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Lecture 05 - binding quant - Cal State LA
... (theoretically, KD = EC50), it does not account for agonists that do not produce the maximum effect. Modified occupancy theory: modified to separate the binding affinity from the intrinsic activity () of the compound. That is, a compound can bind tightly, but cause a little or no effect. ...
... (theoretically, KD = EC50), it does not account for agonists that do not produce the maximum effect. Modified occupancy theory: modified to separate the binding affinity from the intrinsic activity () of the compound. That is, a compound can bind tightly, but cause a little or no effect. ...
Lecture
... 3. Structure, nomenclature, methods of getting and physical and chemical properties of acridine. Acridine was first isolated in 1871 by Carl Gräbe and Heinrich Caro. Acridine occurs naturally in coal tar. It is separated from coal tar by extracting with dilute sulfuric acid; addition of potassium d ...
... 3. Structure, nomenclature, methods of getting and physical and chemical properties of acridine. Acridine was first isolated in 1871 by Carl Gräbe and Heinrich Caro. Acridine occurs naturally in coal tar. It is separated from coal tar by extracting with dilute sulfuric acid; addition of potassium d ...
Chapter 3 - mychemcourse
... Know what a substance is and be able to give two examples. Know what a physical property is and be able to list five physical properties of substances. Know the difference between extensive and intensive properties and know examples of each. Know what a chemical property is and be able to give an ex ...
... Know what a substance is and be able to give two examples. Know what a physical property is and be able to list five physical properties of substances. Know the difference between extensive and intensive properties and know examples of each. Know what a chemical property is and be able to give an ex ...
Membrane Sanitation
... of your final product. They also reduce energy consumption and increase production time by reducing mineral scaling, minimizing evaporator cleaning time. Hydrite Chemical Co. technical staff is skilled at assisting customers with reducing their evaporator cleaning time through modifications in proce ...
... of your final product. They also reduce energy consumption and increase production time by reducing mineral scaling, minimizing evaporator cleaning time. Hydrite Chemical Co. technical staff is skilled at assisting customers with reducing their evaporator cleaning time through modifications in proce ...
May 2015 ToxTidbits - Maryland Poison Center
... synthe c cannabinoid compounds that have been studied have nonselec ve affinity for and agonist ac on at cannabinoid receptors CB1 and CB2. This is similar to delta-9-tetrahydrocannabinol (THC), the psychoac ve cannabinoid in cannabis plants. However, there are important differences. THC is a par al ...
... synthe c cannabinoid compounds that have been studied have nonselec ve affinity for and agonist ac on at cannabinoid receptors CB1 and CB2. This is similar to delta-9-tetrahydrocannabinol (THC), the psychoac ve cannabinoid in cannabis plants. However, there are important differences. THC is a par al ...
Biology Cytology (study of the cells) Basic characteristics of the cells
... quaternary structure due to association of two alpha globin and two beta globin polyproteins. Enzymes and enzymatic reactions. - Enzymes speeds up a reaction by lowering its activation energy. - Some enzymes consist of only a protein. Others have two components: a protein, apoenzyme + a cofactor. Th ...
... quaternary structure due to association of two alpha globin and two beta globin polyproteins. Enzymes and enzymatic reactions. - Enzymes speeds up a reaction by lowering its activation energy. - Some enzymes consist of only a protein. Others have two components: a protein, apoenzyme + a cofactor. Th ...
Guidance for NCAP FA-713 Chemical Container HCS 2012 Labeling
... these items OR the council/camp may use their own label that provides all of the pertinent information from the chemical’s safety data sheet (SDS). The secondary container workplace (in-house) label must include: ...
... these items OR the council/camp may use their own label that provides all of the pertinent information from the chemical’s safety data sheet (SDS). The secondary container workplace (in-house) label must include: ...
ppt - Chair of Computational Biology
... their binary fingerprints. The comparison of binary data is computationally simple, but there are a number of different similarity indices. For the comparison of molecules the Tanimoto index is most frequently being used. More about similarity indices in lecture 6 ...
... their binary fingerprints. The comparison of binary data is computationally simple, but there are a number of different similarity indices. For the comparison of molecules the Tanimoto index is most frequently being used. More about similarity indices in lecture 6 ...
P h a rmaceutical industry is short ... drugs. Whereas in past decades about 50-60 new
... precursor of fibrin), HIV GAG and GAG-POL proteins (the precursor proteins of HIV protease and other HIV proteins), and many enzyme and receptor ligands, e.g. the serpins, enkephalins, neurokinins, somatostatin, fibrinogen (as a GP IIb/IIIa receptor ligand), vitronectin, etc., are either peptides or ...
