Atypical Urinary Opiate Excretion Pattern*
... provided urine specimens for clinical drug abuse screening twice each week as a condition of participation in the treatment program. In some specimens obtained from these men, an unusual pattern of heroin metabolites was noted. Initially, these isolated findings were viewed as artifacts, but several ...
... provided urine specimens for clinical drug abuse screening twice each week as a condition of participation in the treatment program. In some specimens obtained from these men, an unusual pattern of heroin metabolites was noted. Initially, these isolated findings were viewed as artifacts, but several ...
Pharmacology Section - American Epilepsy Society
... Pharmacokinetic Principles Elimination: removal of active drug from the blood by metabolism and excretion • Metabolism/biotransformation - generally hepatic; usually rate-limiting step • Excretion - mostly renal • Active and inactive metabolites • Changes in metabolism over time (auto-induction w ...
... Pharmacokinetic Principles Elimination: removal of active drug from the blood by metabolism and excretion • Metabolism/biotransformation - generally hepatic; usually rate-limiting step • Excretion - mostly renal • Active and inactive metabolites • Changes in metabolism over time (auto-induction w ...
Do You Know Amphetamines
... Where do amphetamines come from? Amphetamines were first introduced in the 1930s as a remedy for nasal congestion, and marketed over-the-counter as an inhaler named Benzedrine. These drugs were also used medically to treat obesity and depression. Different types of amphetamines were available from t ...
... Where do amphetamines come from? Amphetamines were first introduced in the 1930s as a remedy for nasal congestion, and marketed over-the-counter as an inhaler named Benzedrine. These drugs were also used medically to treat obesity and depression. Different types of amphetamines were available from t ...
anatomy (phl 281)(2 + 1) - KSU Faculty Member websites
... - Structure and mechanism of action of antibody molecules. - Plasma proteins. - Denaturation of proteins. - Clinical correlations: a) The use of amino acid analysis in the diagnosis of disease. b) Differences in the primary structure of insulins utilized in the treatment of diabetemellitus. Enzymes: ...
... - Structure and mechanism of action of antibody molecules. - Plasma proteins. - Denaturation of proteins. - Clinical correlations: a) The use of amino acid analysis in the diagnosis of disease. b) Differences in the primary structure of insulins utilized in the treatment of diabetemellitus. Enzymes: ...
STIMULANTS: Amphetamines, Cocaine (p.1) 1. History of
... tolerance develops fairly rapidly, so increased doses frequently seen increased risk for OD toxic effects that mimic paranoid psychosis occurs at dose levels 60-300 mg/day and can last for longer duration than that seen with cocaine requires tx with high-potency antipsychotics (e.g. Haldol/haloperid ...
... tolerance develops fairly rapidly, so increased doses frequently seen increased risk for OD toxic effects that mimic paranoid psychosis occurs at dose levels 60-300 mg/day and can last for longer duration than that seen with cocaine requires tx with high-potency antipsychotics (e.g. Haldol/haloperid ...
1 Anish et al Journal of Drug Delivery & Therapeutics; 2012, 2(1)
... crosslinked structure allows immobilization of active agents, biomolecules effectively, and allows for its release in well-defined specific manner. Thus the hydrogels biocompatibility and crosslinked structure are responsible for its varied applications. 1. Mechanical properties: For non biodegradab ...
... crosslinked structure allows immobilization of active agents, biomolecules effectively, and allows for its release in well-defined specific manner. Thus the hydrogels biocompatibility and crosslinked structure are responsible for its varied applications. 1. Mechanical properties: For non biodegradab ...
Solubility enhancement technique for an anti-malarial
... drug. Therefore, one of the major challenges of the pharmaceutical industry is to apply strategies that improve the dissolution and apparent solubility of poorly soluble drugs to develop such problematic compounds into orally bioavailable and therapeutic effective drugs. Physical modifications often ...
... drug. Therefore, one of the major challenges of the pharmaceutical industry is to apply strategies that improve the dissolution and apparent solubility of poorly soluble drugs to develop such problematic compounds into orally bioavailable and therapeutic effective drugs. Physical modifications often ...
neuro 2009 - addiction education home
... Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we describe PET imaging studies that investigate dopamine's involvement in drug abuse in the human brain. In humans the reinforcing effects of drugs are associated with large and fast increases in extracellular ...
... Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we describe PET imaging studies that investigate dopamine's involvement in drug abuse in the human brain. In humans the reinforcing effects of drugs are associated with large and fast increases in extracellular ...
