Impairment of a parabolic bursting rhythm by the ectopic expression
... bursting activity by rSK2 overexpression is unlikely to be due to reduced spike duration, and is more likely to be due to rSK2-induced slow AHP that decays with a time constant of , 150 ms [14]. It is widely held that slowly activating, voltagedependent currents play a key role in producing the burs ...
... bursting activity by rSK2 overexpression is unlikely to be due to reduced spike duration, and is more likely to be due to rSK2-induced slow AHP that decays with a time constant of , 150 ms [14]. It is widely held that slowly activating, voltagedependent currents play a key role in producing the burs ...
Optical probing of neuronal ensemble activity
... In spite of the success of in vivo calcium imaging for visualizing neuronal ensemble activity, a number of challenges remain. One crucial issue is the limited temporal resolution. A first strategy to improve imaging speed is to simultaneously excite fluorescence at multiple spots. For example, wide- ...
... In spite of the success of in vivo calcium imaging for visualizing neuronal ensemble activity, a number of challenges remain. One crucial issue is the limited temporal resolution. A first strategy to improve imaging speed is to simultaneously excite fluorescence at multiple spots. For example, wide- ...
Mechanisms of Magnetic Stimulation of Central Nervous System
... funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. ...
... funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. ...
BCM Theory
... complex spikes, making it possible to lump the activity of the PC population together. We also verified the equivalence of the two models by following the trajectory of the PC population output and DCN activity of the original model up to one day in simulation time after lesion (see Supplementary Fi ...
... complex spikes, making it possible to lump the activity of the PC population together. We also verified the equivalence of the two models by following the trajectory of the PC population output and DCN activity of the original model up to one day in simulation time after lesion (see Supplementary Fi ...
Subthalamic Stimulation-Induced Synaptic Responses in Substantia
... and form asymmetric contacts with nigral and entopeduncular neurons (Bevan et al. 1994; Chang et al. 1984; Hammond et al. 1978; Shink et al. 1996), reports of the effects of STN stimulation on the activity of substantia nigra dopaminergic neurons in vivo are somewhat contradictory. In the earliest r ...
... and form asymmetric contacts with nigral and entopeduncular neurons (Bevan et al. 1994; Chang et al. 1984; Hammond et al. 1978; Shink et al. 1996), reports of the effects of STN stimulation on the activity of substantia nigra dopaminergic neurons in vivo are somewhat contradictory. In the earliest r ...
Chapter 8 The Nervous System
... • Second largest part of the human brain • Helps control muscle contractions to produce coordinated movements so that we can maintain balance, move smoothly, and sustain normal postures ...
... • Second largest part of the human brain • Helps control muscle contractions to produce coordinated movements so that we can maintain balance, move smoothly, and sustain normal postures ...
The fate of Nissl-stained dark neurons following
... neurons that had intact neuronal bodies [23]. The N-DNs were deWned as neurons with abnormal morphologies of massive shrunken, hyperbasophilic features, and corkscrew-like dendrites. No correlation factor was applied because the somata were smaller than the distance between the two sections stained ...
... neurons that had intact neuronal bodies [23]. The N-DNs were deWned as neurons with abnormal morphologies of massive shrunken, hyperbasophilic features, and corkscrew-like dendrites. No correlation factor was applied because the somata were smaller than the distance between the two sections stained ...
Comprehensive imaging of cortical networks
... The vast majority of cellular in vivo imaging studies have been performed using 2-photon laser scanning microscopy [50]. 2-Photon excitation provides localization of excitation in scattering tissue, which in turn produces threedimensional contrast and resolution. As a result of localization of excit ...
... The vast majority of cellular in vivo imaging studies have been performed using 2-photon laser scanning microscopy [50]. 2-Photon excitation provides localization of excitation in scattering tissue, which in turn produces threedimensional contrast and resolution. As a result of localization of excit ...
electrophysiological studies of rat substantia nigra neurons in an in
... H. NAKANISHI,*‡ A. TAMURA,† K. KAWAI† and K. YAMAMOTO* *Department of Pharmacology, Faculty of Dentistry, Kyushu University, Fukuoka 812, Japan †Department of Neurosurgery, Teikyo University, School of Medicine, Tokyo 173, Japan Abstract––We studied sequential changes in electrophysiological profile ...
