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No Slide Title
No Slide Title

... • VISTA: Visualization of alignment and various sequence features for any number of species C. Mayor, M. Brudno, J.R. Schwartz, A. Poliakov, E. M. Rubin, K. A. Frazer, L. Pachter and I. Dubchak, VISTA: Visualizing global DNA sequence alignments of arbitrary length, ...
DNA-guided genome editing using the
DNA-guided genome editing using the

... +Dnase I ...
RESEARCH ARTICLES
RESEARCH ARTICLES

... exponentially from these early studies. The ability to rapidly digitize genomic information has increased by more than eight orders of magnitude over the past 25 years (3). Efforts to understand all this new genomic information have spawned numerous new computational and experimental paradigms, yet ...
Discovering conserved DNA
Discovering conserved DNA

... All ChIP-selected targets ...
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Document

... Allozymes-different forms of an enzyme Used in the past frequently, rarely today. Gives presence/absence of enzyme types. Can have 2 allozymes per sample (2 alleles of a gene=heterozygous). More difficult to code for phylogenetic study. ...
The Difference Makers
The Difference Makers

... times cells make copies of these transposons while attemptthinking that transposons are friends, but don’t be fooled, ing to repair damage created when the transposons sliced the Feschotte says. “They are not there to make us happy.” TransDNA. But because they don’t actively copy themselves, DNA pos ...
Overview
Overview

RefGen_v3_status_20120522
RefGen_v3_status_20120522

... organisms; ii) inappropriate gap placement and length representation; iii) unacceptable construction of a “chr0” to represent unanchored scaffolds (chr0 needs to be broken up into individual scaffolds). We are fortunate that GenBank is making allowances for RefGen_v2 so as to maintain consistency of ...
Draft of first homework
Draft of first homework

... to be unbiased in terms of annotation, so that you can see any mRNAs, including unknown ones. In the same line of thinking, the mRNA tracks are not the whole truth, just the mRNAs we know about at present. If we wanted to just detect known mRNAs we could have settled for one probe per gene (= an old ...
U.S. – Russia Scientific Forum Rare Diseases
U.S. – Russia Scientific Forum Rare Diseases

... advance the cause of rare disease research • David Adams: [email protected] For an updated copy of these slides, go to: ftp://ftp.nhgri.nih.gov/pub/NIHUDP/MOSCOW2011/presentation.pdf ...
Cancer Genetics I (Chapter 11/12)
Cancer Genetics I (Chapter 11/12)

... Keep in mind the mechanistic heterogeneity; multiple ways to gain or loose protein function ...
Journal of Biotechnology
Journal of Biotechnology

... gaps revealed that most of the gaps (25 of 34) between scaffolded contigs were relatively small (3 ± 10 bp). They seem to be due to inverted repeats forming stable secondary structures which might result in no or poor amplification during the various PCR steps involved in library preparation and NGS ...
Karyotyping, FISH and CGH array
Karyotyping, FISH and CGH array

... A single nucleotide polymorphism (SNP), a variation at a single site in DNA, is the most frequent type of variation in the genome. For example, there are around 50 million SNPs that have been identified in the human genome. Most of them are non pathological. The basic principles and techniques of SN ...
PAN PROSTATE GENOMICS CONSORTIUM October 2016
PAN PROSTATE GENOMICS CONSORTIUM October 2016

... from different stages of progression from normal, to organ confined disease, to metastases; (iii) early onset prostate cancer; (iv) prostate cancer from aggressive and indolent disease; and (v) prostate cancer patients managed by different treatments with information linked to detailed and ongoing c ...
14–3 Human Molecular Genetics
14–3 Human Molecular Genetics

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CapeTownGenomes
CapeTownGenomes

... Single contiguous section of DNA (a set of overlapping DNA segments derived from a single genetic source) ...
Career Advancement Workshop
Career Advancement Workshop

... Workshop on FCP Accelerated NGS Srinivas Aluru Iowa State University ...
Powerpoint document
Powerpoint document

... Genome Project when company officials announced they would create a map in only three years, while the government project had been working on it for about a decade. (http://www.wirednews.cmo/news/tecnology/0,1282,41 ...
bbr038online 474..484 - Oxford Academic
bbr038online 474..484 - Oxford Academic

... Recent development of deep sequencing technologies has facilitated de novo genome sequencing projects, now conducted even by individual laboratories. However, this will yield more and more genome sequences that are not well assembled, and will hinder thorough annotation when no closely related refer ...
2001_butterfield_THE SUGARCANE GENOME
2001_butterfield_THE SUGARCANE GENOME

... robustum and S. officinarum, and a monoploid number of 10 for ancestral Saccharum may indicate a more ancient origin for these species than S. spontaneum. This would agree with the conclusions of Wilson et al. (1999). An alternative explanation for preferential pairing, however, could be the presenc ...
- CSHL Institutional Repository
- CSHL Institutional Repository

... build a new model organism database. We provide a brief description of the GMOD core components used to build ParameciumDB. Chado is a modular relational database schema developed at FlyBase. ParameciumDB implements the Chado schema using the PostgreSQL open source relational database management sys ...
One system, one workflow, powerful new sequencing applications
One system, one workflow, powerful new sequencing applications

... The Supernova™ Assembler utilizes Linked-Reads to de novo construct multi-megabase diploid assemblies, preserving phasing information for small variants, structural rearrangements and novel sequence. ...
Genome Biology and
Genome Biology and

... • The two genome sequences diverge by nearly one substitution for every two nucleotides ...
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... Direction for use of these tools is available at the above sites and is beyond the scope of this tutorial For a small number of BLASTs, you can use web-based methods and common programs such as Word and Excel plus any of a number of downloadable tree drawing programs to make these kinds of trees on ...
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Human Genome Project



The Human Genome Project (HGP) is an international scientific research project with the goal of determining the sequence of chemical base pairs which make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and functional standpoint. It remains the world's largest collaborative biological project. The project was proposed and funded by the US government; planning started in 1984, got underway in 1990, and was declared complete in 2003. A parallel project was conducted outside of government by the Celera Corporation, or Celera Genomics, which was formally launched in 1998. Most of the government-sponsored sequencing was performed in twenty universities and research centers in the United States, the United Kingdom, Japan, France, Germany, and China.The Human Genome Project originally aimed to map the nucleotides contained in a human haploid reference genome (more than three billion). The ""genome"" of any given individual is unique; mapping ""the human genome"" involves sequencing multiple variations of each gene.
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