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Experimental Brain Research 221(1)
Experimental Brain Research 221(1)

... et al. 2002; Chang et al. 2008; Andersen and Cui 2009). PRR is more medial and posterior to the putative ‘parietal eye field’ (PEF) (Andersen et al. 1992), which is situated in approximately the middle third of the lateral bank of IPS (lateral intraparietal area, LIP; Fig. 1a, blue ellipse), and is ...
Prescribing Information
Prescribing Information

... cytochrome P450; reboxetine is not metabolised by CYP2D6. Therefore potent inhibitors of CYP3A4 (ketoconazole, nefazadone, erythromycin and fluvoxamine), would be expected to increase plasma concentrations of reboxetine. In a study in healthy volunteers, ketoconazole, a potent inhibitor of CYP3A4, w ...
NIH Public Access
NIH Public Access

... and contextual fear induced freezing in rats (Pamplona et al., 2006). In addition, increasing availability of endogenous cannabinoids (eCB) by blocking eCB reuptake and breakdown (Chhatwal et al., 2005) or activating this receptor with an agonist (Pamplona et al., 2006) both facilitate fear extincti ...
Quality Control, Screening, Toxicity, and Regulation of Herbal Drugs 2
Quality Control, Screening, Toxicity, and Regulation of Herbal Drugs 2

... Typically, there is no one single herb that is recommended for a given health disorder; and there is no one single health disorder linked with just one single herb. Herbal products often contain a variety of biochemicals found naturally in the plants and many different biochemicals contribute to a p ...
Gymnotiform JAR and communication
Gymnotiform JAR and communication

... Over the past decade, research on the neural basis of have gained some insight into the concerted action of the communication and jamming avoidance in gymnotiform brainstem, the diencephalon and the long-neglected electric fish has concentrated on comparative studies of forebrain in sensory processi ...
draft report - Canadian Ophthalmological Society
draft report - Canadian Ophthalmological Society

... organizations and governmental support. In the absence of information from the manufacturer to the contrary, the Committee noted that the inclusion of bevacizumab in the scope of the therapeutic review was appropriate based on: the amount of clinical evidence available with which to assess the relat ...
Posterior White Column
Posterior White Column

... to lamina IV, these tracts cells are also known as the Nucleus Proprius (e.g. spinal thalamic tract or anterolateral system; pain and temperature, some tactile) • Receives afferent input from dorsal roots and descending fibers, most importantly Corticospinal ...
Comparison of antiepileptic drug prescribing in children in three
Comparison of antiepileptic drug prescribing in children in three

... type (conventional vs. newer AEDs). We also analyzed the frequency of AEDs prescribed for children and adolescents with an indication/diagnosis of epilepsy for all three databases together. Due to the absence of adolescent data in PEDIANET, prevalence of AED use for comparison in three countries was ...
Visual Adaptation: Physiology, Mechanisms, and Functional Benefits
Visual Adaptation: Physiology, Mechanisms, and Functional Benefits

... input independently at each processing stage or perhaps whenever a large number of presynaptic signals are pooled (Baccus and Meister 2004). Alternatively, it could implement effects early in the processing stream and pass this altered representation to downstream areas. Studies of how adaptation af ...
The Spinal Cord
The Spinal Cord

... to lamina IV, these tracts cells are also known as the Nucleus Proprius (e.g. spinal thalamic tract or anterolateral system; pain and temperature, some tactile) • Receives afferent input from dorsal roots and descending fibers, most importantly Corticospinal ...
Kir2 potassium channels in rat striatum are strategically
Kir2 potassium channels in rat striatum are strategically

... Inwardly rectifying K+ (Kir) channels represent the minimal requirement for a potassium channel, however, it is involved centrally in physiological functions. The Kir current was first observed electrophysiologically in frog sceletal muscle by KATZ in 19496 and named an anomalous rectifier due to it ...
13: Skin - Gateshead Health NHS Foundation Trust
13: Skin - Gateshead Health NHS Foundation Trust

... - Yellow soft paraffin (yellow petroleum jelly): apply as often as required. Prescribing notes ...
Down - 서울대 Biointelligence lab
Down - 서울대 Biointelligence lab

