Neuropharmacology of N,N-dimethyltryptamine
... and 2,5-dimethoxy-4- methylamphetamine (DOM) cause sensory distortion, depersonalization at high doses, and at least one (N,Ndiisopropyltryptamine, DiPT) causes auditory distortions, whereas some compounds such as DMT (found in ayahuasca), psilocybin (mushrooms) or mescaline (peyote) cause episodic ...
... and 2,5-dimethoxy-4- methylamphetamine (DOM) cause sensory distortion, depersonalization at high doses, and at least one (N,Ndiisopropyltryptamine, DiPT) causes auditory distortions, whereas some compounds such as DMT (found in ayahuasca), psilocybin (mushrooms) or mescaline (peyote) cause episodic ...
A Literature Review on the Status and Effects of Salvia Divinorum on
... early as five minutes after ingestion. Despite the powerful nature of Salvia divinorum, the hallucinatory effects are short-lasting and often peak and reside within three to ten minutes after smoking the leaves. The psychoactive effects are largely subjective which make them difficult to study. The ...
... early as five minutes after ingestion. Despite the powerful nature of Salvia divinorum, the hallucinatory effects are short-lasting and often peak and reside within three to ten minutes after smoking the leaves. The psychoactive effects are largely subjective which make them difficult to study. The ...
Codeine use in children and ultra-rapid metabolisers
... © Commonwealth of Australia 2015 This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction fo ...
... © Commonwealth of Australia 2015 This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction fo ...
Codeine use in children and ultra-rapid metabolisers
... © Commonwealth of Australia 2015 This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction fo ...
... © Commonwealth of Australia 2015 This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction fo ...
Pharmacological effects of meldonium: Biochemical mechanisms
... esters into the mitochondrial matrix (Fig. 1). The effects of meldonium treatment on CPT1 activity have been extensively studied (Table 1), and the results largely depend on the l-carnitine concentrations used in the experiment. Meldonium treatment results in increased mRNA levels [23] and protein e ...
... esters into the mitochondrial matrix (Fig. 1). The effects of meldonium treatment on CPT1 activity have been extensively studied (Table 1), and the results largely depend on the l-carnitine concentrations used in the experiment. Meldonium treatment results in increased mRNA levels [23] and protein e ...
From Medscape General Medicine
... Melatonin antagonizes several effects of exogenous corticoids: immune depression [28] and hypercatabolism, thymic involution, and adrenal suppression.[29] These findings have led to the suggestion that melatonin might work as an antiadrenocortical or antistress factor. [29] The melatonin/corticoid r ...
... Melatonin antagonizes several effects of exogenous corticoids: immune depression [28] and hypercatabolism, thymic involution, and adrenal suppression.[29] These findings have led to the suggestion that melatonin might work as an antiadrenocortical or antistress factor. [29] The melatonin/corticoid r ...
week counts®
... the risk of preterm birth in women who are currently pregnant with one baby and who have unexpectedly delivered a baby preterm (before 37 weeks) in the past.8 Makena is made in a facility that follows FDA’s Good Manufacturing Practices (GMPs).9,10 Before it was approved, the FDA thoroughly reviewed ...
... the risk of preterm birth in women who are currently pregnant with one baby and who have unexpectedly delivered a baby preterm (before 37 weeks) in the past.8 Makena is made in a facility that follows FDA’s Good Manufacturing Practices (GMPs).9,10 Before it was approved, the FDA thoroughly reviewed ...
Stability and aerosolization of pressurized metered dose inhalers
... emitted dose and size characteristics, which lead to poor inhalation therapy (Nyambura et al., 2009a). It has not reported that nanoparticles could be dispersed in pure HFA propellants to form self-stabilized nanosuspensions. The application of stabilizers is the most commonly used strategy in achie ...
... emitted dose and size characteristics, which lead to poor inhalation therapy (Nyambura et al., 2009a). It has not reported that nanoparticles could be dispersed in pure HFA propellants to form self-stabilized nanosuspensions. The application of stabilizers is the most commonly used strategy in achie ...
A review on pharmacological property of Mimusops elengi Linn.
... the doses of 250 mg/kg and 500 mg/kg body weight respectively which is comparable to the standard drug diclofenac sodium was found to be 76.69% at a dose of 25 mg/kg body weight. In hot plate test the extract exerted significant (P<0.001) prolongation in the response of latency time to the heat stim ...
