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Contained Chemistry - SafeBridge Consultants, Inc.
Contained Chemistry - SafeBridge Consultants, Inc.

... "Because the quantities are smaller, a lot of companies think this is easier to do," Van Tilburg says about high-potency manufacturing. "But it's a completely different ballgame—you need different people, different expertise, different equipment, and different motivation." For these reasons, compani ...
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... field of drug discovery. We outline here the fundamental concepts and processes of drug discovery. Our goal is to guide researchers toward the steps necessary to translate benchside findings into bedside applications, and to locate resources that can help provide reagents and services needed in this ...
LTD/1801
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Living Environment
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Agricultural and Veterinary Chemicals Code Amendment
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NA/503 - NICNAS

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5.3 Explaining How Fungi Grow: Digestion and Biosynthesis

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PerspectiVe

... are similar; otherwise, the data could become very misleading. This information can be used to quickly build up which parts of the active site are “hot spots” for gaining affinity and which groups on the inhibitor are the most effective. GE can also be used to elegantly illustrate how the addition o ...
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DNA-encoded chemical library



DNA-encoded chemical libraries (DEL) is a technology for the synthesis and screening of collections of small molecule compounds of unprecedented size. DEL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology. The aim of DEL technology is to accelerate the drug discovery process and in particular early phase discovery activities such as target validation and hit identification.DEL technology involves the conjugation of chemical compounds or building blocks to short DNA fragments that serve as identification bar codes and in some cases also direct and control the chemical synthesis. The technique enables the mass creation and interrogation of libraries via affinity selection, typically on an immobilized protein target. A homogeneous method for screening DNA-encoded libraries has recently been developed which uses water-in-oil emulsion technology to isolate, count and identify individual ligand-target complexes in a single-tube approach. In contrast to conventional screening procedures such as high-throughput screening, biochemical assays are not required for binder identification, in principle allowing the isolation of binders to a wide range of proteins historically difficult to tackle with conventional screening technologies. So, in addition to the general discovery of target specific molecular compounds, the availability of binders to pharmacologically important, but so-far “undruggable” target proteins opens new possibilities to develop novel drugs for diseases that could not be treated so far. In eliminating the requirement to initially assess the activity of hits it is hoped and expected that many of the high affinity binders identified will be shown to be active in independent analysis of selected hits, therefore offering an efficient method to identify high quality hits and pharmaceutical leads.
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