Citeline Pharma R&D Annual Review 2015 Supplement: New Active
... industry has to do is work out how to get them to all of the patients who would benefit from them. Pricing issues are thus far proving restrictive, but as more and better molecules continue to join the first generation of direct anti-HCV antivirals, the situation is in rapid flux. In fact, with most ...
... industry has to do is work out how to get them to all of the patients who would benefit from them. Pricing issues are thus far proving restrictive, but as more and better molecules continue to join the first generation of direct anti-HCV antivirals, the situation is in rapid flux. In fact, with most ...
Senate HCV Drug Pricing Investigation Federal Needle Exchange Ban Lifted
... senior committee member Chuck Grassley, R-Iowa, released a 144-page report detailing the results of their 18-month investigation of Gilead Science’s pricing and marketing of Hepatitis C Virus (HCV) drugs sofosbuvir (Sovaldi) and sofosbuvir/ledipasvir (Harvoni). The full report, as well as the variou ...
... senior committee member Chuck Grassley, R-Iowa, released a 144-page report detailing the results of their 18-month investigation of Gilead Science’s pricing and marketing of Hepatitis C Virus (HCV) drugs sofosbuvir (Sovaldi) and sofosbuvir/ledipasvir (Harvoni). The full report, as well as the variou ...
汤慧芳
... NXL 103, a new oral streptogramin currently in phase II trials (As of). It will be used to treat respiratory tract ...
... NXL 103, a new oral streptogramin currently in phase II trials (As of). It will be used to treat respiratory tract ...
Olszewska Tibotec ERJ paper 2010 - Spiral
... validated in our lab. Three sections from the upper, medium and lower lung were scored blindly in a random order according to the degree of inflammation in interstitium, alveoli, surrounding airways and vessels. A value of 0 (none), 1 (minimal), 2 (mild), 3 (moderate), or 4 (severe) was assigned to ...
... validated in our lab. Three sections from the upper, medium and lower lung were scored blindly in a random order according to the degree of inflammation in interstitium, alveoli, surrounding airways and vessels. A value of 0 (none), 1 (minimal), 2 (mild), 3 (moderate), or 4 (severe) was assigned to ...
Pharm
... Which of the following is true of cycloserine? a. Can be used for tuberculosis or mycobacterium avium complex as a first line agent b. Works by destabilizing the cell membrane in mycobacterium c. Is an antimicrobial that is effective against resistant organisms d. Can block D-alanine racemase and L ...
... Which of the following is true of cycloserine? a. Can be used for tuberculosis or mycobacterium avium complex as a first line agent b. Works by destabilizing the cell membrane in mycobacterium c. Is an antimicrobial that is effective against resistant organisms d. Can block D-alanine racemase and L ...
Mechanism of action
... They are potent inhibitors of many bacterial beta-lactamases and can protect hydrolyzable penicillins from inactivation by these enzymes. They are included in combination with amoxacillin (Augmentum) or with ticaricillin. In particular, clavulanic acid is an irreversible, "suicide" inhibitor of beta ...
... They are potent inhibitors of many bacterial beta-lactamases and can protect hydrolyzable penicillins from inactivation by these enzymes. They are included in combination with amoxacillin (Augmentum) or with ticaricillin. In particular, clavulanic acid is an irreversible, "suicide" inhibitor of beta ...
- BioTek Instruments
... labs. For dual emission assays, such as time-resolved fluorescence resonance energy transfer (TR-FRET), the unit uses a filter cube design that allows simultaneous measurement of donor and acceptor fluorescence using dual photomultiplier tubes (PMTs), one which is a red-shifted PMT with high sensiti ...
... labs. For dual emission assays, such as time-resolved fluorescence resonance energy transfer (TR-FRET), the unit uses a filter cube design that allows simultaneous measurement of donor and acceptor fluorescence using dual photomultiplier tubes (PMTs), one which is a red-shifted PMT with high sensiti ...