... the doses of 250 mg/kg and 500 mg/kg body weight respectively which is comparable to the standard drug diclofenac sodium was found to be 76.69% at a dose of 25 mg/kg body weight. In hot plate test the extract exerted significant (P<0.001) prolongation in the response of latency time to the heat stim ...
Sedation for diagnostic and therapeutic procedures in children and
... between sedation and anaesthesia will depend on the type of procedure. Some procedures are very common and healthcare providers and practitioners need to understand under which circumstances either sedation or anaesthesia is most cost effective. In adults, many procedures can be undertaken with loca ...
... between sedation and anaesthesia will depend on the type of procedure. Some procedures are very common and healthcare providers and practitioners need to understand under which circumstances either sedation or anaesthesia is most cost effective. In adults, many procedures can be undertaken with loca ...
Diazepam - EWU Institutional Repository
... For IV administration the onset of action is one to five minutes and the duration of peak pharmacological effects is 15 min to 1 hr. ...
... For IV administration the onset of action is one to five minutes and the duration of peak pharmacological effects is 15 min to 1 hr. ...
Non-steroidal anti-inflammatory drugs (NSAIDs)
... NSAIDs, respondents expressed generally good knowledge, with 89% of the 664 text responses being correct. The most common correct side effects reported by respondents to this question were upper gastrointestinal tract problems (31%), ulcers (22%) and bleeding (15%). However, when asked the same ques ...
... NSAIDs, respondents expressed generally good knowledge, with 89% of the 664 text responses being correct. The most common correct side effects reported by respondents to this question were upper gastrointestinal tract problems (31%), ulcers (22%) and bleeding (15%). However, when asked the same ques ...
Illicit anabolic–androgenic steroid use
... Soon after the introduction of AAS as possible therapeutic agents, athletes discovered that these drugs could allow them to gain high levels of muscle mass, often far beyond that obtainable by natural means (Fitzpatrick, 2002). AAS quickly began to spread through the elite athletic community, and by ...
... Soon after the introduction of AAS as possible therapeutic agents, athletes discovered that these drugs could allow them to gain high levels of muscle mass, often far beyond that obtainable by natural means (Fitzpatrick, 2002). AAS quickly began to spread through the elite athletic community, and by ...
The ibogaine medical subculture
... HCl is the only iboga alkaloid that has reportedly been administered to humans, with apparently only one exception, a study in which 12 normal volunteers were evaluated with some brief neuropsychological tests after receiving the naturally occurring iboga alkaloid ibogaline (Schmid, 1967). Ibogaine ...
... HCl is the only iboga alkaloid that has reportedly been administered to humans, with apparently only one exception, a study in which 12 normal volunteers were evaluated with some brief neuropsychological tests after receiving the naturally occurring iboga alkaloid ibogaline (Schmid, 1967). Ibogaine ...
Naloxone: Frequently Asked Questions
... treatment. There is, however, less risk of overdose than with other opioids. Most buprenorphine overdoses involve intravenous injection and/or combination of buprenorphine with other drugs, particularly sedatives, benzodiazepines or neuroleptics. Unfortunately, naloxone doesn’t work as well for bupr ...
... treatment. There is, however, less risk of overdose than with other opioids. Most buprenorphine overdoses involve intravenous injection and/or combination of buprenorphine with other drugs, particularly sedatives, benzodiazepines or neuroleptics. Unfortunately, naloxone doesn’t work as well for bupr ...
Turmeric - OpenLab
... mice receiving curcumin lost much more weight than the control group, and when researchers checked their intestinal cell function, all signs of typical colitis were reduced. Researchers are not exactly sure of how curcumin achieves its protective effects but believe it is due to the antioxidant acti ...
... mice receiving curcumin lost much more weight than the control group, and when researchers checked their intestinal cell function, all signs of typical colitis were reduced. Researchers are not exactly sure of how curcumin achieves its protective effects but believe it is due to the antioxidant acti ...
© Information - Universitätsmedizin Mainz
... d distribution as well as translation in any langua age. This leaflet is intended for p private p purp poses by p y patients p – anyy other use needs written consent of the authors. Version Sep 2014 ...
... d distribution as well as translation in any langua age. This leaflet is intended for p private p purp poses by p y patients p – anyy other use needs written consent of the authors. Version Sep 2014 ...
