HCV Protease Inhibitors
... Integrase Inhibitors – Elvitegravir (GS 9137): RTV boosted, in development ...
... Integrase Inhibitors – Elvitegravir (GS 9137): RTV boosted, in development ...
2-Sulfonamide & Fluo..
... induce bacterial resistance than either agent alone. These agents block sequentially at two different steps in the same essential pathway, and this combination is extremely difficult for a naive microorganism to survive. Combined with sulfamethoxazole, it is used for oral treatment of urinary tr ...
... induce bacterial resistance than either agent alone. These agents block sequentially at two different steps in the same essential pathway, and this combination is extremely difficult for a naive microorganism to survive. Combined with sulfamethoxazole, it is used for oral treatment of urinary tr ...
Combination Therapy of HIV Infection
... Drug resistance can be more appropriately termed "altered drug susceptibility." It is a phenomenon that can occur in vivo and in vitro, in response to the exposure of HIV to a drug or to a combination of drugs. The high rate of viral replication found throughout the course of HIV infection and the h ...
... Drug resistance can be more appropriately termed "altered drug susceptibility." It is a phenomenon that can occur in vivo and in vitro, in response to the exposure of HIV to a drug or to a combination of drugs. The high rate of viral replication found throughout the course of HIV infection and the h ...
Action of and Resistance to drugs and toxic metals
... • Acts as a competetive inhibitor in synthesis of Folic acid • CoF participates in several biosynthetic reactions – aa, ...
... • Acts as a competetive inhibitor in synthesis of Folic acid • CoF participates in several biosynthetic reactions – aa, ...
File
... SSRIs have little activity to block muscarinic, histamine H1, α-adrenergic receptors & relatively safe in over dose ...
... SSRIs have little activity to block muscarinic, histamine H1, α-adrenergic receptors & relatively safe in over dose ...
The use of beta-lactamase inhibitors to reconquer resistance
... before. Soon after the introduction of penicillin, Staphylococcus aureus strains that contained a beta-lactamase rapidly emerged and at present around 90% of strains are beta-lactamase positive and resistant to penicillin and amoxicillin. In Gram-negatives, various beta-lactamases have been found; s ...
... before. Soon after the introduction of penicillin, Staphylococcus aureus strains that contained a beta-lactamase rapidly emerged and at present around 90% of strains are beta-lactamase positive and resistant to penicillin and amoxicillin. In Gram-negatives, various beta-lactamases have been found; s ...
Limitations of Antiretroviral Therapy
... HIV makes copies of itself very rapidly ~ 1-10 billion new virus particles/day During its replication, HIV is prone to make errors when copying itself ...
... HIV makes copies of itself very rapidly ~ 1-10 billion new virus particles/day During its replication, HIV is prone to make errors when copying itself ...
Causes of anaphylaxis
... INH + rifampin + PZA + ethambutol (or streptomycin) for 2 months 2. Continuation phase INH + rifampin for 4 (or 7) months ...
... INH + rifampin + PZA + ethambutol (or streptomycin) for 2 months 2. Continuation phase INH + rifampin for 4 (or 7) months ...
Biochemistry I, Spring Term 2002 - Second Exam:
... 1. The binding affinity of a ligand to a protein is affected by temperature if: a) the enthalpy of binding is zero. b) the entropy of binding is zero. c) the enthalpy of binding is not zero. d) the entropy of binding is not zero. 2. In comparing the binding of two drugs to an enzyme, one would compa ...
... 1. The binding affinity of a ligand to a protein is affected by temperature if: a) the enthalpy of binding is zero. b) the entropy of binding is zero. c) the enthalpy of binding is not zero. d) the entropy of binding is not zero. 2. In comparing the binding of two drugs to an enzyme, one would compa ...
Corticosteroid
... nucleus where it homodimerizes with another occupied receptor (like estrogen and all other vertebrate steroids). The chaperone proteins are released and the homodimer complex becomes a ligand‐activated transcription factor that interacts with DNA to initiate transcription of proteins (like anti‐ ...
... nucleus where it homodimerizes with another occupied receptor (like estrogen and all other vertebrate steroids). The chaperone proteins are released and the homodimer complex becomes a ligand‐activated transcription factor that interacts with DNA to initiate transcription of proteins (like anti‐ ...
Antibiotic Selection
... differences between prokaryotic and eukaryotic RNA polymerase: (Rifampcin) • Inhibitors of DNA Synthesis: Selectivity due to differences between prokaryotic and eukaryotic enzymes: (Quinolones) • Inhibitors of Folic Acid Synthesis :bacteria make it, we get it from diet (Sulfonamides) ...
... differences between prokaryotic and eukaryotic RNA polymerase: (Rifampcin) • Inhibitors of DNA Synthesis: Selectivity due to differences between prokaryotic and eukaryotic enzymes: (Quinolones) • Inhibitors of Folic Acid Synthesis :bacteria make it, we get it from diet (Sulfonamides) ...
86a-CO-Pharmacology
... Roll - Meditation/breath of arrival, What will be covered today ( •Some say average person in the U.S. is on 10 medications (over and under counter). •This can be a godsend or a misfortune. •In any case, we generally are seeing clients on some form or forms of medication. •This is important info to ...
... Roll - Meditation/breath of arrival, What will be covered today ( •Some say average person in the U.S. is on 10 medications (over and under counter). •This can be a godsend or a misfortune. •In any case, we generally are seeing clients on some form or forms of medication. •This is important info to ...
