Introduction
... brain is consistent with the ability of cannabinoids to alter pain perception, affect motor function, impair cognition and memory, and stimulate feeding (Hohmann and Herkenham, 2000; Herkenham et al., 1990; Matsuda et al., 1993; Freund et al., 2003). Those actions are effectively inhibited by the CB ...
... brain is consistent with the ability of cannabinoids to alter pain perception, affect motor function, impair cognition and memory, and stimulate feeding (Hohmann and Herkenham, 2000; Herkenham et al., 1990; Matsuda et al., 1993; Freund et al., 2003). Those actions are effectively inhibited by the CB ...
PRODUCT MONOGRAPH Pr CLINDOXYL® ADV Gel Pr
... or CLINDOXYL® ADV Gel should not be administered to a pregnant woman unless the expected benefits to the mother outweigh the potential risks to the fetus. Nursing Women: Topical CLINDOXYL® Gel or CLINDOXYL® ADV Gel has not been studied during breast-feeding. It is not known whether benzoyl peroxide ...
... or CLINDOXYL® ADV Gel should not be administered to a pregnant woman unless the expected benefits to the mother outweigh the potential risks to the fetus. Nursing Women: Topical CLINDOXYL® Gel or CLINDOXYL® ADV Gel has not been studied during breast-feeding. It is not known whether benzoyl peroxide ...
Gemcitabine 1g Powder for Solution for Infusion
... advanced NSCLC. In the elderly, gemcitabine is an example of a single agent of choice in NSCLC. The clinical overview adds that many chemotherapy drugs have been evaluated in pancreatic cancer and that the results have been disappointing. Gemcitabine has been found to be more effective than 5-FU in ...
... advanced NSCLC. In the elderly, gemcitabine is an example of a single agent of choice in NSCLC. The clinical overview adds that many chemotherapy drugs have been evaluated in pancreatic cancer and that the results have been disappointing. Gemcitabine has been found to be more effective than 5-FU in ...
Ciprofloxacin hydrochloride
... (1) Ciprofloxacine ratiopharm 250 mg/500 mg/750 mg tabletten; (2) Cipro—1 A Pharma1 100 mg Filmtabletten (Mono); (3) Cipro—1 A Pharma1 250 mg/ 500 mg/750 mg Filmtabletten (Mono); (4) CIPRO BASICS 250 mg/500 mg Filmtabletten (Mono); (5) Ciprobay1 250 mg/500 mg/750 mg Filmtabletten (Mono); (6) Ciproba ...
... (1) Ciprofloxacine ratiopharm 250 mg/500 mg/750 mg tabletten; (2) Cipro—1 A Pharma1 100 mg Filmtabletten (Mono); (3) Cipro—1 A Pharma1 250 mg/ 500 mg/750 mg Filmtabletten (Mono); (4) CIPRO BASICS 250 mg/500 mg Filmtabletten (Mono); (5) Ciprobay1 250 mg/500 mg/750 mg Filmtabletten (Mono); (6) Ciproba ...
The safety of hydroquinone
... 45.3%, with peak plasma concentration at 4 hours of 0.04 !g-Eq/mL. Also, excretion was determined to be primarily via the urine as the glucuronide and was essentially complete by 24 hours after application. Absorption from forearm skin was estimated at 24%, raising the possibility that forehead appl ...
... 45.3%, with peak plasma concentration at 4 hours of 0.04 !g-Eq/mL. Also, excretion was determined to be primarily via the urine as the glucuronide and was essentially complete by 24 hours after application. Absorption from forearm skin was estimated at 24%, raising the possibility that forehead appl ...
The Acceleration of Articular Cartilage Degeneration in
... the treatment of osteoarthritis (OA) symptoms, and are taken by 20-30% of elderly people in developed countries. Because of the potential for significant side effects of these medications on the liver, stomach, gastrointestinal tract and heart, including death, treatment guidelines advise against th ...
... the treatment of osteoarthritis (OA) symptoms, and are taken by 20-30% of elderly people in developed countries. Because of the potential for significant side effects of these medications on the liver, stomach, gastrointestinal tract and heart, including death, treatment guidelines advise against th ...
Inhaled nicotine replacement therapy
... as NRTs (at least in the US) but instead as tobacco products [15]. E-cigarettes are gaining in popularity and may offer some safety benefits over cigarettes in terms of harm reduction due to elimination of exposure to carcinogenic tobacco combustion products [16]. However, much is unknown about the ...
