Introduction of Microarray - genomics-lab
... Cross-hybridization of sequences with high identity Chip to chip variation True measure of abundance? Does mRNA levels reflect protein levels? ...
... Cross-hybridization of sequences with high identity Chip to chip variation True measure of abundance? Does mRNA levels reflect protein levels? ...
Title Non-coding functions of alternative pre-mRNA - DR-NTU
... Subsequent studies showed that such alternative splicing (AS) events are extensively controlled by cis-regulatory RNA sequences and trans-acting splicing factors [3, 10, 11]. Moreover, a number of AS topologies have been described including selection between alternative 5’ or 3’ splice sites, casset ...
... Subsequent studies showed that such alternative splicing (AS) events are extensively controlled by cis-regulatory RNA sequences and trans-acting splicing factors [3, 10, 11]. Moreover, a number of AS topologies have been described including selection between alternative 5’ or 3’ splice sites, casset ...
Computational Pharmacology
... – Anomalous drug effects (don’t ignore compounds that have therapeutic profiles that do not “fit”) – Molecular biology in isozyme discovery and characterization ...
... – Anomalous drug effects (don’t ignore compounds that have therapeutic profiles that do not “fit”) – Molecular biology in isozyme discovery and characterization ...
Chapter 3 Topic: Biomolecules Main concepts: •In chemistry, the
... into longer molecules called polymers to build tissues. Some examples of polymers include proteins (chains of amino acids) and complex carbohydrates (chains of simple sugars). • Monomers are assembled into polymers through a process called dehydration synthesis. Polymers are broken down into monomer ...
... into longer molecules called polymers to build tissues. Some examples of polymers include proteins (chains of amino acids) and complex carbohydrates (chains of simple sugars). • Monomers are assembled into polymers through a process called dehydration synthesis. Polymers are broken down into monomer ...
Proteins
... •Central question of molecular biology: “Given a particular sequence of amino acid residues (primary structure), what will the tertiary/quaternary structure of the resulting protein be?” •Input: AAVIKYGCAL… Output: 11, 22… = backbone conformation: (no side chains yet) ...
... •Central question of molecular biology: “Given a particular sequence of amino acid residues (primary structure), what will the tertiary/quaternary structure of the resulting protein be?” •Input: AAVIKYGCAL… Output: 11, 22… = backbone conformation: (no side chains yet) ...
Topic Definition 3` Refers to the third carbon of the nucleic acid
... A procedure to separate molecules in an electric field. DNA migration takes place through a gel matrix (agarose or polyacrylamide) that acts as a molecular sieve. Since DNA is negatively charged, when placed in an electric field, it is attracted toward the positive electrode. Because the negative ch ...
... A procedure to separate molecules in an electric field. DNA migration takes place through a gel matrix (agarose or polyacrylamide) that acts as a molecular sieve. Since DNA is negatively charged, when placed in an electric field, it is attracted toward the positive electrode. Because the negative ch ...
structure
... •Central question of molecular biology: “Given a particular sequence of amino acid residues (primary structure), what will the tertiary/quaternary structure of the resulting protein be?” •Input: AAVIKYGCAL… Output: 11, 22… = backbone conformation: (no side chains yet) ...
... •Central question of molecular biology: “Given a particular sequence of amino acid residues (primary structure), what will the tertiary/quaternary structure of the resulting protein be?” •Input: AAVIKYGCAL… Output: 11, 22… = backbone conformation: (no side chains yet) ...
05 DetailLectOut 2012
... When a cell synthesizes a polypeptide, the chain generally folds spontaneously to assume the functional structure for that protein. The folding is reinforced by a variety of bonds between parts of the chain, which in turn depend on the sequence of amino acids. Many proteins are globular, while other ...
... When a cell synthesizes a polypeptide, the chain generally folds spontaneously to assume the functional structure for that protein. The folding is reinforced by a variety of bonds between parts of the chain, which in turn depend on the sequence of amino acids. Many proteins are globular, while other ...
SWISS-PROT + TrEMBL
... (established 1984). The entries arise from international collaborative efforts and are organised biologically e.g. by structural, functional or evolutioary relationships. The entries include amino acid sequences, and in many cases further annotation including: citations (linked to Medline for abstra ...
