HST-151 Final Exam p
... 12. The medicinal chemistry department of your company has come up with a statin that is 10x more potent than atorvastatin and twice as efficacious. Does this sound like a promising drug for development? Explain [5] Probably not, since lack of potency and efficacy aren’t the major drawbacks for exis ...
... 12. The medicinal chemistry department of your company has come up with a statin that is 10x more potent than atorvastatin and twice as efficacious. Does this sound like a promising drug for development? Explain [5] Probably not, since lack of potency and efficacy aren’t the major drawbacks for exis ...
movement disorders and ataxia
... a. Levodopa: a precursor to dopamine, used in Parkinson’s disease. Given with carbidopa, which blocks peripheral, but not central, levodopa use. b. Side-effects: N/V, low BP, confusion, dyskinesias, hallucinations. c. D2 agonists: e.g. bromocriptine, ropinrole, pramiprexole (D3 >D2). Side-effects li ...
... a. Levodopa: a precursor to dopamine, used in Parkinson’s disease. Given with carbidopa, which blocks peripheral, but not central, levodopa use. b. Side-effects: N/V, low BP, confusion, dyskinesias, hallucinations. c. D2 agonists: e.g. bromocriptine, ropinrole, pramiprexole (D3 >D2). Side-effects li ...
1 - u.arizona.edu
... 1.,2. Stages of sleep - for humans, sleep is s state of decreased but not abolished consciousness, from which we can be aroused - sleep is an actively induced state - sleep stages defined by EEG criteria (measures movement of ions across cell membranes in layers 4-5 of cortex), 2 types: 1. synchroni ...
... 1.,2. Stages of sleep - for humans, sleep is s state of decreased but not abolished consciousness, from which we can be aroused - sleep is an actively induced state - sleep stages defined by EEG criteria (measures movement of ions across cell membranes in layers 4-5 of cortex), 2 types: 1. synchroni ...
Serotonin Syndrome - Available Courses
... increase in CNS (mainly lower brainstem and/or spinal cord) serotonin neurotransmission which is typically associated with initiation of use or an increase in dose of a seritomimetic agent or if these agents are used in conjunction with a monoamine oxidase inhibitor (MAOI). With the latter it is oft ...
... increase in CNS (mainly lower brainstem and/or spinal cord) serotonin neurotransmission which is typically associated with initiation of use or an increase in dose of a seritomimetic agent or if these agents are used in conjunction with a monoamine oxidase inhibitor (MAOI). With the latter it is oft ...
Lecture 15: The Brain
... • Regulates the ANS, including heart rate and force of contraction, blood pressure, and respiratory rate. • Also involved in coughing, sneezing, salivating, swallowing, gagging and barfing. • Contains visceral motor nuclei, including respiratory centers ...
... • Regulates the ANS, including heart rate and force of contraction, blood pressure, and respiratory rate. • Also involved in coughing, sneezing, salivating, swallowing, gagging and barfing. • Contains visceral motor nuclei, including respiratory centers ...
8-Anti-mycobacterial drugs
... Clofazimine is a phenazine dye with Antimycobacterial and Antiinflammatory effect. Clofazimine is bactericidal against M. tuberculosis, is bacteriostatic against M. leprae, and is active against M. avium intracellulare. The drug enhances the phagocytic activity of Neutrophils and Macrophages, and re ...
... Clofazimine is a phenazine dye with Antimycobacterial and Antiinflammatory effect. Clofazimine is bactericidal against M. tuberculosis, is bacteriostatic against M. leprae, and is active against M. avium intracellulare. The drug enhances the phagocytic activity of Neutrophils and Macrophages, and re ...
Self harm and Eating Disorders - King Edward VI College
... receives when they reveal their self-harm has a major impact on whether they will go on to receive help . If you receive a disclosure stay calm and demonstrate high levels of empathy, recognising how hard it is for the young person to discuss these issues. Remember that the behaviour provides a func ...
... receives when they reveal their self-harm has a major impact on whether they will go on to receive help . If you receive a disclosure stay calm and demonstrate high levels of empathy, recognising how hard it is for the young person to discuss these issues. Remember that the behaviour provides a func ...
Feeding Pathways
... Hunger vs. Satiety Controlled by communication between the gut and parasympathetic nervous system ...
... Hunger vs. Satiety Controlled by communication between the gut and parasympathetic nervous system ...