... H. NAKANISHI,*‡ A. TAMURA,† K. KAWAI† and K. YAMAMOTO* *Department of Pharmacology, Faculty of Dentistry, Kyushu University, Fukuoka 812, Japan †Department of Neurosurgery, Teikyo University, School of Medicine, Tokyo 173, Japan Abstract––We studied sequential changes in electrophysiological profile ...
Cellular, synaptic and network effects of neuromodulation
... model neurons in the top and bottom panels show similar firing properties although their maximal conductances are very different (shown in the insets). (b) Conversely, two model neurons whose maximum conductance values are similar give rise to different activity patterns. Modified from Goldman et al ...
... model neurons in the top and bottom panels show similar firing properties although their maximal conductances are very different (shown in the insets). (b) Conversely, two model neurons whose maximum conductance values are similar give rise to different activity patterns. Modified from Goldman et al ...
Center-Surround Interactions in the Middle Temporal Visual Area of
... could be controlled either manually, using a mouse and a “dial-andbutton” box, or by a second computer via a serial port interface. This second computer also collected and stored the unit data using a counter-timer board (Metrabyte CTM05). Neuronal signals were recorded using glass-coated tungsten m ...
... could be controlled either manually, using a mouse and a “dial-andbutton” box, or by a second computer via a serial port interface. This second computer also collected and stored the unit data using a counter-timer board (Metrabyte CTM05). Neuronal signals were recorded using glass-coated tungsten m ...
Single Nigrostriatal Dopaminergic Neurons Form Widely Spread
... nuclei of the basal ganglia circuit. Furthermore, the neostriatum is known to have a mosaic organization and be composed of patch/striosome and matrix compartments which are distinguishable from each other by the expression of neurochemical markers and by input– output organization (Graybiel and Rag ...
... nuclei of the basal ganglia circuit. Furthermore, the neostriatum is known to have a mosaic organization and be composed of patch/striosome and matrix compartments which are distinguishable from each other by the expression of neurochemical markers and by input– output organization (Graybiel and Rag ...
Neuronal Activity and Ion Homeostasis in the Hypoxic Brain
... Many of the individual processes playing a role have already been identified. These include cerebral energy consumption and metabolism, neuronal membrane voltage dynamics and action potential generation, synaptic functioning, changes in extra- and intracellular concentrations (ions, molecular messen ...
... Many of the individual processes playing a role have already been identified. These include cerebral energy consumption and metabolism, neuronal membrane voltage dynamics and action potential generation, synaptic functioning, changes in extra- and intracellular concentrations (ions, molecular messen ...
Response of Integrate-and-Fire Neurons to Noisy Inputs Filtered by
... and τGABAB ∼ 100 ms (Otis, De Koninck, & Mody, 1993), which are activated by release of GABA from GABAergic presynaptic cells. Therefore, spikes arriving at the presynaptic terminals can initiate a variety of synaptic currents on the postsynaptic neuron with different time courses and lasting for qu ...
... and τGABAB ∼ 100 ms (Otis, De Koninck, & Mody, 1993), which are activated by release of GABA from GABAergic presynaptic cells. Therefore, spikes arriving at the presynaptic terminals can initiate a variety of synaptic currents on the postsynaptic neuron with different time courses and lasting for qu ...
Different Subthreshold Mechanisms Underlie Song Selectivity in
... this idea, in vivo intracellular recordings from X-projecting neurons reveal that they have song-selective auditory responses (Lewicki, 1996). Furthermore, certain X-projecting neurons display BOSevoked hyperpolarizations (Lewicki, 1996), perhaps driven by HVc interneurons, that might refine these r ...
... this idea, in vivo intracellular recordings from X-projecting neurons reveal that they have song-selective auditory responses (Lewicki, 1996). Furthermore, certain X-projecting neurons display BOSevoked hyperpolarizations (Lewicki, 1996), perhaps driven by HVc interneurons, that might refine these r ...
local connectivity between neurons of the rat globus pallidus
... The results of early Golgi-impregnation studies in the mouse, rat and primate demonstrated the presence of local axon collaterals arising from neurons of the GP (Iwahori and Mizuno, 1981; Francois et al., 1984; Millhouse, 1986). Similarly, intracellular labelling, juxtacellular labelling, single-axo ...
