novel aspects of carnitine function and metabolism
... Furthermore, we observed that trans-2-enoyl-CoAs are poor substrates for both acyltransferases and even act as CPT2 inhibitors, possibly by interfering with the catalytic mechanism of the enzyme. This may explain not only the absence of some of the respective trans-2-enoyl-carnitine intermediates fr ...
... Furthermore, we observed that trans-2-enoyl-CoAs are poor substrates for both acyltransferases and even act as CPT2 inhibitors, possibly by interfering with the catalytic mechanism of the enzyme. This may explain not only the absence of some of the respective trans-2-enoyl-carnitine intermediates fr ...
Methods and strategies of peptide ligation
... at the side chain or at the ␣-amine (or as an ester). A common combination for an NT-amine-nucleophile is to place the nucleophile at the side chain of an NT-amino acid. This spatial configuration is found in many naturally occurring amino acids. Essentially, all ␣-amino acids containing heteroatomi ...
... at the side chain or at the ␣-amine (or as an ester). A common combination for an NT-amine-nucleophile is to place the nucleophile at the side chain of an NT-amino acid. This spatial configuration is found in many naturally occurring amino acids. Essentially, all ␣-amino acids containing heteroatomi ...
Milk production and energy metabolism in ruminants fed 2
... contributes no more than 20% of the carbon for de novo synthesis, and more than 80% of the total BHB incorporated into fatty acids is found in the initial four carbons (Smith and McCarthy, 1969). The other 80% of de novo fatty acid-carbon is derived primarily from acetate. Although glucose is the ma ...
... contributes no more than 20% of the carbon for de novo synthesis, and more than 80% of the total BHB incorporated into fatty acids is found in the initial four carbons (Smith and McCarthy, 1969). The other 80% of de novo fatty acid-carbon is derived primarily from acetate. Although glucose is the ma ...
Biochemistry 304 2014 Student Edition Glycolysis Lectures
... Hexokinase Control Hexokinase is inhibited by Glucose –6-P (its product). Indicates that the cell has sufficient energy supply. This will leave glucose in the blood. Special case of liver: glucokinase (an isozyme) not inhibited by glucose-6-P. Has a 50-fold LOWER affinity for glucose. Functions to ...
... Hexokinase Control Hexokinase is inhibited by Glucose –6-P (its product). Indicates that the cell has sufficient energy supply. This will leave glucose in the blood. Special case of liver: glucokinase (an isozyme) not inhibited by glucose-6-P. Has a 50-fold LOWER affinity for glucose. Functions to ...
glycolysis, gluconeogenesis, and the pentose phosphate pathway
... animals and vascular plants, glucose has three major fates: it may be stored (as a polysaccharide or as sucrose); oxidized to a three-carbon compound (pyruvate) via glycolysis to provide ATP and metabolic intermediates; or oxidized via the pentose phosphate (phosphogluconate) pathway to yield ribose ...
... animals and vascular plants, glucose has three major fates: it may be stored (as a polysaccharide or as sucrose); oxidized to a three-carbon compound (pyruvate) via glycolysis to provide ATP and metabolic intermediates; or oxidized via the pentose phosphate (phosphogluconate) pathway to yield ribose ...
Specific and ubiquitous expression of different Zn finger protein
... In addition.the Tyr/Phe,Phe,Leu and the H-C link sequence TGEKP is also conserved. Structural analysis of mkr3.mkr4 and mkr5 Mkr3 contains a total of 428 amino acids including 14 full and 1 partial fingers(fig.1 and 2). At the 3' end.there is a termination codon at nt. 1307 preceeded by 27 unique no ...
... In addition.the Tyr/Phe,Phe,Leu and the H-C link sequence TGEKP is also conserved. Structural analysis of mkr3.mkr4 and mkr5 Mkr3 contains a total of 428 amino acids including 14 full and 1 partial fingers(fig.1 and 2). At the 3' end.there is a termination codon at nt. 1307 preceeded by 27 unique no ...
