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REVIEW ARTICLE
REVIEW ARTICLE

... Neural architecture of the ELL 1247 evoked from StF or parallel fibers peak at 4–6 ms and last more than 10 ms. Such rapid electroreceptor afferent postsynaptic potential (PSP) dynamics may be essential for the conservation of timing information for the detection of coincident electrosensory inputs ...
Encoding and Retrieval of Episodic Memories: Role of Hippocampus
Encoding and Retrieval of Episodic Memories: Role of Hippocampus

... previous theories of the function of individual hippocampal subregions (Marr, 1971; McNaughton and Morris, 1987; Levy, 1989; Eichenbaum and Buckingham, 1990; McNaughton, 1991; Treves and Rolls, 1992; O’Reilly and McClelland, 1994; McClelland et al., 1995; McClelland and Goddard, 1996). However, in i ...
Predictions, perception, and a sense of self
Predictions, perception, and a sense of self

... sampled. For example, if we consider the control of our eye movements during visual searches, this visual “palpation” has natural time constants that are relatively easy to simulate using predictive coding. Typically, we make saccadic movements every 250 ms,6 during which time the evidence for hypot ...
Nasal Drug Delivery in EMS
Nasal Drug Delivery in EMS

... Most potent (highly concentrated) drug should be used ...
A1 - 58 - University of Pittsburgh
A1 - 58 - University of Pittsburgh

... a colored photo of the microscopic neuromuscular junction is shown, depicting how each muscle cell is in contact with at least one neuronal synapse. ...
Fractionating Human Intelligence
Fractionating Human Intelligence

... that test measures tend to form distinctive clusters. When combined with the intractability of developing tests that measure individual cognitive processes, it is likely that a more complex set of factors contribute to correlations in performance (Carroll, 1993). Defining the biological basis of the ...
Cell 146
Cell 146

... Evolution of the neocortex in mammals is considered to be a key advance that enabled higher cognitive function. However, neocortices of different mammalian species vary widely in shape, size, and neuron number (reviewed by Herculano-Houzel, 2009). These differences are presumably reflected in the or ...
DIABETES AND LIPID - Shahid Sadoughi University of Medical
DIABETES AND LIPID - Shahid Sadoughi University of Medical

... are influenced by the coexistence of CHD and the number of cardiac risk factors.  There are five major steps to determining an individual's risk category, which serves as the basis for the treatment guidelines ...
DESIGNING OF POTENTIAL NEW ESTROGEN ANTAGONISTS FOR TREATMENT OF
DESIGNING OF POTENTIAL NEW ESTROGEN ANTAGONISTS FOR TREATMENT OF

... It has become a chronic disease nowadays and it can be controlled by estrogen antagonist as estrogen antagonist inhibits the action of estrogen and proliferation of endometrial cell is stopped [6, 13, 18]. The discovery of the first design of Estrogen antagonist drug has inspired a number of continu ...
Slide 1
Slide 1

...  Chemical synapse  The synaptic terminal releases a neurotransmitter that binds to the postsynaptic plasma membrane  Produces temporary, localized change in permeability or function of postsynaptic cell  Changes affect cell, depending on nature and number of stimulated receptors ...
Grossman_PPT_Ch_21
Grossman_PPT_Ch_21

... Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins ...
Consciousness: Confessions of a Romantic Reductionist
Consciousness: Confessions of a Romantic Reductionist

... In which I introduce the ancient mind–body problem, explain why I am on a quest to use reason and empirical inquiry to solve it, acquaint you with Francis Crick, explain how he relates to this quest, make a confession, and end on a sad note I can’t tell you what it really is, I can only tell you wha ...
Action-based language: A theory of language acquisition
Action-based language: A theory of language acquisition

... representations active during the actual execution of those same actions (Buccino et al., 2001). These findings strongly support the existence of mirror neurons in the human motor system and have lead to the notion of a human MM involving areas in the frontal lobes (notably, Broca’s area) and pariet ...
Drugs of Abuse - Americans for Safe Access
Drugs of Abuse - Americans for Safe Access