IMPAACT P1093: Phase I/II, Multi-Center, Open
... KVX: p=0.021 vs. EFV KVX: p=0.115 vs. EFV KVX: p=0.128 vs. EFV ...
... KVX: p=0.021 vs. EFV KVX: p=0.115 vs. EFV KVX: p=0.128 vs. EFV ...
Statistical potentials and scoring functions applied to protein–ligand
... implicitly incorporates physical effects not yet fully understood from a theoretical point of view, for example, (de)solvation and polarization. A major concern with statistical potentials is that they might only model geometric properties close to experimental (near-native) situations previously ob ...
... implicitly incorporates physical effects not yet fully understood from a theoretical point of view, for example, (de)solvation and polarization. A major concern with statistical potentials is that they might only model geometric properties close to experimental (near-native) situations previously ob ...
Antibiotic Update
... • Drugs vary widely regarding spectrum of activity, and detailed knowledge of this will require much study and/or experience – Even within same class, spectrum can be quite different ...
... • Drugs vary widely regarding spectrum of activity, and detailed knowledge of this will require much study and/or experience – Even within same class, spectrum can be quite different ...
cardiovascular drugs and autacoids
... 9- This effect is particularly valuable in diabetes, and these drugs are now recommended in diabetes even in the absence of hypertension. ...
... 9- This effect is particularly valuable in diabetes, and these drugs are now recommended in diabetes even in the absence of hypertension. ...
Kinetic models
... summary can be useful is that two critical features of the data are captured. The first is an estimate of the “midpoint” of the amount/effect relationship of y on [A] given by EC50. This gives a (rough) estimate of the affinity of the interaction between drug and site. The second is an estimate of t ...
... summary can be useful is that two critical features of the data are captured. The first is an estimate of the “midpoint” of the amount/effect relationship of y on [A] given by EC50. This gives a (rough) estimate of the affinity of the interaction between drug and site. The second is an estimate of t ...
Anti-tuberculous drugs
... • Taken 30 min before the breakfast as absorption of rifampicin is influenced by food ...
... • Taken 30 min before the breakfast as absorption of rifampicin is influenced by food ...
On the specificity of antibiotics targeting the large ribosomal subunit
... M),10 which could reflect the CAM-1 and CAM-2 sites, respectively. Although no evidence for CAM-2 was seen in the E70S structure determined using 0.5 mM CAM,6 cross-linking of CAM to E. coli and archaeal H. halobium ribosomes identified modifications within the ERY binding site consistent with the ...
... M),10 which could reflect the CAM-1 and CAM-2 sites, respectively. Although no evidence for CAM-2 was seen in the E70S structure determined using 0.5 mM CAM,6 cross-linking of CAM to E. coli and archaeal H. halobium ribosomes identified modifications within the ERY binding site consistent with the ...
Case Report - Thalidomide and hyperkalemia
... proliferation In some tumor types, such as RCC and certain lymphomas, mTOR as key role in tumor cell proliferation and angiogenesis Temsirolimus and everolimus are approved as monotherapy in advanced RCC ...
... proliferation In some tumor types, such as RCC and certain lymphomas, mTOR as key role in tumor cell proliferation and angiogenesis Temsirolimus and everolimus are approved as monotherapy in advanced RCC ...
Application of drugs based on release-active
... Reports in international press on adverse events associated with the drug use ...
... Reports in international press on adverse events associated with the drug use ...
Chapter 1 - Drug Discovery and Development: An Overview of
... complexity is a common feature of the vast majority of disease states and must be addressed in order to successfully develop any new medication. Given the large number of complex issues associated with drug design and development, it should be abundantly clear that no one individual could possibly c ...
... complexity is a common feature of the vast majority of disease states and must be addressed in order to successfully develop any new medication. Given the large number of complex issues associated with drug design and development, it should be abundantly clear that no one individual could possibly c ...
Non commercial use only - Italian Journal of Medicine
... they do share one common characteristic: they act all as indirect drugs. Vitamin K antagonists act by reducing the synthesis of clotting factors so reducing the power of clotting ability.1 Heparins act through their link with antithrombin so inducing an increased and fast inhibition of activated clo ...