Mysteries of Development
... They are best known for helping determine patterns during development. But some also influence the size of organs, tissues, and limbs. One theory is that when a morphogen gradient is steep— that is, there is a large difference in its concentration from one cell to another—then cells continue to divi ...
... They are best known for helping determine patterns during development. But some also influence the size of organs, tissues, and limbs. One theory is that when a morphogen gradient is steep— that is, there is a large difference in its concentration from one cell to another—then cells continue to divi ...
Positron Emission Tomography Imaging: A Quantitative Biomarker in
... metabolism of radiotracers [4]. These modeling approaches depend upon the tracer assumption, i.e., that the mass concentration of the radiotracer is minute, and thus does not affect the saturation of any enzyme or the occupancy of any receptor or transporter (e.g., radiotracer concentration << KD, t ...
... metabolism of radiotracers [4]. These modeling approaches depend upon the tracer assumption, i.e., that the mass concentration of the radiotracer is minute, and thus does not affect the saturation of any enzyme or the occupancy of any receptor or transporter (e.g., radiotracer concentration << KD, t ...
(Nimesulide Tablets*) - Amson Vaccines and Pharma, Pvt Ltd
... results in Clinically significant adverse reactions especially regarding the risk of gastrotoxicity. Amsolide is the leading molecule of a new chemical class Sulphonanilides, which has shown a significant inhibitory selectivity towards cyclooxygenase 2 without affecting cyclooxygenase 1, this result ...
... results in Clinically significant adverse reactions especially regarding the risk of gastrotoxicity. Amsolide is the leading molecule of a new chemical class Sulphonanilides, which has shown a significant inhibitory selectivity towards cyclooxygenase 2 without affecting cyclooxygenase 1, this result ...
Overview of Synaptic Transmission
... the presynaptic fiber produces a depolarizing postsynaptic potential that is often large enough to discharge an action potential. The lIltency-the time between the presynaptic spike and the postsynaptic potential-is remarkably short (Figure to-2B). Such a short latency is incompatible with chemical ...
... the presynaptic fiber produces a depolarizing postsynaptic potential that is often large enough to discharge an action potential. The lIltency-the time between the presynaptic spike and the postsynaptic potential-is remarkably short (Figure to-2B). Such a short latency is incompatible with chemical ...
424 brain mechanisms in language, cognition, and
... cortico-cortical organization in man stands the test of future research, a major difference between functional anatomy of the brains of men and beasts will have been established. Hitherto no anatomical differences have been accepted as accounting for hemispheric specialization or man's linguistic an ...
... cortico-cortical organization in man stands the test of future research, a major difference between functional anatomy of the brains of men and beasts will have been established. Hitherto no anatomical differences have been accepted as accounting for hemispheric specialization or man's linguistic an ...
Document
... Receptors and Sensations 1. Chemoreceptors = stimulated by changes in chemical concentration of substances 2. Pain receptors = respond to tissue damage 3. Thermoreceptors = by changes in temperture 4. Mechanoreceptors = changes in pressure or movement 5. Photoreceptors = by light energy Sensation ...
... Receptors and Sensations 1. Chemoreceptors = stimulated by changes in chemical concentration of substances 2. Pain receptors = respond to tissue damage 3. Thermoreceptors = by changes in temperture 4. Mechanoreceptors = changes in pressure or movement 5. Photoreceptors = by light energy Sensation ...
Absorption, distribution, metabolism and excretion
... * Two drugs may have affinity for plasma protein binding sites, thus compete with each other leading to drug interactions. * An example: Phenylbutazone and salicylates can displace warfarin (oral anticoagulant) and oral hypoglycemics from plasma proteins. * Drugs highly bound to plasma proteins are ...
... * Two drugs may have affinity for plasma protein binding sites, thus compete with each other leading to drug interactions. * An example: Phenylbutazone and salicylates can displace warfarin (oral anticoagulant) and oral hypoglycemics from plasma proteins. * Drugs highly bound to plasma proteins are ...
No Slide Title
... Below the threshold = local potential ~ “______” Above the threshold = action ~ “______” ...
... Below the threshold = local potential ~ “______” Above the threshold = action ~ “______” ...
Chapter Two - CogConfluence
... begin to close close. At this point, the potassium channels open, allowing the excess potassium to flow out of the cell, bringing the membrane potential back to it’s resting state. The sodium-potassium pumps then work to bring potassium back into the cell while getting rid of sodium, allowing the ce ...
