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Ophthalmic adverse drug reactions to systemic drugs
Ophthalmic adverse drug reactions to systemic drugs

... ADRs can occur after the correct prescription of each drug. A systematic review would be useful not only to identify drugs in which ophthalmic ADRs are frequent or serious, but also to increase knowledge of physicians (prescribing physicians and ophthalmologists), enabling a greater detection of oph ...
Macrolids
Macrolids

Neural and psychological mechanisms underlying compulsive drug
Neural and psychological mechanisms underlying compulsive drug

... Acquisition and performance of drug seeking – pavlovian and instrumental processes There is now abundant evidence showing that limbic cortical–ventral striatal circuitry mediates pavlovian influences on appetitive behaviour, including drug seeking (Everitt et al., 1999; Robbins et al., 2008). The bas ...
  STUDY OF EFFECTS OF POST­COMPRESSION CURING ON KOLLIDON  SR BASED FLOATING  TABLETS
  STUDY OF EFFECTS OF POST­COMPRESSION CURING ON KOLLIDON  SR BASED FLOATING  TABLETS

... curing  at  temperature  above  Tg  significantly  improved  film  formation which could reduce the permeability of the film and avoid  accelerated  and  irreproducible  dissolution  results.13  KSR  which  contains 80 % of polyvinylacetate (PVAc) polymer is amorphous in  nature  and  has  got  unus ...
Skin Barrier and Transdermal Drug Delivery
Skin Barrier and Transdermal Drug Delivery

... limits transdermal delivery of hydrophilic drugs, but also the so-called stratum corneum “reservoir ”5, within which lipid-soluble drugs, such as topical corticosteroids, can accumulate and be slowly released. Human stratum corneum is typically comprised of about 20 corneocyte cell layers, which dif ...
) PCH
) PCH

... would need 18 to 35 vials of product to prepare an appropriate dose. In preparing such a dose using the RLD, the volume could be as high as 1,400 mL. The proposed configuration, 1,000 mg of Methotrexate as a ready to use preservative free liquid at a concentration of 100 mg/mL would provide practiti ...
nanotechnology-based cosmeceuticals: a review
nanotechnology-based cosmeceuticals: a review

... to 1000 nm [25]. These were developed at the beginning of the nineties as a substitute to other carriers such as liposomes, emulsions, and polymeric nanomaterials [26]. SLNs are widespread in the field of cosmeceuticals because of their inherent features such as controlledrelease properties; reduced ...
COMPARATIVE STUDY ON EFFECT OF DIFERENT TECHNIQUES USED IN THE FORMULATION  OF FELODIPINE FAST DISSOLVING TABLETS 
COMPARATIVE STUDY ON EFFECT OF DIFERENT TECHNIQUES USED IN THE FORMULATION  OF FELODIPINE FAST DISSOLVING TABLETS 

... Now a day fast dissolving tablets are gaining more importance in the  market.  Currently  these  tablets  are  available  in  the  market  for  treating  many  disease  conditions.  More  is  concerned  on  hypertension  3,  migraine  4,  dysphasia  5,  nausea  and  vomiting  6,  Parkinson’s disease ...
Macromolecules in drug delivery
Macromolecules in drug delivery

... SECTION 3 – Macromolecular drugs Therapeutic proteins are examples of carriers which are simultaneously drugs  Proteins that are engineered in the laboratory for pharmaceutical use are known as therapeutic proteins.  The majority of biopharmaceuticals marketed to date are recombinant therapeutic ...
.-4 L
.-4 L

... FDA’s September 30 decision is premised upon three erroneous findings-First, FDA believes that in marketing Cholestin, Pharrnanex is marketing the drug lovastatin rather than a food product, red yeast rice, containing a range of naturally beneficial constituents. The agency states that “Pharmanex pu ...
Sample
Sample

... Incorrect Feedback: It was the amendment to The Food and Drugs Act of 1912 that ensured this, not the Food, Drug, and Cosmetic Act of 1938. d. stated that the government no longer needed proof of fraud to stop the sale of a drug Feedback: Correct! 10. In response to criticism related to the time lag ...
IOSR Journal of Pharmacy and Biological Sciences (IOSRJPBS)
IOSR Journal of Pharmacy and Biological Sciences (IOSRJPBS)

... results it was found that the % RSD is less than 2% which indicates that the method has good reproducibility. From the results shown in accuracy table-2 it was found that the percent recovery values of pure drug from the preanalysed solutions of formulations were in between 98.3% -100.16%, which ind ...
Polymer Science -1
Polymer Science -1

... Most of the materials used in swelling-controlled release systems are based on hydrogels, which are polymers that will swell without dissolving when placed in water or other biological fluids. These hydrogels can absorb a great deal of fluid and, at equilibrium, typically comprise 60–90% fluid and o ...
Drug Monitoring: Simultaneous Analysis of Lamotrigine
Drug Monitoring: Simultaneous Analysis of Lamotrigine

