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D.4 pH Regulation of the Stomach
D.4 pH Regulation of the Stomach

... • The body keeps a tight control over the pH in cells and extra-cellular fluiids, as changes in the H+ concentration have significant effects on the activity of many molecules, especially enzymes. • The gastrointestinal tract generates and maintains different pH environments along its length, which ...
Novel targets for tuberculosis drug discovery
Novel targets for tuberculosis drug discovery

... Targeting amino acid biosynthesis M. tuberculosis auxotrophs have been described that are attenuated in mouse infection models, including mutants in the biosynthesis of lysine (lysA) [28], proline ( proC), tryptophan (trpD) and leucine (leuD) [29]. The structures of both LeuA [30] and LysA in comple ...
Arginine metabolism in human infants
Arginine metabolism in human infants

... – Enterocyte has high levels of ASS and ASL, low arginase – Hence, arginine synthesis takes place in enterocyte – Precursor proline or glutamate? ...
Protein Function
Protein Function

... tenths of a nanometer at the GTP binding site. This tiny movement causes a large conformational change to propagate along the switch helix. The helix serves as a latch that adheres to a specific site in another domain of the molecule. After GTP hydrolysis, the switch helix detaches, allowing the two ...
a review on biochemical mechanism of fatty acids synthesis and oil
a review on biochemical mechanism of fatty acids synthesis and oil

... have been identified. The quality of seed oil depends on the type of fatty acids esterified to glycerol. Finally, the TAGs are stored as lipid in seeds. The biosynthesis process of fatty acids and oil formation in seeds is reviewed in this manuscript. Keywords: Fatty Acids, Biosynthesis, Triacylglyc ...
Carbon metabolism in transgenic roots with altered levels
Carbon metabolism in transgenic roots with altered levels

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Metabolism of pentoses, glycogen, Fru and Gal
Metabolism of pentoses, glycogen, Fru and Gal

...  source of energy in animals (liver, muscles)  highly branched structure (rapid degradation and synthesis, better solubility) Nonreducing end ...
Characterization of epitopes on zucchini yellow mosaic potyvirus
Characterization of epitopes on zucchini yellow mosaic potyvirus

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Protein Calorie Malnutrition

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Isolation of Vibrio harveyi Acyl Carrier Protein and the fabG, acpP

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Diseases/Disorders

... Defect in N-acetylglutamate synthase: cannot make N-acetylglutamate and cannot activate CPS-I; elevated ammonia in blood and urine; death in only reported case Defect in carbamoyl phosphate synthetase (CPS)-I: no accumulation of urea cycle intermediates; elevated ammonia in blood and urine; treat wi ...
Chapter 4.32
Chapter 4.32

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An Introduction to Metabolism

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Enzyme Activities Associated with Carbohydrate
Enzyme Activities Associated with Carbohydrate

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... greater than those non-biological catalysts. • Enzymes often have a high degree of specificity for their substrates. • Enzymes are often regulatory. • Enzymes usually work under very mild conditions of temperature and pH. • The substance acted on by an enzyme is called a substrate, which binds to th ...
Adenovirus-associated Virus Structural Protein Sequence Homology
Adenovirus-associated Virus Structural Protein Sequence Homology

... (unlike the helper adenovirus proteins). The amino acid composition data presented here provide more complete evidence demonstrating the similarity of the amino acid compositions of the three virion proteins. The relative concentration (mole percentage) of each amino acid is also similar for each of ...
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... OAA is diverted for gluconeogenesis and TCA cycle intermediates fall. Decrease in citrate further reduces FA synthesis (loss of activation of phosphorylated AcCoA carboxylase by citrate) and enhanced FA oxidation (less inhibition of acylcarnitine transferase I because of further decrease in malonylC ...
View Full PDF - Biochemical Society Transactions
View Full PDF - Biochemical Society Transactions

... substrate, however, non-linear-slope replots were obtained. Non-linear-slope effects normally reflect multiple combination of an inhibitor with the enzyme. It is notable therefore that the non-linear-slope replots were seen with both products, but only when pyruvate was the variable substrate. This ...
biochemistry - Textbooks Online
biochemistry - Textbooks Online

... water, water tends to flow from the latter to the former. The property of the movement of solvent particles is called as osmosis. Osmosis is the net diffusion of water from the dilute solution to the concentrated solution. Osmosis is a colligative property of solution that depends on the number of m ...
Overview of Carbohydrate Digestion and Metabolism
Overview of Carbohydrate Digestion and Metabolism

... Water retention – diarrhea/bloating ...
Overview of Carbohydrate Digestion and Metabolism
Overview of Carbohydrate Digestion and Metabolism

... Water retention – diarrhea/bloating ...
biochem ch 46 [9-4
biochem ch 46 [9-4

...  Major functions of pentose phosphate pathway – generation of NADPH and 5-C sugars o All cell types, including RBCs carry out this pathway because they need to generate NADPH so activity of glutathione reductase (enzyme that catalyzes conversion of oxidized glutathione (GSSG) back to reduced glutat ...
Overview of Carbohydrate Digestion and Metabolism
Overview of Carbohydrate Digestion and Metabolism

... Water retention – diarrhea/bloating ...
Overview of Carbohydrate Digestion and Metabolism
Overview of Carbohydrate Digestion and Metabolism

... Water retention – diarrhea/bloating ...
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Amino acid synthesis

Amino acid synthesis is the set of biochemical processes (metabolic pathways) by which the various amino acids are produced from other compounds. The substrates for these processes are various compounds in the organism's diet or growth media. Not all organisms are able to synthesise all amino acids. Humans are excellent example of this, since humans can only synthesise 11 of the 20 standard amino acids (aka non-essential amino acid), and in time of accelerated growth, arginine, can be considered an essential amino acid.A fundamental problem for biological systems is to obtain nitrogen in an easily usable form. This problem is solved by certain microorganisms capable of reducing the inert N≡N molecule (nitrogen gas) to two molecules of ammonia in one of the most remarkable reactions in biochemistry. Ammonia is the source of nitrogen for all the amino acids. The carbon backbones come from the glycolytic pathway, the pentose phosphate pathway, or the citric acid cycle.In amino acid production, one encounters an important problem in biosynthesis, namely stereochemical control. Because all amino acids except glycine are chiral, biosynthetic pathways must generate the correct isomer with high fidelity. In each of the 19 pathways for the generation of chiral amino acids, the stereochemistry at the α-carbon atom is established by a transamination reaction that involves pyridoxal phosphate. Almost all the transaminases that catalyze these reactions descend from a common ancestor, illustrating once again that effective solutions to biochemical problems are retained throughout evolution.Biosynthetic pathways are often highly regulated such that building-blocks are synthesized only when supplies are low. Very often, a high concentration of the final product of a pathway inhibits the activity of enzymes that function early in the pathway. Often present are allosteric enzymes capable of sensing and responding to concentrations of regulatory species. These enzymes are similar in functional properties to aspartate transcarbamoylase and its regulators. Feedback and allosteric mechanisms ensure that all twenty amino acids are maintained in sufficient amounts for protein synthesis and other processes.
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