Poisons Information Monograph 859
... glutathione metabolism. Another possible mechanism for hepatic toxicity is the increased lipid metabolism. Inhibition of Mg2+ATPase activity has been observed in rat liver tissue, suggesting an ATPase enzyme sensitivity to the action of gamma-HCH. The researchers suggested that some toxic effects ap ...
... glutathione metabolism. Another possible mechanism for hepatic toxicity is the increased lipid metabolism. Inhibition of Mg2+ATPase activity has been observed in rat liver tissue, suggesting an ATPase enzyme sensitivity to the action of gamma-HCH. The researchers suggested that some toxic effects ap ...
Clinical pharmacology and abuse potential of gamma‐hydroxybutyric acid (GHB)
... biological fluids including alternative matrices. Furthermore, although GHB was being abused by humans, preclinical evaluation of the relative reinforcing effects of GHB was fairly inconsistent. In humans, a number of cases of GHB abuse and dependence have been reported, but no abus ...
... biological fluids including alternative matrices. Furthermore, although GHB was being abused by humans, preclinical evaluation of the relative reinforcing effects of GHB was fairly inconsistent. In humans, a number of cases of GHB abuse and dependence have been reported, but no abus ...
Cathinone derivatives: A review of their chemistry, pharmacology
... UK. The next cathinone derivative to appear was flephedrone (4- fluoromethcathinone), and its related structural isomers 2and 3-fluoromethcathinone.[18,19] The reasons for the increased interest in this range of cathinone derivatives (most particularly mephedrone) have been ascribed to the low cost, ...
... UK. The next cathinone derivative to appear was flephedrone (4- fluoromethcathinone), and its related structural isomers 2and 3-fluoromethcathinone.[18,19] The reasons for the increased interest in this range of cathinone derivatives (most particularly mephedrone) have been ascribed to the low cost, ...
Hydrocortisone, Hydrocortisone Acetate, Hydrocortisone
... 4- to 6-hour intervals if constant high blood concentrations of hydrocortisone are required. After the initial emergency period, a longer-acting injectable corticosteroid preparation or oral administration of a corticosteroid should be considered. Dosage for infants and children should be based on t ...
... 4- to 6-hour intervals if constant high blood concentrations of hydrocortisone are required. After the initial emergency period, a longer-acting injectable corticosteroid preparation or oral administration of a corticosteroid should be considered. Dosage for infants and children should be based on t ...
Traveler`s Diarrhea - Division of General Internal Medicine
... in camping stores in the United States or in pharmacies in other countries. Because infants and toddlers normally can have three or more loose stools, an alternate definition of diarrhea in this age group is a twofold increase in the frequency of unformed stool.37 Nursing infants should continue to ...
... in camping stores in the United States or in pharmacies in other countries. Because infants and toddlers normally can have three or more loose stools, an alternate definition of diarrhea in this age group is a twofold increase in the frequency of unformed stool.37 Nursing infants should continue to ...
Drug interactions involving warfarin
... agent has reached a steady state (about 5 halflives).6 Second, given the indirect effect of warfarin, time must be allowed for the newly established “warfarin concentration” to affect the vitamin K– dependent clotting factors being newly synthesized by the liver. Concomitantly, clotting factors pres ...
... agent has reached a steady state (about 5 halflives).6 Second, given the indirect effect of warfarin, time must be allowed for the newly established “warfarin concentration” to affect the vitamin K– dependent clotting factors being newly synthesized by the liver. Concomitantly, clotting factors pres ...
About the National Institute of Allergy and Infectious Diseases
... seek immediate medical treatment. Epinephrine should be used with caution if you have heart disease or are taking certain medicines that can cause heart-related (cardiac) symptoms. Tell your doctor if you have certain medical conditions such as asthma, depression, thyroid disease, Parkinson’s diseas ...
... seek immediate medical treatment. Epinephrine should be used with caution if you have heart disease or are taking certain medicines that can cause heart-related (cardiac) symptoms. Tell your doctor if you have certain medical conditions such as asthma, depression, thyroid disease, Parkinson’s diseas ...
Effects of Acute Caffeine Administration on Adolescents
... intake, specifically from high-sugar, low-fat foods and also positively associated with protein and fat consumption outside of the laboratory. When taken together, these data suggest that acute caffeine administration has a broad range of effects in adolescents and that the magnitude of these effect ...
... intake, specifically from high-sugar, low-fat foods and also positively associated with protein and fat consumption outside of the laboratory. When taken together, these data suggest that acute caffeine administration has a broad range of effects in adolescents and that the magnitude of these effect ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.