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comparative studies of safi and ferrous gluconate on human
comparative studies of safi and ferrous gluconate on human

... Majority of Pakistani population (about 70 percent) lives in far-flung rural areas where modern medicines are not available. Much of this population must therefore rely on traditional herbal medicine for relief from diseases. This signifies the importance of Eastern System of medicine in our society ...
working draft - DAVID KAPLAN | Macquarie University
working draft - DAVID KAPLAN | Macquarie University

... For example, Fitts’ law describes the tradeoff (negative correlation) between speed and accuracy in goal-directed, human motor behavior. The WeberFechner law describes the robust psychological finding that the just-noticeable difference between two sensory stimuli is proportional to their magnitudes ...
Carbapenem
Carbapenem

... • They cause alteration of bacterial flora in the gut and this can be associated with GI disturbances, such as Diarrhoea. (happened to a greater extent with those have an extended antibacterial spectrum). • All Penicillins, particularly Methicillin, have the potential to cause acute nephritis, thus ...
Traditional Chinese Medicines Wu Wei Zi (Schisandra chinensis
Traditional Chinese Medicines Wu Wei Zi (Schisandra chinensis

... John’s Wort can also affect the drug transporter multidrug resistance protein 1/P-glycoprotein (Dresser et al., 2003; Weber et al., 2004). Dan-Shen (Radix salviae Miltiorhizae), a TCM herb, has been shown to alter the pharmacokinetics of warfarin, a CYP2C substrate (Lo et al., 1992). In addition to ...
Thiazide and Thiazide
Thiazide and Thiazide

... 2) Substitutents in the 3-position determine the potency and duration of action of the thiazides. 3) Saturation of C-N bond between the 3 and 4 positions of the benzothiadiazine-1,1-dioxide nucleus increases the potency of this class of diuretics approximately 3-10 fold. 4) Direct substitution of th ...
Cxcl12/Cxcr4 signaling controls the migration and
Cxcl12/Cxcr4 signaling controls the migration and

... α-chemokine subfamily and, together with its cognate receptor, CXCR4, represent the best-known chemokine ligand/receptor pair. Interestingly, besides their involvement in a battery of processes in the immune system, chemokines and their receptors are expressed by all major cell types in the central ...
a scaling cross platform tool for the analysis of neurophysiological data
a scaling cross platform tool for the analysis of neurophysiological data

... In case (i) neuron A delivers an electrochemical signal directly to neuron B while in case (ii) neurons B and C share a common input from neuron A. In each case the resulting spike train recordings will show a strong synchronisation (or correlation) between A and B / C while B and C will show a weak ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.

... Plants have always been a common source of med icament either in the form of t raditional preparat ion or pure active principles. Synthetic products of the modern civilizat ion have overshadowed the usage of herbal med icines. But once having realized their serious side effects people are going back ...
ANALYTICAL METHODS FORTAXANES QUANTIFICATION IN DILUTED FORMULATIONS AND
ANALYTICAL METHODS FORTAXANES QUANTIFICATION IN DILUTED FORMULATIONS AND

... mobile and stationary phases. This method is currently used for the analysis of DNA, proteins, glycosides, polyphenols, drugs and toxins, among many others [82-86]. Routine use of this technique involves quantification of analytes in biological samples, such as blood, urine and other body fluids. Fo ...
Neuroscience and Biobehavioral Reviews Michael T. Treadway , David H. Zald
Neuroscience and Biobehavioral Reviews Michael T. Treadway , David H. Zald

... first presented the highly influential dopamine deficiency hypothesis of anhedonia, he argued that dopamine (DA) critically mediated an organism’s experience of pleasure, or “yumminess”, in response to rewarding stimuli (Wise, 1980). Consequently, it was posited that anhedonia in mood disorders could b ...
Dopamine Receptor Antagonists Reverse Amphetamine
Dopamine Receptor Antagonists Reverse Amphetamine

