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09107sgp04
... some adverse effects on human, a similar study was taken on human. The result had shown that no clinically relevant serious adverse cardiac effects have been observed in studies in man. Co-administration did not modify other class-related toxicities in animals. Besides, The use of inhaled salmeterol ...
... some adverse effects on human, a similar study was taken on human. The result had shown that no clinically relevant serious adverse cardiac effects have been observed in studies in man. Co-administration did not modify other class-related toxicities in animals. Besides, The use of inhaled salmeterol ...
Drugs and Human Performance Fact Sheets
... equipotent psychoactivity. The 11-hydroxy-THC is then rapidly metabolized to the 11nor-9-carboxy-THC (THC-COOH) which is not psychoactive. A majority of THC is excreted via the feces (~65%) with approximately 30% of the THC being eliminated in the urine as conjugated glucuronic acids and free THC hy ...
... equipotent psychoactivity. The 11-hydroxy-THC is then rapidly metabolized to the 11nor-9-carboxy-THC (THC-COOH) which is not psychoactive. A majority of THC is excreted via the feces (~65%) with approximately 30% of the THC being eliminated in the urine as conjugated glucuronic acids and free THC hy ...
Drugs and Human Performance Fact Sheets
... equipotent psychoactivity. The 11-hydroxy-THC is then rapidly metabolized to the 11nor-9-carboxy-THC (THC-COOH) which is not psychoactive. A majority of THC is excreted via the feces (~65%) with approximately 30% of the THC being eliminated in the urine as conjugated glucuronic acids and free THC hy ...
... equipotent psychoactivity. The 11-hydroxy-THC is then rapidly metabolized to the 11nor-9-carboxy-THC (THC-COOH) which is not psychoactive. A majority of THC is excreted via the feces (~65%) with approximately 30% of the THC being eliminated in the urine as conjugated glucuronic acids and free THC hy ...
midazolam sedation in paediatrics: comparative study of intranasal
... at the start of infusion. Rectal medications may sometimes make the children feel uncomfortable and they may cause defecation and occasionally burning sensation. Rapid and reliable onset of action, avoidance of painful injections, ease of administration and predictability, have made intranasal and s ...
... at the start of infusion. Rectal medications may sometimes make the children feel uncomfortable and they may cause defecation and occasionally burning sensation. Rapid and reliable onset of action, avoidance of painful injections, ease of administration and predictability, have made intranasal and s ...
Selective Suppression of Cocaine- versus Food
... One clear disadvantage of amphetamine as a candidate medication for cocaine dependence is its high abuse liability, and as with cocaine, the abuse-related effects of amphetamine are thought to be mediated by its actions as an indirect dopamine agonist (Gold et al., 1989). However, the abuserelated e ...
... One clear disadvantage of amphetamine as a candidate medication for cocaine dependence is its high abuse liability, and as with cocaine, the abuse-related effects of amphetamine are thought to be mediated by its actions as an indirect dopamine agonist (Gold et al., 1989). However, the abuserelated e ...
Discovery of PF-04457845: A Highly Potent
... reduced potency for hFAAH but increased potency for rFAAH. For example, the dimethylisoxazole 24 was 5-fold less potent for hFAAH but 2-fold more potent for rFAAH as compared to 23. This highlights the importance of screening compounds against both the hFAAH and the rFAAH enzymes.17-18,22 Thus, the ...
... reduced potency for hFAAH but increased potency for rFAAH. For example, the dimethylisoxazole 24 was 5-fold less potent for hFAAH but 2-fold more potent for rFAAH as compared to 23. This highlights the importance of screening compounds against both the hFAAH and the rFAAH enzymes.17-18,22 Thus, the ...
wet granulation
... Compressed tablets usually contain a number of pharmaceutical adjuncts, known as excipients, in addition to the medicinal substance. The use of appropriate excipients is important in the development of the optimum tablets. Excipients determine the bulk of the final product in dosage forms such as ta ...
... Compressed tablets usually contain a number of pharmaceutical adjuncts, known as excipients, in addition to the medicinal substance. The use of appropriate excipients is important in the development of the optimum tablets. Excipients determine the bulk of the final product in dosage forms such as ta ...
- Wiley Online Library
... to permit an accurate determination of the complete drug concentration–effect relationship. This partially accounts for the fact that dose-titration approaches, based on pre-challenge NSAID administration, have been preferred. A further drawback of rodent models is that they do not readily permit me ...
... to permit an accurate determination of the complete drug concentration–effect relationship. This partially accounts for the fact that dose-titration approaches, based on pre-challenge NSAID administration, have been preferred. A further drawback of rodent models is that they do not readily permit me ...
Making sense of itraconazole pharmacokinetics
... effective bioavailability. The physicochemical properties of the drug make it insoluble in water but strongly protein bound. The absorption and blood levels of the original capsular formulation were predictable with non-linear, saturation kinetics in normal volunteers. Tissue penetration was high an ...
