Ciprofloxacin sensitizes hormone-refractory prostate cancer cell
... 8-fold, respectively, after a pre-treatment with ciprofloxacin. In contrast, the referred combinations yielded moderate antagonistic effects when used concurrently in this in vitro system. Conclusions Ciprofloxacin sensitized HRPC cells to doxorubicin or docetaxel-induced growth inhibition and, ther ...
... 8-fold, respectively, after a pre-treatment with ciprofloxacin. In contrast, the referred combinations yielded moderate antagonistic effects when used concurrently in this in vitro system. Conclusions Ciprofloxacin sensitized HRPC cells to doxorubicin or docetaxel-induced growth inhibition and, ther ...
liquid dosage forms - New Age International
... Wetting agents are routinely used in pharmaceutical formulations, especially in liquid dosage forms to create a homogeneous dispersion of solid particles in a liquid vehicle. This process can be challenging due to a layer of adsorbed air on the particle’s surface. Hence, even particles with a high d ...
... Wetting agents are routinely used in pharmaceutical formulations, especially in liquid dosage forms to create a homogeneous dispersion of solid particles in a liquid vehicle. This process can be challenging due to a layer of adsorbed air on the particle’s surface. Hence, even particles with a high d ...
Parrish Waters
... Systemic administration of a m-opiate receptor antagonist (naltrexone) inhibits heroin primed relapse, but not FS mediated relapse. CRF antagonist (a-H-CRF) decrease FS mediated relapse, but not heroin primed relapse ...
... Systemic administration of a m-opiate receptor antagonist (naltrexone) inhibits heroin primed relapse, but not FS mediated relapse. CRF antagonist (a-H-CRF) decrease FS mediated relapse, but not heroin primed relapse ...
doc
... body immediately surrounding the area where the drug was administered, eg local anaesthetic, creams applied directly to the skin. ...
... body immediately surrounding the area where the drug was administered, eg local anaesthetic, creams applied directly to the skin. ...
patrick_tb_ch05
... Patrick: An Introduction to Medicinal Chemistry 3e Page reference: 86 a. The maximum biological effect resulting from a drug binding to its target. *b. The measure of how strongly a drug binds to a receptor. c. The amount of drug required to produce a defined biological effect. d. The lifetime of t ...
... Patrick: An Introduction to Medicinal Chemistry 3e Page reference: 86 a. The maximum biological effect resulting from a drug binding to its target. *b. The measure of how strongly a drug binds to a receptor. c. The amount of drug required to produce a defined biological effect. d. The lifetime of t ...
Inappropriate long-term use of antipsychotic drugs is
... over 6–8 weeks was associated with a decline in cognition measured using the Mini-Mental State Examination (MMSE) [9]. However, one study showed that the MMSE score did not worsen after treatment with risperidone among people with dementia [10], which might be due to the lack of anticholinergic acti ...
... over 6–8 weeks was associated with a decline in cognition measured using the Mini-Mental State Examination (MMSE) [9]. However, one study showed that the MMSE score did not worsen after treatment with risperidone among people with dementia [10], which might be due to the lack of anticholinergic acti ...
VIRTUAL SCREENING AND LEAD OPTIMIZATION TO IDENTIFY
... an optimal fit. The central assumption is that a good fit results from structural and chemical complementarities to the target receptor. The steps involved are: ...
... an optimal fit. The central assumption is that a good fit results from structural and chemical complementarities to the target receptor. The steps involved are: ...
Control of intravenous medication wastage at a teaching hospital in
... basis in most of the local hospitals, but not given close attention from the hospital practicing pharmacists or the management. The pharmacy departments in most local hospitals are concerned with the excessive number of IV medication doses wasted, and the time being consumed by pharmacists to handle ...
... basis in most of the local hospitals, but not given close attention from the hospital practicing pharmacists or the management. The pharmacy departments in most local hospitals are concerned with the excessive number of IV medication doses wasted, and the time being consumed by pharmacists to handle ...
Introduction of new drugs and drug regimens for the management of
... benefits from our previous local experience gathered during the Bedaquiline Clinical Access Programme (BCAP)2. The Medicines Control Council (MCC) of South Africa approved a national clinical access programme to treat selected DR- TB patients with bedaquiline (BDQ) in March 2013. In October 2014, th ...
... benefits from our previous local experience gathered during the Bedaquiline Clinical Access Programme (BCAP)2. The Medicines Control Council (MCC) of South Africa approved a national clinical access programme to treat selected DR- TB patients with bedaquiline (BDQ) in March 2013. In October 2014, th ...
Role of nanotechnology in targeted drug delivery and imaging: T
... bution are reduced [4]. Nanoscale drug delivery systems also have the ability to improve the pharmacokinetics and increase biodistribution of therapeutic agents to target organs, which will result in improved efficacy [5-8]. Second, drug toxicity is reduced as a consequence of preferential accumulat ...
... bution are reduced [4]. Nanoscale drug delivery systems also have the ability to improve the pharmacokinetics and increase biodistribution of therapeutic agents to target organs, which will result in improved efficacy [5-8]. Second, drug toxicity is reduced as a consequence of preferential accumulat ...
PDF(180KB)
... often used to detect polymorphic forms because they typically have different melting points and heats of fusion. For example, the three crystalline forms of sulfanilimide are shown in Figure 1 at heating rates of 1 and 10 ºC/min. Heating rate has no significant effect on the melting peaks except for ...
... often used to detect polymorphic forms because they typically have different melting points and heats of fusion. For example, the three crystalline forms of sulfanilimide are shown in Figure 1 at heating rates of 1 and 10 ºC/min. Heating rate has no significant effect on the melting peaks except for ...
