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PPT Version - OMICS International
PPT Version - OMICS International

... OMICS Group International through its Open Access Initiative is committed to make genuine and reliable contributions to the scientific community. OMICS Group hosts over 400 leading-edge peer reviewed Open Access Journals and organizes over 300 International Conferences annually all over the world. O ...
April, Number 4 - UF Health Professionals
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CYP2C9 Master Drug List
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... Sublingual administration means placement of the dosage form under the tongue and the drug reaches passes directly into the blood stream through ventral surface of the tongue and floor of the mouth. The drug solutes are rapidly absorbed into the reticulated vein which lies underneath the oral mucosa ...
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... and delayed ischemia onset without significantly modifying heart rate, blood pressure or both4.Because of its high solubility, short half life(6±1.4 hrs)5 and therapeutic use in chronic disease it is considered as an ideal drug candidate for the design of oral controlled release dosage form. The use ...
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... Wellcome Pharmaceuticals has filed for a US New Drug Application with the FDA for Malarone®. This drug is a fixed dose combination of atovaquone and proguanil, which acts as against blood stages of malaria. It has been shown to be highly effective in the treatment of uncomplicated multi-drug resista ...
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... conventional process of isolation and spectral analysis, which is tedious and time consuming. The hyphenated techniques are in focus for the purpose, among which LC-MS tools have been explored more strongly due to their potential to directly characterize small quantities of DPs [4]. Satranidazole is ...
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... Ciprofloxacin hydrochloride, 1-cyclopropyl-6fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-3quinolinecarboxilic acid, is a broad spectrum fluoroquinolone antibacterial agent used in the treatment of various bacterial infections caused by gram-positive and gram-negative microorganisms 1-2. Ciprofloxacin ...
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Neuroleptic malignant syndrome

...  Encoded by ABCB1 gene, ethnic polymorphisms  ATP-dependent cell membrane transporter  Similar substrates, inducers, inhibitors as 3A4  Example- loperamide, an opioid antidiarrheal, does not cross the BBB due to P-glycoprotein  Quinidine inhibits Pgp, leading to respiratory depression and somna ...
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Drug design



Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.
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