affinity biosensor for antitumoral drugs determination
... with increasing concentration of carboplatin was observed meaning that other groups are involved in the interaction reaction and contribute to the stabilization of the products. After these experiments it seemed that in order to determine carboplatin in serum samples of patients with cancer disease ...
... with increasing concentration of carboplatin was observed meaning that other groups are involved in the interaction reaction and contribute to the stabilization of the products. After these experiments it seemed that in order to determine carboplatin in serum samples of patients with cancer disease ...
Flunixin Injection
... As a class, cyclo-oxygenase inhibitory NSAIDs may be associated with gastrointestinal and renal toxicity. Sensitivity to drug-associated adverse effects varies with the individual patient. Patients at greatest risk for renal toxicity are those that are dehydrated, on concomitant diuretic therapy, or ...
... As a class, cyclo-oxygenase inhibitory NSAIDs may be associated with gastrointestinal and renal toxicity. Sensitivity to drug-associated adverse effects varies with the individual patient. Patients at greatest risk for renal toxicity are those that are dehydrated, on concomitant diuretic therapy, or ...
Site-specific conjugation of a cytotoxic drug to an antibody improves
... a proportional increase in efficacy. This suggests that it would be desirable to selectively generate only conjugates with a moderate drug stoichiometry, perhaps two drugs per antibody. However, the purification process used in that study is not practical on the scale required for clinical testing, ...
... a proportional increase in efficacy. This suggests that it would be desirable to selectively generate only conjugates with a moderate drug stoichiometry, perhaps two drugs per antibody. However, the purification process used in that study is not practical on the scale required for clinical testing, ...
“Synthesis, characterization and biomedical applications of microbial polymalic and polyglutamic acids derivatives.”
... either chemical synthesis or biological fermentation of myxomycetes and certain filamentous fungi1. Both α- and β-structures, either racemic or optically pure, may be obtained by chemical methods whereas microorganisms exclusively generate PMLA of extremely high optical purity. Since production cost ...
... either chemical synthesis or biological fermentation of myxomycetes and certain filamentous fungi1. Both α- and β-structures, either racemic or optically pure, may be obtained by chemical methods whereas microorganisms exclusively generate PMLA of extremely high optical purity. Since production cost ...
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION of
... vildagliptin to the FDA, as of July 2008 [3]. The Food and Drug Administration had demanded additional clinical data before it could approve vildagliptin including extra evidence that skin lesions and kidney impairment seen during an early study on animals have not occurred in human trials. While th ...
... vildagliptin to the FDA, as of July 2008 [3]. The Food and Drug Administration had demanded additional clinical data before it could approve vildagliptin including extra evidence that skin lesions and kidney impairment seen during an early study on animals have not occurred in human trials. While th ...
Evidence that Diclofenac and Celecoxib are thyroid hormone
... Non-steroidal anti-inflammatory drugs (NSAIDS) inhibit cyclooxygenase (COX), the enzymes that are responsible for prostaglandin production [1]. There are two isoforms, COX-1 which is constitutively expressed, and COX-2 which is inducible. NSAIDS are widely used for their analgesic, antipyretic and a ...
... Non-steroidal anti-inflammatory drugs (NSAIDS) inhibit cyclooxygenase (COX), the enzymes that are responsible for prostaglandin production [1]. There are two isoforms, COX-1 which is constitutively expressed, and COX-2 which is inducible. NSAIDS are widely used for their analgesic, antipyretic and a ...
Committee on Drugs 1998;101;1079 Pediatrics
... should be attributed solely to drug withdrawal without appropriate assessment and diagnostic tests to rule out other causes. Thus, the identification of infants at risk for withdrawal is important. A detailed maternal drug history should be obtained, including prescription and nonprescription drugs ...
... should be attributed solely to drug withdrawal without appropriate assessment and diagnostic tests to rule out other causes. Thus, the identification of infants at risk for withdrawal is important. A detailed maternal drug history should be obtained, including prescription and nonprescription drugs ...
Nicotinamide adenine dinucleotide metabolism as an
... significant structural differences among the enzymes. These include a movement of a β-strand by ∼ 2 Å and the replacement of several small residues in the tunnel in NMPRTase by larger residues in the other two PRTases. In fact, single-site mutations in the tunnel of NMPRTase can abolish the binding ...
... significant structural differences among the enzymes. These include a movement of a β-strand by ∼ 2 Å and the replacement of several small residues in the tunnel in NMPRTase by larger residues in the other two PRTases. In fact, single-site mutations in the tunnel of NMPRTase can abolish the binding ...
The challenge of selecting protein kinase assays
... oncology targets (Table 1), and many more are now in clinical trials for the treatment of such diseases as cancer and cardiovascular and inflammatory diseases [4]. At present, ∼ 24% of all research spending on drug discovery and development is focused on kinases [5]. Given the huge demand for small ...
... oncology targets (Table 1), and many more are now in clinical trials for the treatment of such diseases as cancer and cardiovascular and inflammatory diseases [4]. At present, ∼ 24% of all research spending on drug discovery and development is focused on kinases [5]. Given the huge demand for small ...
Ranibizumab or bevacizumab in AMD?
... could be easily reduced (as you say it should be) without actual competition from a much less expensive drug like bevacizumab. The safety and effectiveness of bevacizumab were evaluated favourably by the WHO itself, and this drug was included in the EML (but the much more expensive ranibizumab was n ...
... could be easily reduced (as you say it should be) without actual competition from a much less expensive drug like bevacizumab. The safety and effectiveness of bevacizumab were evaluated favourably by the WHO itself, and this drug was included in the EML (but the much more expensive ranibizumab was n ...
