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A 29 kDa Intracellular Chloride Channel p64H1 Is Associated with
... some biogenic amines are sorted into LDC Vs and released extrasynaptically. In contrast, classical neurotransmitters are released at synapses from SSVs. LDC Vs and SSVs have different regulatory mechanisms for neurotransmitter exocytosis (De Ca- ...
... some biogenic amines are sorted into LDC Vs and released extrasynaptically. In contrast, classical neurotransmitters are released at synapses from SSVs. LDC Vs and SSVs have different regulatory mechanisms for neurotransmitter exocytosis (De Ca- ...
Mitochondria, Chloroplasts, and Peroxisomes
... these presequences to receptors on the surface of mitochondria. The polypeptide chains are then inserted into a protein complex that directs translocation across the outer membrane (the translocase of the outer membrane or Tom complex). The proteins are then transferred to a second protein complex i ...
... these presequences to receptors on the surface of mitochondria. The polypeptide chains are then inserted into a protein complex that directs translocation across the outer membrane (the translocase of the outer membrane or Tom complex). The proteins are then transferred to a second protein complex i ...
Emerging biological roles of Cl− intracellular channel proteins
... The Cl− intracellular channel (CLIC) protein family consists of six members (CLIC1–6) that are highly conserved and exist in both soluble and membrane-associated forms. CLICs are small globular proteins (∼28 kDa) that are structurally related to the omega-class of glutathione S-transferases (GSTs) b ...
... The Cl− intracellular channel (CLIC) protein family consists of six members (CLIC1–6) that are highly conserved and exist in both soluble and membrane-associated forms. CLICs are small globular proteins (∼28 kDa) that are structurally related to the omega-class of glutathione S-transferases (GSTs) b ...
"Dot and Slot Blotting of DNA". In: Current Protocols in Molecular
... The protocols for blotting uncharged nylon and nitrocellulose membranes attempt to ensure complete denaturation through the use of two denaturation steps—a heat denaturation before application to the membrane and an alkaline denaturation after application. Heat denaturation on its own is rarely adeq ...
... The protocols for blotting uncharged nylon and nitrocellulose membranes attempt to ensure complete denaturation through the use of two denaturation steps—a heat denaturation before application to the membrane and an alkaline denaturation after application. Heat denaturation on its own is rarely adeq ...
Chapter 3
... Movement of Molecules in Fluids Definitions relevant to substance movement • A fluid is a substance that can move or change shape in response to external forces • A solute is a substance that can be dissolved (dispersed as ions or molecules) in a solvent • A solvent is a fluid capable of dissolvi ...
... Movement of Molecules in Fluids Definitions relevant to substance movement • A fluid is a substance that can move or change shape in response to external forces • A solute is a substance that can be dissolved (dispersed as ions or molecules) in a solvent • A solvent is a fluid capable of dissolvi ...
Mechanisms of enveloped RNA virus budding
... be involved in the release of other pathogenic human viruses because structural proteins in both Ebola virus (VP40) and human T cell leukemia virus type I (Gag) contain PTAP motifs, and the Ebola VP40 protein has been shown to recruit Tsg101 to assembly sites on the plasma membrane [13]. Tsg101 and ...
... be involved in the release of other pathogenic human viruses because structural proteins in both Ebola virus (VP40) and human T cell leukemia virus type I (Gag) contain PTAP motifs, and the Ebola VP40 protein has been shown to recruit Tsg101 to assembly sites on the plasma membrane [13]. Tsg101 and ...
Lipids and Proteins Are Associated in Membranes Chapter 8
... - There are two advantages in using triacylglycerols as stored fuels, rather than polysaccharides such as glycogen and starch 1) Oxidation of tryacylglycerols (~ 9 kcal/g) yields more than twice as much energy as the oxidation of carbohydrates (~ 4 kcal/g) 2) The organism that carries fat as fuel do ...
... - There are two advantages in using triacylglycerols as stored fuels, rather than polysaccharides such as glycogen and starch 1) Oxidation of tryacylglycerols (~ 9 kcal/g) yields more than twice as much energy as the oxidation of carbohydrates (~ 4 kcal/g) 2) The organism that carries fat as fuel do ...
GPCR–G fusion proteins
... DNA restriction enzyme or polymerase chain reaction (PCR)-based techniques, or both. Figure 1 illustrates the two-dimensional topology of GPCR–Ga fusion proteins in the plasma membrane. In most GPCRs, the second and third intracellular loops are crucial for G-protein coupling21,28–30, although the f ...