Chapter 3
... Mosby items and derived items © 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ...
... Mosby items and derived items © 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ...
Wrightia tinctoria R. Br. - Journal of Coastal Life Medicine
... (Marathi) and Mitha indrajau (Hindi)[1]. The whole plant or its specific parts (bark, leaf, seed and root) are known ...
... (Marathi) and Mitha indrajau (Hindi)[1]. The whole plant or its specific parts (bark, leaf, seed and root) are known ...
The Texas Tech University – HSC
... The compounding of sterile preparations is an integral part of any health-system setting. While the majority of perenteral products are prepared using commercially available medications and diluents solutions, pharmacy departments still prerform intravenous manufacturing. The reasons for this vary g ...
... The compounding of sterile preparations is an integral part of any health-system setting. While the majority of perenteral products are prepared using commercially available medications and diluents solutions, pharmacy departments still prerform intravenous manufacturing. The reasons for this vary g ...
Pharmaceutical Dosage Forms
... original preparation. PK parameters (Cmax, tmax, AUC) are within 80-125 % range as compared with the original preparation. – The proof of therapeutic equivalence (comparing directly the clinical effectiveness) is not commonly required (due to the technical, financial and ethical issues). Hence, it c ...
... original preparation. PK parameters (Cmax, tmax, AUC) are within 80-125 % range as compared with the original preparation. – The proof of therapeutic equivalence (comparing directly the clinical effectiveness) is not commonly required (due to the technical, financial and ethical issues). Hence, it c ...
Cytochrome P450 Drug Interactions Table
... Inhibitors: drugs that prevent the enzyme from metabolizing the substrates Activators: drugs that increase the enzyme’s ability to metabolize the substrates • The table contains lists of drugs in columns under the designation of specific cytochrome P450 isoforms. A drug appears in a column if there ...
... Inhibitors: drugs that prevent the enzyme from metabolizing the substrates Activators: drugs that increase the enzyme’s ability to metabolize the substrates • The table contains lists of drugs in columns under the designation of specific cytochrome P450 isoforms. A drug appears in a column if there ...
PowerPoint プレゼンテーション
... The identification of driver oncogenes has provided important targets for drugs that can change the landscape of cancer therapies. One such example is the BRAF oncogene, which is found in about half of all melanomas as well as several other cancers. As a druggable kinase, oncogenic BRAF has become a ...
... The identification of driver oncogenes has provided important targets for drugs that can change the landscape of cancer therapies. One such example is the BRAF oncogene, which is found in about half of all melanomas as well as several other cancers. As a druggable kinase, oncogenic BRAF has become a ...
Guideline on Clinical follow-up gene therapy
... up, with additional specificities for advanced therapy medicinal products described in the guideline on safety and efficacy follow-up – risk management of advanced therapy medicinal products (EMEA/149995/2008). The scientific principles of follow-up of the patients included in or after GT medicinal ...
... up, with additional specificities for advanced therapy medicinal products described in the guideline on safety and efficacy follow-up – risk management of advanced therapy medicinal products (EMEA/149995/2008). The scientific principles of follow-up of the patients included in or after GT medicinal ...
Innovation Track: Pharmacogenomics
... enzymes such as the cytochrome P450 isozyme P450 2D6. Such individuals are referred to as "poor metabolizers" of drugs such as debrisoquin, dextromethorphan, the tricyclic antidepressants, and clozapine. These individuals may develop higher than expected plasma concentrations of clozapine when given ...
... enzymes such as the cytochrome P450 isozyme P450 2D6. Such individuals are referred to as "poor metabolizers" of drugs such as debrisoquin, dextromethorphan, the tricyclic antidepressants, and clozapine. These individuals may develop higher than expected plasma concentrations of clozapine when given ...
Reciprocity Meeting PowerPoint Presentation (Review)
... The generic name of the drug, even if the generic drug is unavailable to dispense or even if the substitution of a generic drug is not authorized. Directions for use. Appropriate cautionary statements. “Filled by” or “dispensed by” with the name of the dispensing pharmacist. The name must include, a ...
... The generic name of the drug, even if the generic drug is unavailable to dispense or even if the substitution of a generic drug is not authorized. Directions for use. Appropriate cautionary statements. “Filled by” or “dispensed by” with the name of the dispensing pharmacist. The name must include, a ...
Why Biodegradable Polymer
... polymers, considerable interest in being focused on the development of biodegradable polymers so that, they would mix themselves with soil after their applications being over. For ecological balance, the development of biodegradable polymers is one of the leading edges of research in polymer science ...
... polymers, considerable interest in being focused on the development of biodegradable polymers so that, they would mix themselves with soil after their applications being over. For ecological balance, the development of biodegradable polymers is one of the leading edges of research in polymer science ...
Drugs working template
... subjects. Some progress has been made in defining the optimum dosage and safety of tafenoquine [Rajapakse, 2015] but development of this drug has been disappointingly slow; the first trial was reported 16 years ago, and it appears that this has not been given the priority that it should have been ac ...
... subjects. Some progress has been made in defining the optimum dosage and safety of tafenoquine [Rajapakse, 2015] but development of this drug has been disappointingly slow; the first trial was reported 16 years ago, and it appears that this has not been given the priority that it should have been ac ...
Slide 1
... ➢ The rhizomes are boiled in water, drained, dried, and grounded into turmeric powder ...
... ➢ The rhizomes are boiled in water, drained, dried, and grounded into turmeric powder ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.