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Lecture 4
Lecture 4

... Effective only against luminal forms of ameba Has direct amebicidal action (causes leakage by its action on cell membrane of parasite). Indirect killing of bacterial flora essential for proliferation of pathogenic amoebae. Small amount absorbed is excreted unchanged in ...
as a PDF
as a PDF

... referred to as catabolic-effector pathways (9). Both pathways also regulate energy expenditure in ways that complement their effects on energy intake and enhance the overall response to a change in body fat content. Activation of anabolic pathways, for example, increases food intake and decreases en ...
found that in flight, 3D hippocampal place cells had nearly spherical
found that in flight, 3D hippocampal place cells had nearly spherical

... cells from the hippocampus of different bats. Same notation as in (A). When a neuron had more than one place field, different fields were marked with different colors (K). The neuron in (J) was recorded in the cubic enclosure; the other neurons are from the rectangular-cuboid room. ...
Tutorial Planner - Collegiate Medical Centre
Tutorial Planner - Collegiate Medical Centre

... Drugs that speed gastric emptying, such as metoclopramide (Reglan) and powdered ginger root may be helpful in managing emesis (Grontved et al, 1988). Metoclopramide, a dopamine antagonist and a potent central antiemetic, is ineffective in preventing motion sickness (Kohl, 1987). Of these agents, dro ...
An Introduction To Human Neuroanatomy
An Introduction To Human Neuroanatomy

... capillaries, thus influencing brain metabolism. They serve as “guide-wires” during the development of the cerebral cortex and other brain regions, guiding cells to their proper place in the tissue. They also react to damage caused by neurological diseases, stroke, and trauma. This image shows astroc ...
The neural basis of puberty and adolescence
The neural basis of puberty and adolescence

... nisms can be categorized as those that act without hormonal information from the gonads (steroid independent) and those that act in the presence of gonadal steroids (steroid dependent). In some altricial species, those that are not well developed at birth, steroid-independent mechanisms are primaril ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... GABAb receptors as it does not have significant affinity for GHB receptors the modulation of GABAb receptors is what produces its range of therapeutic properties[1] DOSAGE:40-80mg/day. 6.6.GABAPENTIN: This drug is commonly used to treat nerve pain .It was started to treat trigeminal neuralgia in the ...
PRESYNAPTIC IONOTROPIC RECEPTORS AND CONTROL OF
PRESYNAPTIC IONOTROPIC RECEPTORS AND CONTROL OF

... there is clear evidence for enhanced GABA and glutamate release that depends on activation of presynaptic nicotinic acetylcholine (nACh) receptors — cation channels that are permeable to Ca2+ and monovalent cations. In this case, the observation that Ca2+ entry through nACh channels enhanced spontan ...
2. Thyroid gland
2. Thyroid gland

... • The short t½ of these drugs has little effect on their effect because they are selectively accumulated in the thyroid. • Propylthiouracil is preferable during pregnancy because it does not cross placental barrier (because it is strongly bound to plasma protein). ...
Morphological Changes in the Hippocampus Following Nicotine and
Morphological Changes in the Hippocampus Following Nicotine and

... (10 mg/kg). Direct magnification 100x. D. CA1 area of the hippocampus (arrows show degenerating cells). Fluoro-Jade B staining. Kainic acid-treated rat (10 mg/kg). Direct magnification 100x. E. CA1 area of the hippocampus (arrows). Bis-benzimide, Hoechst 33342 staining. Nicotine treated rat (1 mg/kg ...
How Do Dreams Differ in People With Schizophrenia From Those
How Do Dreams Differ in People With Schizophrenia From Those

... One flaw in most of the articles was that they mostly dealt with patients having other disorders rather than normal people which was in my initial question, however there were some articles that explained the processes in the brain of how dreams occur in normal people. I thought it was important to ...
Thyroid gland and antithyroid drugs
Thyroid gland and antithyroid drugs

... • The short t½ of these drugs has little effect on their effect because they are selectively accumulated in the thyroid. • Propylthiouracil is preferable during pregnancy because it does not cross placental barrier (because it is strongly bound to plasma protein). ...
Restraining influence of A2 neurons in chronic control of arterial
Restraining influence of A2 neurons in chronic control of arterial