2. Mechanisms
... in CSF ( sulfadiazine and sulfisoxazole, may be effective in meningeal infections) ;readily passing through the placenta. • Metabolized in the liver by acetylation. • Eliminated mainly in the urine as the unchanged drug and metabolic product. In acid urine, the eliminated may precipitate, thus induc ...
... in CSF ( sulfadiazine and sulfisoxazole, may be effective in meningeal infections) ;readily passing through the placenta. • Metabolized in the liver by acetylation. • Eliminated mainly in the urine as the unchanged drug and metabolic product. In acid urine, the eliminated may precipitate, thus induc ...
Gene therapy vNS 20015 F_7
... • Retroviruses have diploid genome of about 7-10kb composed of four gene regions gag, pro (core proteins), pol (RT &integrase) and env • Packaging signal ...
... • Retroviruses have diploid genome of about 7-10kb composed of four gene regions gag, pro (core proteins), pol (RT &integrase) and env • Packaging signal ...
Pharmacogenomics PGx Personalized Medicine
... • bb thumb bends at 90 degree angle (homozygous recessive) ...
... • bb thumb bends at 90 degree angle (homozygous recessive) ...
Recent Trends in Challenges to Forensic Evidence Used in Criminal
... with the goal of mimicking those substances Often marketed as herbal incense, bath salts, jewelry cleaner, or plant food, and have caused significant abuse, addiction, overdoses, and emergency room visits They are labeled “not for human consumption” to mask their intended purpose and avoid Food and ...
... with the goal of mimicking those substances Often marketed as herbal incense, bath salts, jewelry cleaner, or plant food, and have caused significant abuse, addiction, overdoses, and emergency room visits They are labeled “not for human consumption” to mask their intended purpose and avoid Food and ...
chapt12_lecture
... resistant cells due to prior mutations or transfer of plasmids – no growth advantage until exposed to drug • If exposed, sensitive cells are inhibited or destroyed while resistance cells will survive and proliferate. • Eventually population will be resistant – selective ...
... resistant cells due to prior mutations or transfer of plasmids – no growth advantage until exposed to drug • If exposed, sensitive cells are inhibited or destroyed while resistance cells will survive and proliferate. • Eventually population will be resistant – selective ...
cancer - ichapps.com
... vomiting. Myelosuppression (thrombocytopenia and neutropenia) occur later in the treatment cycle. Hepatotoxicity with hepatic vascular occlusion may also occur in long-term treatments. Procarbazine: Procarbazine is an orally active methyl hydrazine derivative, it is used in combination regimens for ...
... vomiting. Myelosuppression (thrombocytopenia and neutropenia) occur later in the treatment cycle. Hepatotoxicity with hepatic vascular occlusion may also occur in long-term treatments. Procarbazine: Procarbazine is an orally active methyl hydrazine derivative, it is used in combination regimens for ...
... 'Peptide 3' which was a small peptide derived from the chemokine MCP-1. It was found that the critical motif for activity was the tripeptide WVG, tryptophan and valine represents a hydrophobic component next to an amide functionality of glutamine. A number of small molecules have been synthesised as ...
Lecture 7 - Antidepressants new 11-12
... Too long (3-11 days): Fluoxetine (Prozac) Moderate length (~24hr): Sertraline, Paroxetine, Citalopram. Metabolism: P450 then conjugation They are enzyme inhibitors Weak inhibitors < Sertraline, Citalopram interaction Strong inhibitors > Fluoxetine, Paroxetine metabolism of TCA, neurolep ...
... Too long (3-11 days): Fluoxetine (Prozac) Moderate length (~24hr): Sertraline, Paroxetine, Citalopram. Metabolism: P450 then conjugation They are enzyme inhibitors Weak inhibitors < Sertraline, Citalopram interaction Strong inhibitors > Fluoxetine, Paroxetine metabolism of TCA, neurolep ...
Cancer - Different Fates
... to very subtle changes in proteins. For example, if a SNP causes the codon GAU to change to GAG, the amino acid changes from aspartic acid to glutamic acid. These amino acids have very similar chemical properties, but glutamic acid is just a little bigger. If the SNP causes a change in a part of the ...
... to very subtle changes in proteins. For example, if a SNP causes the codon GAU to change to GAG, the amino acid changes from aspartic acid to glutamic acid. These amino acids have very similar chemical properties, but glutamic acid is just a little bigger. If the SNP causes a change in a part of the ...
Nanostructures for the Inhibition of Viral Infections
... must lead that machinery to replicate successfully. In each viral replication cycle, 100–1000 new viral particles are produced. All viruses replicate via a broadly similar sequence of events, as highlighted schematically in Figure 2A. The first course of action is the attachment of the surface prote ...
... must lead that machinery to replicate successfully. In each viral replication cycle, 100–1000 new viral particles are produced. All viruses replicate via a broadly similar sequence of events, as highlighted schematically in Figure 2A. The first course of action is the attachment of the surface prote ...
5-HIV-Pharmacotherapy-Update-2016-no
... • 800mg daily boosted with ritonavir for treatment naïve patients, 600mg BID boosted for treatment experienced • Take with food • Very high barrier to resistance • Not recommended in severe liver disease • Less metabolic side effects than older PIs • Possible rash on initiation ...
... • 800mg daily boosted with ritonavir for treatment naïve patients, 600mg BID boosted for treatment experienced • Take with food • Very high barrier to resistance • Not recommended in severe liver disease • Less metabolic side effects than older PIs • Possible rash on initiation ...