... precursor of fibrin), HIV GAG and GAG-POL proteins (the precursor proteins of HIV protease and other HIV proteins), and many enzyme and receptor ligands, e.g. the serpins, enkephalins, neurokinins, somatostatin, fibrinogen (as a GP IIb/IIIa receptor ligand), vitronectin, etc., are either peptides or ...
the chembiobank and eu-openscreen initiatives in chemical
... have boosted an urgent need for new antibacterial agents with novel modes of action.1 In this sense, FtsZ (Figure 1) “a widely conserved tubulin-like GTPase” has recently been proposed as an attractive target for antibacterial drug discovery due to its essential role in bacterial cell division.2 Rec ...
... have boosted an urgent need for new antibacterial agents with novel modes of action.1 In this sense, FtsZ (Figure 1) “a widely conserved tubulin-like GTPase” has recently been proposed as an attractive target for antibacterial drug discovery due to its essential role in bacterial cell division.2 Rec ...
drug master file: [18f]fdg
... 1. Name of Radiopharmaceutical (active ingredient) [11C]Acetate 2. Indicate the chemical structure for low molecular weight drug molecules (not required for antibodies, proteins, or polymeric agents) CH3COOH ...
... 1. Name of Radiopharmaceutical (active ingredient) [11C]Acetate 2. Indicate the chemical structure for low molecular weight drug molecules (not required for antibodies, proteins, or polymeric agents) CH3COOH ...
Increased Risk of Revision after ACL Reconstruction with Soft
... allografts processed with >1.8Mrads without chemical processing after 2.5 years (HR: 3.88 95%CI 1.48‐ 10.12), and >1.8Mrads with chemical processing after only 1 year (HR: 3.43 95%CI 1.58‐7.47) and with BioCleanse processed grafts (HR: 3.02 95%CI 1.40‐6.50). Compared to BPTB autografts, an increase ...
... allografts processed with >1.8Mrads without chemical processing after 2.5 years (HR: 3.88 95%CI 1.48‐ 10.12), and >1.8Mrads with chemical processing after only 1 year (HR: 3.43 95%CI 1.58‐7.47) and with BioCleanse processed grafts (HR: 3.02 95%CI 1.40‐6.50). Compared to BPTB autografts, an increase ...
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... the studies. For the pharmacological evaluation, the compounds were suspended in water using Tween 80 as a suspending agent. For all the studies, animals were divided into groups of 4 animals. The control group received the calculated amount of normal saline. All the experiments were carried out at ...
... the studies. For the pharmacological evaluation, the compounds were suspended in water using Tween 80 as a suspending agent. For all the studies, animals were divided into groups of 4 animals. The control group received the calculated amount of normal saline. All the experiments were carried out at ...
Knowledge Discovery in Academic Drug Discovery Programs
... Smaller companies also drive innovation, conducting basic research, drug discovery, preclinical experiments and, in some cases, clinical trials. The NIH provides leadership and funding support to universities, medical schools, research centers and other nonprofit institutions, and stimulates basic r ...
... Smaller companies also drive innovation, conducting basic research, drug discovery, preclinical experiments and, in some cases, clinical trials. The NIH provides leadership and funding support to universities, medical schools, research centers and other nonprofit institutions, and stimulates basic r ...
Fragment-Based Drug Discovery Applied to Hsp90
... efficiently optimized into potent lead series. The results are discussed together with any learning points that are relevant to either Hsp90 inhibition or FBDD. A companion paper (DOI: 10.1021/jm100060b) describes how one of these leads was optimized into an Hsp90 inhibitor that is currently in clin ...
... efficiently optimized into potent lead series. The results are discussed together with any learning points that are relevant to either Hsp90 inhibition or FBDD. A companion paper (DOI: 10.1021/jm100060b) describes how one of these leads was optimized into an Hsp90 inhibitor that is currently in clin ...
Hazardous Materials Reporting Packet
... Irritating Material: A chemical that is not corrosive, but causes a reversible inflammatory effect on living tissue by chemical action at the site of contact. Organic Peroxide: An organic compound that contains the bivalent -O-O- structure and which may be considered to be a structural derivative o ...
... Irritating Material: A chemical that is not corrosive, but causes a reversible inflammatory effect on living tissue by chemical action at the site of contact. Organic Peroxide: An organic compound that contains the bivalent -O-O- structure and which may be considered to be a structural derivative o ...
Investigative study on the angiotensin converting enzyme (ACE
... deposition 1UZF, 1UZE and 1O86 was read into SYBYL® (SYBYL 7.3, Tripos International, Cartera™) with precautions being taken to preserve the bound co-ordinates and consequently the bioactive conformation of each. All moeities considered as superfluous to binding were edited. This means that in the c ...
... deposition 1UZF, 1UZE and 1O86 was read into SYBYL® (SYBYL 7.3, Tripos International, Cartera™) with precautions being taken to preserve the bound co-ordinates and consequently the bioactive conformation of each. All moeities considered as superfluous to binding were edited. This means that in the c ...