... The results of early Golgi-impregnation studies in the mouse, rat and primate demonstrated the presence of local axon collaterals arising from neurons of the GP (Iwahori and Mizuno, 1981; Francois et al., 1984; Millhouse, 1986). Similarly, intracellular labelling, juxtacellular labelling, single-axo ...
Bayesian Spiking Neurons II: Learning
... spike train. This holds for a single neuron receiving Poisson-distributed synaptic inputs, as described in the companion letter in this issue. More important, the same learning rule can be applied to the output spike trains coming from other Bayesian neurons. As a consequence, these neurons can be u ...
... spike train. This holds for a single neuron receiving Poisson-distributed synaptic inputs, as described in the companion letter in this issue. More important, the same learning rule can be applied to the output spike trains coming from other Bayesian neurons. As a consequence, these neurons can be u ...
ADDLs - CiteSeerX
... specific aberrations in synaptic signaling, ADDLs first cause early-stage memory loss, with broader-scale effects of ADDLs subsequently leading to synapse degeneration and nerve cell death. The ADDL hypothesis includes three distinguishing features: (1) involvement of small globular neurotoxins, whi ...
... specific aberrations in synaptic signaling, ADDLs first cause early-stage memory loss, with broader-scale effects of ADDLs subsequently leading to synapse degeneration and nerve cell death. The ADDL hypothesis includes three distinguishing features: (1) involvement of small globular neurotoxins, whi ...
Optogenetics in a transparent animal: circuit function in the larval
... optogenetic approaches have been applied in larval zebrafish to explore the neural basis of behavior. Optogenetics not only allows us to monitor neural activity but also to perform loss-of-function and gain-of-function experiments to test the necessity and sufficiency, respectively, of neural activi ...
... optogenetic approaches have been applied in larval zebrafish to explore the neural basis of behavior. Optogenetics not only allows us to monitor neural activity but also to perform loss-of-function and gain-of-function experiments to test the necessity and sufficiency, respectively, of neural activi ...
OLED_Optogenetics_abstract_v3_wo_links
... OCIS codes: (170.2945) Medical optics and biotechnology – lllumination design; (310.6860) Thin film devices and applications; (160.4890) Organic materials ...
... OCIS codes: (170.2945) Medical optics and biotechnology – lllumination design; (310.6860) Thin film devices and applications; (160.4890) Organic materials ...
“Black” Responses Dominate Macaque Primary Visual Cortex
... viewing distance of ⬃114 cm. The basic attributes of each cell were estimated using small drifting sinusoidal gratings surrounded by gray background (both the gratings and the gray background had a mean luminance of 59 cd/m 2). Visual stimuli. We used both sparse noise (Jones and Palmer, 1987) and s ...
... viewing distance of ⬃114 cm. The basic attributes of each cell were estimated using small drifting sinusoidal gratings surrounded by gray background (both the gratings and the gray background had a mean luminance of 59 cd/m 2). Visual stimuli. We used both sparse noise (Jones and Palmer, 1987) and s ...
Function of Peripheral Olfactory Organs
... Responses to both contact with and loss of sex pheromone filaments by male moths can be as fast as 0.15s [Grapholita rnolesta (Busck), Baker and Haynes 19871,but usually are between 0.3-0.6s [Heliothis virescens (F.), Helicoverpa zea (Boddie), and Antheraea polyphemus (Cramer), respectively; Vickers ...
... Responses to both contact with and loss of sex pheromone filaments by male moths can be as fast as 0.15s [Grapholita rnolesta (Busck), Baker and Haynes 19871,but usually are between 0.3-0.6s [Heliothis virescens (F.), Helicoverpa zea (Boddie), and Antheraea polyphemus (Cramer), respectively; Vickers ...
Short-Term Synaptic Plasticity Orchestrates the Response of Pyramidal
... The Integration Time Constant ...
... The Integration Time Constant ...