CURRICULUM VITAE Stacey C. Sigmon, Ph.D. February 2014
... substance use disorders: Trends in the literature. In P. Ruiz & E. Strain (Eds.), Lowinson & Ruiz’s Substance Abuse: A Comprehensive Textbook, Fifth Edition. Maryland: Lippincott Williams & Wilkins, pp. 603-621. (R) Sigmon, S.C. & Griffiths, R.R. (2011). Caffeine choice prospectively predicts positi ...
... substance use disorders: Trends in the literature. In P. Ruiz & E. Strain (Eds.), Lowinson & Ruiz’s Substance Abuse: A Comprehensive Textbook, Fifth Edition. Maryland: Lippincott Williams & Wilkins, pp. 603-621. (R) Sigmon, S.C. & Griffiths, R.R. (2011). Caffeine choice prospectively predicts positi ...
Hard Shell Capsules
... capsules to be lined up all in the same direction, i.e., body-end downward, as they are introduced into the filling mechanism. For capsule separation, the rectified capsules are introduced into a split bushing, or its equivalent. The bushing consists of an upper part and a lower part. A vacuum is ap ...
... capsules to be lined up all in the same direction, i.e., body-end downward, as they are introduced into the filling mechanism. For capsule separation, the rectified capsules are introduced into a split bushing, or its equivalent. The bushing consists of an upper part and a lower part. A vacuum is ap ...
Innovative Biotechnology Companies and their Academic Origins
... ! The RaPID cycle is repeated several times to enrich the mRNA pool ! One round of selection and enrichment is completed in < 1 day ! Once complete, the enriched pools are subjected to DNA sequencing - Binding is confirmed by resubjecting to target protein - Each peptide is then chemically synthesiz ...
... ! The RaPID cycle is repeated several times to enrich the mRNA pool ! One round of selection and enrichment is completed in < 1 day ! Once complete, the enriched pools are subjected to DNA sequencing - Binding is confirmed by resubjecting to target protein - Each peptide is then chemically synthesiz ...
1 Name: Thyroglobulin (Proloid) Class: Thyroid Hormone Mech.: T3
... Mech.: Increases intestinal absorption of calcium and phosphate. Stimulates bone resorption by facilitating effects of PTH. Stimulates renal reabsorption of calcium and phosphate. Net result = ↑↑ calcium, ↑↑ phosphate. Absorpt.: Oral usu → adequate absorption. Bile essential for absorpt. Parenteral. ...
... Mech.: Increases intestinal absorption of calcium and phosphate. Stimulates bone resorption by facilitating effects of PTH. Stimulates renal reabsorption of calcium and phosphate. Net result = ↑↑ calcium, ↑↑ phosphate. Absorpt.: Oral usu → adequate absorption. Bile essential for absorpt. Parenteral. ...
Secundum Artem
... Another potential problem involves the source of the active drug. The best source is the pure drug. If the pure drug substance is not available, it is common practice to use injectables, tablets, capsules or other dosage forms to obtain the active drug. Where this is necessary, the presence of exci ...
... Another potential problem involves the source of the active drug. The best source is the pure drug. If the pure drug substance is not available, it is common practice to use injectables, tablets, capsules or other dosage forms to obtain the active drug. Where this is necessary, the presence of exci ...
DISSOLUTION PROFILING OF BILAYERED CONVENTIONAL RELEASE PARACETAMOL AND
... prostaglandin inhibitor in peripheral tissues and possesses no significant ant inflammatory effects. Its one of the most important drugs used for the treatment of mild to moderate pain when an anti inflammatory effect is not necessary. Paracetamol preferred over aspirin as an analgesic antipyretic f ...
... prostaglandin inhibitor in peripheral tissues and possesses no significant ant inflammatory effects. Its one of the most important drugs used for the treatment of mild to moderate pain when an anti inflammatory effect is not necessary. Paracetamol preferred over aspirin as an analgesic antipyretic f ...
HYDROPHILIC POLYMERS FOR DISSOLUTION ENHANCEMENT OF CELECOXIB Research Article PROF.M.V.NAGABHUSHANAM
... cyclooxygenase-2 (COX-2) and at therapeutic concentrations in humans, celecoxib does not inhibit the cyclooxygenase-1 (COX-1) isoenzyme. Celecoxib is absorbed slowly from the gastrointestinal tract, peak plasma concentrations (4) being achieved approximately 4hrs after an oral dose. Most of the NSAI ...
... cyclooxygenase-2 (COX-2) and at therapeutic concentrations in humans, celecoxib does not inhibit the cyclooxygenase-1 (COX-1) isoenzyme. Celecoxib is absorbed slowly from the gastrointestinal tract, peak plasma concentrations (4) being achieved approximately 4hrs after an oral dose. Most of the NSAI ...
