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Immunity Hemopoiesis and Cellular Drosophila
Immunity Hemopoiesis and Cellular Drosophila

... cellular response involves phagocytosis, nodule formation, and encapsulation of pathogens. Over the past few decades, our understanding of how the humoral response is regulated has grown considerably (4 – 6). Yet, the processes that govern the cellular response are unclear, and only recently has it ...
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FoldIndex©: a simple tool to predict whether a given protein
FoldIndex©: a simple tool to predict whether a given protein

... of hydrophobic amino acids and charged amino acids, and generate a detailed report of values for each stage of the sliding window during the analysis. A file containing multiple sequences in ‘fasta’ format can also be uploaded, yielding a detailed report of the IFKD values for each sequence. The use ...
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... also be used to investigate the intracellular compartmentation of metabolites. However, this is technically more challenging than enzyme localization because the turnover times of many metabolites are much shorter than the time needed for the fractionation. One way to overcome this problem is to rem ...
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Paracrine signalling



Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.
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