... (2) There is significant diversion of the drug or other substance from legitimate drug channels. (3) Individuals are taking the drug or other substance on their own initiative rather than on the basis of medical advice from a practitioner. (4) The drug is a new drug so related in its action to a dru ...
Conclusion - Computing Services
Conclusion - Computing Services

... Aim: To elucidate the molecular mechanisms of how drugs act on their specific T cell receptors (TCR). Methods: Two sulfamethoxazole (SMX)–specific TCR were transfected into mouse T-cell hybridoma devoid of endogenous TCR. Together with Ebstein Barr virus (EBV)-transformed B cells as antigen presenti ...
(MDMA), Amphetamine, and LSD
(MDMA), Amphetamine, and LSD

... rate, sweating and dehydration. These can easily lead to medical emergencies, particularly in the hot and crowded conditions of raves and dances. The confused person may dehydrate through hyperthermia, or overcompensate and drink too much water, thus lethally diluting their plasma electrolytes (Maxw ...
Spike-timing dependent plasticity and the cognitive map
Spike-timing dependent plasticity and the cognitive map

... In further simulations, theta-coded neural dynamics are dictated by a phenomenological phase precession model (O’Keefe and Recce, 1993; O’Keefe, 2007; Huxter et al., 2008). A variable θ, which oscillates sinsuoidally in the range (0:1) at a rate of 8 Hz, is used to represent theoretical theta freque ...
BOX 34.3 DISEASES AND AGING IMPAIR THE AUTONOMIC
BOX 34.3 DISEASES AND AGING IMPAIR THE AUTONOMIC

... aware of any adjustments. Nevertheless, loss of an autonomic response can be disruptive, and autonomic disorders can be debilitating (Bannister, 1989). In a classic example of ANS degeneration known as multiple system atrophy and autonomic failure, or the Shy–Drager syndrome, individuals exhibit pos ...
Hepatocyte Growth Factor (HGF): Neurotrophic Functions and
Hepatocyte Growth Factor (HGF): Neurotrophic Functions and

... nonsyndromic hearing loss, at the autosomal-recessive NSHI locus DFNB39 [42]. Two of the mutations occurred in a region contained in the 3’ UTR of an alternate splice form of HGF that had not been previously discovered. The third mutation, a third-position nucleotide change predicted to make a synon ...
PDF
PDF

... extending  it  further  is  not  possible.  Considerations   like  these  make  some  movements  more  likely  than   others,   resulting   in   probability   distributions   over   possible   movements   (Fig.   1a).   To   understand   everyday ...
Chemotherapeutic agents induce the expression
Chemotherapeutic agents induce the expression

... to fatty acid metabolism, CYP4F enzymes take part in several metabolic pathways that are involved in both physiological and pathological aspects such as hypertension and inflammation (9). Similarly to CYP3As, the CYP4F subfamily is subjected to transcriptional induction in response to stimuli. For i ...
Research article DOPING AND PERFORMANCE ENHANCING
Research article DOPING AND PERFORMANCE ENHANCING

... and about 18.7% of them admitted using doping substances, 42% being tempted of using them, and 38% of being in the know of some other soccer players using a doping substance (Dah et al., 2002). Our data are in accordance with the previous reports (Dah et al., 2002; Laure, 2001). The main drugs used ...
9 Propagated Signaling: The Action Potential
9 Propagated Signaling: The Action Potential

... Voltage-Gated Sodium and Potassium Conductances Are Calculated From Their Currents The Na+ and K+ currents depend on two factors: the conductance for each ion and the electrochemical driving force acting on the ion. Since the Na+ and K+ membrane conductance is directly proportional to the number of ...
Sample pages 1 PDF
Sample pages 1 PDF

... absorption, distribution, metabolism, and excretion; that is why, average doses will produce average responses, and for many drugs with wide safety margins, this is sufficient. However, some drugs do not have wide safety margins and knowledge of clinical pharmacokinetics in the individual is vital t ...
Drugs of Abuse - Southwestern University
Drugs of Abuse - Southwestern University

... (2) There is significant diversion of the drug or other substance from legitimate drug channels. (3) Individuals are taking the drug or other substance on their own initiative rather than on the basis of medical advice from a practitioner. (4) The drug is a new drug so related in its action to a dru ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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