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Outcomes-Based Drug Coverage in British Columbia
Outcomes-Based Drug Coverage in British Columbia

... that could impede access to necessary medicines. 5 In light of evidence that most of PharmaCare’s cost growth was attributable to increased use of newer, higher-price drugs, decisionmakers saw evidence-based coverage as an appropriate way to control the public drug plan’s costs while maintaining acc ...
Mirror Neurons and Mirror Systems in Monkeys and Humans
Mirror Neurons and Mirror Systems in Monkeys and Humans

... the notion that the activity of mirror neurons underpins the understanding of motor acts. This is regardless of whether this comprehension is based on vision, sound, or mental representation. Although single mirror neurons code the motor act that is going on in front of the observer, there is recent ...
Cholinergic modulation of cognitive processing: insights drawn from computational models Kishan Gupta
Cholinergic modulation of cognitive processing: insights drawn from computational models Kishan Gupta

... well as noncholinergic) projections to a broad range of sites in the neocortex as well as limbic cortices such as cingulate cortex, entorhinal cortex and hippocampus, and other structures including the basolateral amygdala and the olfactory bulb (Mesulam et al., 1983a). The entorhinal cortex receive ...
Myths - Cholesterol , Heart Attack and Statins
Myths - Cholesterol , Heart Attack and Statins

... them…Every information sheet on the most commonly prescribed cholesterol-lowering drugs will tell you that they cause cancer in rodents when taken long-term in relatively normal doses. It is also well-known that they can cause severe emotional imbalances in men along with a wide array of life-threat ...
cannabis or hashish - KSU Faculty Member websites
cannabis or hashish - KSU Faculty Member websites

... For thousands of years and in various parts of the World, human beings were stimulated by curiosity and boredom to experiment with the surrounding plants and mushrooms to relieve pain, tension or frustration. These trials led the primitive man to discover the ability of some plants to relieve pain, ...
Medicinal Chem II 2ndTerm course syllubus 2016
Medicinal Chem II 2ndTerm course syllubus 2016

... Phone 5 355 000, Ext. 23378. E-mail: [email protected] Office hours to be announced ...
Functional characterization of the synaptic
Functional characterization of the synaptic

... tumor or an infection in the adult brain and span throughout life. Although the underlying etiology of the various disorders might be different, all of them lead to similar brain dysfunctions (defects of the sensory and motor system) and to comparable cognitive deficits in learning and memory. Epile ...
Jennifer Sims-Early safety assessment of biologicals
Jennifer Sims-Early safety assessment of biologicals

... • Off target toxicity due to binding to unrelated  targets not common for biologics • Small but, increasing number of case studies of  “unusual PK behavior” and “off‐target” effects – Greater protein engineering of candidates? ...
Disruption of the Blood-Brain Barrier and Neuronal Cell Death in
Disruption of the Blood-Brain Barrier and Neuronal Cell Death in

... it is generally believed that the neurological symptoms displayed by PGW veterans are due to a synergistic interaction of PB with other chemicals such as DEET and permethrin and the stress (Institute of Medicine, 1995; Friedman et al., 1996; Hyams et al., 1996; David et al., 1997; Everson et al., 19 ...
Therapeutic Drug Monitoring of Antiepileptic Drugs in the 21st Century
Therapeutic Drug Monitoring of Antiepileptic Drugs in the 21st Century

... generation of antiepileptic drugs? Few sources address third generation AEDs TDM and its relevance. Only one group has estimated TDM usefulness for these drugs, which they considered to range between “possibly useful”, “remains to evaluate” or “not useful”, based on very limited data (French Society ...
Conduction Velocity and Patellar Reflex Blah A. Blah Partner B
Conduction Velocity and Patellar Reflex Blah A. Blah Partner B

... ipsilateral, which means the motor neuron activity occurs on the same side as of the motor synapse. The stretch reflex is also monosynaptic, meaning the reflex only uses a single synapse. ...
Chapter 49 and 50 Presentations-Sensory and Motor Mechanisms
Chapter 49 and 50 Presentations-Sensory and Motor Mechanisms