Synthesis of Heme
... The Zn++ binding sites in the homo-octomeric mammalian Porphobilinogen Synthase, which include cysteine S ligands, can also bind Pb++ (lead). Inhibition of Porphobilinogen Synthase by Pb++ results in elevated blood ALA, as impaired heme synthesis leads to de-repression of transcription of the ALA S ...
... The Zn++ binding sites in the homo-octomeric mammalian Porphobilinogen Synthase, which include cysteine S ligands, can also bind Pb++ (lead). Inhibition of Porphobilinogen Synthase by Pb++ results in elevated blood ALA, as impaired heme synthesis leads to de-repression of transcription of the ALA S ...
New insight into the photoheterotrophic growth of the
... second compartment of the MELiSSA loop, will be used to photoassimilate these volatile fatty acids. The assimilation of carbon sources that enter central carbon metabolism through acetyl-CoA requires an alternative cycle to replenish the TCA cycle intermediates used for the synthesis of all cell com ...
... second compartment of the MELiSSA loop, will be used to photoassimilate these volatile fatty acids. The assimilation of carbon sources that enter central carbon metabolism through acetyl-CoA requires an alternative cycle to replenish the TCA cycle intermediates used for the synthesis of all cell com ...
Biological ontologies for human functional annotation and
... model of cell signaling reactions in human. ... use of the GENIA ontology is to provide a basis for integrated view of multiple databases“ ...
... model of cell signaling reactions in human. ... use of the GENIA ontology is to provide a basis for integrated view of multiple databases“ ...
PowerPoint Presentation - Biotin Conclusion and Discussion
... – most takes place in proximal SI by active transport. ...
... – most takes place in proximal SI by active transport. ...
Biodegradation of Melamine and Cyanuric Acid by a Newly
... because, cyanuric acid is a key intermediate in the metabolic pathway for melamine, it is nephrotoxic, and the cleavage of its ring is the rate-limiting step in the degradation process. The microorganisms present in soil were collected from 100 different places in three prefectures in Japan, and wer ...
... because, cyanuric acid is a key intermediate in the metabolic pathway for melamine, it is nephrotoxic, and the cleavage of its ring is the rate-limiting step in the degradation process. The microorganisms present in soil were collected from 100 different places in three prefectures in Japan, and wer ...
NAGS - BMC Biochemistry
... NAG is produced enzymatically by N-acetylglutamate synthase (NAGS), which is also found in bacteria and plants as the first enzyme of arginine biosynthesis. Arginine is an allosteric inhibitor of microbial and plant NAGS, and allosteric activator of mammalian NAGS. Results: Information from mutagene ...
... NAG is produced enzymatically by N-acetylglutamate synthase (NAGS), which is also found in bacteria and plants as the first enzyme of arginine biosynthesis. Arginine is an allosteric inhibitor of microbial and plant NAGS, and allosteric activator of mammalian NAGS. Results: Information from mutagene ...
Investigating the Role of ADP-forming Acetyl-CoA
... activity and His533, the proposed second phosphorylation site, is important but not essential. Likewise, Glu213, proposed to play a role in phosphorylation/ dephosphorylation of His252, is also required but Asp674 thought to stabilize the phosphohistidine is not. These results suggest that EhACD fo ...
... activity and His533, the proposed second phosphorylation site, is important but not essential. Likewise, Glu213, proposed to play a role in phosphorylation/ dephosphorylation of His252, is also required but Asp674 thought to stabilize the phosphohistidine is not. These results suggest that EhACD fo ...
Inorganic Chemistry
... many examples of polar molecules in groups C2v (such as SO2) and C3v (such as NH3). There are many linear molecules, which belong to the groups C"v (HCl, OCS) and D"h (Cl2 and CO2), and a number of planar-trigonal molecules, D3h (such as BF3, 5), trigonal-bipyramidal molecules (such as PCl5, 6), whi ...