... effective bioavailability. The physicochemical properties of the drug make it insoluble in water but strongly protein bound. The absorption and blood levels of the original capsular formulation were predictable with non-linear, saturation kinetics in normal volunteers. Tissue penetration was high an ...
Pharmacology
... E. Treatment with acetylcysteine tremor, thyroid enlargement, and leukocytosis. The drug he is taking is most likely to be 1298. The first local anesthetic used clinically was A. Clomipramine (Anafranil®) A. Cocaine B. Haloperidol (Haldol®) B. Tetracaine C. Imipramine(Tofranil®) C. Lidocaine D. Lith ...
... E. Treatment with acetylcysteine tremor, thyroid enlargement, and leukocytosis. The drug he is taking is most likely to be 1298. The first local anesthetic used clinically was A. Clomipramine (Anafranil®) A. Cocaine B. Haloperidol (Haldol®) B. Tetracaine C. Imipramine(Tofranil®) C. Lidocaine D. Lith ...
EXTEMPORANEOUS PREPARATION OF PAEDIATRIC ORAL
... nifedipine amount was less than 80% of the theoretical value. Three quarters of the missing amount was located on the emptied powder papers. Oral powders were stable for up to one year. Nifedipine capsules, whose contents were simply emptied prior to use, were faster to prepare and when comparing th ...
... nifedipine amount was less than 80% of the theoretical value. Three quarters of the missing amount was located on the emptied powder papers. Oral powders were stable for up to one year. Nifedipine capsules, whose contents were simply emptied prior to use, were faster to prepare and when comparing th ...
Drug Metabolism Test Results
... Deoxyribonucleic acid (DNA) was isolated from buccal swabs and the alleles were characterized using Taqman® SNP Genotyping Assays.Copy number variation in CYP2D6 was assessed using a TaqMan® Copy Number Assay. The specific alleles detected by the assays are indicated in the accompanying table and in ...
... Deoxyribonucleic acid (DNA) was isolated from buccal swabs and the alleles were characterized using Taqman® SNP Genotyping Assays.Copy number variation in CYP2D6 was assessed using a TaqMan® Copy Number Assay. The specific alleles detected by the assays are indicated in the accompanying table and in ...
ETO-Thesis-Final 061214. - JScholarship
... As stated above, dapivirine is another antiretroviral drug that has made significant progress in HIV PrEP trials. Dapivirine is one of the diarylpyrimidine non-nucleoside reverse transcriptase inhibitors (NNRTI), which inhibit HIV reverse transcriptase through allosteric binding. First generation N ...
... As stated above, dapivirine is another antiretroviral drug that has made significant progress in HIV PrEP trials. Dapivirine is one of the diarylpyrimidine non-nucleoside reverse transcriptase inhibitors (NNRTI), which inhibit HIV reverse transcriptase through allosteric binding. First generation N ...
The Potential of Cyclodextrins as Novel Active Pharmaceutical
... Cyclodextrins (CDs) are chemical entities of natural origin, which are derived from bacterial degradation of starch through the metabolic action of cyclodextrin glycosyl transferase enzyme (GCTase). This peculiar enzyme is present in several species of alkalophilic bacillus species (e.g., Bacillus m ...
... Cyclodextrins (CDs) are chemical entities of natural origin, which are derived from bacterial degradation of starch through the metabolic action of cyclodextrin glycosyl transferase enzyme (GCTase). This peculiar enzyme is present in several species of alkalophilic bacillus species (e.g., Bacillus m ...
Methadone—metabolism, pharmacokinetics and interactions
... The elimination of methadone and its metabolites occurs mainly through the kidneys: 15–60% during the first 24 h (20% as unmodified drug, and 13% as 2-ethylidene1,5-dimethyl-3,3-diphenylpyrrolidine; EDDP). Elimination in the faeces accounts for 20–40% [32]. According to Inturrisi [16] the overall el ...
... The elimination of methadone and its metabolites occurs mainly through the kidneys: 15–60% during the first 24 h (20% as unmodified drug, and 13% as 2-ethylidene1,5-dimethyl-3,3-diphenylpyrrolidine; EDDP). Elimination in the faeces accounts for 20–40% [32]. According to Inturrisi [16] the overall el ...
Design and physicochemical characterisation of novel
... We describe formulation and evaluation of novel dissolving polymeric microneedle (MN) arrays for the facilitated delivery of low molecular weight, high dose drugs. Ibuprofen sodium was used as the model here and was successfully formulated at approximately 50% w/w in the dry state using the copolyme ...
... We describe formulation and evaluation of novel dissolving polymeric microneedle (MN) arrays for the facilitated delivery of low molecular weight, high dose drugs. Ibuprofen sodium was used as the model here and was successfully formulated at approximately 50% w/w in the dry state using the copolyme ...
752ANSModule1_2005
... 28. ____ Muscarine and pilocarpine are natural products that have similar pharmacological actions, but only one is useful as a drug to treat glaucoma. What key structural difference supports the use of pilocarpine rather than muscarine? (3 pts) A. Muscarine lacks the ester group that is crucial for ...