Young Innovators 2009
... In our effort to understand the mechanisms of actions of drugs predicted from the cmap as treatments for AD, a new study was conducted where gene signatures for the Alzheimer’s disease (AD) were used to query the cmap to identify potential anti-AD agents. Concurrently, QSAR models were developed for ...
... In our effort to understand the mechanisms of actions of drugs predicted from the cmap as treatments for AD, a new study was conducted where gene signatures for the Alzheimer’s disease (AD) were used to query the cmap to identify potential anti-AD agents. Concurrently, QSAR models were developed for ...
Structural Biology: Modeling applications and techniques at a glance
... Due to invaluable information which can be obtained from a molecular dynamic simulation [31], the MD methodology has founded applications in various areas and has successfully been used to simulate different biological and bio-molecular systems such ligand-DNA systems [33-38], enzymes and enzyme kin ...
... Due to invaluable information which can be obtained from a molecular dynamic simulation [31], the MD methodology has founded applications in various areas and has successfully been used to simulate different biological and bio-molecular systems such ligand-DNA systems [33-38], enzymes and enzyme kin ...
Immunology Stack - University of Arizona
... (azoles). Other unique compounds are also targeted but these are the big hitters. ...
... (azoles). Other unique compounds are also targeted but these are the big hitters. ...
Introduction to Fragment-Based Drug Discovery
... difficulty is that chemical bonds have strict length and geometric requirements, so if the two fragments are not perfectly positioned much of the potency gain expected will be lost due to strain in the linker [10, 11]. Therefore, a frequent alternative to fragment linking is fragment growing, as sho ...
... difficulty is that chemical bonds have strict length and geometric requirements, so if the two fragments are not perfectly positioned much of the potency gain expected will be lost due to strain in the linker [10, 11]. Therefore, a frequent alternative to fragment linking is fragment growing, as sho ...
PPT CH 4
... • H2O – 2 atoms of hydrogen and 1 atom of oxygen, lack of subscript means one atom • NaCl – 1 atom each of sodium and chlorine • Ca(OH)2 – 1 atom of calcium and 2 atoms each of oxygen and hydrogen, subscript outside parentheses applies to all atoms inside ...
... • H2O – 2 atoms of hydrogen and 1 atom of oxygen, lack of subscript means one atom • NaCl – 1 atom each of sodium and chlorine • Ca(OH)2 – 1 atom of calcium and 2 atoms each of oxygen and hydrogen, subscript outside parentheses applies to all atoms inside ...
pps - Chair of Computational Biology
... their binary fingerprints. The comparison of binary data is computationally simple, but there are a number of different similarity indices. For the comparison of molecules the Tanimoto index is most frequently being used. More about similarity indices in lecture 6 ...
... their binary fingerprints. The comparison of binary data is computationally simple, but there are a number of different similarity indices. For the comparison of molecules the Tanimoto index is most frequently being used. More about similarity indices in lecture 6 ...
Chapter 1 - Drug Discovery and Development: An Overview of
... can be delivered as safe and effective therapeutic agents? How does one determine which of the nearly infinite possibilities are useful and which ones are not? Of the useful compounds, which ones will be of interest to the companies that manufacture drugs and which ones will not? These issues are ex ...
... can be delivered as safe and effective therapeutic agents? How does one determine which of the nearly infinite possibilities are useful and which ones are not? Of the useful compounds, which ones will be of interest to the companies that manufacture drugs and which ones will not? These issues are ex ...
DNA-encoded chemical library
DNA-encoded chemical libraries (DEL) is a technology for the synthesis and screening of collections of small molecule compounds of unprecedented size. DEL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology. The aim of DEL technology is to accelerate the drug discovery process and in particular early phase discovery activities such as target validation and hit identification.DEL technology involves the conjugation of chemical compounds or building blocks to short DNA fragments that serve as identification bar codes and in some cases also direct and control the chemical synthesis. The technique enables the mass creation and interrogation of libraries via affinity selection, typically on an immobilized protein target. A homogeneous method for screening DNA-encoded libraries has recently been developed which uses water-in-oil emulsion technology to isolate, count and identify individual ligand-target complexes in a single-tube approach. In contrast to conventional screening procedures such as high-throughput screening, biochemical assays are not required for binder identification, in principle allowing the isolation of binders to a wide range of proteins historically difficult to tackle with conventional screening technologies. So, in addition to the general discovery of target specific molecular compounds, the availability of binders to pharmacologically important, but so-far “undruggable” target proteins opens new possibilities to develop novel drugs for diseases that could not be treated so far. In eliminating the requirement to initially assess the activity of hits it is hoped and expected that many of the high affinity binders identified will be shown to be active in independent analysis of selected hits, therefore offering an efficient method to identify high quality hits and pharmaceutical leads.