NIH Public Access
... noscapinoid family currently in Phase I/II clinical trials for chemotherapy of multiple myeloma.1 In an attempt to develop more efficacious analogs based on the phthalideisoquinoline noscapine scaffold, our lab has been continually engaged in rational drug design and chemical synthesis to yield seve ...
... noscapinoid family currently in Phase I/II clinical trials for chemotherapy of multiple myeloma.1 In an attempt to develop more efficacious analogs based on the phthalideisoquinoline noscapine scaffold, our lab has been continually engaged in rational drug design and chemical synthesis to yield seve ...
Herb-drug interactions
... Other PK interactions P-glycoprotein (PgP): involved in multidrug resistance, acts as a pump to remove drugs ...
... Other PK interactions P-glycoprotein (PgP): involved in multidrug resistance, acts as a pump to remove drugs ...
formulation and evaluation of meloxicam gels
... For topical administration of meloxicam (ME), microemulsion gels and lipogels containing either ethyl oleate or oleic acid as an oil phase were prepared. In addition, Hydrogel and hydroalcoholic gels containing carbopol 940 as a gelling agent were also prepared. In-vitro drug release through celloph ...
... For topical administration of meloxicam (ME), microemulsion gels and lipogels containing either ethyl oleate or oleic acid as an oil phase were prepared. In addition, Hydrogel and hydroalcoholic gels containing carbopol 940 as a gelling agent were also prepared. In-vitro drug release through celloph ...
Articaine: Efficacy and Paresthesia in Dental Local
... 2. A highly lipid-soluble thiophene aromatic ring 3. An ester hydrolysis component (90%) that contributes to the drug’s rapid metabolism Figure 1. Structural formula and physico-chemical data for articaine. ...
... 2. A highly lipid-soluble thiophene aromatic ring 3. An ester hydrolysis component (90%) that contributes to the drug’s rapid metabolism Figure 1. Structural formula and physico-chemical data for articaine. ...
Introduction to Anabolic Steroids
... This is not to say that differing AAS may give differing results for other reasons. Once a molecule of AAS is bound to the AR, the receptor now travels to the nucleus of the cell, and forms a dimer (pair) with another activated AR. The dimer then binds to certain parts of the DNA, and certain genes ...
... This is not to say that differing AAS may give differing results for other reasons. Once a molecule of AAS is bound to the AR, the receptor now travels to the nucleus of the cell, and forms a dimer (pair) with another activated AR. The dimer then binds to certain parts of the DNA, and certain genes ...
vitekta - Gilead
... upon coadministration with VITEKTA. Patients should be closely monitored for sedation and cognitive effects. ...
... upon coadministration with VITEKTA. Patients should be closely monitored for sedation and cognitive effects. ...
organic volatile impurities and their regulatory limits
... While solvents play a key role in the production of pharmaceuticals, many of the solvents used have toxic or environmentally hazardous properties. Presence of this unwanted impurities may influence the efficacy & safety the pharmaceutical products[3]. But sometimes the presence of some impurities ma ...
... While solvents play a key role in the production of pharmaceuticals, many of the solvents used have toxic or environmentally hazardous properties. Presence of this unwanted impurities may influence the efficacy & safety the pharmaceutical products[3]. But sometimes the presence of some impurities ma ...
Advances in phage display technology for drug discovery
... billions of components with a fast screening or selection procedure [3-8]. One of the most widely used library methods is based on the use of filamentous phages, which seems to play an increasingly important role in the future of drug discovery [1,2,9,10]. Phage display was first described more than ...
... billions of components with a fast screening or selection procedure [3-8]. One of the most widely used library methods is based on the use of filamentous phages, which seems to play an increasingly important role in the future of drug discovery [1,2,9,10]. Phage display was first described more than ...
Poster
... The leucine biosynthetic pathway begins when IPMS catalyzes a reaction between three ligands in its active site: alpha-KIV, acetyl-CoA, and Zn2+. Leucine will bind to the enzyme to inhibit the the production of additional leucine, which can be taken advantage of in drug development. Researchers woul ...
... The leucine biosynthetic pathway begins when IPMS catalyzes a reaction between three ligands in its active site: alpha-KIV, acetyl-CoA, and Zn2+. Leucine will bind to the enzyme to inhibit the the production of additional leucine, which can be taken advantage of in drug development. Researchers woul ...
Talwin Nx (pentazocine and naloxone hydrochlorides)
... Pentazocine is a potent analgesic which when administered orally in a 50 mg dose appears equivalent in analgesic effect to 60 mg (1 grain) of codeine. Onset of significant analgesia usually occurs between 15 and 30 minutes after oral administration, and duration of action is usually three hours or l ...
... Pentazocine is a potent analgesic which when administered orally in a 50 mg dose appears equivalent in analgesic effect to 60 mg (1 grain) of codeine. Onset of significant analgesia usually occurs between 15 and 30 minutes after oral administration, and duration of action is usually three hours or l ...
Influence of CYP2D6 genotype on the
... fatal overdoses have been reported for VEN alone or in combination with other compounds [14,15]. VEN has also been shown to have a relatively higher toxicity compared to the SSRIs [10,13,16-18]. Further, it has been suggested that VEN may be more toxic in PMs of CYP2D6 [19-21]. Consequently, therap ...
... fatal overdoses have been reported for VEN alone or in combination with other compounds [14,15]. VEN has also been shown to have a relatively higher toxicity compared to the SSRIs [10,13,16-18]. Further, it has been suggested that VEN may be more toxic in PMs of CYP2D6 [19-21]. Consequently, therap ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.