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Investigating - The Biotechnology Institute
Investigating - The Biotechnology Institute

... signals travel from neuron to neuron to design drugs. For example, they might design a drug that blocks ion channels and prevents the action potential so the sensation of pain is not transmitted to the brain; that is how a local anesthetic works. Next you will read about two examples of drugs that e ...
Association of type I neurons positive for NADPH
Association of type I neurons positive for NADPH

... Positive neurons were densely filled, in Golgi-like detail, and therefore unambiguously classified as type 1 (Yan et al., 1996; Estrada and DeFelipe, 1998). No examples of type 2 neurons, defined as small, lightly stained neurons, were evident. Within the broad category of type 1, however, further subp ...
Consciousness Operates Beyond the Timescale
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... like vision and hearing have more complex organization and up to six relay neurons before the information enters the brain cortex where it is consciously realized. The clinical practice has shown that the brain cortex is the only conscious structure, while all the electric impulses in structures sub ...
Document
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How is the stimulus represented in the nervous system?
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Information Theory and Neural Coding

... neurons transmit information about sound stimuli with highest efficiency if the properties of these stimuli match the time scales and amplitude distributions of natural songs. Mrsic-Flogel et al (Nature Neurosci 2003) found that responses of A1 neurons in adult ferrets carry more information about t ...
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pdf - Llano Lab

... receive receptive field information from one cortical area and relay it to another (Guillery, 1995). In contrast to the higher-order nuclei, primary sensory nuclei receive receptive field information from the sensory periphery and relay this information to the cortex, and have been referred to as ‘‘fir ...
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The Physiology of the Senses Lecture 5
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Ch5slides - Blackwell Publishing
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NEUROSCIENCE Review Questions CHOOSE THE LETTER THAT
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Nervous System Powerpoint
Nervous System Powerpoint

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Synaptic gating



Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.
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