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Nitrogen Excretion in Fish
Nitrogen Excretion in Fish

... Ornithine-Urea Cycle (OUC) • Only elasmobranchs, coelacanths and a few teleostean fish that survive periods of air ...
Predicting the impact of diet and enzymopathies on human small
Predicting the impact of diet and enzymopathies on human small

... flow to the liver via the hepatic portal system (6) and the liver, in turn, supplies biliary constituents through the common bile duct to the duodenum. The liver synthesizes bile acids from cholesterol, which are then delivered to the intestinal lumen to aid in the digestion and absorption of fat wi ...
Mitochondria and energy production
Mitochondria and energy production

... kinase-mediated mechanism. The other mechanism involves amino acids (e.g. leucine, phenylalanine and tyrosine) that are not concentrated within the liver but appear to exert their actions via an mTOR-mediated pathway. Recent studies have clarified the mechanism by which glutamine and system A substr ...
Proteome of amyloplasts isolated from developing wheat
Proteome of amyloplasts isolated from developing wheat

... MgCl2) and incubated for 1 h on ice. Plasmolysed endosperm was chopped twice for 30 s with an electric knife, the blades of which were replaced with holders fitted with single-edge razor blades. The resulting homogenate was filtered through two layers of Miracloth and gently pipetted onto a 4 ml cus ...
IOSR Journal Of Environmental Science, Toxicology And Food Technology (IOSR-JESTFT)
IOSR Journal Of Environmental Science, Toxicology And Food Technology (IOSR-JESTFT)

... The uterus or womb is a major female hormone responsive reproductive sex organ of most mammals including human in which foetus is developed (Blackburn and Flemming, 2011). One of the major and pathological disorder affecting the uterus is a disease called uterine myomas, fibromyomas and leiomyomas ( ...
Amino Acid Residues Critical for the Specificity for
Amino Acid Residues Critical for the Specificity for

... interactions of its indole ring carbon atoms CH2 and CZ3 with the phenol oxygen of Tyr-160. These interactions contribute to maintain the position of Tyr-160, which allows binding of the trimethylammonium group (see below). The mutant enzymes exhibited decreased Vmax values, but to a lesser extent t ...
Systems Biology Investigation to Discover Metabolic Biomarkers of
Systems Biology Investigation to Discover Metabolic Biomarkers of

... were employed to study urinary metabolic perturbations induced by APAP administration [15] and the drug’s metabolites profile [14]. These results showed the depletion of antioxidants (e.g., ferulic acid), trigonelline, S-adenosyl-methionine (SAMe), and energy-related metabolites caused by APAP admin ...
Silica Particles
Silica Particles

... Low autofluorescence and low nonspecific binding of many biomolecules Suitable for applications over 1000˚C Wide range of solvent compatibility SPHEROTM Silica Nano Superparamagnetic Particles ...
Living on the edge: substrate competition explains loss of
Living on the edge: substrate competition explains loss of

... (purple) mouse livers. Data represents median and each individual data point (n = 4). Panels c–f show the dynamic profiles of the Cn-acylcarnitines upon addition of the substrate palmitoylcarnitine (C16; panel c and d) and octanoylcarnitine (C8; panel e and f) to isolated mitochondria of wild-type l ...
Glycolysis
Glycolysis

... - Pyruvate: enters the mitochondria & is converted into acetyl CoA. Acetyl CoA enters citric acid cycle (Krebs cycle) to yield energy in the form of ATP - NADH: utilizes mitochondria & oxygen to yield energy 2- In cells with no mitochondria or adequate oxygen (or Both) (Anaerobic glycolysis) Lactate ...
A Review of Issues of Dietary Protein Intake in Humans
A Review of Issues of Dietary Protein Intake in Humans

... diet history, training status, and was undertaken more than 30 y ago. The dangers of excessive protein intake should not be underestimated and have been recognized historically through the excess consumption of lean wild meat by early American explorers leading to a condition referred to as “rabbit ...
Relationships Analyzing Amino-Acid Sequences to Determine
Relationships Analyzing Amino-Acid Sequences to Determine

... 1. According to your data from Cytochrome C, which organism is most closely related to humans? Which is least closely related to humans? 2. In the study of hemoglobin, which vertebrate is most closely related to humans? Least closely related? 3. Why can it be said that proteins behave like molecular ...
Evolutionary Potential and Requirements for Minimal Protocells
Evolutionary Potential and Requirements for Minimal Protocells

... 5. The membrane must be able to grow, either through direct incorporation of membranogenic molecules from the environment or through conversion of appropriate precursors. 6. Reproduction in space of the protocells must happen. 7. Catalysis, replication and growth must be synchronised well. The chemo ...
Prediction of Maximum Yields of Metabolites and Optimal Pathways
Prediction of Maximum Yields of Metabolites and Optimal Pathways

... flux analysis can also suggest suitable culture conditions for metabolites production. As shown in Fig. 2, aerobic culture condition is suitable for acetic acid and ethanol production, while anaerobic culture condition is more appropriate for the production of lactic acid and succinic acid. As menti ...
Development of Software Package for Determining Protein
Development of Software Package for Determining Protein