Thermodynamic and Biophysical Characterization of Cytochrome P450
... Macdonald, I. D. G., Chapman, S. K., and Munro, A. W. (2001) J. Biol. Inorg. Chem. 6, 523-533. Stok, J. E., and De Voss, J. J. (2000) Arch. Biochem. Biophys. 384, 351-360]. Here we show novel binding features of P450 BioIsspecifically that it binds steroids (including testosterone and progesterone) ...
... Macdonald, I. D. G., Chapman, S. K., and Munro, A. W. (2001) J. Biol. Inorg. Chem. 6, 523-533. Stok, J. E., and De Voss, J. J. (2000) Arch. Biochem. Biophys. 384, 351-360]. Here we show novel binding features of P450 BioIsspecifically that it binds steroids (including testosterone and progesterone) ...
Disintegration of Tablets and Capsules Measured by Isothermal
... Tablets are solid dosage forms containing one or more active ingredients. They are obtained by single or multiple compression (in certain cases they are moulded) and may be uncoated or coated. They are usually intended for oral administration, but preparations for alternative applications, such as i ...
... Tablets are solid dosage forms containing one or more active ingredients. They are obtained by single or multiple compression (in certain cases they are moulded) and may be uncoated or coated. They are usually intended for oral administration, but preparations for alternative applications, such as i ...
Frequently Asked Questions
... 13. Is there a potential for ionic interaction with certain APIs when Carbopol® polymers are incorporated in a matrix tablet? Due to their anionic character, Carbopol® polymers may form ionic complexes with cationic drugs. Carbopol® polymers are weak acids (pKa=6 ±0.5). It is important to note that ...
... 13. Is there a potential for ionic interaction with certain APIs when Carbopol® polymers are incorporated in a matrix tablet? Due to their anionic character, Carbopol® polymers may form ionic complexes with cationic drugs. Carbopol® polymers are weak acids (pKa=6 ±0.5). It is important to note that ...
Stability indicating RP-HPLC method development and validation for
... degraded products were well resolved from the actual drug. The developed method was simple, rapid, accurate, precise and stability indicating for the simultaneous estimation of candesartan cilexetil and hydrochlorothiazide in active pharmaceutical ingredient and in tablet dosage form. Keywords: Cand ...
... degraded products were well resolved from the actual drug. The developed method was simple, rapid, accurate, precise and stability indicating for the simultaneous estimation of candesartan cilexetil and hydrochlorothiazide in active pharmaceutical ingredient and in tablet dosage form. Keywords: Cand ...
Diminished Cocaine-Like Effects in Dopamine Transporter Ligands
... the top center of the front panel (house light). Levers were set 17 cm apart, with pairs of lamps (light-emitting diodes; LEDs) above each of the levers, also on the front panel. A downward force on either lever of 0.4 N through about 1 mm was defined as a response and produced an audible click. Rei ...
... the top center of the front panel (house light). Levers were set 17 cm apart, with pairs of lamps (light-emitting diodes; LEDs) above each of the levers, also on the front panel. A downward force on either lever of 0.4 N through about 1 mm was defined as a response and produced an audible click. Rei ...
Advice to The Expert Advisory Committee on drugs on: LSD
... contaminated grain and bread, the medicinal uses of ergot in midwifery have been referred to since the Middle Ages. Lysergic acid was isolated from ergot alkaloids in the early 1930s by W Jacobs and LC Craig at the Rockefeller Institute. In the late 1930s, Hofmann systematically reacted lysergic aci ...
... contaminated grain and bread, the medicinal uses of ergot in midwifery have been referred to since the Middle Ages. Lysergic acid was isolated from ergot alkaloids in the early 1930s by W Jacobs and LC Craig at the Rockefeller Institute. In the late 1930s, Hofmann systematically reacted lysergic aci ...
In Vitro Kinetic Characterization of Axitinib Metabolism
... CYP3A5. Axitinib N-glucuronidation was primarily catalyzed by UDPglucuronosyltransferase (UGT) UGT1A1, which was verified by chemical inhibitors and UGT1A1 null expressers, with lesser contributions from UGTs 1A3, 1A9, and 1A4. The Km and Vmax values describing the formation of the N-glucuronide in ...
... CYP3A5. Axitinib N-glucuronidation was primarily catalyzed by UDPglucuronosyltransferase (UGT) UGT1A1, which was verified by chemical inhibitors and UGT1A1 null expressers, with lesser contributions from UGTs 1A3, 1A9, and 1A4. The Km and Vmax values describing the formation of the N-glucuronide in ...
SEIKO ABUBAKARI - Kwame Nkrumah University of Science
... formulated product. Changes in percentage contents and pH were used as a tool for the study. UV-spectrophotometer was used for the analysis. This was done by preparing different concentrations of pure quinine sulphate in 0.1 M HCl solution and their respective absorbance determined at 250 nm. A cali ...
... formulated product. Changes in percentage contents and pH were used as a tool for the study. UV-spectrophotometer was used for the analysis. This was done by preparing different concentrations of pure quinine sulphate in 0.1 M HCl solution and their respective absorbance determined at 250 nm. A cali ...
