Thesis - doktori
... species [4], most of them are non-pathogenic to human being. Several species are, however, associated with human disease such as tuberculosis or leprosy. The causative agent of TB is a fairly large, non-motile, rod-shaped bacterium, belongs to the obligate aerobe group and it is found mainly in the ...
... species [4], most of them are non-pathogenic to human being. Several species are, however, associated with human disease such as tuberculosis or leprosy. The causative agent of TB is a fairly large, non-motile, rod-shaped bacterium, belongs to the obligate aerobe group and it is found mainly in the ...
Annexin-Phospholipid Interactions. Functional Implications
... third group can be established with annexins that possess a long N-terminus with more than 100 amino acid residues (annexins A7 and A11). Even though the N-terminus of annexins is significantly smaller than the C-terminal protein core, it is essentially involved in the structural and functional pecu ...
... third group can be established with annexins that possess a long N-terminus with more than 100 amino acid residues (annexins A7 and A11). Even though the N-terminus of annexins is significantly smaller than the C-terminal protein core, it is essentially involved in the structural and functional pecu ...
Interactions of Annexins with the mu Subunits of the Clathrin
... demonstrated in vitro to be direct, to require calcium, and to be functional in the sense that annexin A2 was able to recruit the mu2 to immobilized lipids. Examination of other annexins and mu subunits demonstrated that annexin A2 also binds the mu1 subunit of the AP-1 complex, that annexin A6 bind ...
... demonstrated in vitro to be direct, to require calcium, and to be functional in the sense that annexin A2 was able to recruit the mu2 to immobilized lipids. Examination of other annexins and mu subunits demonstrated that annexin A2 also binds the mu1 subunit of the AP-1 complex, that annexin A6 bind ...
Forced Expression of Dystrophin Deletion Constructs Reveals
... all of the COOH-terminal domains is able to localize correctly to the sarcolemmal membrane (5, 18, 19, 29). However, these situations have resulted in severe DMD in patients who are old enough for a diagnosis. Furthermore, point mutations and frameshifting deletions that prevent translation of the d ...
... all of the COOH-terminal domains is able to localize correctly to the sarcolemmal membrane (5, 18, 19, 29). However, these situations have resulted in severe DMD in patients who are old enough for a diagnosis. Furthermore, point mutations and frameshifting deletions that prevent translation of the d ...
Spectrin functions upstream of ankyrin in a spectrin cytoskeleton
... 2002). The “immediate family” of the founding member spectrin includes a group of closely related gene products that assemble as tetramers of α and β subunits, that associate with specific subdomains of the plasma membrane in many cells, and that share the ability to form cross-linked arrays with ac ...
... 2002). The “immediate family” of the founding member spectrin includes a group of closely related gene products that assemble as tetramers of α and β subunits, that associate with specific subdomains of the plasma membrane in many cells, and that share the ability to form cross-linked arrays with ac ...
Purification, Characterization and Antibacterial Mechanism of
... bacteriocin indicated was not entirely dependent on the peptide or protein fraction [18]. The eluate of cellufine A-500 column had antimicrobial activity, but cellufine C-500 column had no antimicrobial activity. It showed that the bacteriocin was a protein with more acidic ...
... bacteriocin indicated was not entirely dependent on the peptide or protein fraction [18]. The eluate of cellufine A-500 column had antimicrobial activity, but cellufine C-500 column had no antimicrobial activity. It showed that the bacteriocin was a protein with more acidic ...
Phylogenetic Co-Occurrence of ExoR, ExoS, and ChvI, Components
... functional protein (ExoRm) that interacts with the periplasmic domain of ExoS (ExoSp), a sensor kinase [16,18]. It has been experimentally demonstrated that ExoRm can be digested by a yet unidentified periplasmic protease to yield a nonfunctional product ExoRc20 [16]. Our current model suggests that ...
... functional protein (ExoRm) that interacts with the periplasmic domain of ExoS (ExoSp), a sensor kinase [16,18]. It has been experimentally demonstrated that ExoRm can be digested by a yet unidentified periplasmic protease to yield a nonfunctional product ExoRc20 [16]. Our current model suggests that ...
Results of Bacterial Culture and Sensitivity Testing From
... CSG were Pasteurella multocida, which were found more frequently in young rabbits. The second more frequent bacteria isolated in the CSG was Enterobacter cloacae. The bacteria isolated in the CSG seem to act as opportunistic pathogens (due to the lack of strain identification tests, it was impossibl ...
... CSG were Pasteurella multocida, which were found more frequently in young rabbits. The second more frequent bacteria isolated in the CSG was Enterobacter cloacae. The bacteria isolated in the CSG seem to act as opportunistic pathogens (due to the lack of strain identification tests, it was impossibl ...
