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PHYSIOLOGICAL ROLE OF CELL ORGANELLE
PHYSIOLOGICAL ROLE OF CELL ORGANELLE

...  Vesicle contains proteins destined for extracellular release.  After packaging the vesicles bud off and immediately move towards the plasma membrane.  Where they fuse and release the contents into the extracellular space in a process known as constitutive secretion.  Antibodies release by activ ...
Epilepsy and Seizure Disorders
Epilepsy and Seizure Disorders

... Partial seizures spread into the other hemisphere via the corpus callosum Increase in extracellular K+ and accumulation of Ca2+ in presynaptic terminals also causes recruitment of more neurons  Type, number and distribution of voltage- and ligand-gated channels ...
Distinct Requirements for Evoked and Spontaneous Release of
Distinct Requirements for Evoked and Spontaneous Release of

Neuronal cytoskeleton in synaptic plasticity and regeneration
Neuronal cytoskeleton in synaptic plasticity and regeneration

... Actin and actin-regulatory proteins in synaptic plasticity The post-synaptic elements of the majority of excitatory (glutamatergic) synapses on cortical and hippocampal neurons are formed by small, actin-rich protrusions called dendritic spines that emerge from the shafts of dendrites. Neuronal acti ...
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... • Can be the end of a sensory neuron • Can be a specialized cell (such as light receptor or chemical receptor cells) that detect a specific stimulus and influence the activity of a sensory neuron ...
The Nervous System - Science-with
The Nervous System - Science-with

... two motor neurons.  the impulse causes the quadriceps to contract and hamstring to relax.  this causes your lower leg to rise. ...
BrainMechanismsofUnconsciousInference2011
BrainMechanismsofUnconsciousInference2011

... is moving in a certain direction. – Destroy MT on one side of the brain, and perception of motion in the opposite side of space is greatly impaired. ...
Autonomic Nervous System
Autonomic Nervous System

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Nervous System - Princeton ISD
Nervous System - Princeton ISD

... Neurotransmitter bound to a postsynaptic neuron: ...
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+ -80 mV

... Ex is the potential at which the flux due to diffusion is equal and opposite to the flux due to electrophoresis ...
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Anti-5HT1D Receptor antibody

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APCHAPTER14
APCHAPTER14

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I joined the Smith lab in the spring of 2000, as a
I joined the Smith lab in the spring of 2000, as a

... complex circuitry of the basal ganglia. The approach of the lab to try to understand the relations between anatomy and physiology is very appealing to me. Also, since the lab is part of the Yerkes National Primate Research Center, I consider that it is a major privilege to be able to explore these q ...
Solving the Distal Reward Problem through
Solving the Distal Reward Problem through

... where sd is the time constant of DA uptake and DA(t) models the source of DA due to the activity of dopaminergic neurons in the midbrain structures VTA and substantia nigra pars compacta. A better description of DA kinetics, based on Michaelis--Menten formalism, was recently suggested by Montague et ...
Autonomic nervous system
Autonomic nervous system

... the pupils, micturition (urination), and sexual arousal. Whereas most of its actions are involuntary, some, such as breathing, work in tandem with the conscious mind. It is classically divided into two subsystems: the parasympathetic nervous system and sympathetic nervous system.[1][2] Relatively re ...
Biology 232
Biology 232

... sympathetic, splanchnic, and pelvic nerves – preganglionic and postganglionic axons traveling to ganglia or effectors in body cavities Neurotransmitters of the ANS cholinergic neurons – release acetylcholine (ACh) all preganglionic neurons all parasympathetic postganglionic neurons a few sympathetic ...
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... expression of LIM class homeodomain proteins regulates this dorsoventral projection. The LIM homeodomain protein Isl1 expressed by medial LMC neurons directs a high level of expression of EphB receptors, such that as the axons of these cells enter the limb they are prevented from projecting dorsally ...
Spike-Timing Theory of Working Memory
Spike-Timing Theory of Working Memory

Autonomic Nervous System
Autonomic Nervous System

... 2. Adrenergic receptor sites • a. Located on membranes of effectors innervated by sympathetic division • b. Respond to epinephrine or norepinephrine • c. May be excitatory or inhibitory depending on effector • d. These receptors can respond to ANS or to adrenalin released from the adrenal medulla • ...
Active dendrites, potassium channels and synaptic plasticity
Active dendrites, potassium channels and synaptic plasticity

... Strong support for the importance of back-propagating APs and LTP induction was provided by a technically challenging set of experiments carried out by Jeff Magee (Magee & Johnston 1997). Dendritic recordings were made during synaptic stimulation alone, and when EPSPs were paired with b-APs. When th ...
A soft-wired hypothalamus
A soft-wired hypothalamus

... recording in slice preparations together with stereology to quantify the synaptic density onto these cells. The results showed that leptin-deficient ob/ob mice differed from wild-type mice in the numbers of excitatory and inhibitory synapses and postsynaptic currents onto NPY and POMC neurons. When ...
Nervous System
Nervous System

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What is “membrane potential”
What is “membrane potential”

... “Neuro transmitters” are the chemical signal passed from cell-to-cell Common examples -- Dopamine -- Serotonin -- Acetylcholine Some are inhibitory -- GABA ...
Beyond Spikes: Neural Codes and the Chemical Vocabulary of
Beyond Spikes: Neural Codes and the Chemical Vocabulary of

Presentation 5: The Role of the Nervous System
Presentation 5: The Role of the Nervous System

... Synapse: Area between the synaptic knob of one neuron and the membrane of another neuron ...
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Chemical synapse



Chemical synapses are specialized junctions through which neurons signal to each other and to non-neuronal cells such as those in muscles or glands. Chemical synapses allow neurons to form circuits within the central nervous system. They are crucial to the biological computations that underlie perception and thought. They allow the nervous system to connect to and control other systems of the body.At a chemical synapse, one neuron releases neurotransmitter molecules into a small space (the synaptic cleft) that is adjacent to another neuron. The neurotransmitters are kept within small sacs called vesicles, and are released into the synaptic cleft by exocytosis. These molecules then bind to receptors on the postsynaptic cell's side of the synaptic cleft. Finally, the neurotransmitters must be cleared from the synapse through one of several potential mechanisms including enzymatic degradation or re-uptake by specific transporters either on the presynaptic cell or possibly by neuroglia to terminate the action of the transmitter.The adult human brain is estimated to contain from 1014 to 5 × 1014 (100–500 trillion) synapses. Every cubic millimeter of cerebral cortex contains roughly a billion (short scale, i.e. 109) of them.The word ""synapse"" comes from ""synaptein"", which Sir Charles Scott Sherrington and colleagues coined from the Greek ""syn-"" (""together"") and ""haptein"" (""to clasp""). Chemical synapses are not the only type of biological synapse: electrical and immunological synapses also exist. Without a qualifier, however, ""synapse"" commonly means chemical synapse.
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