Define therapeutic index and briefly outline its significance. Briefly
... - LD50 not good guide to toxicity in humans (measured in animals)→adverse effects limiting use in clinical practice may be overlooked in animal models - ED50 is not definable i.e. it depends on the measure of effectiveness being applied (eg differences in dosage of aspirin to treat a headache vs Rx ...
... - LD50 not good guide to toxicity in humans (measured in animals)→adverse effects limiting use in clinical practice may be overlooked in animal models - ED50 is not definable i.e. it depends on the measure of effectiveness being applied (eg differences in dosage of aspirin to treat a headache vs Rx ...
crampfort : prescribing information
... CRAMPFORT is indicated for the treatment of severe or constant leg cramps in pregnant women in their 2nd and 3rd trimester. Dosage and administration: One sachet once a day after dissolving in half glass of water. Missed Dose: If a dose is missed, an extra dose should not be taken. The usual schedul ...
... CRAMPFORT is indicated for the treatment of severe or constant leg cramps in pregnant women in their 2nd and 3rd trimester. Dosage and administration: One sachet once a day after dissolving in half glass of water. Missed Dose: If a dose is missed, an extra dose should not be taken. The usual schedul ...
consisting of diuretics to remove excess water, beta blockers and
... each year in the United States for CHF (AMA 2009). Urocortin 2 is an endogenous peptide ligand of the CRF2 receptor present in the cardiovascular system, notably the heart and cerebral arterial system. Urocortin 2 plays a role in the control of the hormonal, cardiovascular, gastrointestinal, and beh ...
... each year in the United States for CHF (AMA 2009). Urocortin 2 is an endogenous peptide ligand of the CRF2 receptor present in the cardiovascular system, notably the heart and cerebral arterial system. Urocortin 2 plays a role in the control of the hormonal, cardiovascular, gastrointestinal, and beh ...
Glicron CR Capsule
... Nursing mothers: It has not been established whether gliclazide is secreted in human milk. However, other sulfonylureas have been found in breast milk and there is evidence to suggest that gliclazide differs from the group in this respect. ADVERSE REACTION All sulfonylureas are capable of producing ...
... Nursing mothers: It has not been established whether gliclazide is secreted in human milk. However, other sulfonylureas have been found in breast milk and there is evidence to suggest that gliclazide differs from the group in this respect. ADVERSE REACTION All sulfonylureas are capable of producing ...
Pritor® 40(80) mg and Co-Pritor® 40(80/12.5 mg)
... Adults: 40 mg telmisartan once daily, which may be increased after 4 to 8 weeks to a maximum of 80 mg once daily. Alternatively, hydrochlorothiazide 12.5 mg once daily may be added. No dosage adjustment is required in elderly patients. ...
... Adults: 40 mg telmisartan once daily, which may be increased after 4 to 8 weeks to a maximum of 80 mg once daily. Alternatively, hydrochlorothiazide 12.5 mg once daily may be added. No dosage adjustment is required in elderly patients. ...
VIOXX (ROFECOXIB)
... isoform, thus is free from the side effects of conventional NSAIDs. ROFETAB is rapidly and almost completely absorbed from the gastrointestinal tract with a bioavailability of 93%. Food has no significant effect on either the peak plasma concentration or extent of absorption of rofecoxib. ROFETAB ca ...
... isoform, thus is free from the side effects of conventional NSAIDs. ROFETAB is rapidly and almost completely absorbed from the gastrointestinal tract with a bioavailability of 93%. Food has no significant effect on either the peak plasma concentration or extent of absorption of rofecoxib. ROFETAB ca ...
Unituxin
... treatment of patients with high-risk neuroblastoma,” said Richard Pazdur, M.D., director of the Office of Hematology and Oncology Products in the FDA’s Center for Drug Evaluation and Research. “Unituxin fulfills a critical need by providing a treatment option that prolongs survival in children with ...
... treatment of patients with high-risk neuroblastoma,” said Richard Pazdur, M.D., director of the Office of Hematology and Oncology Products in the FDA’s Center for Drug Evaluation and Research. “Unituxin fulfills a critical need by providing a treatment option that prolongs survival in children with ...
MEDICAL TREATMENT OF ALLERGIC RHINITIS
... It is recommended to try non-sedating antihistamines and then move progressively towards the sedating ones to try to get more effectiveness if needed, as listed: Claritin, Zyrtec, Chlorpheniramine, Benadryl. One to two week periods when symptoms are active are adequate to assess whether the drug is ...
... It is recommended to try non-sedating antihistamines and then move progressively towards the sedating ones to try to get more effectiveness if needed, as listed: Claritin, Zyrtec, Chlorpheniramine, Benadryl. One to two week periods when symptoms are active are adequate to assess whether the drug is ...
4.4 Special warnings and precautions for use
... Interaction with other medicinal products and other forms of interaction ▪ The pharmacological gastrointestinal effects of lanreotide may reduce the intestinal absorption of co-administered drugs including cyclosporin. Concomitant administration of cyclosporine with lanreotide may decrease the relat ...
... Interaction with other medicinal products and other forms of interaction ▪ The pharmacological gastrointestinal effects of lanreotide may reduce the intestinal absorption of co-administered drugs including cyclosporin. Concomitant administration of cyclosporine with lanreotide may decrease the relat ...
Zaditen® (ketotifen)
... Zaditen may potentiate the effects of CNS depressants, antihistamines, anticoagulants and alcohol. The simultaneous administration of oral antidiabetic drugs and Zaditen should be avoided. (see section 4.4, Special warnings and special precautions for use). Ketotifen increases the effects of broncho ...