... control of arterial pressure [2–5] it seems pertinent to focus on potential roles of defined groups of central neurons for chronic control of arterial pressure. One such group are the A2 noradrenergic (NEergic) neurons in the nucleus of the solitary tract (NTS). Three ...
Combating substance abuse: A review of therapeutic management
Combating substance abuse: A review of therapeutic management

... • Efficacy: Mixed results, but a RCT showed that disulfiram has a higher rate of abstinence when compared to naltrexone (79.3% vs. 51.7%) in adolescent patients. More beneficial in combination with CBT. • Adverse effects: Metallic aftertaste, rash and hepatotoxicity Kalra G, Sousa A and Shrivastava ...
Mental Processes -- How the Mind Arises from the Brain Roger Ellman
Mental Processes -- How the Mind Arises from the Brain Roger Ellman

... - recognition of all beings that are human as human beings; - recognition of all shirts. The universal is the common characteristic of all elements of the group, that is Eness, human-ness, shirt-ness in the above three examples. Not only humans recognize universals; most animals do also, but the abi ...
Use of rabies virus as a transneuronal tracer of neuronal
Use of rabies virus as a transneuronal tracer of neuronal

... PRIMATES: differences in monosynaptic pathways to motoneurons of the lateral rectus muscle (LR) which innervate slow and fast muscle fibers - Muscle: defective replication in fibrocytes, no virus in myocites. - No spread within the muscle: uptake occurs only at the site of inoculation. - Combined v ...
Electrophysiological Identification of Tonic and Phasic Neurons in
Electrophysiological Identification of Tonic and Phasic Neurons in

... overshoot and decreased AP durations. In the present study, we find that tonic neurons are more hyperexcitable than phasic neurons after peripheral noxious inflammatory stimulation. The results indicate the distinct contributions of two types of DRG neurons in inflammatory pain. Key words Action pot ...
ppt - of Dushyant Arora
ppt - of Dushyant Arora

... A small step (learning rate) in the opposite direction will result in the maximum decrease of the (local) error function: wnew = wold – α ∂E/∂wold where α is the learning rate Calculation of the derivatives flows backwards through the network, hence the ...
NMDA Receptor Antagonists
NMDA Receptor Antagonists

... property of this drug and limits its safe use as sole anaesthetic. ...
Antihistamine - People Server at UNCW
Antihistamine - People Server at UNCW

... • 1938: President Roosevelt signed the Federal Food, Drug and Cosmetic Act into law. This law required new drugs to be tested for safety before marketing, the results of which would be submitted to FDA in a new drug application (NDA). The law also required that drugs have adequate labeling for safe ...
New Insights on Neural Basis of Choice
New Insights on Neural Basis of Choice

Pharmcokinetics in Critical Care
Pharmcokinetics in Critical Care

... How can this level be explained? due to quadriplegia, her baseline SCr = 30 µmol/L so an increase to 110 µmol/L is suggestive of acute renal failure ...
Sponsor vs. Investigator
Sponsor vs. Investigator

... Phase 2 & 3 – any change significantly affecting the safety of subjects, scope of the investigation or the scientific quality of the study. 21 CFR 312.30(b) ...
Acute Dystonic Reaction Associated with Increase in Trazodone
Acute Dystonic Reaction Associated with Increase in Trazodone

... modulator (12). Therefore, trazadone acts both like a serotonin agonist and an antagonist. Among the other mechanisms of action, there are pre-synaptic alpha 2 and post-synaptic alpha 1 adrenergic receptors as well as H1 histaminergic receptor blockage. It is also known that it connects T type calci ...
Stem cell-based cellular replacement strategies following traumatic
Stem cell-based cellular replacement strategies following traumatic

... The NTera2 (NT2) cell line is a human derived teratocarcinoma cell line that terminally differentiates into postmitotic neuronal NT2N cells when treated in vitro with retinoic acid (36). Grafting of predifferentiated NT2N cells into the periinjured brains of immunocompetent rats following lateral fl ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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