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Profile Documents Logout
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UCSC genome support forum
UCSC genome support forum

... 2.2. Enter your assembly of choice and enter your coordinates in the “search term” box 2.3. Click the “submit” button 3. In the blue navigation bar at the top of the screen, click “View/DNA” 4. Click the “get DNA” button 5. Copy the DNA sequence 6. Navigate to http://genome.ucsc.edu/cgi-bin/hgBlat 7 ...
Sample Chapter
Sample Chapter

... The Human Genome Project (HGP) is an 13-year effort, which formally initiated in October 1990. The first idea of Human Genome Project came from the discussions held during scientific meetings, which were organized by the US department of energy and other scientific organizations between 1984 and 198 ...
Molecular Technologies and Diagnostics
Molecular Technologies and Diagnostics

SEGMENTAL VARIATION
SEGMENTAL VARIATION

... • Can’t detect translocations and inversions • Resolution still limited by number of probes on the array—typical resolution about 100 kb • Still a fair amount of variability in results depending on exactly which array is used ...
To Release or Not to Release: Evaluating Information Leaks
To Release or Not to Release: Evaluating Information Leaks

... • In June 2000, the majority of the human genome had in fact been sequenced.[1] • 2010, the cost of genotyping one person is also small. Estimated less than ...
Sequence - andreawise
Sequence - andreawise

... Each sequence record in the NCBI sequence databases is organized into three sections: Header – general information about the sequence including the organism it came from and the paper in which it was first published. Features - information about the role of the sequence in the biology of the organis ...
Genome Sequence Quality - Rice Genome Annotation Project
Genome Sequence Quality - Rice Genome Annotation Project

... NCBI – National Center for Biotechnology Information is one of several organizations (DDBJ and EMBL are two othes) created for this purpose Within NCBI, there are number of databases that hold different types of sequence and sequence related data of varying levels of quality Some of those databases ...
DNA sequencing - Rarechromo.org
DNA sequencing - Rarechromo.org

... as highly repetitive changes (for example those found in Huntington’s disease), are hard to detect using current genome sequencing technologies. For disorders caused by these sorts of changes, a different technique is used. ...
DNA sequencing - Rarechromo.org
DNA sequencing - Rarechromo.org

... as highly repetitive changes (for example those found in Huntington’s disease), are hard to detect using current genome sequencing technologies. For disorders caused by these sorts of changes, a different technique is used. ...
Variant - NC DNA Day
Variant - NC DNA Day

... April 1953 Drs. James Watson and Francis Crick determined the structure of DNA (double helix) ...
Lecture PPT - Carol Lee Lab
Lecture PPT - Carol Lee Lab

... Less than 1.5% of the human genome consists of the suspected ~30,000 protein-coding sequences. By contrast, a large majority is made up of non-coding sequences such as introns (almost 26%) and (mostly defunct) transposable elements (nearly 45%). Synergy between sequence and size in Large-scale genom ...
SEGMENTAL VARIATION
SEGMENTAL VARIATION

... • Can’t detect translocations and inversions • Resolution still limited by number of probes on the array—typical resolution about 100 kb • Still a fair amount of variability in results depending on exactly which array is used ...
Lecture PPT - Carol Lee Lab
Lecture PPT - Carol Lee Lab

... Less than 1.5% of the human genome consists of the suspected ~30,000 protein-coding sequences. By contrast, a large majority is made up of non-coding sequences such as introns (almost 26%) and (mostly defunct) transposable elements (nearly 45%). Synergy between sequence and size in Large-scale genom ...
Individualized Medicine - Federation of American Societies for
Individualized Medicine - Federation of American Societies for

... Knowing the Enemy: Sequencing Pathogens The first genome sequence to be completely deciphered was that of a bacterium, Haemophilus influenzae, which can cause pneumonia and meningitis. Since that publication in 1995, researchers have generated close to 2,000 complete bacterial genome sequences, with ...
(1) in ppt - NYU Computer Science Department
(1) in ppt - NYU Computer Science Department

Lecture 1 - Portal UniMAP
Lecture 1 - Portal UniMAP

... • 1975 George Kohler and Cesar Milstein show that fusing cells can generate monoclonal antibodies. • • 1982 First genetically engineered product - human insulin produced by Eli Lilly and Company using E. coli bacteria - is approved for use by diabetics. ...
12711_2011_2534_MOESM1_ESM
12711_2011_2534_MOESM1_ESM

... 2 contamination present in laboratory reagents may be so small that it is detected only sporadically in negative controls. Repeated amplifications from the same or different extracts from the same specimen are 3 necessary to detect contamination of a particular extraction or amplification and to ide ...
Assignment1
Assignment1

... humans’ by Ingman et al. - available on the course website. You may have to do some background reading to answer some of the questions. (a) Explain what is meant by the ‘recent African origin’ hypothesis, and describe the main reasons why the data in this paper support this hypothesis. (5 marks) (b) ...
Chapter 13 – Genetic Mapping of Mendelian Characters
Chapter 13 – Genetic Mapping of Mendelian Characters

... • Controversy! Science published Celera’s sequence without requiring deposition to GenBank • Celera provides full access, with a catch… ...
Finding the Fault in Nick`s Genome – sp2015
Finding the Fault in Nick`s Genome – sp2015

... Can sequencing Nic's DNA solve this mystery? Nic's doctor and other specialists had already tested Nic for a number of genetic mutations that could cause the observed symptoms, and found nothing. Now they wondered if they could sequence Nic's entire genome, quickly enough to save him, at a reasonab ...
No Slide Title
No Slide Title

... More details about the mouse physical map • found 51,486 homologous crosslinks btw two genomes ...
rabbit - Ensembl Mobile Site
rabbit - Ensembl Mobile Site

... domains/signatures of interest and labelled where appropriate. Stable identifiers were assigned to each gene, transcript, exon and translation. (When annotating a species for the first time, these identifiers are autogenerated. In all subsequent annotations for a species, the stable identifiers are ...
Media:GWAS_lecture__Nov_2011_SB
Media:GWAS_lecture__Nov_2011_SB

... significant associations • Many of these associations have been replicated in independent studies ...
GWAS_lecture_Nov_2010_SB
GWAS_lecture_Nov_2010_SB

... significant associations • Many of these associations have been replicated in independent studies ...
presentation UCSC part 1 - Biomedical Genomics Group
presentation UCSC part 1 - Biomedical Genomics Group

... …are all saved on your computer. When you come back in a couple of days to use it again, these will still be set. You may— or may not—intend this. ...
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Human Genome Project



The Human Genome Project (HGP) is an international scientific research project with the goal of determining the sequence of chemical base pairs which make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and functional standpoint. It remains the world's largest collaborative biological project. The project was proposed and funded by the US government; planning started in 1984, got underway in 1990, and was declared complete in 2003. A parallel project was conducted outside of government by the Celera Corporation, or Celera Genomics, which was formally launched in 1998. Most of the government-sponsored sequencing was performed in twenty universities and research centers in the United States, the United Kingdom, Japan, France, Germany, and China.The Human Genome Project originally aimed to map the nucleotides contained in a human haploid reference genome (more than three billion). The ""genome"" of any given individual is unique; mapping ""the human genome"" involves sequencing multiple variations of each gene.
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