... begin to close close. At this point, the potassium channels open, allowing the excess potassium to flow out of the cell, bringing the membrane potential back to it’s resting state. The sodium-potassium pumps then work to bring potassium back into the cell while getting rid of sodium, allowing the ce ...
Drugs of Abuse 2 CEUs
... Treatment is largely supportive with airway and respiratory protection being paramount. Sedative intoxication can cause peripheral vasodilatation as well. Blood pressure and heart rate need to be closely monitored. IV fluids may be necessary. This is especially true in the case of alcohol, which cau ...
... Treatment is largely supportive with airway and respiratory protection being paramount. Sedative intoxication can cause peripheral vasodilatation as well. Blood pressure and heart rate need to be closely monitored. IV fluids may be necessary. This is especially true in the case of alcohol, which cau ...
The biological approach: the basics
... What assumptions do biopsychologists make? Psychologists from the biological approach assume that behaviour and experiences are caused by activity in the nervous system of the body. The things that people think and feel, say and do are caused, one way or another, by electrochemical events occurring ...
... What assumptions do biopsychologists make? Psychologists from the biological approach assume that behaviour and experiences are caused by activity in the nervous system of the body. The things that people think and feel, say and do are caused, one way or another, by electrochemical events occurring ...
ch15 autonomic nervous system
... 1. The adrenergic neurons release norepinephrine (Figure 15.7) and include most sympathetic postganglionic neurons. 2. The main types of adrenergic receptors are alpha and beta receptors. a. These receptors are further classified into subtypes. b. Depending on the subtype, activation of the receptor ...
... 1. The adrenergic neurons release norepinephrine (Figure 15.7) and include most sympathetic postganglionic neurons. 2. The main types of adrenergic receptors are alpha and beta receptors. a. These receptors are further classified into subtypes. b. Depending on the subtype, activation of the receptor ...
Degenerative diseases of the CNS
... It is not true that the nervous system tissue do not produce an immune reaction. The non prominant immune reactions of the CNS in the normal situations are due to the very low permeability of the blood-brain barrier. Upon its destruction there will be a whole series of diseases that have immunologic ...
... It is not true that the nervous system tissue do not produce an immune reaction. The non prominant immune reactions of the CNS in the normal situations are due to the very low permeability of the blood-brain barrier. Upon its destruction there will be a whole series of diseases that have immunologic ...
Signals and Receptors
... Induction of cellular response • Cellular changes – Activation or suppression of enzyme activity – Activation or suppression of transcription or translation – Changes in the permeability of the cell – Release of stored proteins • Cellular responses – Generation of nerve impulse – Metabolizing nutr ...
... Induction of cellular response • Cellular changes – Activation or suppression of enzyme activity – Activation or suppression of transcription or translation – Changes in the permeability of the cell – Release of stored proteins • Cellular responses – Generation of nerve impulse – Metabolizing nutr ...
Dendritic organization of sensory input to cortical neurons in vivo
... The results reveal basic insights into the dendritic organization of sensory inputs to neurons of the visual cortex in vivo. • Identified discrete dendritic hotspots as synaptic entry sites for specific sensory features • Afferent sensory inputs with the same orientation preference are widely disper ...
... The results reveal basic insights into the dendritic organization of sensory inputs to neurons of the visual cortex in vivo. • Identified discrete dendritic hotspots as synaptic entry sites for specific sensory features • Afferent sensory inputs with the same orientation preference are widely disper ...
Treating Allergies
... Less serious side effects include dry mouth, nose, or throat, hoarseness, headache, dizziness, and nausea. More serious side effects should be reported to your doctor. They include rapid or pounding heartbeats, unusual weakness, nervousness, stomach pain, yellowing of the skin, problems urinating, a ...
... Less serious side effects include dry mouth, nose, or throat, hoarseness, headache, dizziness, and nausea. More serious side effects should be reported to your doctor. They include rapid or pounding heartbeats, unusual weakness, nervousness, stomach pain, yellowing of the skin, problems urinating, a ...
Ch 41 Bowel Disorders - Imperial Valley College
... Treatment of Irritable Bowel Syndrome (continued) Tegaserod One of few drugs approved for IBS with constipation ...
... Treatment of Irritable Bowel Syndrome (continued) Tegaserod One of few drugs approved for IBS with constipation ...