Plant pathogenic bacteria
... molecules, coding few proeteins, responsibles for few properties (eg. antibiotic resistance) • Ribosomes and RNAs, producing proteins ...
... molecules, coding few proeteins, responsibles for few properties (eg. antibiotic resistance) • Ribosomes and RNAs, producing proteins ...
Chemosynthetic endosymbioses: adaptations to
... within membrane-bound vacuoles, either singly or in groups of two or more. Abbreviations: arrowZdividing bacterium; bZbacteria; mZmitochondria; tcZtrunk coelomic cavity; Scale barZ3 mm. Figure reprinted, with permission, from Ref. [78]. (c,d) Solemya velum (coastal bivalve), intracellular chemoautot ...
... within membrane-bound vacuoles, either singly or in groups of two or more. Abbreviations: arrowZdividing bacterium; bZbacteria; mZmitochondria; tcZtrunk coelomic cavity; Scale barZ3 mm. Figure reprinted, with permission, from Ref. [78]. (c,d) Solemya velum (coastal bivalve), intracellular chemoautot ...
Identification and Characterization of A Novel Salmonella
... virulence genes clustered within pathogenicity islands, numerous additional genes scattered throughout the genome are also involved in various aspects of Salmoenlla virulence and pathogenesis. In this study, I identified a Salmonella putative transcriptional regulator encoded by a previously unchara ...
... virulence genes clustered within pathogenicity islands, numerous additional genes scattered throughout the genome are also involved in various aspects of Salmoenlla virulence and pathogenesis. In this study, I identified a Salmonella putative transcriptional regulator encoded by a previously unchara ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... barrier by restricting the rate of molecule transport to the interior of the biofilm, or by chemically reacting with the molecules themselves. The exopolysaccharide which is negatively charged, restricts the penetration of the positively charged molecules of antibiotics by chemical interactions or b ...
... barrier by restricting the rate of molecule transport to the interior of the biofilm, or by chemically reacting with the molecules themselves. The exopolysaccharide which is negatively charged, restricts the penetration of the positively charged molecules of antibiotics by chemical interactions or b ...
Biochemical Properties and Mechanism of Action of Enterocin LD3
... that show several LAB bacteriocins inhibiting Gram-negative bacteria [1–4]. Presently, only nisin and pediocin PA1/AcH found their commercial use as food preservatives, while many more were characterized for application in food safety [5, 6]. Based on their properties such as charge, hydrophobicity ...
... that show several LAB bacteriocins inhibiting Gram-negative bacteria [1–4]. Presently, only nisin and pediocin PA1/AcH found their commercial use as food preservatives, while many more were characterized for application in food safety [5, 6]. Based on their properties such as charge, hydrophobicity ...
The interaction between the mucosal immune system and the
... Preparation of pure cultured bacteria for flow cytometry: Pure cultured bacteria were washed once with PBS, adjusted to the optimal bacterial concentration (108 bacteria / ml) in 500 µl, added to 20 µl PI (final concentration: 4 mg /l), stored on ice in the dark and analysed within two hours. For vi ...
... Preparation of pure cultured bacteria for flow cytometry: Pure cultured bacteria were washed once with PBS, adjusted to the optimal bacterial concentration (108 bacteria / ml) in 500 µl, added to 20 µl PI (final concentration: 4 mg /l), stored on ice in the dark and analysed within two hours. For vi ...
haemagglutinins, serum resistance and
... to mucosal surfaces, thereby enhancing the ability of the bacteria to cause infection. Type 1 ®mbriae are primarily associated with the pathogenesis of lower urinary tract infections caused by E. coli [28] but they may also be involved in the pathogenesis of pyelonephritis [29, 30]. Although they ar ...
... to mucosal surfaces, thereby enhancing the ability of the bacteria to cause infection. Type 1 ®mbriae are primarily associated with the pathogenesis of lower urinary tract infections caused by E. coli [28] but they may also be involved in the pathogenesis of pyelonephritis [29, 30]. Although they ar ...
Consortia of cyanobacteria/microalgae and bacteria
... phototrophic bacteria and sulfate-reducing bacteria. These mats have complex relationships with trophically-related bacterial groups and the physiologies of habitat-forming (edificatory) cyanobacteria. These cyanobacterial mats were credited with self-cleaning properties in the Arabian Gulf Coasts (S ...
... phototrophic bacteria and sulfate-reducing bacteria. These mats have complex relationships with trophically-related bacterial groups and the physiologies of habitat-forming (edificatory) cyanobacteria. These cyanobacterial mats were credited with self-cleaning properties in the Arabian Gulf Coasts (S ...
Structural and functional characterization of peptides
... In this study the structural characteristics and antibacterial activities of two peptides derived from the carboxy-terminal of a tick defensin were investigated. Two defensin isoforms (OsDef1 and OsDef2) were previously identified in the midgut of the tick, Ornithodoros savignyi. Both OsDef1 and OsD ...