... as NRTs (at least in the US) but instead as tobacco products [15]. E-cigarettes are gaining in popularity and may offer some safety benefits over cigarettes in terms of harm reduction due to elimination of exposure to carcinogenic tobacco combustion products [16]. However, much is unknown about the ...
Medical Emergencies and Adverse Events in Ecstasy Users
... related to MDMA/ecstasy. Published analyses suggest that most ecstasy pills contain MDMA. However, many other drugs have been detected in these pills, and some pills sold as ecstasy do not contain any MDMA. This chapter does not discuss cases involving drugs sold as ecstasy that were determined to c ...
... related to MDMA/ecstasy. Published analyses suggest that most ecstasy pills contain MDMA. However, many other drugs have been detected in these pills, and some pills sold as ecstasy do not contain any MDMA. This chapter does not discuss cases involving drugs sold as ecstasy that were determined to c ...
A Closer Look at the Risks vs. Benefits of Kava (Piper methysticum)
... on Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R). The results were not statistically significant due to the small size of participants in all of the seven studies. 2 In another review by Ernst, analysis of six data sets of randomized clinical trials concluded that there is strong ...
... on Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R). The results were not statistically significant due to the small size of participants in all of the seven studies. 2 In another review by Ernst, analysis of six data sets of randomized clinical trials concluded that there is strong ...
clozapine - Law Project for Psychiatric Rights
... than 1 to 2 times weekly in increments not exceeding 100 mg. For maintenance therapy, the lowest dose of clozapine to maintain remission should be used. In schizophrenia, initial doses of oral clozapine have been suggested (Taniguchi & Icaza, 1996): day 1 12.5 milligrams twice daily day 2 25 milligr ...
... than 1 to 2 times weekly in increments not exceeding 100 mg. For maintenance therapy, the lowest dose of clozapine to maintain remission should be used. In schizophrenia, initial doses of oral clozapine have been suggested (Taniguchi & Icaza, 1996): day 1 12.5 milligrams twice daily day 2 25 milligr ...
Bipolar Disorders and Lithium: Pharmacokinetics
... anomaly 1/1000 (20X greater risk than the general population). Those who use lithium should receive regular serum level tests and should monitor thyroid and kidney function for abnormalities, as it interferes with the regulation of sodium and water levels in the body, and can cause dehydration. Dehy ...
... anomaly 1/1000 (20X greater risk than the general population). Those who use lithium should receive regular serum level tests and should monitor thyroid and kidney function for abnormalities, as it interferes with the regulation of sodium and water levels in the body, and can cause dehydration. Dehy ...
Potential Novel Uses of Thalidomide
... studies that report contradictory observations. Overall, it does not seem possible to identify a single dominant mechanism of action for thalidomide. The multiplicity of actions may explain the large variety of therapeutic results achieved with the administration of thalidomide. There are numerous r ...
... studies that report contradictory observations. Overall, it does not seem possible to identify a single dominant mechanism of action for thalidomide. The multiplicity of actions may explain the large variety of therapeutic results achieved with the administration of thalidomide. There are numerous r ...
Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs
... and Drug Administration, 2010). This review article is concerned with procedures for preclinical behavioral pharmacology studies. More specifically, drug use and abuse can be conceptualized as a type of operant behavior. In operant behavior, an “operant” is defined as any active behavior that operat ...
... and Drug Administration, 2010). This review article is concerned with procedures for preclinical behavioral pharmacology studies. More specifically, drug use and abuse can be conceptualized as a type of operant behavior. In operant behavior, an “operant” is defined as any active behavior that operat ...
Visualization and Quantification of Nasal and Olfactory Deposition in
... demonstrated in rats using this device (17). However, considering the interspecies variability in the nasal anatomy, direct extrapolation of the rat results to humans is questionable (18). One apparent anatomical disparity is the ratio of olfactorynasal area, which is about 50% in rats and is only 5 ...
... demonstrated in rats using this device (17). However, considering the interspecies variability in the nasal anatomy, direct extrapolation of the rat results to humans is questionable (18). One apparent anatomical disparity is the ratio of olfactorynasal area, which is about 50% in rats and is only 5 ...
Polysaccharide peptides from COV-1 strain of Coriolus versicolor
... inhibitor, showed a Ki value of 30.8 lM and IC50 at 44.0 lM in the test system. In the pharmacokinetic studies in vivo, acute PSP (4 lmol/kg, i.p.) treatment did not produce significant changes in tolbutamide clearance, but produced a decrease in the Cinitial (7.4%) and an increase in the Vd (7.4%). ...
