Neural ensemble dynamics underlying a long
... To study ensemble coding, we tested whether CS+ and CS− presentations were identifiable from their evoked activity patterns. We trained three-way, Fisher linear decoders to distinguish baseline conditions from CS+ and CS− presentations on each day. These decoders classified the three conditions accu ...
... To study ensemble coding, we tested whether CS+ and CS− presentations were identifiable from their evoked activity patterns. We trained three-way, Fisher linear decoders to distinguish baseline conditions from CS+ and CS− presentations on each day. These decoders classified the three conditions accu ...
Jan 2015 - Palatin Technologies
... differ materially from those expressed or implied in this presentation. We have based these forward-looking statements largely on our current expectations and projections about future events and financial trends that we believe may affect our financial condition, results of operations, business stra ...
... differ materially from those expressed or implied in this presentation. We have based these forward-looking statements largely on our current expectations and projections about future events and financial trends that we believe may affect our financial condition, results of operations, business stra ...
In-Vitro-In-Vivo Correlation Definitions and Regulatory
... than 100, the equation will yield a negative number (22). Normalization of the data is required to compare values in which the difference is not between 1 and 100. ...
... than 100, the equation will yield a negative number (22). Normalization of the data is required to compare values in which the difference is not between 1 and 100. ...
Synthetic Drugs - Ohio Crime Prevention Association
... two kilograms of flakka to a suspect who was believed to have direct ties to at least six of the nine kilograms of seized flakka. Agents arrested two individuals—a 22-year-old woman and her boyfriend--and seized a black Audi Q7, Chevy Silverado 2500, $68,725 in cash, a Glock .40-caliber Model 27 pis ...
... two kilograms of flakka to a suspect who was believed to have direct ties to at least six of the nine kilograms of seized flakka. Agents arrested two individuals—a 22-year-old woman and her boyfriend--and seized a black Audi Q7, Chevy Silverado 2500, $68,725 in cash, a Glock .40-caliber Model 27 pis ...
Gout - KSUMSC
... decision was made to put her on chronic drug therapy to try to prevent subsequent attacks. Which of the following drugs could be used to decrease this woman's rate of production of uric acid? (A) Allopurinol (B) Aspirin (C) Colchicine D) Hydroxychloroquine (E) Probenecid ...
... decision was made to put her on chronic drug therapy to try to prevent subsequent attacks. Which of the following drugs could be used to decrease this woman's rate of production of uric acid? (A) Allopurinol (B) Aspirin (C) Colchicine D) Hydroxychloroquine (E) Probenecid ...
Berberine Information - Health Walk Medical Clinic
... Depression, Anxiety, Bipolar Affective Disorder, Schizophrenia: In animal models of depression, Berberine has been shown to have an anti-depressant effects, potentially through modulation of noradrenaline, serotonin and dopamine levels in the brain. Berberine is also reported to have an inhibitory e ...
... Depression, Anxiety, Bipolar Affective Disorder, Schizophrenia: In animal models of depression, Berberine has been shown to have an anti-depressant effects, potentially through modulation of noradrenaline, serotonin and dopamine levels in the brain. Berberine is also reported to have an inhibitory e ...
Expression of Cux-1 and Cux-2 in the Subventricular Zone and
... (II–IV) of the murine cortex, suggesting that they may define the molecular identity of these neurons. An antibody against Cux-1 labels the nucleus of most of the postmitotic upper layer neurons but does not label parvoalbumin-positive cortical interneurons that derive from the medial ganglionic emin ...
... (II–IV) of the murine cortex, suggesting that they may define the molecular identity of these neurons. An antibody against Cux-1 labels the nucleus of most of the postmitotic upper layer neurons but does not label parvoalbumin-positive cortical interneurons that derive from the medial ganglionic emin ...
Interaction of quinidine, disopyramide and
... into eumelanin (brown or black pigment), and when combined with cysteine or glutathione it turns into phaeomelanin (yellow or red pigment) [3–5]. Pharmazie 58 (2003) 7 ...
... into eumelanin (brown or black pigment), and when combined with cysteine or glutathione it turns into phaeomelanin (yellow or red pigment) [3–5]. Pharmazie 58 (2003) 7 ...
