ...
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... • For Gram +, the secreted proteins must be transported across a single membrane. Then through a relatively porous peptidoglycan into either: – the external environment – become embedded /attached to the peptidoglycan ...
Tutorial 9: Excitatory Postsynaptic Potentials Figure 9: Excitatory
Tutorial 9: Excitatory Postsynaptic Potentials Figure 9: Excitatory

... intracellularly from voltage-sensitive dyes applied to neurons within brain slices (Gelperin & Flores, 1997; Sabatini & Regehr, 1998; Zecevic & Antic, 1998). These approaches allow for spatial analysis of more complex neurophysiological relationships. Recent studies using these various techniques of ...
LECTURES 1,2 Membranes, lipids and phospholipases.ppt
LECTURES 1,2 Membranes, lipids and phospholipases.ppt

... PPAR receptor is located at the nuclear membrane and dimerizes with 9-cis retiniose acid receptor following ligand binding; this causes binding to DNA at PPAR response elements. PPAR response elements are located near genes involved in lipid metabolism 3 types PPAR receptors: alpha, beta, and gamma. ...
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Chapter 8. Movement across the Membrane

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MB-JASS 2007 – Session III – Properties of Channels Formed by

... C2II. The heptamer binds to a N-linked complex carbohydrate on the surface of target cells (Eckhardt et al, 2000) and is also able to bind the enzymatic component C2I (Ohishi et al, 1992; Barth et al, 1998; Blöcker et al, 2003). The complex is endocytosed into the cell. Acidification of the endosome ...
Neural Tissue – Chapter 12
Neural Tissue – Chapter 12

... This is called local current. (As sodium ions move into the cell, other sodium ions fill in the gaps.) This causes adjacent portions of the cell membrane to become depolarized. The degree of depolarization decreases with distance away from the stimulation site and because some of the sodium ions mov ...
ACTION POTENTIALS
ACTION POTENTIALS

... the membrane potential reached the threshold membrane depolarization opens both Na+ & K+ channels but Na+ opens faster initiating the action potential Na+ channels become inactivated as action potential proceeds (gates close) & remain so until after membrane returns to resting potential ...
Chapter 48: Neurons, Synapses, and Signaling 48.1: Neuron
Chapter 48: Neurons, Synapses, and Signaling 48.1: Neuron

...  At the axon hillock where an action potential is initiated Na+ inflow creates an electrical current that depolarizes neighboring part of axon membrane o Depolarization is big enough to reach threshold causing action potential to be reinitiated  repeated along length of axon  Action potentials on ...
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07_Lecture_Presentation

... plasma membrane occurs by exocytosis and endocytosis  Small molecules and water enter or leave the cell through the lipid bilayer or via transport proteins  Large molecules, such as polysaccharides and proteins, cross the membrane in bulk via vesicles  Bulk transport requires energy ...
Structures and Functions Lecture 2
Structures and Functions Lecture 2

... Figure 11.11 The action potential (AP) is a brief change in membrane potential in a “patch” of membrane that is depolarized by local currents. (1 of 3) ...
m5zn_7e2104c47c4f1d9
m5zn_7e2104c47c4f1d9

... •Forth tube: 4ml of distilled water 3- Add 2 drops of fresh blood to each of the fore tube. 4- Shake well, then leaves the tube to stand from 10-30 minutes. 5- Take one drop from each tube and put it on a cleaned & labeled slide then cover it with cover slip. 6- Examine under the microscope using X1 ...
Physiology
Physiology

... Establishment of the Resting Membrane Potential Membranes are polarized or, in other words, exhibit a RESTING MEMBRANE POTENTIAL. This means that there is an unequal distribution of ions (atoms with a positive or negative charge) on the two sides of the nerve cell membrane. This POTENTIAL generally ...


... critical residues in the LacY ligand-binding site. However, an additional important observation from the structures of LacY, GlpT, and other membrane proteins is that transmembrane helices can be bent or exhibit other types of irregular features (see the figure). Together with the conformational fle ...
TIBS review article by Killian & Heijne
TIBS review article by Killian & Heijne

... so that they cannot form secondary structures. The partitioning of these host peptides between water and the interface of lipid bilayers was measured and compared with partitioning in octanol or cyclohexane. In this way, the energetics of the interface interaction of several side chains was characte ...
Chemistry of Neurotransmitters
Chemistry of Neurotransmitters

... Explain the mechanism of action of acetylcholine in modulating muscle contraction. ...
Structure and Function of the Plasma Membrane A biochemical
Structure and Function of the Plasma Membrane A biochemical

... themselves the fundamental units of both structure and function (4, 5) (Fig. 2). This approach has the appeal of shifting the emphasis from the lipids to the proteins, which are the usual, but not exclusive, biological mechanism for specificity and versatility. It has the additional attraction of re ...
Structure and Function of the Plasma Membrane
Structure and Function of the Plasma Membrane

... themselves the fundamental units of both structure and function (4, 5) (Fig. 2). This approach has the appeal of shifting the emphasis from the lipids to the proteins, which are the usual, but not exclusive, biological mechanism for specificity and versatility. It has the additional attraction of re ...
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SNARE (protein)



SNARE proteins (an acronym derived from ""SNAP (Soluble NSF Attachment Protein) REceptor"") are a large protein superfamily consisting of more than 60 members in yeast and mammalian cells. The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.
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