... Fig. 3.5 Normalized histogram of interspike intervals (ISIs). (A) data from recordings of one cortical cell (Brodmann’s area 46) that fired without task-relevant characteristics with an average firing rate of about 15 spikes/s. The coefficient of variation of the spike trains is Cv ≈ 1.09. (B) Simul ...
SECHIUM EDULE FRUITS IN EXPERIMENTAL RATS  Research Article
SECHIUM EDULE FRUITS IN EXPERIMENTAL RATS Research Article

... Peptic ulcers are a deep gastrointestinal erosion disorder that involves the entire mucosal thickness, penetrating the muscular mucosa. For decades it was believed that the excessive secretion of gastric acid caused gastrointestinal ulcerations, but many patients presenting such ulcerations had norm ...
Document
Document

... to lamina IV, these tracts cells are also known as the Nucleus Proprius (e.g. spinal thalamic tract or anterolateral system; pain and temperature, some tactile) • Receives afferent input from dorsal roots and descending fibers, most importantly Corticospinal ...
PDF
PDF

... with the youngest GRN mutation case thus far reported being 35 (Leverenz et al., 2007) and the oldest case being 83 years old at onset (Gass et al., 2006) with wide variability even within the same family. Some studies have shown evidence of non-penetrance which may be age related (Gass et al., 2006 ...
Reaching beyond the classical receptive field of V1 neurons
Reaching beyond the classical receptive field of V1 neurons

... There are different ways to measure the size of a cortical neuron’s receptive field (RF) center (Fig. 1a). One method consists in measuring the visual field region that elicits an excitatory response (i.e. an increase in firing rate) when stimulated by a small high contrast stimulus, such as a light or ...
Checking Drug Sensitivity of Cell Lines Used in Signatures
Checking Drug Sensitivity of Cell Lines Used in Signatures

... The fact that daunorubicin and epirubicin exhibit similar response patterns to doxorubicin but vincristine does not is not surprising, as the first (Dauno, Epi, D) share a common mechanism of action and the last (Vinc) does not. The lack of agreement between doxorubicin and vincristine is troubling ...
Pharmaceutical Chemistry-IX - Keshav Group Of Institutions
Pharmaceutical Chemistry-IX - Keshav Group Of Institutions

... SYLLABUS FOR SESSION 2014 ...
Hypergravity hinders axonal development of motor neurons
Hypergravity hinders axonal development of motor neurons

... Earth and its stable gravitational conditions. Altering gravity can have profound impacts on the human body. This is especially relevant with the possibility of long-term space travel and habitation and the associated changes in gravity in different space environments. Although some of the effects o ...
Ibogaine as an Alternative and Efficacious Treatment for Heroin
Ibogaine as an Alternative and Efficacious Treatment for Heroin

... after the drug is administered and peak within 2 to 3 hours. The first symptom to appear in patient reports is a persistent oscillating sound. This disruption of balance in the ear is the likely cause of ataxia and nausea. Nausea is worse when a patient attempts movement, so protocols state that the ...
melanogaster
melanogaster

... compared to the responses in quiescent ies. Given these similar observations in ies, mice and primates, state-dependent sensory modulation is likely to be quite general, although the cellular mechanisms underlying such changes are not known. Given the relatively small number of neurons in the ...
MicroRNA profiling of multiple sclerosis lesions
MicroRNA profiling of multiple sclerosis lesions

... (at least 2-fold) and significance (P50.01; U-test) to establish miRNA signatures of the different types of multiple sclerosis lesions. Using these criteria, in active lesions 20 miRNAs were at least twice more abundant and 8 miRNAs at least twice less abundant than in normal white matter (Table 1). ...
Implementing Active Management of the Third Stage of Labor
Implementing Active Management of the Third Stage of Labor

... Misoprostol is a synthetic prostaglandin E1 (PGE1) analogue and is an alternative drug for AMTSL and directions on its use for AMTSL is included in the International Federation of Gynaecology and Obstetrics (FIGO)/International Confederation of Midwives (ICM) statement, Prevention and Treatment of P ...
Controlling drug delivery
Controlling drug delivery

... can be differentiated according to the state and dispersion of their phases: & A drug solution is a one-phase system as the dissolved drug does not fulfil the requirements for a phase. In a solution the molecularly dispersed drug will not separate out to form larger particles if the concentration of ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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