... they do share one common characteristic: they act all as indirect drugs. Vitamin K antagonists act by reducing the synthesis of clotting factors so reducing the power of clotting ability.1 Heparins act through their link with antithrombin so inducing an increased and fast inhibition of activated clo ...
Antiviral Drugs for Viruses Other Than Human Immunodeficiency Virus
... Symposium on Antimicrobial Therapy will be available for purchase from our Web site www.mayoclinicproceedings.com. © 2011 Mayo Foundation for Medical Education and Research ...
... Symposium on Antimicrobial Therapy will be available for purchase from our Web site www.mayoclinicproceedings.com. © 2011 Mayo Foundation for Medical Education and Research ...
Teck TalkCEJanENG - Canadian Healthcare Network
... selective inhibitors can lose their selectivity when used in higher than normal doses used for arthritis, so they can potentially cause stomach problems in some patients. COX-2 selective inhibitors do not inhibit production of thromboxane, a substance that causes platelets in the blood to stick toge ...
... selective inhibitors can lose their selectivity when used in higher than normal doses used for arthritis, so they can potentially cause stomach problems in some patients. COX-2 selective inhibitors do not inhibit production of thromboxane, a substance that causes platelets in the blood to stick toge ...
Structural studies on molecular mechanisms of Nelfinavir resistance
... nonfunctional polyproteins that include gag and pol proteins, reverse transcriptase, integrase, and protease itself, and is responsible for creating the mature and functional components of the protein [9]. Functional inhibition of HIV-1 PR leads to incomplete viral replication and therefore makes it ...
... nonfunctional polyproteins that include gag and pol proteins, reverse transcriptase, integrase, and protease itself, and is responsible for creating the mature and functional components of the protein [9]. Functional inhibition of HIV-1 PR leads to incomplete viral replication and therefore makes it ...
Selective Inhibition of Human Solute Carrier Transporters by
... conducted after a further 24 hours, as described by Zhou et al. (2011). Protein was estimated by the method of Bradford (1976). In these experiments, substrate concentrations were as follows: OATP1A2, OATP1B1, OATP2B1, and OAT3 ([3H]E3S 300 nM, 68.8 nCi); OATP1B3 ([3H]CCK-8 2 nM, 23.4 nCi); OAT1 ([3 ...
... conducted after a further 24 hours, as described by Zhou et al. (2011). Protein was estimated by the method of Bradford (1976). In these experiments, substrate concentrations were as follows: OATP1A2, OATP1B1, OATP2B1, and OAT3 ([3H]E3S 300 nM, 68.8 nCi); OATP1B3 ([3H]CCK-8 2 nM, 23.4 nCi); OAT1 ([3 ...
Nonsteroidal anti-inflammatory drugs
... ‡ In clinical practice acetylsalicylic acid is used in children with inflammatory diseases of all ages, but it is not recommended in cases with suspected viral etiology because of the increased risk of Reye syndrome. § Indomethacin is used to treat persistent ductus arteriosus in newborns and to con ...
... ‡ In clinical practice acetylsalicylic acid is used in children with inflammatory diseases of all ages, but it is not recommended in cases with suspected viral etiology because of the increased risk of Reye syndrome. § Indomethacin is used to treat persistent ductus arteriosus in newborns and to con ...
P h a rmaceutical industry is short ... drugs. Whereas in past decades about 50-60 new
... and of neurotransmitter uptake inhibitors has not been fully exploited. Similar success stories can be told about the steroid hormones and their more selective synthetic analogs. A first breakthrough in the development of bioavailable analogs resulted from the introduction of 17a-residues, especiall ...
... and of neurotransmitter uptake inhibitors has not been fully exploited. Similar success stories can be told about the steroid hormones and their more selective synthetic analogs. A first breakthrough in the development of bioavailable analogs resulted from the introduction of 17a-residues, especiall ...