Molecular modification
... product is made, marketed and sold by Pfizer Pharmaceuticals, which acquired Pharmacia and Upjohn in 2002. In fact, it is now one of the most prescribed psychotropic drugs and is available under more than 40 brand names on market nowadays. Mostly it is prescribed as "Xanax”. However, in Latin-Americ ...
... product is made, marketed and sold by Pfizer Pharmaceuticals, which acquired Pharmacia and Upjohn in 2002. In fact, it is now one of the most prescribed psychotropic drugs and is available under more than 40 brand names on market nowadays. Mostly it is prescribed as "Xanax”. However, in Latin-Americ ...
(Zofran) Training Module - Nor
... trigger nausea and vomiting. Zofran is a serotonin 5HT3receptor antagonist. One part is to reduce the activity of the vagus nerve. The vagus nerve activates the vomiting center in the medulla oblongata. Zofran does NOT have an effect on the dopamine or muscarinicreceptors. ...
... trigger nausea and vomiting. Zofran is a serotonin 5HT3receptor antagonist. One part is to reduce the activity of the vagus nerve. The vagus nerve activates the vomiting center in the medulla oblongata. Zofran does NOT have an effect on the dopamine or muscarinicreceptors. ...
Is GERD a Factor in Osteonecrosis of the Jaw? Evidence of
... times as likely to be found in the target set A AND B as would be predicted assuming independence. It turns out to be a very powerful method of extracting synergistic relationships among features in the data, as will be shown in Results. A simplified example may be helpful to elucidate the concept. ...
... times as likely to be found in the target set A AND B as would be predicted assuming independence. It turns out to be a very powerful method of extracting synergistic relationships among features in the data, as will be shown in Results. A simplified example may be helpful to elucidate the concept. ...
IDENTIFICATION OF NATURAL PRODUCTS AS ANTIDIABETIC AGENTS Laura Guasch Pàmies
... been demonstrated to reduce macrovascular events in T2DM, its use is not recommended in conditions in which a patient has decreased renal or hepatic function. Metformin is the first-line drug of choice for the treatment of T2DM, particularly in overweight and obese patients and those with normal kid ...
... been demonstrated to reduce macrovascular events in T2DM, its use is not recommended in conditions in which a patient has decreased renal or hepatic function. Metformin is the first-line drug of choice for the treatment of T2DM, particularly in overweight and obese patients and those with normal kid ...
ASHP Guidelines on Surgery and Anesthesi
... continuation of maintenance medications and discontinuation of unnecessary medications postoperatively. Medication-Use Evaluation. The pharmacist should take a leadership role in the performance of medication-use evaluations by establishing criteria, collecting data, analyzing the data, making recom ...
... continuation of maintenance medications and discontinuation of unnecessary medications postoperatively. Medication-Use Evaluation. The pharmacist should take a leadership role in the performance of medication-use evaluations by establishing criteria, collecting data, analyzing the data, making recom ...
Inhaled Adrenergic Bronchodilators: Historical
... receptors, ␣ and .10 The ␣ receptor was associated with excitatory functions, with the exception of the intestine, where an inhibitory effect was observed. The  receptor was associated with inhibition, with the exception of the myocardium, where an excitatory effect was observed. This concept of t ...
... receptors, ␣ and .10 The ␣ receptor was associated with excitatory functions, with the exception of the intestine, where an inhibitory effect was observed. The  receptor was associated with inhibition, with the exception of the myocardium, where an excitatory effect was observed. This concept of t ...
TASTE MASKED CHEWABLE DISPERSIBLE TABLET OF ATOMOXETINE HYDROCHLORIDE Research Article HUDA.I.G*
... The bitter taste of the drugs which are orally administered often contributes to patient non-compliance in taking medicines, especially for children and elderly (1). Unfortunately, majority of the drugs have a natural bitter taste that can create a burning feeling in the throat or in the mouth. In p ...
... The bitter taste of the drugs which are orally administered often contributes to patient non-compliance in taking medicines, especially for children and elderly (1). Unfortunately, majority of the drugs have a natural bitter taste that can create a burning feeling in the throat or in the mouth. In p ...