... 28. ____ Muscarine and pilocarpine are natural products that have similar pharmacological actions, but only one is useful as a drug to treat glaucoma. What key structural difference supports the use of pilocarpine rather than muscarine? (3 pts) A. Muscarine lacks the ester group that is crucial for ...
DENDRIMERS - Pharmawiki.in
... found widespread applications in material science as well as in biology. As an alternative name to PPI, POPAM is sometimes used to describe this class of dendrimers. POPAM stands for Poly (Propylene Amine) In addition, these dendrimers are also sometimes denoted “DAB-dendrimers” where DAB refers to ...
... found widespread applications in material science as well as in biology. As an alternative name to PPI, POPAM is sometimes used to describe this class of dendrimers. POPAM stands for Poly (Propylene Amine) In addition, these dendrimers are also sometimes denoted “DAB-dendrimers” where DAB refers to ...
Molly: The Not So Convincing Truth of MDMA
... have lurked in the shadows, scaring off anyone who has a ‘decent’ amount of common sense. However, these rumors are just that- rumors. The truth is, the long held stigmas about MDMA have little support through scientific evidence and the opposite may in fact be true- MDMA should not be a schedule 1 ...
... have lurked in the shadows, scaring off anyone who has a ‘decent’ amount of common sense. However, these rumors are just that- rumors. The truth is, the long held stigmas about MDMA have little support through scientific evidence and the opposite may in fact be true- MDMA should not be a schedule 1 ...
Full-Text PDF
... thrombin in the coagulation cascade. Selective inhibition of FXa was unable to affect the pre-existing thrombin level, and activation and aggregation of the platelets reduced the risk of bleeding when compared with traditional anti-coagulants [2]. In addition, FXa plays a vital role in amplifying th ...
... thrombin in the coagulation cascade. Selective inhibition of FXa was unable to affect the pre-existing thrombin level, and activation and aggregation of the platelets reduced the risk of bleeding when compared with traditional anti-coagulants [2]. In addition, FXa plays a vital role in amplifying th ...
Escherichia coli ATP Synthase
... affect both human and animals have been associated with ATP synthase ([1, 17] and references therein). The presence of ATP synthase on the surfaces of multiple cell types, and its involvement in a number of cellular processes, makes this enzyme an attractive molecular target in the development of tre ...
... affect both human and animals have been associated with ATP synthase ([1, 17] and references therein). The presence of ATP synthase on the surfaces of multiple cell types, and its involvement in a number of cellular processes, makes this enzyme an attractive molecular target in the development of tre ...
Name_:_Hicham Hussein Khodr
... I would be interested to lecture subjects related to physical-chemical properties of organic molecules as prodrugs and their relative stabilities(oxidation, hydrolysis, side interaction). I will undertake a teaching responsibility in the area of physical and inorganic chemistry in particular spectro ...
... I would be interested to lecture subjects related to physical-chemical properties of organic molecules as prodrugs and their relative stabilities(oxidation, hydrolysis, side interaction). I will undertake a teaching responsibility in the area of physical and inorganic chemistry in particular spectro ...
methods of preparation and applications
... encapsulation efficiency of up to 75% could be obtained. 14 Aqueous dispersions of liposomes often have tendency to aggregate or fuse and may he susceptible to hydrolysis and or oxidation. Two solutions have been proposed: Proliposomes In proliposomes, lipid and drug are coated onto a soluble carrie ...
... encapsulation efficiency of up to 75% could be obtained. 14 Aqueous dispersions of liposomes often have tendency to aggregate or fuse and may he susceptible to hydrolysis and or oxidation. Two solutions have been proposed: Proliposomes In proliposomes, lipid and drug are coated onto a soluble carrie ...
Effect of compression force, humidity and disintegrant concentration
... Marais et al Introduction For tablets containing sparingly watersoluble drugs, the start of dissolution is often delayed by the poor wettability of the tablet surface and/or slow liquid penetration into the tablet matrix. This property causes increased disintegration time and retarded drug release ...
... Marais et al Introduction For tablets containing sparingly watersoluble drugs, the start of dissolution is often delayed by the poor wettability of the tablet surface and/or slow liquid penetration into the tablet matrix. This property causes increased disintegration time and retarded drug release ...
Evidence for the roles of ... mediators in exercise-induced asthma: the ...
... whether administered alone or in combination with flurbiprofen had a major inhibitory action in 5 of 8 subjects. Flurbiprofen alone also inhibited the response in the majority of subjects, but had a lesser effect on the maximum post-exercise fall in FEY1 than that achieved with terfenadine alone. Th ...
... whether administered alone or in combination with flurbiprofen had a major inhibitory action in 5 of 8 subjects. Flurbiprofen alone also inhibited the response in the majority of subjects, but had a lesser effect on the maximum post-exercise fall in FEY1 than that achieved with terfenadine alone. Th ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.