Ampicillin - IARC Monographs on the Evaluation of Carcinogenic
... mammary gland fibroadenomas in females were: control, 16/50; low-dose, 25/50 (p ...
... mammary gland fibroadenomas in females were: control, 16/50; low-dose, 25/50 (p ...
Synergistic Interactions between Commonly
... combined adverse effects are unclear and have not been widely studied. Food additives are typically used in combination within processed foods and therefore collectively may have some adverse effects at the cellular level, even if their individual concentrations are below the recommended ADI value. ...
... combined adverse effects are unclear and have not been widely studied. Food additives are typically used in combination within processed foods and therefore collectively may have some adverse effects at the cellular level, even if their individual concentrations are below the recommended ADI value. ...
Function of Basal Ganglia (Summary)
... o Ipsilataral side of the body is affected o Mainly posterior lobe o Dystaxia/hypotonia of ipsilateral extremities ...
... o Ipsilataral side of the body is affected o Mainly posterior lobe o Dystaxia/hypotonia of ipsilateral extremities ...
A direct quantitative relationship between the functional properties of
... Correspondence should be addressed to G.R. ([email protected]) ...
... Correspondence should be addressed to G.R. ([email protected]) ...
Cylene Builds on Success, Presents Second CK2 Inhibitor at AACR
... need for agents that hit multiple key cancer processes becomes ever more pressing. Cylene’s CK2 platform is exploiting the unique properties of CK2 as a drug target to deliver agents that can play a major role in future cancer combination strategies.” About CK2 Protein kinase CK2 has emerged as a va ...
... need for agents that hit multiple key cancer processes becomes ever more pressing. Cylene’s CK2 platform is exploiting the unique properties of CK2 as a drug target to deliver agents that can play a major role in future cancer combination strategies.” About CK2 Protein kinase CK2 has emerged as a va ...
Pharmacy_Lecture_08_..
... • Measurement of a physical property (pKa) as well as serum half-life in dogs was the guide for the synthesis program. • Several generations of leads were refined and ultimately led to a successful structure with an acceptable safety and activity profile: ...
... • Measurement of a physical property (pKa) as well as serum half-life in dogs was the guide for the synthesis program. • Several generations of leads were refined and ultimately led to a successful structure with an acceptable safety and activity profile: ...
Prevalent Presence of Periodic Actin-spectrin-based
... neuronal subtypes exhibited a periodic distribution of βII spectrin in their axons, with a spacing of ~190 nm. Autocorrelation analyses showed that the degree of periodicity (i.e. autocorrelation amplitude) was similar among most of these excitatory and inhibitory neurons (Fig. 2J, K). Two exception ...
... neuronal subtypes exhibited a periodic distribution of βII spectrin in their axons, with a spacing of ~190 nm. Autocorrelation analyses showed that the degree of periodicity (i.e. autocorrelation amplitude) was similar among most of these excitatory and inhibitory neurons (Fig. 2J, K). Two exception ...
Severe Reduction of Rat Defensive Behavior to a Predator by
... responses resembling the behavior of animals facing natural threats have now been obtained from a number of hypothalamic medial zone sites [34]. However, a great deal remains to be learned about the functional role of these centers, and about how they are integrated into neural systems or circuits s ...
... responses resembling the behavior of animals facing natural threats have now been obtained from a number of hypothalamic medial zone sites [34]. However, a great deal remains to be learned about the functional role of these centers, and about how they are integrated into neural systems or circuits s ...
THE SPINAL CORD
... of the leg at the knee. At the same time as the quadriceps contracts there is a reciprocal inhibition of the antagonistic muscles, the flexors of the knee. The inhibition of the flexors is mediated by polysynaptic reflex arcs, and since the motor neurons for the flexors are located in more caudal s ...
... of the leg at the knee. At the same time as the quadriceps contracts there is a reciprocal inhibition of the antagonistic muscles, the flexors of the knee. The inhibition of the flexors is mediated by polysynaptic reflex arcs, and since the motor neurons for the flexors are located in more caudal s ...