... many examples of polar molecules in groups C2v (such as SO2) and C3v (such as NH3). There are many linear molecules, which belong to the groups C"v (HCl, OCS) and D"h (Cl2 and CO2), and a number of planar-trigonal molecules, D3h (such as BF3, 5), trigonal-bipyramidal molecules (such as PCl5, 6), whi ...
Physiological meaning and potential for application of reductive
... c o r r i n o i d / F e - S protein is one of the central enzymes, had dechlorinating activity [13-15,26] supports this hypothesis. Attempts to lay a direct link between corrinoid content and dechlorinating activity of cell-free in vitro systems of Acetobacterium woodii have failed [12]. Apparently ...
... c o r r i n o i d / F e - S protein is one of the central enzymes, had dechlorinating activity [13-15,26] supports this hypothesis. Attempts to lay a direct link between corrinoid content and dechlorinating activity of cell-free in vitro systems of Acetobacterium woodii have failed [12]. Apparently ...
Read Article - Roald Hoffmann
... of the bridging groups; (3) direct bonding or antibonding overlap of primarily metal-centered orbitals. The mix of these contributions is variable. In many cases, especially those in which compounds are compared which differ from each other only by one or two electrons, the last effect is important. ...
... of the bridging groups; (3) direct bonding or antibonding overlap of primarily metal-centered orbitals. The mix of these contributions is variable. In many cases, especially those in which compounds are compared which differ from each other only by one or two electrons, the last effect is important. ...
animal nutrition - e
... that deal with the calculation of requirements include problems and solutions to aid student learning. Other chapters include essay-type questions that students can use as a guide to revision. ...
... that deal with the calculation of requirements include problems and solutions to aid student learning. Other chapters include essay-type questions that students can use as a guide to revision. ...
Structure-based design and functional studies of novel noroviral 3C
... acids in the P5–P2 and P2 positions flanking the scissile bond dipeptide (P1–P1 ) [6,7,16,22–25]. Comparison of the amino acid sequences flanking the scissile bonds between HNV and MNV reveal some significant diversity, suggesting differences in the temporal processing of the HNV and MNV ORF1 poly ...
... acids in the P5–P2 and P2 positions flanking the scissile bond dipeptide (P1–P1 ) [6,7,16,22–25]. Comparison of the amino acid sequences flanking the scissile bonds between HNV and MNV reveal some significant diversity, suggesting differences in the temporal processing of the HNV and MNV ORF1 poly ...
Enzyme Inhibition and Bioapplications
... Second, enzyme inhibitors do behave very precise at the exact location of enzyme active site in the ‘lock-key’ configuration. The 3D structure and conformation of active site permits very powerful enzyme inhibitors or substrate analogues to bind with enzyme molecule to make desirable product and acc ...
... Second, enzyme inhibitors do behave very precise at the exact location of enzyme active site in the ‘lock-key’ configuration. The 3D structure and conformation of active site permits very powerful enzyme inhibitors or substrate analogues to bind with enzyme molecule to make desirable product and acc ...
CHARACTERIZATION OF B-LACTAMASES FROM TWO B
... P.aeruginosa isolates (Z 33 and Z 90), where the maximum P-lactamase activities were 5.8 and 2.9 u mol/min/ml for the two isolates, respectively. This result was in agreement with the result of Cruchural et al., 1986. The results of the purification steps (Table 2, Fig 2(a.b) and Fig. 3(a,b) indicat ...
... P.aeruginosa isolates (Z 33 and Z 90), where the maximum P-lactamase activities were 5.8 and 2.9 u mol/min/ml for the two isolates, respectively. This result was in agreement with the result of Cruchural et al., 1986. The results of the purification steps (Table 2, Fig 2(a.b) and Fig. 3(a,b) indicat ...
Metalloprotein
Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large number of all proteins are part of this category.