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
... The objective of this guidance is to recommend acceptable amounts for residual solvents in pharmaceuticals for the safety of the patient. The guidance recommends use of less toxic solvents and describes levels considered to be toxicologically acceptable for some residual solvents. Residual solvents ...
... The objective of this guidance is to recommend acceptable amounts for residual solvents in pharmaceuticals for the safety of the patient. The guidance recommends use of less toxic solvents and describes levels considered to be toxicologically acceptable for some residual solvents. Residual solvents ...
Engineering subunit association of multisubunit proteins
... denotes the entropic term associated with the conformational entropy loss of the side chains of the reactants upon association. The last term, DGconst, includes rotational, translational, and cratic free energies, and, as a first-order approximation, it was assumed to be constant at 11 kcalymol. The ...
... denotes the entropic term associated with the conformational entropy loss of the side chains of the reactants upon association. The last term, DGconst, includes rotational, translational, and cratic free energies, and, as a first-order approximation, it was assumed to be constant at 11 kcalymol. The ...
Zopiclone is a drug with very similar effects
... overdose and dependence on benzos. The main medication prescribed tends to be Nytol. ...
... overdose and dependence on benzos. The main medication prescribed tends to be Nytol. ...
Is the Role of the Small Intestine in First
... al., 1996; Fromm et al., 1996). Much of the evidence for such claims has derived indirectly from comparisons of areas under the plasma concentration curves (AUCs)2 after i.v. and oral administration, with assumptions that have not yet been tested. In fact, estimates of intestinal metabolism calculat ...
... al., 1996; Fromm et al., 1996). Much of the evidence for such claims has derived indirectly from comparisons of areas under the plasma concentration curves (AUCs)2 after i.v. and oral administration, with assumptions that have not yet been tested. In fact, estimates of intestinal metabolism calculat ...
Is the Role of the Small Intestine in First
... al., 1996; Fromm et al., 1996). Much of the evidence for such claims has derived indirectly from comparisons of areas under the plasma concentration curves (AUCs)2 after i.v. and oral administration, with assumptions that have not yet been tested. In fact, estimates of intestinal metabolism calculat ...
... al., 1996; Fromm et al., 1996). Much of the evidence for such claims has derived indirectly from comparisons of areas under the plasma concentration curves (AUCs)2 after i.v. and oral administration, with assumptions that have not yet been tested. In fact, estimates of intestinal metabolism calculat ...
Mephedrone: use, subjective effects and health risks
... The indication that mephedrone has a dependence liability is also a matter of concern. Around 30% of our participants experienced three or more DSM‐IV dependence criteria. The predominant symptoms were increased tolerance (the study did not ask about within session develo ...
... The indication that mephedrone has a dependence liability is also a matter of concern. Around 30% of our participants experienced three or more DSM‐IV dependence criteria. The predominant symptoms were increased tolerance (the study did not ask about within session develo ...
bevacizumab
... • Anti VEGF’s have a definitive role in suppressing neovascularization and to some extent the severity of the disease in – Choroidal and Retinal neovascularization. – Neovascular glaucoma. – Corneal vascularization. (still in nascent stage) ...
... • Anti VEGF’s have a definitive role in suppressing neovascularization and to some extent the severity of the disease in – Choroidal and Retinal neovascularization. – Neovascular glaucoma. – Corneal vascularization. (still in nascent stage) ...
FDA Enforcement of Criminal Liability for Clinical
... (calculating average research and development costs of $1.32 billion per new molecule approved by the Food and Drug Administration). ...
... (calculating average research and development costs of $1.32 billion per new molecule approved by the Food and Drug Administration). ...
Pharmacologically Active Drug Metabolites: Impact on Drug
... metabolizer; fu, fraction unbound in plasma; HMGCoA, 3-hydroxy-3-methylglutaryl-coenzyme A; HPLC-MS, high pressure liquid chromatography-mass spectrometry; 5-HT, serotonin; IC50, ligand concentration yielding 50% of the maximum response; Kp,uu, ratio of unbound drug concentration within a tissue to ...
... metabolizer; fu, fraction unbound in plasma; HMGCoA, 3-hydroxy-3-methylglutaryl-coenzyme A; HPLC-MS, high pressure liquid chromatography-mass spectrometry; 5-HT, serotonin; IC50, ligand concentration yielding 50% of the maximum response; Kp,uu, ratio of unbound drug concentration within a tissue to ...
Basics and Potential Applications of Surfactants
... diluted concentrations. These structures are related with the spherulite structure (onion structure). It is possible that spherulites are only out-of-equilibrium transient lamellar phases induced by mechanical work (yet to be proved) or by other stimulus. The thermodynamic stability of spherulites i ...
... diluted concentrations. These structures are related with the spherulite structure (onion structure). It is possible that spherulites are only out-of-equilibrium transient lamellar phases induced by mechanical work (yet to be proved) or by other stimulus. The thermodynamic stability of spherulites i ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.