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Disrupting antibiotic resistance propagation by inhibiting
Disrupting antibiotic resistance propagation by inhibiting

... strains (reviewed in ref. 1), as first described for the Escherichia coli F plasmid by Lederberg and Tatum in 1946 (2). Conjugative DNA transfer is also the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations (reviewed in ref. 3). Indeed, it ...
Chromosomes-and-Inherited-Traits (PowerPoint)
Chromosomes-and-Inherited-Traits (PowerPoint)

... DNA Packaging ...
Slides
Slides

... (automatically) from a multiple alignment of the highest scoring hits in an initial BLAST search. The PSSM is generated by calculating position-specific scores for each position in the alignment. Highly conserved positions receive high scores and weakly conserved positions receive scores near zero. ...
Specific Combinations of Zein Genes and Genetic Backgrounds
Specific Combinations of Zein Genes and Genetic Backgrounds

... In the case of Bo2It, the mutant line from which the o2-Italian allele has been recovered and first described in the sixties (Nelson, 1967), a proper comparison is not possible because its O2 isogenic line is not available in any collection. The two GBs, W22 and Oh43, carrying the o2-676 allele (Auk ...
Lesson title: Nucleic acids Lesson date: 30.12.2013 One sentence
Lesson title: Nucleic acids Lesson date: 30.12.2013 One sentence

... After explanations and playing a nucleic acids puzzle; 1. Students will be able to model and describe the general structure of nucleic acids. 2. Students will be able to apply base pairing rules to assemble nucleic acids and state differences between DNA and RNA. 3. Students will be able to infer th ...
Inheritance of Aldehyde Oxidase in Drosophila melanogaster
Inheritance of Aldehyde Oxidase in Drosophila melanogaster

... The haploid (N) number of chromosomes is 4 and the chromosomes are designated X(1), 2, 3, and 4. The 2, 3, and 4 chromosomes are the same in both sexes and are referred to as autosomes to distinguish them from the X and Y sex chromosomes. Female Drosophila are characterized by having two X chromosom ...
Reconstruction of a 450-My-old ancestral vertebrate protokaryotype
Reconstruction of a 450-My-old ancestral vertebrate protokaryotype

... segments with three or more genes in the sample were considered. Genome data from pufferfish [10] and medaka [9] provided most of the information. The principle used to reconstruct the teleost protokaryotype is illustrated in Figure 2 (Table 2, and Table S2 in supplementary online material). For sim ...
Michigan State University Plant Genomics Program
Michigan State University Plant Genomics Program

... • Since even moving the plants between the filter paper and the plate to the 50mL reaction tube could cause some form of wounding to the small seedlings, to eliminate the chances of RNA levels changing because of those minor stresses, we are treating the seedlings with water on filter paper, which s ...
Initiation of Plant Disease Resistance by Physical Interaction of
Initiation of Plant Disease Resistance by Physical Interaction of

Te gades
Te gades

... Why  Te#gades?   •  *Not  all  Te#gades  species  studied  has  this   double  lineage  of  Hodgkina   •  To  look  at  this  phenomena  phylogene0cally,   we  decided  to  sequence  the  cicadas  harboring   these  bacteria   •  Thus  we ...
Radiation_Unit - Sites@Duke
Radiation_Unit - Sites@Duke

... (Figures 9 and 10, top). So p53 comes to the cells’ defense—it promotes apoptosis of cells with damaged DNA, thereby eliminating cells that might go on to develop into cancerous cells. In this sense, p53 is considered a “tumor suppressor” protein. Under normal conditions, tumor suppressors slow down ...
A1986A459700001
A1986A459700001

... a-amylase in half-grains of barley was proportional to the logarithm of the gibberellie acid concentration and could be detected at hormone concentrations as low as 1 x 10— 10 M. This assay was not sensitive to reducing agents such as those found in organic solvents. Since this bioassay was a simple ...
Leukaemia Section t(2;3)(p21;q26) THADA/MECOM Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(2;3)(p21;q26) THADA/MECOM Atlas of Genetics and Cytogenetics in Oncology and Haematology

... have been found in thyroid adenomas; it would compete with normal THADA, thereby disturbing normal apoptosis of follicular cells (Rippe et al., 2003; Kloth et al., 2011). ...
The construction of an enhanced green fluorescence protein
The construction of an enhanced green fluorescence protein

... Here we describe the construction of eGFP reporter plasmids under control of consitutively active or muscle specific promoters (Figure 6). After eGFP and pCDNA3/pDRIVE vector ligation, analytical digest of transformed colonies provided evidence that eGFP was inserted into the plasmid. For all plasmi ...
10-2008-SAB-Davis
10-2008-SAB-Davis

... – New code looks for polyA runs >10nt – Evaluate sequence post polyA and score. ...
Engineering of steroid biotransformation in rhodococcus van
Engineering of steroid biotransformation in rhodococcus van

... SQ1, encoding the enzymes involved in AD degradation. The genomic loci of these genes appear to be scattered over the genome of R. erythropolis SQ1. No operon (-like) organization was apparent and therefore all four genes needed to be cloned individually. As an exception, a divergently transcribed T ...
Gregor Mendel`s Experiment
Gregor Mendel`s Experiment

... multiple alleles – human genes for blood type ...
Systematic Mutational Analysis of the Yeast ACT1 Gene.
Systematic Mutational Analysis of the Yeast ACT1 Gene.

