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DNA AND PROTEIN SYNTHESIS
DNA AND PROTEIN SYNTHESIS

... 1. DNA unzips (usually a single gene) from a chromosome. 2. Free RNA nucleotides are paired to the exposed bases of one of the DNA strands following base pair rules.  Uracil replaces thymine  Only 1 strand of DNA serves as a template, the other “hangs out” 3. Newly synthesized mRNA separates from ...
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... Two fundamental chemical differences distinguish DNA from RNA: 1. DNA contains 2-deoxyribose instead of ribose. 2. DNA contains thymine instead of uracil. What are the consequences of these differences, and do they hold any significance in common? An argument can be made that, because of these diffe ...
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Replisome



The replisome is a complex molecular machine that carries out replication of DNA. The replisome first unwinds double stranded DNA into two single strands. For each of the resulting single strands, a new complementary sequence of DNA is synthesized. The net result is formation of two new double stranded DNA sequences that are exact copies of the original double stranded DNA sequence.In terms of structure, the replisome is composed of two replicative polymerase complexes, one of which synthesizes the leading strand, while the other synthesizes the lagging strand. The replisome is composed of a number of proteins including helicase, RFC, PCNA, gyrase/topoisomerase, SSB/RPA, primase, DNA polymerase I, RNAse H, and ligase.
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