... DNA restriction enzyme or polymerase chain reaction (PCR)-based techniques, or both. Figure 1 illustrates the two-dimensional topology of GPCR–Ga fusion proteins in the plasma membrane. In most GPCRs, the second and third intracellular loops are crucial for G-protein coupling21,28–30, although the f ...
Membrane nanodomains in plants: capturing form, function, and
... Hydrogen bonding between membrane-intercalated sterols and either long chain bases (fatty acids) or large hydrophobic head groups of SLs are energetically favoured over interactions with PL (Lingwood and Simons, 2010). This increases the potential for SL/sterol partitioning and lateral immiscibility ...
... Hydrogen bonding between membrane-intercalated sterols and either long chain bases (fatty acids) or large hydrophobic head groups of SLs are energetically favoured over interactions with PL (Lingwood and Simons, 2010). This increases the potential for SL/sterol partitioning and lateral immiscibility ...
The Extracellular Matrix
... Early in development, the elastic fibers consists of microfibrils, which define fiber location and morphology. Over time, tropoelastin accumulates within the bed of ...
... Early in development, the elastic fibers consists of microfibrils, which define fiber location and morphology. Over time, tropoelastin accumulates within the bed of ...
Axon - Cloudfront.net
... generating and propagating ACTION POTENTIALS (AP). Only cells with excitable membranes (like muscle cells and neurons) can generate APs. ...
... generating and propagating ACTION POTENTIALS (AP). Only cells with excitable membranes (like muscle cells and neurons) can generate APs. ...
Clathrinmediated transport: assembly required
... of regulatory proteins has been implicated in the temporal and spatial coordination of endocytosis from the cell surface. V. Haucke (Göttingen, Germany) presented evidence that stonin 2, a protein that contains two Eps 15-binding NPF motifs and a μ-homology domain, is recruited to axonal vesicle clu ...
... of regulatory proteins has been implicated in the temporal and spatial coordination of endocytosis from the cell surface. V. Haucke (Göttingen, Germany) presented evidence that stonin 2, a protein that contains two Eps 15-binding NPF motifs and a μ-homology domain, is recruited to axonal vesicle clu ...
PHD domains and E3 ubiquitin ligases: viruses make the connection
... ligases that rely on PHD domains rather than on RING fingers The resulting ubiquitinated MHC class I chains not only undergo enhanced endocytosis but are also directed preferentially to lysosomes. In both yeast and mammalian cells, the latter trafficking steps are usually accomplished through the mu ...
... ligases that rely on PHD domains rather than on RING fingers The resulting ubiquitinated MHC class I chains not only undergo enhanced endocytosis but are also directed preferentially to lysosomes. In both yeast and mammalian cells, the latter trafficking steps are usually accomplished through the mu ...
Memristance can explain Spike-Time- Dependent
... spike (in the order of hundreds of mV) cause a variety of selective molecular membrane channels to open and close allowing for many ionic and molecular substances to flow or not through the membrane. At the same time, synaptic vesicles inside the pre-synaptic cell containing “packages” of neurotrans ...
... spike (in the order of hundreds of mV) cause a variety of selective molecular membrane channels to open and close allowing for many ionic and molecular substances to flow or not through the membrane. At the same time, synaptic vesicles inside the pre-synaptic cell containing “packages” of neurotrans ...
The advantages of being small Stockholm University
... Why are there so many kinds of lipids? Lipids differ in head group, back bone and acyl chain length and chain unsaturation (Dowhan and Bogdanov, 2002). These differences will have effects on the property and function of the lipid. The physical state of membrane lipids has been found to strongly affe ...
... Why are there so many kinds of lipids? Lipids differ in head group, back bone and acyl chain length and chain unsaturation (Dowhan and Bogdanov, 2002). These differences will have effects on the property and function of the lipid. The physical state of membrane lipids has been found to strongly affe ...
Journal of Bacteriology
... However, an alternative possibility should be considered, i.e., the first residue of the PhoE protein part could be on the outside surface of the cell, whereas the 1-lactamase part folds back to span the bilayer such that the bulk of the lactamase part is present in the periplasm. In this case, the ...
... However, an alternative possibility should be considered, i.e., the first residue of the PhoE protein part could be on the outside surface of the cell, whereas the 1-lactamase part folds back to span the bilayer such that the bulk of the lactamase part is present in the periplasm. In this case, the ...