Parazoanthoxanthin A blocks Torpedo nicotinic acetylcholine
... T. marmorata ␣12 ␥␦ nAChR-rich membranes was investigated. The oocytes responded to the ACh application with stable currents from the second day after the injection forward. Each oocyte was first tested with ACh to ascertain consistent responses to ACh. The interval between consecutive 5 s drug chal ...
... T. marmorata ␣12 ␥␦ nAChR-rich membranes was investigated. The oocytes responded to the ACh application with stable currents from the second day after the injection forward. Each oocyte was first tested with ACh to ascertain consistent responses to ACh. The interval between consecutive 5 s drug chal ...
Polymeric micelles as drug carriers. Nanoparticulates as drug carriers.
... different types of hydrophobic blocks have been sufficiently developed as hydrophobic drug loading cores.16 Examples include for diblock copolymers: a) poly(L-amino acids), b) biodegradable poly(esters), which includes poly(glycolic acid), poly(D lactic acid), poly(D,L-lactic acid), copolymers of la ...
... different types of hydrophobic blocks have been sufficiently developed as hydrophobic drug loading cores.16 Examples include for diblock copolymers: a) poly(L-amino acids), b) biodegradable poly(esters), which includes poly(glycolic acid), poly(D lactic acid), poly(D,L-lactic acid), copolymers of la ...
Safety of allopurinol compared with other urate
... using the patient, intervention, comparator, and outcome (PICO) approach. A librarian developed the search strategy. The following electronic databases were searched: The Cochrane Library (2014); MEDLINE (1950–January 2014); and EMBASE (1980–January 2014). The search was limited by language (English ...
... using the patient, intervention, comparator, and outcome (PICO) approach. A librarian developed the search strategy. The following electronic databases were searched: The Cochrane Library (2014); MEDLINE (1950–January 2014); and EMBASE (1980–January 2014). The search was limited by language (English ...
GHB
... Polish Remover, Paint Stripper. There are more than 80 known names for GHB and its equally deadly analogs. ...
... Polish Remover, Paint Stripper. There are more than 80 known names for GHB and its equally deadly analogs. ...
this PDF file
... due to their versatility, biocompatibility and biodegradability properties. The present review focuses on the use of biodegradable polymers in various therapeutic areas like orthopedic and contraceptive device, surgical sutures, implants, depot parenteral injections, etc. Biodegradable polymers have ...
... due to their versatility, biocompatibility and biodegradability properties. The present review focuses on the use of biodegradable polymers in various therapeutic areas like orthopedic and contraceptive device, surgical sutures, implants, depot parenteral injections, etc. Biodegradable polymers have ...
Assessment of the Influence of Histaminergic Actions on Cocaine
... antimuscarinic actions on the behavioral effects of BZT analogs. In one study, the antimuscarinics atropine and scopolamine were examined in combination with cocaine to assess whether the effects of this combination was similar to the effects of the BZT analogs. More specifically, it was hypothesize ...
... antimuscarinic actions on the behavioral effects of BZT analogs. In one study, the antimuscarinics atropine and scopolamine were examined in combination with cocaine to assess whether the effects of this combination was similar to the effects of the BZT analogs. More specifically, it was hypothesize ...
article
... MOHAMMAD HOSEIN BIGTANa AND KAZEM MAHANPOORa* ABSTRACT. In this investigation, α-Fe2O3/SAPO-34 nano-structure were synthesized and characterized by XRD, SEM and FT-IR techniques. Morphologically, the shape of α-Fe2O3/SAPO-34 nanoparticles is close to spherical nanoparticles with an average particle ...
... MOHAMMAD HOSEIN BIGTANa AND KAZEM MAHANPOORa* ABSTRACT. In this investigation, α-Fe2O3/SAPO-34 nano-structure were synthesized and characterized by XRD, SEM and FT-IR techniques. Morphologically, the shape of α-Fe2O3/SAPO-34 nanoparticles is close to spherical nanoparticles with an average particle ...
Marijuana: Facts and Myths - livedrugfree.org
... Other Impairments: Sensory and time perception ...
... Other Impairments: Sensory and time perception ...
the preparation and administration of blincyto ® brochure
... • Neutropenia and Febrile Neutropenia, including life-threatening cases, have been observed. Monitor appropriate laboratory parameters during BLINCYTO® infusion and interrupt BLINCYTO® if prolonged neutropenia occurs. • Preparation and administration errors have occurred. Follow instructions for p ...
