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Neuron PowerPoint
Neuron PowerPoint

3-1-neuron _1
3-1-neuron _1

...  The brain is both specialized and integrated.  The nervous system is “plastic” especially at early ages of development. ...
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... 6) The smaller / bigger the size of the nerve fiber, the slower / faster the speed of nerve impulse. And the less / more myelin, which means larger diameter of the nerve fiber, the greater the speed. 7) Bundles of afferent and efferent neurons outside the CNS but inside the PNS are referred to as ne ...
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Theoretical Neuroscience - Neural Dynamics and Computation Lab
Theoretical Neuroscience - Neural Dynamics and Computation Lab

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Pre-Bötzinger complex



The pre-Bötzinger complex (preBötC) is a cluster of interneurons in the ventrolateral medulla of the brainstem. This complex has been proven to be essential for the generation of respiratory rhythm in mammals. The exact mechanism of the rhythm generation and transmission to motor nuclei remains controversial and the topic of much present research.Several synthetic compounds have been shown to act on neurons specific to the preBötC, most being selective agonists or antagonists to receptor subtypes on neurons in the vicinity. Since many of these neurons express GABA, glutamate, serotonin and adenosine receptors, chemicals custom tailored to bind at these sites are most effective at altering respiratory rhythm.Adenosine modulates the preBötC output via activation of the A1 and A2A receptor subtypes. An adenosine A1 receptor agonist has been shown to depress preBötC rhythmogenesis independent of the neurotransmitters GABA and glycine in ""in vitro"" preparations from 0-7 day old mice. Another synthetic drug specific to the adenosine A2A receptor subtype is CGS-21680 that has been shown to cause apneas in 14-21 day old rat pups in vivo. For this reason, it has been used as a model to study pathological conditions such as apnea of prematurity and SIDS in neonatal infants.
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