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Leukaemia Section 11q23 rearrangements in leukaemia Atlas of Genetics and Cytogenetics
Leukaemia Section 11q23 rearrangements in leukaemia Atlas of Genetics and Cytogenetics

... leukaemia (ALL) grossly represent half cases each; myelodysplasia (MDS) in the remaining 5%; biphenotypic leukaemia at times (likely to be more ...
Correction of copy number induced false positives in
Correction of copy number induced false positives in

OrthoMaM: a database of orthologous genomic markers for
OrthoMaM: a database of orthologous genomic markers for

Chromosomal Abnormalities
Chromosomal Abnormalities

... analyzed. Be sure to include the type of abnormality, the total number of chromosomes in the karyotype, the specific chromosome involved, the gender of karyotype, and the reason for the gender in your discussion. 3. Using your knowledge of meiosis discuss how the chromosome abnormality could have oc ...
GAL4 enhancer trap strains with reporter gene expression during
GAL4 enhancer trap strains with reporter gene expression during

Human Pedigrees - Downtown Magnets High School
Human Pedigrees - Downtown Magnets High School

... Table of Contents ...
9 Enhancement and Synthetic Phenotypes
9 Enhancement and Synthetic Phenotypes

... of one pathway can be tolerated, but not the loss of both. Therefore, a mutation blocking one pathway alone mayhave a slight mutant phenotype but two mutations each of which blocks one of the pathways will have a severe mutant phenotype. This is illustrated in Model 1 in Figure 9.1. Mutation of GENl ...
To Taste or Not to Taste?
To Taste or Not to Taste?

Harvard Medical School - MGH-PGA
Harvard Medical School - MGH-PGA

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Transcriptional activity and role of plasmids of

Cloning of the Papaya Chromoplast-Specific
Cloning of the Papaya Chromoplast-Specific

... cDNA probe. These seven BACs were mapped to a single fingerprint contig FPC-1648 of the papaya physical map (Supplemental Fig. S1; Yu et al., 2009). Colocalization of the flesh color-linked SCAR marker and the CYC-b cDNA probe on a single contig indicated that the papaya CYC-b orthologous gene was a ...


The Jumping SHOX Gene—Crossover in the Pseudoautosomal
The Jumping SHOX Gene—Crossover in the Pseudoautosomal

... PAR1 region. In males, the recombination frequency in PAR1 is extraordinarily high, about 20 times higher than the genome average (12, 13). It decreases rapidly at the proximal boundary of the 2.6 Mb pseudoautosomal segment in conjunction with a decrease in homology (10, 11). One explanation for the ...
Gene Mapping in Eukaryotes—Recombination
Gene Mapping in Eukaryotes—Recombination

... •If the genes are not assorting independently, what is the recombination frequency between them? For chi-square tests of linkage, we can only directly test “no linkage” (indep assortment. We cannot directly test for “linkage” with chi-square analysis (too many different possible map distances to tes ...
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... With reference to Table 4.2, and the information in (iii), state the cause or causes of reduced fertility in these mutant worms at each temperature. ...
MiRNA_GO_Meeting_August2015
MiRNA_GO_Meeting_August2015

... The focus of our guidelines is on gene silencing by miRNA via the 3’UTR of mRNAs, including; • annotation of the protein components of the canonical mammalian miRNA processing pathway • annotation of proteins that affect the levels of miRNAs • annotation of the miRNA’s role in gene silencing • annot ...
Ancestry of neuronal monoamine transporters in the Metazoa
Ancestry of neuronal monoamine transporters in the Metazoa

... assessed on 3–5 plates of cells. The uptake data were corrected for Na+-independent uptake by exposing the cells to an identical treatment except for the substitution of choline+ for Na+ in the saline. Sf9 cells also have an endogenous low-affinity Na+dependent uptake mechanism for amines that contr ...
A Paint Horse owner`s guide to demystifying the genetics of spotting
A Paint Horse owner`s guide to demystifying the genetics of spotting

... Find out exactly which colors and patterns your stallion or mare carries before the breeding season begins. APHA’s official genetics testing partner, the Veterinary Genetics Laboratory at the University of California– Davis, offers a Comprehensive Coat Color test for $125. This simple procedure, don ...
Reveal—visual eQTL analytics
Reveal—visual eQTL analytics

... Manhattan plots. Although the Manhattan plot is useful for a small number of traits, problems arise with a fully genome-wide screen where millions of SNPs, for example in the human genome, are tested for association with hundreds or thousands of traits. Many applications in this area combine the (vi ...
Defining a Centromere-like Element in Bacillus
Defining a Centromere-like Element in Bacillus

... that progeny are genetically identical. This challenge is particularly acute in cells that divide asymmetrically, which must faithfully segregate sister chromosomes to progeny that are often decidedly unequal in size. Asymmetric cell division occurs in eukaryotes and prokaryotes as a basic mechanism ...
Title A Fluorescently Labeled, Hyperbranched Polymer
Title A Fluorescently Labeled, Hyperbranched Polymer

Epigenetic inheritance of expression states in plant development
Epigenetic inheritance of expression states in plant development

... the multimeric PcG complexes specifies the onset of repression. Furthermore, it is possible that PcG repression requires silenced genes as templates, allowing the PcG complex to lock a previously established expression pattern in place, whereby active genes are unaffected and silent genes become sta ...
McFil: metabolic carbon flow in leaves
McFil: metabolic carbon flow in leaves

... Protein. Stoichiometries for amino acid biosynthesis pathways are outlined below ...
Human clonning: Status and Ethics
Human clonning: Status and Ethics

... The abnormalities do not arise from mutations in the genes but from changes in the normal activation or expression of certain genes. ...
heterozygous nephew cystic fibrosis symptoms than her codon in
heterozygous nephew cystic fibrosis symptoms than her codon in

... Dot blot analysis (fig 1) showed that the CF girl (II.2) was homozygous and her cousin (11.1) heterozygous for the G542X mutation. Direct sequencing of an amplified fragment, containing exon 9, of patient II.1 detected a new mutation (fig 2), resulting in a substitution of a conserved glycine (GGA) ...
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Artificial gene synthesis

Artificial gene synthesis is a method in synthetic biology that is used to create artificial genes in the laboratory. Currently based on solid-phase DNA synthesis, it differs from molecular cloning and polymerase chain reaction (PCR) in that the user does not have to begin with preexisting DNA sequences. Therefore, it is possible to make a completely synthetic double-stranded DNA molecule with no apparent limits on either nucleotide sequence or size. The method has been used to generate functional bacterial or yeast chromosomes containing approximately one million base pairs. Recent research also suggests the possibility of creating novel nucleobase pairs in addition to the two base pairs in nature, which could greatly expand the possibility of expanding the genetic code.Synthesis of the first complete gene, a yeast tRNA, was demonstrated by Har Gobind Khorana and coworkers in 1972. Synthesis of the first peptide- and protein-coding genes was performed in the laboratories of Herbert Boyer and Alexander Markham, respectively.Commercial gene synthesis services are now available from numerous companies worldwide, some of which have built their business model around this task. Current gene synthesis approaches are most often based on a combination of organic chemistry and molecular biological techniques and entire genes may be synthesized ""de novo"", without the need for precursor template DNA. Gene synthesis has become an important tool in many fields of recombinant DNA technology including heterologous gene expression, vaccine development, gene therapy and molecular engineering. The synthesis of nucleic acid sequences is often more economical than classical cloning and mutagenesis procedures.
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