... • Neutropenia and Febrile Neutropenia, including life-threatening cases, have been observed. Monitor appropriate laboratory parameters during BLINCYTO® infusion and interrupt BLINCYTO® if prolonged neutropenia occurs. • Preparation and administration errors have occurred. Follow instructions for p ...
Amidine: Structure, Reactivity and Complexation Behaviour
... interactions between the benzamidines and their respective environments in the two physical states[24]. Structure and Reactivity Most fundamental aspects in chemical and biochemical studies are the concepts of structure, energetic and reactivity as well as their interrelationships. In most chemical ...
... interactions between the benzamidines and their respective environments in the two physical states[24]. Structure and Reactivity Most fundamental aspects in chemical and biochemical studies are the concepts of structure, energetic and reactivity as well as their interrelationships. In most chemical ...
The trends of the antioxidant drug “U
... U-74389G administration, reoxygenation time and their interaction have miscellaneous non significant short – term trends on K+ levels. Perhaps, a longer study time or a higher U-74389G dosage may reveal clearer and significant effects; including also an equal number of male rats for probable gender ...
... U-74389G administration, reoxygenation time and their interaction have miscellaneous non significant short – term trends on K+ levels. Perhaps, a longer study time or a higher U-74389G dosage may reveal clearer and significant effects; including also an equal number of male rats for probable gender ...
Thin-layer agar for detection of resistance to rifampicin, ofloxacin
... THE EMERGENCE of multidrug-resistant tuberculosis (MDR-TB, defined as resistance to both isoniazid [INH] and rifampicin [RMP]) and, more recently, extensively drug-resistant tuberculosis (XDR-TB, defined as MDR-TB with additional resistance to any fluoroquinolone [FQ] and to at least one of three in ...
... THE EMERGENCE of multidrug-resistant tuberculosis (MDR-TB, defined as resistance to both isoniazid [INH] and rifampicin [RMP]) and, more recently, extensively drug-resistant tuberculosis (XDR-TB, defined as MDR-TB with additional resistance to any fluoroquinolone [FQ] and to at least one of three in ...
Clinical Use of Diuretics
... cast formation in up to 50% of patients – Known cause of interstitial nephritis • Approximately 1 case/year at NNMC ...
... cast formation in up to 50% of patients – Known cause of interstitial nephritis • Approximately 1 case/year at NNMC ...
Diversity in P-loop Structure of A-ATP Synthase
... subunit B, providing information on the ATP traversing pathway to the final binding pocket. 3-5 However, the mechanism of nucleotide-binding and ATP synthesis in subunit A of A-ATP synthases still remains a puzzle. Here we describe the crystal structure of subunit A from P. horikoshii OT3 A-ATP synt ...
... subunit B, providing information on the ATP traversing pathway to the final binding pocket. 3-5 However, the mechanism of nucleotide-binding and ATP synthesis in subunit A of A-ATP synthases still remains a puzzle. Here we describe the crystal structure of subunit A from P. horikoshii OT3 A-ATP synt ...
Prescribing Information
... INTELENCE®*, in combination with other antiretroviral agents, is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-experienced patients ages 6 years and older, who have evidence of viral replication and HIV-1 strains resistant to a non ...
... INTELENCE®*, in combination with other antiretroviral agents, is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-experienced patients ages 6 years and older, who have evidence of viral replication and HIV-1 strains resistant to a non ...
0316065.01 - Society of Nuclear Medicine
... Further, CMS will not recognize diagnostic radiopharmaceuticals as drugs, but rather as diagnostic tests, under Social Security Act § 1861(s)(3). This section specifically lists: (3) diagnostic X-ray tests (including tests under the supervision of a physician, furnished in a place of residence used ...
... Further, CMS will not recognize diagnostic radiopharmaceuticals as drugs, but rather as diagnostic tests, under Social Security Act § 1861(s)(3). This section specifically lists: (3) diagnostic X-ray tests (including tests under the supervision of a physician, furnished in a place of residence used ...
Master-Thesis
... in which, for instance, stable mammalian cell lines are developed over-expressing the target of issue. Affinity screening techniques like nuclear magnetic resonance (NMR) and mass spectrometry (MS) or X-ray crystallography are more suitable for the primary screening of small fragment-like molecules. ...
... in which, for instance, stable mammalian cell lines are developed over-expressing the target of issue. Affinity screening techniques like nuclear magnetic resonance (NMR) and mass spectrometry (MS) or X-ray crystallography are more suitable for the primary screening of small fragment-like molecules. ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.