... Zaditen may potentiate the effects of CNS depressants, antihistamines, anticoagulants and alcohol. The simultaneous administration of oral antidiabetic drugs and Zaditen should be avoided. (see section 4.4, Special warnings and special precautions for use). Ketotifen increases the effects of broncho ...
2.27 R-Fludarabine version1.2 Jul08
... Patients MUST have tolerated their first cycle of rituximab (at the standard recommended infusion rates as specified above) before being given the rapid infusion rate. All rituximab doses are prepared in 250mls 0.9% sodium chloride, with 50mls being given over the first 30 minutes and the remaining ...
... Patients MUST have tolerated their first cycle of rituximab (at the standard recommended infusion rates as specified above) before being given the rapid infusion rate. All rituximab doses are prepared in 250mls 0.9% sodium chloride, with 50mls being given over the first 30 minutes and the remaining ...
Treatment of Hayfever Vol 3 No 2 (PDF 46Kb)
... Astemizole has a slow onset of action and a long half-life so dosing should ideally be started some days ahead of expected onset of symptoms. It should be taken at least an hour before food and it can cause weight gain in some individuals. The other agents have a rapid onset of clinical effect and a ...
... Astemizole has a slow onset of action and a long half-life so dosing should ideally be started some days ahead of expected onset of symptoms. It should be taken at least an hour before food and it can cause weight gain in some individuals. The other agents have a rapid onset of clinical effect and a ...
Sinarest Levo Syrup
... is 2-fold higher than that of cetirizine. Levocetirizine dissociates from H1-receptors with a halflife of 115±38 minutes. Pharmacodynamic studies in healthy volunteers demonstrate that, at half the dose, levocetirizine has comparable activity to cetirizine. Pharmacokinetics Levocetirizine exhibits l ...
... is 2-fold higher than that of cetirizine. Levocetirizine dissociates from H1-receptors with a halflife of 115±38 minutes. Pharmacodynamic studies in healthy volunteers demonstrate that, at half the dose, levocetirizine has comparable activity to cetirizine. Pharmacokinetics Levocetirizine exhibits l ...
(Nimesulide Tablets*) - Amson Vaccines and Pharma, Pvt Ltd
... — At this stage basic research has not shown any embryo-fetal toxicity for Amsolide, but the administration during pregnancy and lactation is discouraged, as for all new drugs. — Drug should be administered with the particular care in elderly patients. Side effects: G .I .T. : Nausea, gastralgia, py ...
... — At this stage basic research has not shown any embryo-fetal toxicity for Amsolide, but the administration during pregnancy and lactation is discouraged, as for all new drugs. — Drug should be administered with the particular care in elderly patients. Side effects: G .I .T. : Nausea, gastralgia, py ...
Value of low dose combination treatment with blood pressure
... effects of different categories of drugs were additive. Symptoms attributable to thiazides, beta blockers, and calcium channel blockers were strongly dose related; symptoms caused by ACE inhibitors (mainly cough) were not dose related. Angiotensin II receptor antagonists caused no excess of symptoms ...
... effects of different categories of drugs were additive. Symptoms attributable to thiazides, beta blockers, and calcium channel blockers were strongly dose related; symptoms caused by ACE inhibitors (mainly cough) were not dose related. Angiotensin II receptor antagonists caused no excess of symptoms ...
CONCLUSIONS INTRODUCTION METHODS Pieter Okkerse*1
... reporting, standard laboratory tests, physical and neurological examinations and ECGs. • Study specific tests included intraepidermal nerve fiber density [IENFD] analysis and quantitative sensory testing [QST] (including vibration, cold and heat thermal thresholds). Both analyses were performed on ...
... reporting, standard laboratory tests, physical and neurological examinations and ECGs. • Study specific tests included intraepidermal nerve fiber density [IENFD] analysis and quantitative sensory testing [QST] (including vibration, cold and heat thermal thresholds). Both analyses were performed on ...
Antihistamines - Interstitial Cystitis Association
... acts somewhat earlier in the allergic process than histamine or leukotriene blockers do by affecting IgE. Suplatast tosilate helps suppress the production of IgE. It also helps to block production of cytokines and suppresses allergy-related eosinophils. This medicine remains under investigation in t ...
... acts somewhat earlier in the allergic process than histamine or leukotriene blockers do by affecting IgE. Suplatast tosilate helps suppress the production of IgE. It also helps to block production of cytokines and suppresses allergy-related eosinophils. This medicine remains under investigation in t ...
Translational Medicine - PEER
... Veterinary Small Animal Clinical Sciences College of Veterinary Medicine and Biomedical ...
... Veterinary Small Animal Clinical Sciences College of Veterinary Medicine and Biomedical ...
IKOREL® - Product Information
... excessive vasodilation or reduction in blood pressure, but only at doses higher than the therapeutic recommended dosage. Pharmacokinetics Absorption After oral administration, nicorandil is absorbed rapidly and maximum plasma concentrations are reached after about 30-60 minutes. The absolute bioavai ...
... excessive vasodilation or reduction in blood pressure, but only at doses higher than the therapeutic recommended dosage. Pharmacokinetics Absorption After oral administration, nicorandil is absorbed rapidly and maximum plasma concentrations are reached after about 30-60 minutes. The absolute bioavai ...
Core Concepts in Pharmacology
... • Describes drugs duration of action • Describe h0w the frequency of dosing differs depending upon the drugs half-life. • How does renal or liver disease affect drug half-life? ...
... • Describes drugs duration of action • Describe h0w the frequency of dosing differs depending upon the drugs half-life. • How does renal or liver disease affect drug half-life? ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.