THE ROLE OF CYP3A4/5 IN ALPRAZOLAM METABOLISM
... It is well known that patients may respond differently to the same drug therapy. These inter-individual variations can result in drug toxicity in some patients, while others will experience therapeutic failure. The existence of large population differences with small intra-patient variability is con ...
... It is well known that patients may respond differently to the same drug therapy. These inter-individual variations can result in drug toxicity in some patients, while others will experience therapeutic failure. The existence of large population differences with small intra-patient variability is con ...
Transdermal Drug Delivery Systems
... Solubility of a drug influences its ability to penetrate the skin. pKa is index of solubility of drug in vehicle and ST corneum has influence on transfer of drug from vehicle to skin. Drug solubility determines concentration presented to absorption site which will effect rate and extent of abso ...
... Solubility of a drug influences its ability to penetrate the skin. pKa is index of solubility of drug in vehicle and ST corneum has influence on transfer of drug from vehicle to skin. Drug solubility determines concentration presented to absorption site which will effect rate and extent of abso ...
Conscious_Sedation - ARIN Golden Gate Chapter
... Ethicon expects to introduce the system into clinical practice on a limited basis in 2014 to address “the growing preference for propofol sedation in gastroenterology by more closely matching the skill level of the sedation delivery team with the actual requirements of less complex cases.” According ...
... Ethicon expects to introduce the system into clinical practice on a limited basis in 2014 to address “the growing preference for propofol sedation in gastroenterology by more closely matching the skill level of the sedation delivery team with the actual requirements of less complex cases.” According ...
... check, while active serine proteases are regulated by specific inhibitors of which there are at least 16 different families (Bode and Huber, 1992). The PI-I, PI-2, STI-Kunitz, Bowman-Birk and squas h seed inhibitors are all from plants. The most extensively characterized inhibitors are the serpins, ...
Development and Evaluation of Enteric Coated Tablet Containing
... coating formula using shacryl and non-aqueous coating formula using HPMCP and optimized the best aqueous coating formula. Coating was performed in a mini coating pan at 107 rpm using low-pressure air atomized liquid spray techniques. Comparative dissolution, disintegration and antiulcer studies were ...
... coating formula using shacryl and non-aqueous coating formula using HPMCP and optimized the best aqueous coating formula. Coating was performed in a mini coating pan at 107 rpm using low-pressure air atomized liquid spray techniques. Comparative dissolution, disintegration and antiulcer studies were ...
development and validation of rapid hplc
... validated.The separation and quantification were achieved on waters spherisorb 5µ ODS 24.6mm x 250mm column using a mobile phase of buffer: acetonitrile : THF (30:60:10, v/v/v ) at a flow rate of 1.5 ml/min with detection of analyte at 255 nm. The separation was achieved within 3.91± 0.1 min for ari ...
... validated.The separation and quantification were achieved on waters spherisorb 5µ ODS 24.6mm x 250mm column using a mobile phase of buffer: acetonitrile : THF (30:60:10, v/v/v ) at a flow rate of 1.5 ml/min with detection of analyte at 255 nm. The separation was achieved within 3.91± 0.1 min for ari ...
Full-Text - Academic Journals
... extract that has a greater affinity with hemin maintains more hemin in solution and is thus more effective. This ...
... extract that has a greater affinity with hemin maintains more hemin in solution and is thus more effective. This ...
The Dopamine Transporter and Cocaine Medication Development
... use of nonhuman subjects that are anatomically and physiologically similar to humans have allowed for the development of a clear and clinically relevant characterization of medication effectiveness in subjects with a documented history of drug use under well controlled laboratory conditions. The pro ...
... use of nonhuman subjects that are anatomically and physiologically similar to humans have allowed for the development of a clear and clinically relevant characterization of medication effectiveness in subjects with a documented history of drug use under well controlled laboratory conditions. The pro ...
The role of drug metabolism in drug discovery and
... adequacy nonclinical animal exposure was evaluated. The major human cytochrome P450 enzymes involved in the formation of principal metabolites were also identified and the clinical consequences assessed. Finally, the interaction potential of ospemifene as a cytochrome P450 enzyme inducer or inhibito ...
