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Influence of comorbid conditions on asthma REVIEW
Influence of comorbid conditions on asthma REVIEW

... surprising to note an increase in symptoms of rhinitis in a large population of severe allergic asthmatics treated with omalizumab compared with placebo [29]. Although there is still some controversy about the benefits of adequately treating rhinitis for asthma outcomes, there is evidence that this ...
cover 2.p65
cover 2.p65

... the task from many individuals. From the beginning of the development in mid-2000 through production stages in 2004, Susan M. Conrath, PhD, MPH, MPhil, and Laura S. Kolb, MPH, from EPA’s Indoor Environments Division contributed helpful suggestions, shared their insight, and provided a systematic rev ...
The Management of Community-Acquired Pneumonia in Infants and
The Management of Community-Acquired Pneumonia in Infants and

... 20. Sensitive and specific tests for the rapid diagnosis of influenza virus and other respiratory viruses should be used in the evaluation of children with CAP. A positive influenza test may decrease both the need for additional diagnostic studies and antibiotic use, while guiding appropriate use of ...
New Asthma Guidelines: How to Put in Your Daily Practice
New Asthma Guidelines: How to Put in Your Daily Practice

... 7. During the last 4 weeks, on average, how many days per month did your child wake up during the night because of asthma? ...
The Role of Pathogenic Autoantibodies in Autoimmunity
The Role of Pathogenic Autoantibodies in Autoimmunity

... Autoimmunity was first identified as a cause of disease based on the recognition of self-reactive autoantibodies in the sera of patients. In these early studies, the autoantigens were not well defined and antibodies were considered in terms of reactivity with whole cells, cell extracts or relatively ...
primer - Incor
primer - Incor

... who contracted the disease in industrialized countries in the ARF epidemics of the early to mid‑twentieth century did not survive or were not physically able to bear offspring. In this context, the most severe genetic predispositions for ARF susceptibility might have been transferred to the next gen ...
Immunisation Guidelines for Ireland
Immunisation Guidelines for Ireland

... Facial flushing or pallor can occur as breath-holding continues. Some episodes end with a resumption of crying, but others can be followed by a brief period of unconsciousness during which breathing resumes. Swelling and an urticarial rash may appear at the injection site but are not always caused b ...
Effectiveness of pharmacist intervention for asthma control improvement
Effectiveness of pharmacist intervention for asthma control improvement

... and maintain control of the disease (defined as ‘‘asthma control’’). Although clinical trials have shown that good asthma control can be achieved in a majority of patients [1], this is not the case in real-life situation studies [2]. A large number of patients have not yet benefited from the advance ...
Plague into the 21st Century
Plague into the 21st Century

... plague. The index patient usually starts with bubonic or septicemic illness from a fleabite, which develops into secondary pneumonia from bacteremic spread. Coughing produces airborne droplets that are inhaled by family or other close personal contacts. In Madagascar in 1997, an outbreak occurred th ...
Asthma
Asthma

... Confirm variation in lung function is greater than in healthy individuals  The greater the variation, or the more times variation is seen, the greater probability that the diagnosis is asthma  Excessive bronchodilator reversibility (adults: increase in FEV1 >12% and >200mL; children: increase >12% ...
Development of the Satisfaction with Inhaled Asthma Treatment Questionnaire J.L. Campbell
Development of the Satisfaction with Inhaled Asthma Treatment Questionnaire J.L. Campbell

... Patients9 views were also highly affected by the frequency of dosing, but not by the route of drug administration. While several instruments exist that are useful in assessing quality of life [16], the presence of symptoms [17] or subject self-efficacy [18] in asthma, the authors were not able to id ...
Population Health Research Institute
Population Health Research Institute

... Hamilton Health Sciences is committed to advancing excellence in health care through research and education to benefit the people and communities we serve. By emphasizing multidisciplinary and collaborative research that enhances our main clinical programs, we strive to share our knowledge beyond bo ...
AVT 9(2) in progress - International Medical Press
AVT 9(2) in progress - International Medical Press

... preventing the complications of influenza is vaccination, antiviral medications can serve as an adjunct to the vaccine for prevention and for treatment when the illness occurs [2]. Oseltamivir phosphate is a neuraminidase inhibitor that has been shown to be effective in decreasing the duration and s ...
Management of severe malaria
Management of severe malaria

... over 40% of the world’s population—more than 3.3 billion people—at risk for malaria to varying degrees in countries with on-going transmission. In addition, with modern, rapid means of travel, large numbers of people from nonmalarious areas are being infected, which may seriously affect them after t ...
Hypomagnesaemia in chronic, stable asthmatics: prevalence, correlation with severity and hospitalization
Hypomagnesaemia in chronic, stable asthmatics: prevalence, correlation with severity and hospitalization

... small to draw a clear conclusion about prevalence of hypomagnesaemia among asthmatics. In addition, the purposes of these two studies were mainly to evaluate the effect of Mg sulphate as bronchodilator, rather than to evaluate the prevalence of hypomagnesaemia among asthmatics. Recently, DE VALK et ...
Community Health Needs Assessment
Community Health Needs Assessment

