Pharmacologically Active Drug Metabolites: Impact on Drug
... Address correspondence to: Dr. R. Scott Obach, Pfizer Inc., Eastern Point Rd., Groton, CT 06340. E-mail: [email protected] dx.doi.org/10.1124/pr.111.005439. ...
... Address correspondence to: Dr. R. Scott Obach, Pfizer Inc., Eastern Point Rd., Groton, CT 06340. E-mail: [email protected] dx.doi.org/10.1124/pr.111.005439. ...
MICROMEDEX® Healthcare Series - Law Project for Psychiatric
... 2) Although considerable interindividual variation in paroxetine pharmacokinetics has been observed, higher plasma levels of paroxetine have been observed, as well as slowed elimination in the elderly, compared with younger subjects (Kaye et al, 1989d; Ghose, 1989a; Bayer et al, 1989a; Lundmark et a ...
... 2) Although considerable interindividual variation in paroxetine pharmacokinetics has been observed, higher plasma levels of paroxetine have been observed, as well as slowed elimination in the elderly, compared with younger subjects (Kaye et al, 1989d; Ghose, 1989a; Bayer et al, 1989a; Lundmark et a ...
LSD (Lysergic acid diethylamide), death? and distraction
... • Some deaths have been associated with inebriated or combative behaviour while under the influence of LSD, including falling or jumping from a height or dying after being beaten by police. Estimated less than one death per million LSD use sessions, with risk of death being higher amongst those pred ...
... • Some deaths have been associated with inebriated or combative behaviour while under the influence of LSD, including falling or jumping from a height or dying after being beaten by police. Estimated less than one death per million LSD use sessions, with risk of death being higher amongst those pred ...
Minocycline - Rebound Health
... slate-grey hyperpigmentation of the skin. Blue or blue-black oral pigmentation was seen in 10% of patients taking minocycline for at least 1 year; the rate increased to 20% after 4 years of continuous use2. Large daily doses of ascorbic acid (vitamin C) may prevent this phenomenon34. Mode of action ...
... slate-grey hyperpigmentation of the skin. Blue or blue-black oral pigmentation was seen in 10% of patients taking minocycline for at least 1 year; the rate increased to 20% after 4 years of continuous use2. Large daily doses of ascorbic acid (vitamin C) may prevent this phenomenon34. Mode of action ...
Thalidomide: A Review, With a Focus on Ocular Findings and New
... crocodile tears) was also described as a manifestation of this potent teratogen (Takemori et al., ’76). External ear, strabismus, facial nerve palsy, and aberrant lacrimation were often noted to occur together. A wide variety of other anomalies have been reported in review articles (Kajii, ’65; Smit ...
... crocodile tears) was also described as a manifestation of this potent teratogen (Takemori et al., ’76). External ear, strabismus, facial nerve palsy, and aberrant lacrimation were often noted to occur together. A wide variety of other anomalies have been reported in review articles (Kajii, ’65; Smit ...
Actinomycosis: etiology, clinical features, diagnosis, treatment, and management Infection and Drug Resistance Dove
... to beta-lactams, and especially penicillin G or amoxicillin. As a consequence, penicillin G or amoxicillin are considered drugs of choice for the treatment of actinomycosis. Third-generation cephalosporins are less frequently used even if they are considered to be active on A. israelii; however, it ...
... to beta-lactams, and especially penicillin G or amoxicillin. As a consequence, penicillin G or amoxicillin are considered drugs of choice for the treatment of actinomycosis. Third-generation cephalosporins are less frequently used even if they are considered to be active on A. israelii; however, it ...
Honey - A Novel Antidiabetic Agent
... Diabetes mellitus remains a burden worldwide in spite of the availability of numerous antidiabetic drugs. Honey is a natural substance produced by bees from nectar. Several evidence-based health benefits have been ascribed to honey in the recent years. In this review article, we highlight findings w ...
... Diabetes mellitus remains a burden worldwide in spite of the availability of numerous antidiabetic drugs. Honey is a natural substance produced by bees from nectar. Several evidence-based health benefits have been ascribed to honey in the recent years. In this review article, we highlight findings w ...
Prevalence and nature of adverse drug events and the potential for
... the medical records, ADEs and their preventability were assessed manually by pharmacists and physicians, in a stepwise manner. A meta-analysis and a systematic literature review were conducted to summarise previous literature on preventable ADRs and methods to assess the preventability of ADEs. Resu ...
... the medical records, ADEs and their preventability were assessed manually by pharmacists and physicians, in a stepwise manner. A meta-analysis and a systematic literature review were conducted to summarise previous literature on preventable ADRs and methods to assess the preventability of ADEs. Resu ...
ibogaine: a review
... ancillary in attempting to characterize a drug’s in vivo mechanism of action, micromolar activity may be pharmacologically important with regard to ibogaine or noribogaine due to the relatively high concentrations reached in the brain (40,44,51). Hough et al. (51) noted a brain level of ibogaine of ...
