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- Journal of Clinical Investigation
- Journal of Clinical Investigation

... The adjective “epigenetic” has been used to describe many types of biological processes, but with the evolution of epigenetics into a subdiscipline of molecular biology, its meaning has become quite focused. Although the term is sometimes used more broadly, epigenetic effects are usually taken to en ...
Multiple Choice
Multiple Choice

... A. a supersecondary protein structure composed of parallel beta sheets B. a supersecondary protein structure composed of antiparallel beta sheets C. a Type I loop D. a Type II loop E. the basic structure of a beta barrel 12.What is the force which is primarily responsible for stabilizing the tertiar ...
Back to Table of Contents
Back to Table of Contents

... tertiary structure cannot be determined (although it should become possible to make predictions when more tertiary sequences are submitted to databases). It can only be determined by complex experimental analyses (X-ray crystallography and Nuclear Magnetic Resonance) and, at present, this informatio ...
No Slide Title
No Slide Title

... – Each iteration involves propagating all elements of the population – Each member of population (“chromosome”) corresponds to one value of  • Genetic algorithms (GAs) are most popular form of EC • Early work in 1950s and 1960s; influential 1975 book by John Holland laid foundation for modern imple ...
Genome Evolution, Chromosomal Mutations, Paralogy
Genome Evolution, Chromosomal Mutations, Paralogy

... [Bejerano Fall09/10] ...
CENTRO ESCOLAR UNIVERSITY
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Archives and Information Retrieval
Archives and Information Retrieval

Pre-Lab: Molecular Biology
Pre-Lab: Molecular Biology

... daughter strands, the replication fork, the enzymes DNA polymerase and DNA ligase. Be sure that template bases appropriately match the bases of both new strands. **Use may use a different colored pencil/pen to draw the daughter strands**. ...
Warren, ST: Trinucleotide repetition and fragile X syndrome. Hospital Practice 32:73 - 98 (1997). cover illustration.
Warren, ST: Trinucleotide repetition and fragile X syndrome. Hospital Practice 32:73 - 98 (1997). cover illustration.

... interruptions. The available data suggest a multistep history in which a normal allele becomes a predisposed allele, which eventually becomes a premutation, which then expands into full mutation. At the outset, safety resides in the shortness of the CGG repetition or in its interruption by one or mo ...
DOC
DOC

HERITABLE AND NON-HERITABLE TRAITS Heritable traits are
HERITABLE AND NON-HERITABLE TRAITS Heritable traits are

... 2. Duplication: When a chromosomal segment is represented twice, it is called a duplication. We can categories duplication by the position and order of the duplicated region. First, the duplication may be adjacent to the original chromosomal region. When this occurs, the order may either be the sam ...
Assignment Sheet
Assignment Sheet

... copy of chromosome 21 to be given in the gamete. With fertilization, the baby will have three copies of this chromosome in each cell instead of the ususal 2 copies. Also called Triosomy 21. ...
PowerPoint - 埼玉医科大学総合医療センター 内分泌・糖尿病内科
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... Transcription factor 7-like 2 (T-cell specific, HMG-box) also known as TCF7L2 or TCF4 is a protein acting as a transcription factor. In humans this protein is encoded by the TCF7L2 gene. A variant of the protein is linked to higher risk to develop type 2 diabetes. ...
Chapter 15 Biochemistry: A Molecular view of Life
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... -Chromosomes are responsible for passing traits of a cell to a new cell. -Chromosomes are made of nucleic acid. Anyway, if you still don't get it. Think of chromosomes as an encyclopedia, chromosomes contain a whole lot of information. They give the cell their information, the way you get informatio ...
DNA Technology and Genomics  I.
DNA Technology and Genomics I.

... D. Nearly all human genes contain several exons, and an estimated 75% of these multiexon genes are alternatively spliced. Along with this is additional polypeptide diversity via posttranslational processing. There are a much greater number of possible interactions between gene products as a result o ...
Amino Acids slides
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... Calculation of pI The isoelectric point for these amino acids is calculated by taking the average of the pKa’s of the groups with same charge when ionized In this case, the total charge on the groups with like charge must equal one (1) so that it can be balanced by the one (1) opposite charge prese ...
Transposable elements
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... Staggered cuts are made in DNA at target site by transposase, IS element inserts, DNA polymerase and ligase fill the gaps (note--transposase behaves like a restriction enzyme). ...
Chapter 24
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... 4. The second DNA strand is synthesized on the first DNA strand. • RT does not have the editing function (3’→5’ exonuclease). Therefore there is high error rate in replication, and thus RT has a high mutation rate. • AZT, ddI, ddC, and 2’3’-didehydro-3’-deoxythymine inhibit the RT activity by stoppi ...
DNA Keychains: Spell Your Initials Using the Genetic Code!!!!! This
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... 2. If  your  last  bead  was  a  sugar,  then  you  will  need  to  add  a   phosphate  bead.    Add  a  phosphate  bead  to  each  strand.    Make   sure  to  thread  BOTH  wires  through  these  beads.       3. If  your  l ...
ppt
ppt

... Kamata, et al. 2004. Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. Structure. 12: 429-438. Zelent, et al. 2005. Glucokinase and glucose homeostasis: proven concepts and new ideas. ...
Preparation of SCRATCHY Hybrid Protein Libraries
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... A genotype refers to the makeup of a specific set of genes. – Your alleles that you inherited A phenotype is the physical expression of a trait. – What you see ...
Milestones of bacterial genetic research: 1944 Avery`s
Milestones of bacterial genetic research: 1944 Avery`s

... specialized transduction, the genome of a temperate phage (such as ) integrates as a prophage into a bacterium's chromosome usually at a specific site. When the phage leaves the bacterium (to infect another bacterial cell) due to a recombination event it leaves part of the phage genome in the chromo ...
What are Math and Computer Science doing in Biology?
What are Math and Computer Science doing in Biology?

... platelet-derived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity.” From the abstract ...
Proteins with
Proteins with

... included. Assumed to be related proteins. This group of sequences is used to define a “profile” that contains the sequence “essence” of the protein family. 3) Now with the important sequence positions highlighted, can look for more distantly related sequences that should still have the “essence” of ...
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Point mutation



A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.
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