...  As the concentration of Ca2+ falls, the muscles relax as the binding sites are covered again. ...
Beta2-Adrenergic Drugs - Aerosolized Agents (short
Beta2-Adrenergic Drugs - Aerosolized Agents (short

... Beta2-adrenergic drugs, used routinely in asthma management, can be identified as long-acting or shortacting agents. Both short- and long-acting compounds can be used to prevent bronchospasm. However, short-acting compounds are the drugs of choice for acute bronchospasm as these agents act within mi ...
The Functional Organization of Perception and Movement
The Functional Organization of Perception and Movement

... system to the cerebral cortex and is transformed into motor commands that descend to the spinal cord to produce movements. We now have a fairly complete understanding of how the physical energy of a tactile stimulus is transduced by mechanoreceptors in the skin into electrical activity, and how this ...
Conduction Velocity and Patellar Reflex Blah A. Blah Parter 1
Conduction Velocity and Patellar Reflex Blah A. Blah Parter 1

... ipsilateral, which means the motor neuron activity occurs on the same side as of the motor synapse. The stretch reflex is also monosynaptic, meaning the reflex only uses a single synapse. ...
Neural correlates for perception of 3d surface orientation from texture
Neural correlates for perception of 3d surface orientation from texture

... could thus correctly perform the crossmatching of texture and disparity gradients even with novel orientations (tests 1 and 3) and patterns (tests 2 and 3) without training. Monkeys regarded texture and disparity gradients as equivalent depth cues, and they perceived a 3D surface orientation from te ...
Chem. Soc. Rev. 2012, 41, 3571–3583
Chem. Soc. Rev. 2012, 41, 3571–3583

... In hot organic solvents in the presence of a strong activator, ...
Reticular Formation
Reticular Formation

... Dr. G. R. Leichnetz ...
Psychotropic Medications Metabolized by Cytochromes P450 (CYP
Psychotropic Medications Metabolized by Cytochromes P450 (CYP

... placenta and Consists of more than 50 isoforms. Cytochromes P450 (CYPs) are major source of catalytic activity for drug oxidation [1-3]. CYP2D6 is a member of the cytochrome P450 super family. It plays a primary role in the metabolism of more than 70 substrate medications, belonging to classes such ...
the evolution of neural-progenitor-cell division
the evolution of neural-progenitor-cell division

... increase in the number of neurons that are generated during development (Table 1)? There are two principal – and not necessarily mutually exclusive – mechanisms by which neuron number (that is, the total number of neurogenic divisions of neural progenitors) could be increased. One is to increase the ...
Tutorial 2 Adverse drug reactions
Tutorial 2 Adverse drug reactions

... These criteria provide useful general guidance but they have some drawbacks. For example, with new medicines there may be only very limited data available. Due to the limited size and controlled nature of pre-marketing clinical trials, only the most common adverse events will be observed and subsequ ...
Falls Prevention Service Level 2
Falls Prevention Service Level 2

... medication changes as needed for the individual patient (at least for first month) or intervention MUR where appropriate Annual Medicines Use Review provided by pharmacist to identify any medicine use issues/support needed by the patient. Basic falls prevention consultation provided once yearly to i ...
Climbing Neuronal Activity as an Event
Climbing Neuronal Activity as an Event

... ␮ yⱖ ␮ 0a . ...
View Paper - Dundee Life Sciences
View Paper - Dundee Life Sciences

... which newly born neurons rise from 3 to 15% of cells in the neural tube (see Fig. S1 in the supplementary material). To validate this approach we compared cell cycle time, length of mitosis and incidence of cell death in this region of the neural tube at day 1.5 in fixed embryos with that observed i ...
Making bigger brains – the evolution of neural-progenitor
Making bigger brains – the evolution of neural-progenitor

... increase in the number of neurons that are generated during development (Table 1)? There are two principal – and not necessarily mutually exclusive – mechanisms by which neuron number (that is, the total number of neurogenic divisions of neural progenitors) could be increased. One is to increase the ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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