... ancillary in attempting to characterize a drug’s in vivo mechanism of action, micromolar activity may be pharmacologically important with regard to ibogaine or noribogaine due to the relatively high concentrations reached in the brain (40,44,51). Hough et al. (51) noted a brain level of ibogaine of ...
ACC/AHA Prevention Guideline
... to reduce ASCVD risk. For this guideline, ASCVD includes coronary heart disease (CHD), stroke, and peripheral arterial disease, all of presumed atherosclerotic origin. These recommendations are intended to provide a strong, evidence-based foundation for the treatment of cholesterol for the primary a ...
... to reduce ASCVD risk. For this guideline, ASCVD includes coronary heart disease (CHD), stroke, and peripheral arterial disease, all of presumed atherosclerotic origin. These recommendations are intended to provide a strong, evidence-based foundation for the treatment of cholesterol for the primary a ...
ACC/AHA Prevention Guideline
... http://www.nhlbi.nih.gov/guidelines/cholesterol/ser/. Table 2 provides an overview to facilitate understanding what is new in the present guideline. The Expert Panel was charged with using data from randomized controlled trials (RCTs) and systematic reviews and meta-analyses of RCTs to update the cl ...
... http://www.nhlbi.nih.gov/guidelines/cholesterol/ser/. Table 2 provides an overview to facilitate understanding what is new in the present guideline. The Expert Panel was charged with using data from randomized controlled trials (RCTs) and systematic reviews and meta-analyses of RCTs to update the cl ...
Performance Enhancing Hormone Doping in Sport
... athletes. Ensuing demands for excessive, often massive, drug doses without medical indications could not be ethically or safely prescribed by doctors. This could convert sporting participation into a potentially dangerous rather than a healthful activity. In practice, creating enforceable boundaries ...
... athletes. Ensuing demands for excessive, often massive, drug doses without medical indications could not be ethically or safely prescribed by doctors. This could convert sporting participation into a potentially dangerous rather than a healthful activity. In practice, creating enforceable boundaries ...
Behavioral Mechanisms of Pramipexole
... Impulsivity represents a substantial and devastating cost to our economic, cultural, and physical prosperity. Using quantitative models of choice behavior, researchers are able to identify environmental conditions likely to promote impulsive decision-making. Such an approach is especially valuable i ...
... Impulsivity represents a substantial and devastating cost to our economic, cultural, and physical prosperity. Using quantitative models of choice behavior, researchers are able to identify environmental conditions likely to promote impulsive decision-making. Such an approach is especially valuable i ...
Dexmedetomidine - National Association of Veterinary Technicians
... atipamezole. But now, more practices are beginning to expand their use of dexmedetomidine to take advantage of its analgesic effects as well. Dexmedetomidine is non-narcotic and can be very useful when combined with opioids for a multimodal analgesic protocol. Dexmedetomidine also comes with the ben ...
... atipamezole. But now, more practices are beginning to expand their use of dexmedetomidine to take advantage of its analgesic effects as well. Dexmedetomidine is non-narcotic and can be very useful when combined with opioids for a multimodal analgesic protocol. Dexmedetomidine also comes with the ben ...
THE ROLE OF % E VAGI ARD CAROTID SINUS MECHANISMS IN
... Sincere appreciation ie extended to my adviser, Dr. John W. Nelson, lAo aroused my initial interest in hypertensive research and tdio, throughout this investigation, has willingly and enthusiastically dis cussed with me the many problems which arose. His experience and know ledge have been a great ...
... Sincere appreciation ie extended to my adviser, Dr. John W. Nelson, lAo aroused my initial interest in hypertensive research and tdio, throughout this investigation, has willingly and enthusiastically dis cussed with me the many problems which arose. His experience and know ledge have been a great ...
Chapter 3 Medicinal Inventions
... (Note) It is known in the field of medical treatment that there are certain compounds etc. having two or more medicinal uses inevitably. However, in the examples listed under (ii) above, it is also well known that all the compounds etc. having a first medicinal use coming under (ii) above do not hav ...
... (Note) It is known in the field of medical treatment that there are certain compounds etc. having two or more medicinal uses inevitably. However, in the examples listed under (ii) above, it is also well known that all the compounds etc. having a first medicinal use coming under (ii) above do not hav ...
1 CURRICULUM VITAE PHILIP J. SCHNEIDER
... Summary of project: This is a two-year planning grant to develop a new innovative integrated Interprofessional curriculum to prepare physicians, nurse practitioners and pharmacists , with an emphasis on primary care practice in rural and underserved areas. Title of Project: Evaluating the impact of ...
