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Improved detection sensitivity in functional MRI data
Improved detection sensitivity in functional MRI data

... This approach has been popularized by K. Friston and co-workers through the distribution of the SPM package1 . Because brain regions activated by a given experimental paradigm generally spread over many contiguous voxels, spatial regularization is used through the application of spatial filters. The ...
Cannabis—A Valuable Drug That Deserves Better Treatment
Cannabis—A Valuable Drug That Deserves Better Treatment

... smoking. In the case series reported by Simonetto et al,10 hyperemesis appeared in most patients after more than 2 years of smoking at least once a week. Surprisingly, most patients (83%) had lost weight (median loss, 12 kg), and 23% had diarrhea. These are not effects expected in cannabis users. On ...
Pharmacology of anaesthetics
Pharmacology of anaesthetics

... ▫ Atracurium better in renal or hepatic failure ▫ Avoid atracurium in asthmatic patients ...
NEURO PresentationWORKING students B
NEURO PresentationWORKING students B

... Function of the Basal Ganglia? • not much is known about the specific functions of each of these structures • thought to function in timing and scaling of motion and in the initiation of motion • most information comes from the result of damage to these structures and the resulting clinical abnorma ...
America`s War on Drugs vs. Legalization
America`s War on Drugs vs. Legalization

... Illegal drug use dates back to the beginning of the 20th century. At this time two to five percent of the entire population of the United States was addicted to drugs.1 Times were very different then though. There are two main reasons for the high rate of drug addiction in the early 1900’s. The firs ...
Safety of ophthalmic drug therapy: focus on adverse efiects
Safety of ophthalmic drug therapy: focus on adverse efiects

... however do not require discontinuation of therapy. In the case of long-term treatment, the risk of side effects increases and has influence on the course of treatment. Sometimes it can be the reason for discontinuation of treatment, e.g. while taking preparations for the treatment of glaucoma (see T ...
sympathetic route to horner`s syndrome: signs and
sympathetic route to horner`s syndrome: signs and

... The pathway that provides the sympathetic innervation to the eye consists of three neurons. The cell bodies of the first order neurons are located in the hypothalamus and rostral midbrain. The axons pass caudally through the brainstem and in the lateral part of the cervical spinal cord (tectotegment ...
sympathetic route to horner`s syndrome: signs and
sympathetic route to horner`s syndrome: signs and

... The pathway that provides the sympathetic innervation to the eye consists of three neurons. The cell bodies of the first order neurons are located in the hypothalamus and rostral midbrain. The axons pass caudally through the brainstem and in the lateral part of the cervical spinal cord (tectotegment ...
Overview_of_drug_development_cmh_with_animatiions
Overview_of_drug_development_cmh_with_animatiions

... Pharmacological activity  Pharmacokinetics and drug metabolism  Toxicology  Pharmaceutics ...
Drugs for Bronchial Asthma, Antitussives, Expectorants
Drugs for Bronchial Asthma, Antitussives, Expectorants

... 5. Anti-Ig-E monoclonal antibody: omalizumab. ...
preclinical evaluation of central nervous system stimulant agents
preclinical evaluation of central nervous system stimulant agents

... hyperactivity disorder (ADHD), a condition in which people have unusually high activity levels and short attention spans. People with this condition are easily distracted and may have trouble sitting still, planning ahead, or finishing what they start. Central nervous system stimulants increase atte ...
View PowerPoint
View PowerPoint

... Basic principles 1. Gradual dosage reduction - individual withdrawal rate - adjuvant drugs 2. Psychological support - simple encouragement to psychological therapies - long term - information - motivation ...
Causes of Alcohol Abuse and Alcoholism
Causes of Alcohol Abuse and Alcoholism

... Changes in the activity of the reward circuit mediating the acute positive reinforcing effects of alcohol and the stress circuit mediating negative reinforcement of dependence during the transition from nondependent alcohol drinking to dependent drinking. Key elements of the reward circuit are dopam ...
Neuromuscular Blocking Agents
Neuromuscular Blocking Agents

... • Studied a refined extract of curare – “South American Arrow Poison” ...
Hearing
Hearing

... Code for the brain 1. Sensory neurons produce spikes 2. Spike rate increases with an increase in the stimulus intensity (here it was a weight on a muscle) ...
axon reaction, which may be displayed in
axon reaction, which may be displayed in

... occurs as a result of recruitment of alternative neuronal circuitry. The distribution of fragments of degenerating axons can provide evidence for the former existence of neuronal connections in the injured or diseased brain or spinal cord. Investigation of neuronal activities, such as axonal transpo ...
From Network Architecture of Forebrain Systems to Brain Wide Web
From Network Architecture of Forebrain Systems to Brain Wide Web

... No doubt, Prof. Napier of Rush University (Chicago, USA) was cognizant how changes in forebrain circuits can be related to addictive behaviour and compulsive drug use. Her research extends from molecular neurobiology and biochemistry to neurophysiology and behavioural studies, using animal models of ...
Nervous communication
Nervous communication

... Nervous signalling is not just fast, but also flexible ● neurones make multiple connections ● this allows us to have many possible responses A sensory neurone passes impulses from receptors to the Central Nervous System ...
Lyme Disease An Integrative Approach
Lyme Disease An Integrative Approach

... IGF-I operates autonomously at the cellular level within diseased cells, and this operation is free from any higher level of integrated control… (Cont’d)… ...
spinal cord
spinal cord

...  Learning is the acquisition of abilities or knowledge as a result of experience or instruction.  Memory is the storage of acquired knowledge for later recall. • Declarative or explicit memory -- learning of facts, events, places, etc. • Procedural or implicit memory -- learning of skilled motor m ...
- Philsci
- Philsci

... that this could happen in a way that does not amount to the expenditure of energy at the synaptic terminal, thus avoiding a conflict with the law of energy conservation.5 On a theory of mental causation such as Eccles’, however, the brain is not the control center of the human body. It is merely an ...
Slide ()
Slide ()

... Organization of the anterior and posterior pituitary gland. Hypothalamic neurons in the supraoptic (SON) and paraventricular (PVN) nuclei synthesize arginine vasopressin (AVP) or oxytocin (OXY). Most of their axons project directly to the posterior pituitary, from which AVP and OXY are secreted into ...
stroke - UCSD Cognitive Science
stroke - UCSD Cognitive Science

... • Typically involves small emboli in an artery that resolves rapidly. • Thus, the physical or cognitive effects typically resolve within an hour to 24 hours. • There is rarely persistent damage following a TIA • TIAs are often a signal of an impending stroke. ...
skinny little pills - Virginia Sole
skinny little pills - Virginia Sole

... than those intended] for weight loss with some success,” says Roy J. Boorady, M.D., an assistant professor of psychiatry at New York University Medical Center and a psychiatrist at the New York University Child Study Center. “But it’s leading to abuse.” Adderall and Wellbutrin stimulate brain chemic ...
Phase I Issues for Novel TB Drugs
Phase I Issues for Novel TB Drugs

... and Regulatory Applications • Objective: explore relationship of drug exposure to response (e.g., biomarkers, potentially valid surrogate endpoints, clinical effects, adverse events) in order to – link preclinical with clinical findings – provide evidence that the hypothesized mechanism of action is ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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