... + Gh-c(pH) + ...
11. Archaea and Bacteria
11. Archaea and Bacteria

... Escherichia coli and Bacillus subtilis are classified in Bacteria, which is a domain of life newly proposed phylogenetic classification of all life [1]. Other domains are Archaea and Eukarya. Because cells of Eukarya are generally accepted as cells emerged by symbiosis of an ancient archaeal and a b ...
Glucose
Glucose

... High intakes of carbohydrate trigger large releases of insulin for compensatory responses, including insulindependent glucose uptake by muscle or fat and active synthesis of glycogen and fat. Blood glucose then drops to a normal range. Approximately 2 hours after a meal, intestinal absorption is co ...
Nucleotide sequence of the Streptococcus pneumoniae ung gene
Nucleotide sequence of the Streptococcus pneumoniae ung gene

... avoidance (2). Indeed, it is likely to prevent transition mutations by removing uracil that results from deamination of cytosine. It has been proposed that the removal of misincorporated uracil by uracil-DNA glycosylase also plays an indirect role in correction of replication errors in nascent stran ...
Ultrasonic Absorption Mechanisms in Aqueous Solutions of Bovine
Ultrasonic Absorption Mechanisms in Aqueous Solutions of Bovine

... the former, and not present in the latter, which may also possess relaxational behavior. A similar situation has been reported for bovine serum albumin.22 The composite ultrasonic absorption titration curve is shown in Figure 2 for the frequency range 8.9-50.5 MHz and over the pH range 1.5-12.3. Sim ...
Microbial degradation of chloroaromatics Mars, Astrid E.
Microbial degradation of chloroaromatics Mars, Astrid E.

Tilting Plant Metabolism for Improved Metabolite Biosynthesis and
Tilting Plant Metabolism for Improved Metabolite Biosynthesis and

... metabolites. With the current level of functional understanding, a more complete appreciation of complex secondary biosynthetic pathways, together with mechanisms of individual biosynthetic reactions, is within reach. The combined information can provide a more practical and rational metabolic engin ...
mineralization of chlorobenzene. of the meta
mineralization of chlorobenzene. of the meta

... been described. These organisms can be differentiated on the basis of the catabolic pathways dealing with the substituents. Chlorosubstituents can be removed by initial oxygenolytic, reductive, or hydrolytic reactions. Further mineralization can then occur via classical pathways such as the 3-oxoadi ...
Full-Text PDF
Full-Text PDF

... a single / domain that contains at the core a Rossmann fold motif similar to lactate dehydrogenase (Figure 1) consisting of 5–6 -strands that form a twisted -sheet surrounded by two pairs of -helices [4]. This represented a novel fold for a zinc metallohydrolase at the time the first structure ...
Metabolism (degradation) of triacylglycerols and fatty acids
Metabolism (degradation) of triacylglycerols and fatty acids

... • HOOC-CH2-CH2-COOH ...
Every dogma has its day
Every dogma has its day

... in the main, still having its day. According to present knowledge, the exceptions to this dogma are mere details when seen in relation to the biosystem as a whole. Nevertheless the exceptions are scientifically interesting and the understanding of them has led to a better comprehension of photosynth ...
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Amino acid synthesis

Amino acid synthesis is the set of biochemical processes (metabolic pathways) by which the various amino acids are produced from other compounds. The substrates for these processes are various compounds in the organism's diet or growth media. Not all organisms are able to synthesise all amino acids. Humans are excellent example of this, since humans can only synthesise 11 of the 20 standard amino acids (aka non-essential amino acid), and in time of accelerated growth, arginine, can be considered an essential amino acid.A fundamental problem for biological systems is to obtain nitrogen in an easily usable form. This problem is solved by certain microorganisms capable of reducing the inert N≡N molecule (nitrogen gas) to two molecules of ammonia in one of the most remarkable reactions in biochemistry. Ammonia is the source of nitrogen for all the amino acids. The carbon backbones come from the glycolytic pathway, the pentose phosphate pathway, or the citric acid cycle.In amino acid production, one encounters an important problem in biosynthesis, namely stereochemical control. Because all amino acids except glycine are chiral, biosynthetic pathways must generate the correct isomer with high fidelity. In each of the 19 pathways for the generation of chiral amino acids, the stereochemistry at the α-carbon atom is established by a transamination reaction that involves pyridoxal phosphate. Almost all the transaminases that catalyze these reactions descend from a common ancestor, illustrating once again that effective solutions to biochemical problems are retained throughout evolution.Biosynthetic pathways are often highly regulated such that building-blocks are synthesized only when supplies are low. Very often, a high concentration of the final product of a pathway inhibits the activity of enzymes that function early in the pathway. Often present are allosteric enzymes capable of sensing and responding to concentrations of regulatory species. These enzymes are similar in functional properties to aspartate transcarbamoylase and its regulators. Feedback and allosteric mechanisms ensure that all twenty amino acids are maintained in sufficient amounts for protein synthesis and other processes.
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