... Summary of project: This is a two-year planning grant to develop a new innovative integrated Interprofessional curriculum to prepare physicians, nurse practitioners and pharmacists , with an emphasis on primary care practice in rural and underserved areas. Title of Project: Evaluating the impact of ...
Mechanistic Studies on Metabolic Interactions between Gemfibrozil
... NMR spectroscopy (Prueksaritanont et al., 1999). Brij 58, alamethicin, GFZ, clofibric acid, and UDPGA were obtained from SigmaAldrich (St. Louis, MO). Sulfaphenazole and ketoconazole were purchased from Ultrafine (Manchester, England) and Research Diagnostics (Flanders, NJ), respectively. All other ...
... NMR spectroscopy (Prueksaritanont et al., 1999). Brij 58, alamethicin, GFZ, clofibric acid, and UDPGA were obtained from SigmaAldrich (St. Louis, MO). Sulfaphenazole and ketoconazole were purchased from Ultrafine (Manchester, England) and Research Diagnostics (Flanders, NJ), respectively. All other ...
Metabotropic Glutamate Receptors
... a condition termed “allostatic load” (McEwen and Stellar, 1993; McEwen and Wingfield, 2003; McEwen, 1998). Accordingly, inappropriate, severe or prolonged stress is associated with changes in the brain that impair its ability to regulate appropriately physiological and behavioral responses (Arnsten, ...
... a condition termed “allostatic load” (McEwen and Stellar, 1993; McEwen and Wingfield, 2003; McEwen, 1998). Accordingly, inappropriate, severe or prolonged stress is associated with changes in the brain that impair its ability to regulate appropriately physiological and behavioral responses (Arnsten, ...
- International Journal of Applied Research in Natural
... 0.001; one-way ANOVA followed by Dunnet’s test as compared to control; n = Number of mice; p.o.: per oral. ...
... 0.001; one-way ANOVA followed by Dunnet’s test as compared to control; n = Number of mice; p.o.: per oral. ...
Licorice - Glycyrrhiza glabra
... Therefore, the German health authorities warn that licorice should not be used for more than four to six weeks in therapeutic doses, without medical advice. During this period of time, a diet rich in potassium (such as bananas and dried apricots) is recommended. The potassium loss can also produce i ...
... Therefore, the German health authorities warn that licorice should not be used for more than four to six weeks in therapeutic doses, without medical advice. During this period of time, a diet rich in potassium (such as bananas and dried apricots) is recommended. The potassium loss can also produce i ...
Effects of Long Acting Methylphenidate on Ghrelin Levels in Male
... hyperactivity disorder between the ages of 6-12 were recruited for this investigation. In addition to ghrelin levels, other laboratory findings, body mass index, body mass index percentiles, body weight-height measures and attention deficit-hyperactivity disorder symptom severity findings were analy ...
... hyperactivity disorder between the ages of 6-12 were recruited for this investigation. In addition to ghrelin levels, other laboratory findings, body mass index, body mass index percentiles, body weight-height measures and attention deficit-hyperactivity disorder symptom severity findings were analy ...
ACC/AHA Prevention Guideline
... reviewing the highest-quality evidence and partner with other organizations to develop recommendations.2,3 Accordingly, in June 2013 the NHLBI initiated collaboration with the ACC and AHA to work with other organizations to complete and publish the 4 guidelines noted above and make them available to ...
... reviewing the highest-quality evidence and partner with other organizations to develop recommendations.2,3 Accordingly, in June 2013 the NHLBI initiated collaboration with the ACC and AHA to work with other organizations to complete and publish the 4 guidelines noted above and make them available to ...
A Solid-State Approach to Enable Early Development Compounds
... dispersion consists of an amorphous active API stabilized by a polymer, with the amorphous form of the drug providing increased apparent solubility. The benefit of these materials is the increased concentration in solution and supersaturation relative to the crystalline material. It has also been su ...
... dispersion consists of an amorphous active API stabilized by a polymer, with the amorphous form of the drug providing increased apparent solubility. The benefit of these materials is the increased concentration in solution and supersaturation relative to the crystalline material. It has also been su ...
Investigator`s Brochure - Multidisciplinary Association for
... result of inconsistent relationship between body weight and pharmacodynamic activity, the sponsor’s human trials use fixed doses that are equivalent to between 1 and 2 mg/kg (active doses in studies range from 75mg to 187.5mg) to achieve a more consistent response between subjects. The pharmacokinet ...
... result of inconsistent relationship between body weight and pharmacodynamic activity, the sponsor’s human trials use fixed doses that are equivalent to between 1 and 2 mg/kg (active doses in studies range from 75mg to 187.5mg) to achieve a more consistent response between subjects. The pharmacokinet ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.