... (established 1984). The entries arise from international collaborative efforts and are organised biologically e.g. by structural, functional or evolutioary relationships. The entries include amino acid sequences, and in many cases further annotation including: citations (linked to Medline for abstra ...
QUESTIONS
... Adenine and thymine are complementary bases. In DNA the number of each must be the same. ...
... Adenine and thymine are complementary bases. In DNA the number of each must be the same. ...
Chapter 6
... 2) Ionized side chains are on the surface of the protein where they are stabilized by water 3) Polar side chains are on surface in contact with water, but 4) Can have buried water molecules in the interior of the protein A long polypeptide strand folds into domains: each domain typically contains 10 ...
... 2) Ionized side chains are on the surface of the protein where they are stabilized by water 3) Polar side chains are on surface in contact with water, but 4) Can have buried water molecules in the interior of the protein A long polypeptide strand folds into domains: each domain typically contains 10 ...
VNTR, STR and RFLP
... energy from food into a form that cells can use. This genetic material is known as mitochondrial DNA or mtDNA. • Mitochondrial DNA contains 37 genes, all of which are essential for normal mitochondrial function. • Thirteen of these genes provide instructions for making enzymes involved in oxidative ...
... energy from food into a form that cells can use. This genetic material is known as mitochondrial DNA or mtDNA. • Mitochondrial DNA contains 37 genes, all of which are essential for normal mitochondrial function. • Thirteen of these genes provide instructions for making enzymes involved in oxidative ...
Document
... bonds - double helix: 2 polynucleotide strands connected by hydrogen bonds -polynucleotide strands are complementary -genetic information is carried in the sequence of nucleotides ...
... bonds - double helix: 2 polynucleotide strands connected by hydrogen bonds -polynucleotide strands are complementary -genetic information is carried in the sequence of nucleotides ...
103 final rev worksheet key
... cytoplasm, to be translated into proteins. Transfer RNA carries amino acids to the ribosomes for synthesis of proteins. 62. Where does processing of mRNA take place? Describe the process. Use drawings to illustrate your answer. Messenger RNA is processed in the nucleus before going to the ribosomes ...
... cytoplasm, to be translated into proteins. Transfer RNA carries amino acids to the ribosomes for synthesis of proteins. 62. Where does processing of mRNA take place? Describe the process. Use drawings to illustrate your answer. Messenger RNA is processed in the nucleus before going to the ribosomes ...
Biomolecular chemistry 4. From amino acids to proteins
... orientation of the peptide bond between residues at (i+1) and (i+2). The torsion angles for the residues (i+1) and (i+2) in the two types of turn lie in distinct regions of the Ramachandran plot. • 2-residue beta-hairpin turns occur between two antiparallel beta-strands as shown in the figure. • The ...
... orientation of the peptide bond between residues at (i+1) and (i+2). The torsion angles for the residues (i+1) and (i+2) in the two types of turn lie in distinct regions of the Ramachandran plot. • 2-residue beta-hairpin turns occur between two antiparallel beta-strands as shown in the figure. • The ...
Biochemistry 2007
... characterized by a series of alpha helices that are separated by random coil regions and by a complete absence of beta sheet domains. (c) As a result of the binding of oxygen to the iron ion Fe2+ in the heme group, the proximal histidine residue, HisF8, rotates by 8 degrees to assume a 90 degree pos ...
... characterized by a series of alpha helices that are separated by random coil regions and by a complete absence of beta sheet domains. (c) As a result of the binding of oxygen to the iron ion Fe2+ in the heme group, the proximal histidine residue, HisF8, rotates by 8 degrees to assume a 90 degree pos ...
Gene Section SH3GL2 (SH3-domain GRB2-like 2) Atlas of Genetics and Cytogenetics
... activity may induce negative membrane curvature by converting an inverted cone shaped lipid to a cone shaped lipid in the cytoplasmic leaflet of the bilayer. Through this action, SH3GL2 works with dynamin to mediate synaptic vesicle invagination from the plasma membrane and fission. SH3GL2 in comple ...