... adequacy nonclinical animal exposure was evaluated. The major human cytochrome P450 enzymes involved in the formation of principal metabolites were also identified and the clinical consequences assessed. Finally, the interaction potential of ospemifene as a cytochrome P450 enzyme inducer or inhibito ...
5-meo-dmt.5ht1a.para..
... levers. The number of responses for each reinforcement was gradually increased from 1 to 10. During this time, the reinforced lever was alternated on a random basis. All subsequent training and testing sessions used a fixed-ratio 10 (FR10) schedule of reinforcement. Discrimination training was then ...
... levers. The number of responses for each reinforcement was gradually increased from 1 to 10. During this time, the reinforced lever was alternated on a random basis. All subsequent training and testing sessions used a fixed-ratio 10 (FR10) schedule of reinforcement. Discrimination training was then ...
Ocular Pharmacokinetics of a Novel Loteprednol
... layer and reach the slow-clearing glycocalyx are likely to reside at the ocular surface longer ...
... layer and reach the slow-clearing glycocalyx are likely to reside at the ocular surface longer ...
Vasoconstrictors: Myths and Realities
... the drawbacks of tachyphylaxis, abuse and toxicity. With emerging evidence that tachyphylaxis appears to be an a1-AR-related phenomenon, research efforts have shifted to a2-AR agonists as potential vasoconstrictors. Studies have shown that nasal decongestion evoked by a2AR activation might have lowe ...
... the drawbacks of tachyphylaxis, abuse and toxicity. With emerging evidence that tachyphylaxis appears to be an a1-AR-related phenomenon, research efforts have shifted to a2-AR agonists as potential vasoconstrictors. Studies have shown that nasal decongestion evoked by a2AR activation might have lowe ...
A molecular basis of the therapeutic and psychoactive
... The binding of THC to its CB-1 or CB-2 G protein7TM coupled receptors is associated with changes in functions of the brain, the immune system, and the reproductive organs. In the brain, binding of THC to CB-1 receptors is associated with marked changes of sensory perception. These changes were first ...
... The binding of THC to its CB-1 or CB-2 G protein7TM coupled receptors is associated with changes in functions of the brain, the immune system, and the reproductive organs. In the brain, binding of THC to CB-1 receptors is associated with marked changes of sensory perception. These changes were first ...
In vivo and in vitro studies on drug metabolism and
... on midazolam 1'-hydroxylation in vitro, and had no statistically significant effects on the pharmacokinetics or pharmacodynamics of midazolam in vivo. Enzyme kinetic, chemical inhibition, recombinant enzyme and immunoinhibition studies consistently showed that both CYP1A2 and CYP3A4 are involved in ...
... on midazolam 1'-hydroxylation in vitro, and had no statistically significant effects on the pharmacokinetics or pharmacodynamics of midazolam in vivo. Enzyme kinetic, chemical inhibition, recombinant enzyme and immunoinhibition studies consistently showed that both CYP1A2 and CYP3A4 are involved in ...
Structure-Guided Discovery of (S)-3
... Editing activity ensures fidelity of protein synthesis - Editing mutants are supersensitive to leucine analogues, like ...
... Editing activity ensures fidelity of protein synthesis - Editing mutants are supersensitive to leucine analogues, like ...
... Rapid drug susceptibility tests are needed, and effective chemotherapy regimens with newly developed drugs in combination with traditional second-line antituberculosis agents for established multidrug-resistant tuberculosis are urgently being sought. There is also a quest for other novel modalities ...
SCLEROTIUM ROLFSII AND ANTIFUNGAL ACTIVITY Research Article
... facilitate the aqueous dispersion of insoluble compounds. Lectins are known to bind carbohydrates with high specificity which involves both hydrophobic and hydrogen bond interactions4. The use of lectins as drug delivery agents has also been considered earlier5. A non‐i ...
... facilitate the aqueous dispersion of insoluble compounds. Lectins are known to bind carbohydrates with high specificity which involves both hydrophobic and hydrogen bond interactions4. The use of lectins as drug delivery agents has also been considered earlier5. A non‐i ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.