2009/05/21 Lecture
... The fluorophore is moderately polar and its fatty acid analogs and the phospholipids derived from these probes tend to sense the lipid–water interface region of membranes instead of the hydrophobic interior. NBD fatty acids are not well metabolized by living cells. The environmental sensitivity of N ...
... The fluorophore is moderately polar and its fatty acid analogs and the phospholipids derived from these probes tend to sense the lipid–water interface region of membranes instead of the hydrophobic interior. NBD fatty acids are not well metabolized by living cells. The environmental sensitivity of N ...
Membrane-coating lattice scaffolds in the nuclear pore
... Gemin2-7 and coordinates the assembly of small nuclear ribonucleoproteins (snRNPS) important to motor neurons. Another example is the Tup1 protein found in yeast, which together with Cyc8 forms a complex that functions as a general repressor of transcription mediated by a diverse collection of repre ...
... Gemin2-7 and coordinates the assembly of small nuclear ribonucleoproteins (snRNPS) important to motor neurons. Another example is the Tup1 protein found in yeast, which together with Cyc8 forms a complex that functions as a general repressor of transcription mediated by a diverse collection of repre ...
Dynamin and the Actin Cytoskeleton Cooperatively Regulate
... (A) Negative staining electron microscopy. Upper panels: Liposomes were incubated with recombinant F-BAR-containing proteins or their isolated F-BAR domains. Lower panels: Liposomes were incubated either with FBP17 or with dynamin alone, or with both proteins together, as indicated. The presence of ...
... (A) Negative staining electron microscopy. Upper panels: Liposomes were incubated with recombinant F-BAR-containing proteins or their isolated F-BAR domains. Lower panels: Liposomes were incubated either with FBP17 or with dynamin alone, or with both proteins together, as indicated. The presence of ...
Structure and function of nucleus-vacuole junctions: outer
... nuclear pores. The inner nuclear membrane (INM) serves as an attachment sites for chromatin and, in higher eukaryotes, is associated with the nuclear lamina (reviewed in Hetzer et al., 2005). The outer nuclear membrane (ONM), like the rough ER, is studded with ribosomes but, uniquely, for example, c ...
... nuclear pores. The inner nuclear membrane (INM) serves as an attachment sites for chromatin and, in higher eukaryotes, is associated with the nuclear lamina (reviewed in Hetzer et al., 2005). The outer nuclear membrane (ONM), like the rough ER, is studded with ribosomes but, uniquely, for example, c ...
a14b NeuroPhysII
... o Short-lived, localized changes in membrane potential o Depolarizations or hyperpolarizations o Graded potential spreads as local currents change the membrane potential of adjacent regions ...
... o Short-lived, localized changes in membrane potential o Depolarizations or hyperpolarizations o Graded potential spreads as local currents change the membrane potential of adjacent regions ...
Lipids of the Plant Plasma Membrane
... associate proteins allow the formation of a barrier that is selectively permeable to macromolecules and solutes. As the plasma membrane delineates the interface between the cell and the environment, it is the primary part of signal recognition and transduction into intracellular responses for nutrit ...
... associate proteins allow the formation of a barrier that is selectively permeable to macromolecules and solutes. As the plasma membrane delineates the interface between the cell and the environment, it is the primary part of signal recognition and transduction into intracellular responses for nutrit ...
Protein translocation channel of mitochondrial inner
... Biomedical Center Munich, Department of Physiological Chemistry, LudwigMaximilians-Universität, Munich, Germany; 2Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität, Munich, Germany ...
... Biomedical Center Munich, Department of Physiological Chemistry, LudwigMaximilians-Universität, Munich, Germany; 2Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität, Munich, Germany ...
Making Membranes in Artificial Chemistries
... We have presented a novel chemical simulation that has a lattice-based physics in which semi-permeable membranes with good flexibility can be created. The low computational cost and rich interactions in the system give it good potential for artificial life experiments. Importantly, the model is comp ...
... We have presented a novel chemical simulation that has a lattice-based physics in which semi-permeable membranes with good flexibility can be created. The low computational cost and rich interactions in the system give it good potential for artificial life experiments. Importantly, the model is comp ...
SNARE (protein)
![](https://commons.wikimedia.org/wiki/Special:FilePath/Exocytosis-machinery.jpg?width=300)
SNARE proteins (an acronym derived from ""SNAP (Soluble NSF Attachment Protein) REceptor"") are a large protein superfamily consisting of more than 60 members in yeast and mammalian cells. The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.