... acid residues.The resulting structure of the EcoRI fragment is depicted in Figure 2B in its genomic context. Oligonucleotide-directed mutagenesis: Thirty-six syntheticoligonucleotideswereusedtochange75selected charged amino acidsin yeast actin to alanine. Oligonucleotides were designed to contain at ...
Essential role of conserved DUF177A protein in plastid 23S rRNA
Essential role of conserved DUF177A protein in plastid 23S rRNA

... DUF177A and DUF177B clades arose via duplication of an ancestral algal DUF177 gene, because some algal sequences grouped with bacterial DUF177 proteins, the alternative possibility that either DUF177A or DUF177B was acquired separately from bacteria by horizontal gene transfer could not be ruled out ...
Designer Babies and 21st Century Cures
Designer Babies and 21st Century Cures

... While defending the use of embryonic science and cloning technology to treat or prevent serious diseases, he argues that the compulsion to use the same science to enhance physical or mental attributes in the unborn is not morally justifiable. “Like most people I disapprove strongly of the idea of an ...
Conservation of Gene Order between Horse and Human X
Conservation of Gene Order between Horse and Human X

... genome [18]. Though the 34 markers placed on the RH map in the present study span almost the entire length of the chromosome, the coverage is not yet even. Some “gaps” in the map are clearly evident, for example, between LEX027 and OTC on the short arm, and PGK1 and LEX013 on the long arm, where mor ...
ecoli lysis - KSU Faculty Member websites
ecoli lysis - KSU Faculty Member websites

... E. coli H10407 genomic DNA by using Vent DNA polymerase and oligonucleotide primers P35 (5'-ATTGTCGGTTATGCAGCGAAGC) and P36 (5'ACTCCTGCAAATTCCAGTTACC). The PCR product was A-tailed with AmpliTaq polymerase, ligated into pGEM-T Easy behind the lac promoter, and electroporated into XL1-Blue to generat ...
Molecular cloning and expression of a novel
Molecular cloning and expression of a novel

Dictyostelium IQGAP-related Protein Specifically
Dictyostelium IQGAP-related Protein Specifically

... an open reading frame interrupted by three putative introns with typical features of Dictyostelium introns (Figs. 1 and 4). The intron–exon boundaries were confirmed by sequence analysis of cDNA clones prepared from the vegetative mRNA (data not shown). It was found that the tag was inserted into th ...
Joanne Ramsey
Joanne Ramsey

... Renal oncocytomas (ROs) are benign epithelial tumours that arise from the intercalated cells of the renal collecting duct The main characteristics of ROs is the accumulation of mitochondria in the cell cytoplasm and their deficiency in electron transport chain complex I Loss of chromosomes 1 and 14 ...
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Artificial gene synthesis

Artificial gene synthesis is a method in synthetic biology that is used to create artificial genes in the laboratory. Currently based on solid-phase DNA synthesis, it differs from molecular cloning and polymerase chain reaction (PCR) in that the user does not have to begin with preexisting DNA sequences. Therefore, it is possible to make a completely synthetic double-stranded DNA molecule with no apparent limits on either nucleotide sequence or size. The method has been used to generate functional bacterial or yeast chromosomes containing approximately one million base pairs. Recent research also suggests the possibility of creating novel nucleobase pairs in addition to the two base pairs in nature, which could greatly expand the possibility of expanding the genetic code.Synthesis of the first complete gene, a yeast tRNA, was demonstrated by Har Gobind Khorana and coworkers in 1972. Synthesis of the first peptide- and protein-coding genes was performed in the laboratories of Herbert Boyer and Alexander Markham, respectively.Commercial gene synthesis services are now available from numerous companies worldwide, some of which have built their business model around this task. Current gene synthesis approaches are most often based on a combination of organic chemistry and molecular biological techniques and entire genes may be synthesized ""de novo"", without the need for precursor template DNA. Gene synthesis has become an important tool in many fields of recombinant DNA technology including heterologous gene expression, vaccine development, gene therapy and molecular engineering. The synthesis of nucleic acid sequences is often more economical than classical cloning and mutagenesis procedures.
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