... In this study the structural characteristics and antibacterial activities of two peptides derived from the carboxy-terminal of a tick defensin were investigated. Two defensin isoforms (OsDef1 and OsDef2) were previously identified in the midgut of the tick, Ornithodoros savignyi. Both OsDef1 and OsD ...
foldpat20-text-092101-dg-jl
... when assigning functional information through structure prediction, as promiscuous structures may often have more than one function (i.e the TIM barrel), in fact almost all superfamilies, due to local sequence variation, have multiple function.33In addition, specific functions may be carried out by ...
... when assigning functional information through structure prediction, as promiscuous structures may often have more than one function (i.e the TIM barrel), in fact almost all superfamilies, due to local sequence variation, have multiple function.33In addition, specific functions may be carried out by ...
NF- B signaling pathways in mammalian and insect innate immunity
... of IKK␣ or IKK. Certain MAP3 kinases (MEKK1, MEKK2, MEKK3, and NIK) are capable of phosphorylating these serines in vitro, and activating NF-B in transfection experiments (Karin and Ben-Neriah 2000). In addition, dominant negative mutants of either MEKK1 or NIK kinase can inhibit NF-B activation ...
... of IKK␣ or IKK. Certain MAP3 kinases (MEKK1, MEKK2, MEKK3, and NIK) are capable of phosphorylating these serines in vitro, and activating NF-B in transfection experiments (Karin and Ben-Neriah 2000). In addition, dominant negative mutants of either MEKK1 or NIK kinase can inhibit NF-B activation ...
Structural Genomics Analysis
... when assigning functional information through structure prediction, as promiscuous structures may often have more than one function (i.e the TIM barrel), in fact almost all superfamilies, due to local sequence variation, have multiple function.33In addition, specific functions may be carried out by ...
... when assigning functional information through structure prediction, as promiscuous structures may often have more than one function (i.e the TIM barrel), in fact almost all superfamilies, due to local sequence variation, have multiple function.33In addition, specific functions may be carried out by ...
MB_23_win
... • DNA – Prokaryotic DNA is a single closed loop of doublestranded DNA attached at one point to the cell membrane. – Along with a single main chromosome, some prokaryotes have plasmids, which are small, circular, self-replicating loops of double-stranded DNA. ...
... • DNA – Prokaryotic DNA is a single closed loop of doublestranded DNA attached at one point to the cell membrane. – Along with a single main chromosome, some prokaryotes have plasmids, which are small, circular, self-replicating loops of double-stranded DNA. ...
MB_23_win
... • DNA – Prokaryotic DNA is a single closed loop of doublestranded DNA attached at one point to the cell membrane. – Along with a single main chromosome, some prokaryotes have plasmids, which are small, circular, self-replicating loops of double-stranded DNA. ...
... • DNA – Prokaryotic DNA is a single closed loop of doublestranded DNA attached at one point to the cell membrane. – Along with a single main chromosome, some prokaryotes have plasmids, which are small, circular, self-replicating loops of double-stranded DNA. ...
Differential recruitment of Dishevelled provides signaling specificity
... Frizzled2 (DFz2) has been proposed to encode the Wg receptor (Bhanot et al. 1996), although confirmation awaits more definitive evidence. This observation also raises the possibility that another member of the Wnt family, of which four have been identified in Drosophila, could function as the PCP li ...
... Frizzled2 (DFz2) has been proposed to encode the Wg receptor (Bhanot et al. 1996), although confirmation awaits more definitive evidence. This observation also raises the possibility that another member of the Wnt family, of which four have been identified in Drosophila, could function as the PCP li ...
Trimeric autotransporter adhesin
In molecular biology, trimeric autotransporter adhesins (TAAs), are proteins found on the outer membrane of Gram-negative bacteria. Bacteria use TAAs in order to infect their host cells via a process called cell adhesion. TAAs also go by another name, oligomeric coiled-coil adhesins, which is shortened to OCAs. In essence, they are virulence factors, factors that make the bacteria harmful and infective to the host organism.TAAs are just one of many methods bacteria use to infect their hosts, infection resulting in diseases such as pneumonia, sepsis, and meningitis. Most bacteria infect their host through a method named the secretion pathway. TAAs are part of the secretion pathway, to be more specific the type Vc secretion system.Trimeric autotransporter adhesins have a unique structure. The structure they hold is crucial to their function. They all appear to have a head-stalk-anchor structure. Each TAA is made up of three identical proteins, hence the name trimeric. Once the membrane anchor has been inserted into the outer membrane, the passenger domain passes through it into the host extracellular environment autonomously, hence the description of autotransporter. The head domain, once assembled, then adheres to an element of the host extracellular matrix, for example, collagen, fibronectin, etc.