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Visual categorization shapes feature selectivity in the primate
Visual categorization shapes feature selectivity in the primate

... Red circles : Neurons with statistically significant selectivity for diagnostic dimension only Blue circles : Neurons with significant selectivity for diagnostic and non-diagnostic feature Black triangles : Neurons with no significant selectivity Red star : Example neuron depicted in previous figure ...
Brain Organization Simulation System
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... 1.! Memory for storing synapses will limit the size of neuronal networks simulated on Blue Gene supercomputers with only 1 GB of memory per node. 2.! Careful parallelization mechanisms and efficient data structures are needed when running brain-scale simulations. For instance, just pre-summing the p ...
Biopsychology 2012 – sec 002
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The Nerve Impulse - hrsbstaff.ednet.ns.ca
The Nerve Impulse - hrsbstaff.ednet.ns.ca

...  The acetylcholine causes muscle cell membrane to become more permeable to sodium, causing an impulse to travel the membrane and the muscle cell to contract. Drugs and the Synapses Many poisons and drugs affect the activity of chemical neurotransmitters at the synapses. Nerve gas, curare, botulin t ...
The State of the Art of Respiratory Control
The State of the Art of Respiratory Control

... pFRG and PreBotC areas of the VRG, it is possible that the respiratory rhythm and pattern generation in the intact system is the emergent property of a distributed network of neurons including, but not restricted to, these two well-studied areas. In the future we may see more areas emerge as importa ...
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Memories of punishment and relief in a mini-brain - Schram

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Topic 6.5 Neuron and Synapses

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Histology of Nervous Tissue
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Nervous System III – Reflexes and Peripheral Nervous System (PNS)

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Lecture 27 Powerpoint File
Lecture 27 Powerpoint File

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Pre-Bötzinger complex



The pre-Bötzinger complex (preBötC) is a cluster of interneurons in the ventrolateral medulla of the brainstem. This complex has been proven to be essential for the generation of respiratory rhythm in mammals. The exact mechanism of the rhythm generation and transmission to motor nuclei remains controversial and the topic of much present research.Several synthetic compounds have been shown to act on neurons specific to the preBötC, most being selective agonists or antagonists to receptor subtypes on neurons in the vicinity. Since many of these neurons express GABA, glutamate, serotonin and adenosine receptors, chemicals custom tailored to bind at these sites are most effective at altering respiratory rhythm.Adenosine modulates the preBötC output via activation of the A1 and A2A receptor subtypes. An adenosine A1 receptor agonist has been shown to depress preBötC rhythmogenesis independent of the neurotransmitters GABA and glycine in ""in vitro"" preparations from 0-7 day old mice. Another synthetic drug specific to the adenosine A2A receptor subtype is CGS-21680 that has been shown to cause apneas in 14-21 day old rat pups in vivo. For this reason, it has been used as a model to study pathological conditions such as apnea of prematurity and SIDS in neonatal infants.
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