... Lamotrigine (Lamictal, GlaxoSmithKline) is a broad-spectrum anti-epileptic drug of the phenyltriazine class chemically unrelated to other anti-convulsants that was approved by the Food and Drug Administration (FDA) for treatment of epilepsy in 1994 (1,2). In 2003, lamotrigine received an additional ...
Act of Sep. 27, 1961,P.L. 1700, No. 699 Cl. 63
Act of Sep. 27, 1961,P.L. 1700, No. 699 Cl. 63

... act of April 9, 1929 (P.L.177, No.175), known as "The Administrative Code of 1929." In case of failure at a first examination, the applicant shall have within two years the privilege of a second and third examination. In case of failure in a third examination, the applicant shall have the privilege ...
The impact of polypharmacology on chemical biology Albert Antolín Hernández
The impact of polypharmacology on chemical biology Albert Antolín Hernández

... natural products as remedial substances likely predates the human race.3 Despite this uncertainty, our knowledge of the medical effects of natural products has increased continuously since the earliest Sumerian writings.4,5 The mechanisms underlying drug action, however, remained elusive for millenn ...
Role of Pharmacokinetics and Metabolism in Drug Discovery and
Role of Pharmacokinetics and Metabolism in Drug Discovery and

Dabigatran
Dabigatran

... 6. INR validated for warfarin relation to bleeding risk 7. Point-of-care testing 8. Rapid turnaround genetic testing ...
Evaluating Drugs Used To Treat: Constipation
Evaluating Drugs Used To Treat: Constipation

Could Science-Based Regulation Make Tobacco Products Less
Could Science-Based Regulation Make Tobacco Products Less

... Henningfield, Jack E. and Zeller, Mitch (2003) "Could Science-Based Regulation Make Tobacco Products Less Addictive?," Yale Journal of Health Policy, Law, and Ethics: Vol. 3: Iss. 1, Article 8. ...
Prescription Drug Use Among Midlife and Older Americans
Prescription Drug Use Among Midlife and Older Americans

... prescription drugs, re-importation from foreign countries, cost, safety, and effectiveness have captured the attention of the media and the American public. Between 1986 and 2002 Americans age 45 and older reported their regular use of prescription drugs increased from 52% to 75%. At the same time, ...
Lipid Nanoparticulate Drug Delivery Systems: A
Lipid Nanoparticulate Drug Delivery Systems: A

... fatty acids linked to a glycerol molecule, known as triacylglycerols. The long-chain fatty acids ranging from C14 to C24 appear widely in common fat while the medium chain fatty acids ranging from C6 to C12 are typical components of coconut oil or palm kernel oil [6]. Examples of homolipids include: ...
In vitro - In vivo Correlation: From Theory to
In vitro - In vivo Correlation: From Theory to

... healthy volunteers may be required to prove that the new formulation is bioequivalent with the old one. Certainly, implementation of these requirements not only halts the marketing of the new formulation but also increases the cost of the optimization processes. It would be, desirable, therefore, to ...
Pharma-Data 2012
Pharma-Data 2012

... main cost driver …” make the national headlines. Very often the facts do not bear out these statements. But what does reality truly look like? How much money is spent on patient care in the German health care system? What are the main cost drivers in the system? How significant is the pharmaceutical ...
WHO Drug Information - World Health Organization
WHO Drug Information - World Health Organization

... transparency in a minimum of time. In spite of many positive developments in the Global regulatory arena it is worrying that the gaps among regulatory systems ...
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Compounding

Pharmaceutical compounding (done in compounding pharmacies) is the creation of a particular pharmaceutical product to fit the unique need of a patient. To do this, compounding pharmacists combine or process appropriate ingredients using various tools. This may be done for medically necessary reasons, such as to change the form of the medication from a solid pill to a liquid, to avoid a non-essential ingredient that the patient is allergic to, or to obtain the exact dose(s) needed or deemed best of particular active pharmaceutical ingredient(s). It may also be done for more optional reasons, such as adding flavors to a medication or otherwise altering taste or texture. Compounding is most routine in the case of intravenous/parenteral medication, typically by hospital pharmacists, but is also offered by privately owned compounding pharmacies and certain retail pharmacies for various forms of medication. Whether routine or rare, intravenous or oral, etc., when a given drug product is made or modified to have characteristics that are specifically prescribed for an individual patient, it is known as ""traditional"" compounding.Due to the rising cost of compounding and the shortage of drugs, many hospitals have shown a tendency to rely more upon large-scale compounding pharmacies to meet their regular requirement, particularly of sterile-injectable medications. When compounding is done on bulk production of a given formulation rather than patient-specific production, it is known as ""non-traditional"" compounding (which, as discussed below, is arguably not ""compounding"" but rather ""manufacturing""). This development raises concerns about patient safety and makes a case for proper regulatory control and monitoring.
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