Free PDF
... many antineoplastic drugs are also metabolized by the CYP450 system, co-administration with HAART could result in either drug accumulation and possible toxicity or decreased efficacy of one or both classes of drugs. In this fields, inter-individual response could be dependent of the genetic variatio ...
... many antineoplastic drugs are also metabolized by the CYP450 system, co-administration with HAART could result in either drug accumulation and possible toxicity or decreased efficacy of one or both classes of drugs. In this fields, inter-individual response could be dependent of the genetic variatio ...
Mild Traumatic Brain Injury
... Global decreases in cerebral glucose metabolism lasting 2-4 weeks after injury (present regardless of severity of injury) ...
... Global decreases in cerebral glucose metabolism lasting 2-4 weeks after injury (present regardless of severity of injury) ...
Paper - Wharton Marketing
... Deciding when to leave a depleting resource to exploit another is a fundamental problem for all decision makers. The neuronal mechanisms mediating patch-leaving decisions remain unknown. We found that neurons in primate (Macaca mulatta) dorsal anterior cingulate cortex, an area that is linked to rew ...
... Deciding when to leave a depleting resource to exploit another is a fundamental problem for all decision makers. The neuronal mechanisms mediating patch-leaving decisions remain unknown. We found that neurons in primate (Macaca mulatta) dorsal anterior cingulate cortex, an area that is linked to rew ...
Physiology of functional and effective networks in epilepsy
... Therefore, recent studies have investigated the interplay between structure and function (Deco et al., 2012; Whalen et al., 2012; Sritharan and Sarma, 2014). A fairly recent study (van den Heuvel et al., 2009) combined 3 Tesla resting-state fMRI (RS-fMRI) time-series data with DTI scans on healthy s ...
... Therefore, recent studies have investigated the interplay between structure and function (Deco et al., 2012; Whalen et al., 2012; Sritharan and Sarma, 2014). A fairly recent study (van den Heuvel et al., 2009) combined 3 Tesla resting-state fMRI (RS-fMRI) time-series data with DTI scans on healthy s ...
illicit drugs and driving
... knowledge of the results of the drug analysis. A study by Drummer (1045 killed drivers) and another one by Terhune (1882 killed drivers) are discussed as examples of responsibility analysis studies. Studies with control groups: the results of the test group are compared with the same drug analysis ...
... knowledge of the results of the drug analysis. A study by Drummer (1045 killed drivers) and another one by Terhune (1882 killed drivers) are discussed as examples of responsibility analysis studies. Studies with control groups: the results of the test group are compared with the same drug analysis ...
Arousal Systems
... All other components of consciousness and cognition are absent . Arousal occurs in the absence of consciousness because awareness is absent. • Extensive bilateral cortical, subcortical white matter, or thalamic injuries, with relative sparing of the brainstem, which accounts for preservation of arou ...
... All other components of consciousness and cognition are absent . Arousal occurs in the absence of consciousness because awareness is absent. • Extensive bilateral cortical, subcortical white matter, or thalamic injuries, with relative sparing of the brainstem, which accounts for preservation of arou ...
Advances in Environmental Biology
... Probably the causes that factors of blood urea nitrogen and uric acid have not significant changes is due to dose and time duration of drug and type of laboratory animal. Previously expressed that Raloxifene by inhibiting AP1 activity prevents stimulation of TGF-B1 and expression of fibronectin. In ...
... Probably the causes that factors of blood urea nitrogen and uric acid have not significant changes is due to dose and time duration of drug and type of laboratory animal. Previously expressed that Raloxifene by inhibiting AP1 activity prevents stimulation of TGF-B1 and expression of fibronectin. In ...
Predicting functional neuroanatomical maps from fusing
... A central aim, from basic neuroscience to psychiatry, is to resolve how genes control brain circuitry and behavior. This is experimentally hard, since most brain functions and behaviors are controlled by multiple genes. In low throughput, one gene at a time, experiments, it is therefore difficult to ...
... A central aim, from basic neuroscience to psychiatry, is to resolve how genes control brain circuitry and behavior. This is experimentally hard, since most brain functions and behaviors are controlled by multiple genes. In low throughput, one gene at a time, experiments, it is therefore difficult to ...