... inhibitor, showed a Ki value of 30.8 lM and IC50 at 44.0 lM in the test system. In the pharmacokinetic studies in vivo, acute PSP (4 lmol/kg, i.p.) treatment did not produce significant changes in tolbutamide clearance, but produced a decrease in the Cinitial (7.4%) and an increase in the Vd (7.4%). ...
Tetracyclines in malaria | Malaria Journal | Full Text
... The pharmacokinetics properties of doxycycline have been investigated in numerous studies with healthy volunteers. One important property of doxycycline is its ability to be rapidly absorbed orally; it is detectable in the blood 15–30 min after its administration [3, 4]. After an oral dose of 200 mg ...
... The pharmacokinetics properties of doxycycline have been investigated in numerous studies with healthy volunteers. One important property of doxycycline is its ability to be rapidly absorbed orally; it is detectable in the blood 15–30 min after its administration [3, 4]. After an oral dose of 200 mg ...
Prescribing Framework for Phenelzine (MAOI) in the treatment of
... 15 mg 3 times daily, increased if necessary to 4 times daily after 2 weeks (hospital patients, max. 30 mg 3 times daily), then reduced gradually to lowest possible maintenance dose (15 mg on alternate days may be adequate). The last dose of the day should be taken before 3pm. The effectiveness of th ...
... 15 mg 3 times daily, increased if necessary to 4 times daily after 2 weeks (hospital patients, max. 30 mg 3 times daily), then reduced gradually to lowest possible maintenance dose (15 mg on alternate days may be adequate). The last dose of the day should be taken before 3pm. The effectiveness of th ...
Effects of Temperature and Drugs on Frog Heart
... pathway in man proceeds through the formation of paraxanthine (1,7-dimethylxanthine), leading to the principal urinary metabolites, l-methylxanthine, 1-methyluric acid, and an acetylated uracil derivative. Minor pathways involve the formation and metabolism of theophylline and theobromine8. There is ...
... pathway in man proceeds through the formation of paraxanthine (1,7-dimethylxanthine), leading to the principal urinary metabolites, l-methylxanthine, 1-methyluric acid, and an acetylated uracil derivative. Minor pathways involve the formation and metabolism of theophylline and theobromine8. There is ...
PRODUCT MONOGRAPH Codeine Contin
... Codeine Contin® (codeine controlled release tablets) is indicated for the relief of mild to moderate pain requiring the prolonged use of an opioid analgesic preparation. Geriatrics (> 65 years of age): In general, dose selection for an elderly patient should be cautious, usually starting at the low ...
... Codeine Contin® (codeine controlled release tablets) is indicated for the relief of mild to moderate pain requiring the prolonged use of an opioid analgesic preparation. Geriatrics (> 65 years of age): In general, dose selection for an elderly patient should be cautious, usually starting at the low ...
Delirium in the Elderly
... at concentrations that are never achieved with normal dosing. A recent investigation looked at six therapeutic concentrations to identify anticholinergic activity by a radioimmune assay. This method provides a more practical reference of agents high in anticholinergic activity. ...
... at concentrations that are never achieved with normal dosing. A recent investigation looked at six therapeutic concentrations to identify anticholinergic activity by a radioimmune assay. This method provides a more practical reference of agents high in anticholinergic activity. ...
Lopinavir/Ritonavir
... midazolam and triazolam) that are highly dependent on CYP3A or CYP2D6 for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events. Coadministration with lopinavir/ritonavir is also not recommended for drugs or herbal products (i.e. rifampicin ...
... midazolam and triazolam) that are highly dependent on CYP3A or CYP2D6 for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events. Coadministration with lopinavir/ritonavir is also not recommended for drugs or herbal products (i.e. rifampicin ...
Deca Durabolin Results, Side Effects and Dosage Cycles
... applications, this drug is widely used in the professional sports scene, many times in much higher doses. Globally, Deca is one of the most widely used anabolic steroids. Its popularity is due to its effectiveness in developing lean muscle tissue, while having low side effects. It is only 20% estrog ...
... applications, this drug is widely used in the professional sports scene, many times in much higher doses. Globally, Deca is one of the most widely used anabolic steroids. Its popularity is due to its effectiveness in developing lean muscle tissue, while having low side effects. It is only 20% estrog ...
Accepted Manuscript
... incorporated where appropriate, but there were no substantive changes as the bulk of the content was undisputed. ...
... incorporated where appropriate, but there were no substantive changes as the bulk of the content was undisputed. ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.