... activity may induce negative membrane curvature by converting an inverted cone shaped lipid to a cone shaped lipid in the cytoplasmic leaflet of the bilayer. Through this action, SH3GL2 works with dynamin to mediate synaptic vesicle invagination from the plasma membrane and fission. SH3GL2 in comple ...
Document
... Lymphoproliferative Disorder Molecular Disease Neoplasm Neoplasm by Morphology Neoplasm by Site Neoplasm by Special Category Neoplasm by Disease NEC Non-Neoplastic Disease, Syndrome, or Condition Precancerous Condition ...
... Lymphoproliferative Disorder Molecular Disease Neoplasm Neoplasm by Morphology Neoplasm by Site Neoplasm by Special Category Neoplasm by Disease NEC Non-Neoplastic Disease, Syndrome, or Condition Precancerous Condition ...
Genetics of Viruses and Bacteria
... Conjugation • Direct transfer of genetic material (usually plasmid DNA) from two bacterial cells that are temporarily joined by a sex pili. • Plasmid genes are not required for survival, but they tend to code for genes that increase fitness (ex. antibiotic resistance) video ...
... Conjugation • Direct transfer of genetic material (usually plasmid DNA) from two bacterial cells that are temporarily joined by a sex pili. • Plasmid genes are not required for survival, but they tend to code for genes that increase fitness (ex. antibiotic resistance) video ...
Bioinformatics Research and Resources at the University of
... “The two-state accuracy by SABLE is 77.3% in the ProSup benchmark, 77.9% in the SALIGN benchmark, 74.3% in the Lindahl benchmark and, 75.3% in the LiveBench 8 benchmark. This accuracy is consistent with the published performance of this and other state-of-the-art predictors.” Liu, Zhang, Liang and Z ...
... “The two-state accuracy by SABLE is 77.3% in the ProSup benchmark, 77.9% in the SALIGN benchmark, 74.3% in the Lindahl benchmark and, 75.3% in the LiveBench 8 benchmark. This accuracy is consistent with the published performance of this and other state-of-the-art predictors.” Liu, Zhang, Liang and Z ...
Folds
... protein solvation sphere and dehydrating the surface protein “salting in” results from protein-counter ion binding and the consequently higher net protein charge and solvation; it occurs where the protein has little net charge near its pI primarily by weakly hydrated anions. protein solubility is mi ...
... protein solvation sphere and dehydrating the surface protein “salting in” results from protein-counter ion binding and the consequently higher net protein charge and solvation; it occurs where the protein has little net charge near its pI primarily by weakly hydrated anions. protein solubility is mi ...
... When resources are scarce, mycobacteria stop growing to make way for genes adaptation allow. Conversely, when growth continues under stress conditions, specific genes metabolic networks for protection are activating. In this sense, the protein encoded by esat-6 (early secretory antigenic target, 6 k ...
DNA STRUCTURE AND FUNCTION
... This occurs by the hydrogen bonds between the nucleotides breaking, allowing for the DNA ladder to unzip. Then, the separated strands unwind, and each strand becomes a template for a new complementary strand. ...
... This occurs by the hydrogen bonds between the nucleotides breaking, allowing for the DNA ladder to unzip. Then, the separated strands unwind, and each strand becomes a template for a new complementary strand. ...
Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as transfer RNA (tRNA) or small nuclear RNA (snRNA) genes, the product is a functional RNA.The process of gene expression is used by all known life - eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses - to generate the macromolecular machinery for life.Several steps in the gene expression process may be modulated, including the transcription, RNA splicing, translation, and post-translational modification of a protein. Gene regulation gives the cell control over structure and function, and is the basis for cellular differentiation, morphogenesis and the versatility and adaptability of any organism. Gene regulation may also serve as a substrate for evolutionary change, since control of the timing, location, and amount of gene expression can have a profound effect on the functions (actions) of the gene in a cell or in a multicellular organism.In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, i.e. observable trait. The genetic code stored in DNA is ""interpreted"" by gene expression, and the properties of the expression give rise to the organism's phenotype. Such phenotypes are often expressed by the synthesis of proteins that control the organism's shape, or that act as enzymes catalysing specific metabolic pathways characterising the organism.