... for a disease, as a proportion of total population. Incidence rate Incidence rate is the number of new cases for a specific disease or health problem within a given time period. It is expressed either as a fraction (e.g. percentage) or a density rate (e.g., x number of cases per 10,000 people), in o ...
N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency
N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency

... levels. Further, aerosol delivery can result in NAC oxidation, which may have negative consequences [27]. Intravenous administration of NAC transiently increases plasma NAC to very high levels (during administration) and is known to cause adverse effects. Although clinical situations sometimes dicta ...
I have also sent you a complimentary 30
I have also sent you a complimentary 30

... to inhaled preparations, due to poor absorption and rapid gastrointestinal metabolism [1]. Further, the therapeutic effect is delayed; peak bronchodilation does not occur until two hours after ingestion [10], making oral administration appropriate only for mild to moderate asthmatic symptoms and per ...
Living with Parkinson`s Disease
Living with Parkinson`s Disease

... Table 5.4 : Health system costs per PWP, by disease stage, 2014 ............................... 43 Table 5.5 : Additional health system costs, 2014 ......................................................... 45 Table 5.6 : Additional health system costs per PWP, by age and sex, 2014 ................. ...
Clinical Practice Guidelines - Oxford Academic
Clinical Practice Guidelines - Oxford Academic

... invasive ventilation via a nonpermanent artificial airway (eg, endotracheal tube). (strong recommendation; high-quality evidence) 6. A child should be admitted to an ICU or a unit with continuous cardiorespiratory monitoring capabilities if the child acutely requires use of noninvasive positive pres ...
Myoclonic Epilepsy in Lysosomal Storage Disorders
Myoclonic Epilepsy in Lysosomal Storage Disorders

... The disease has been classically classified in three major clinical variants based on the presence and progression of central nervous system involvement. Type 1 GD (MIM# 230800), the most common phenotype, is characterized by enlargement and dysfunction of liver and spleen, displacement of normal bo ...
Nursing Management - coursewareobjects.com
Nursing Management - coursewareobjects.com

... are not identified at the time treatment is initiated. The specific antibiotics recommended from the IDSA, ATS, and CIDS/CID for empiric treatment are all fairly similar and start with either a macrolide (erythromycin, azithromycin [Zithromax], clarithromycin [Biaxin]) or doxycycline (Vibramycin). I ...
Okelo SO, Eakin MN, Patino CM, Teodoro AP, Bilderback AL, Thompson DA, Loiaza-Martinez A, Rand CS, Thyne S, Diette GB, Riekert KA. The PACCI Asthma Questionnaire: For Use in Diverse Children of All Ages. Journal of Allergy Clinical Immunology ( In Press)
Okelo SO, Eakin MN, Patino CM, Teodoro AP, Bilderback AL, Thompson DA, Loiaza-Martinez A, Rand CS, Thyne S, Diette GB, Riekert KA. The PACCI Asthma Questionnaire: For Use in Diverse Children of All Ages. Journal of Allergy Clinical Immunology ( In Press)

... (among English-speaking patients only), and (3) lung function for JHCC patients (FEV1 as a percentage of predicted values using Stanojevic equations28 and FEV1/FVC ratio) using Spearman correlation coefficients. We hypothesized that higher PACCI Control domain scores would correlate with worse ratin ...
Obstructive Pulmonary Diseases
Obstructive Pulmonary Diseases

... Respiratory Infections. Respiratory infections (i.e., viral and not bacterial) are often the major precipitating factor of an acute asthma attack. The respiratory syncytial virus (RSV) in children and the rhinovirus are two major factors in the development and possibly the severity of asthma.4 Infec ...
Lupus and Infection - Lupus Research Alliance
Lupus and Infection - Lupus Research Alliance

... The ALR was eager to incorporate Mr. Wolfe’s organization into our efforts to accelerate the discovery of new and more effective treatments for lupus patients. We are launching a multi-year $100 million major donor campaign called Lupus Therapeutics. The name acknowledges Mr. Wolfe’s invaluable cont ...
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Syndemic

A syndemic is the aggregation of two or more diseases in a population in which there is some level of positive biological interaction that exacerbates the negative health effects of any or all of the diseases. The term was developed and introduced by Merrill Singer in several articles in the mid-1990s and has since received growing attention and use among epidemiologists and medical anthropologists concerned with community health and the effects of social conditions on health, culminating in a recent textbook. Syndemics tend to develop under conditions of health disparity, caused by poverty, stress, or structural violence, and contribute to a significant burden of disease in affected populations. The term syndemic is further reserved to label the consequential interactions between concurrent or sequential diseases in a population and in relation to the social conditions that cluster the diseases within the population.The traditional biomedical approach to disease is characterized by an effort to diagnostically isolate, study, and treat diseases as if they were distinct entities that existed in nature separate from other diseases and independent of the social contexts in which they are found. This singular approach proved useful historically in focusing medical attention on the immediate causes and biological expressions of disease and contributed, as a result, to the emergence of targeted modern biomedical treatments for specific diseases, many of which have been successful. As knowledge about diseases has advanced, it is increasingly realized that diseases are not independent and that synergistic disease interactions are of considerable importance for prognosis. Given that social conditions can contribute to the clustering, form and progression of disease at the individual and population level, there is growing interest in the health sciences on syndemics.
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