... mediated by dopamine released in the brain (26). Thus, it might be expected that dopamine receptor antagonists could block the effects of amphetamine for a specific DRL behavior. However, surprisingly, there has been no study testing the effects of amphetamine in combination with specific dopamine r ...
Reconsidering anhedonia in depression
Reconsidering anhedonia in depression

... first presented the highly influential dopamine deficiency hypothesis of anhedonia, he argued that dopamine (DA) critically mediated an organism’s experience of pleasure, or “yumminess”, in response to rewarding stimuli (Wise, 1980). Consequently, it was posited that anhedonia in mood disorders could b ...
The Action Potential - (canvas.brown.edu).
The Action Potential - (canvas.brown.edu).

... 50–100 times larger than mammalian neurons. Fortunately, recent technical advances have made even the smallest vertebrate neurons accessible to intracellular recording methods, and these studies have confirmed that much of what was learned in invertebrates is directly applicable to humans. The goal ...
Galanin-like peptide: a key player in the homeostatic regulation of
Galanin-like peptide: a key player in the homeostatic regulation of

... The hypothalamus has a critical role in the regulation of feeding behavior, energy metabolism and reproduction. Galanin-like peptide (GALP), a novel 60 amino-acid peptide with a nonamidated C-terminus, was first discovered in porcine hypothalamus. GALP is mainly produced in the hypothalamic arcuate ...
Input-driven components of spike-frequency adaptation can be
Input-driven components of spike-frequency adaptation can be

... Spike-frequency adaptation affects the response characteristics of many sensory neurons, and different biophysical processes contribute to this phenomenon. Many cellular mechanisms underlying adaptation are triggered by the spike output of the neuron in a feedback manner (e.g., specific potassium cu ...
Type 2 Diabetes Medications: SGLT2 Inhibitors
Type 2 Diabetes Medications: SGLT2 Inhibitors

... effects. The medications discussed are approved for use in the United States by the U.S. Food and Drug Administration (FDA) unless otherwise noted. Consult individual manufacturer’s prescribing information for approved uses outside the United States. REFERENCES ...
Dense Core Vesicle Release: Controlling the Where as
Dense Core Vesicle Release: Controlling the Where as

... calcium levels and thus decrease premature DCV release, not increase it. Hoover et al. (2014) suggest that perhaps the soma is a site for DCV storage ready for trafficking to the axon in response to changes in activity or neuromodulatory signals. Alternatively, perhaps a switch from DCV release from ...
How do neurons communicate?
How do neurons communicate?

... see depolarization (change from negative inside neuron to more positive) ◦ “threshold” – if a great enough depolarization occurs, an action potential will occur ◦ action potential – very quick – milliseconds  Other terms – spike, firing, generating an AP ...
Mild Traumatic Brain Injury in US Soldiers Returning from Iraq
Mild Traumatic Brain Injury in US Soldiers Returning from Iraq

... nel, a fall, a vehicle accident, or other means and whether the injury involved the head. A soldier was considered to have had a mild traumatic brain injury if any of three questions — regarding “losing consciousness (knocked out),” “being dazed, confused, or ‘seeing stars,’” or “not remembering the ...
A Computational Model of the Amygdala Nuclei`s Role in - laral
A Computational Model of the Amygdala Nuclei`s Role in - laral

... [2]. However, we still lack a comprehensive theory able to explain the full range of these empirical data. Trying to build detailed biologically plausible computational models is a necessary step to overcome this knowledge gap. The current most influential models on classical conditioning, those bas ...
Abstracts for each slide presentation are available here
Abstracts for each slide presentation are available here

... Introduction: The thalamus is well known as a key relay, integration and broadcast point for all cerebral processing. In particular, thalamic GABA-ergic interneurons believed to be critical for (linear) gain control in such cerebral sensory and associative processing. It is therefore not surprising ...
Learning Beyond Finite Memory in Recurrent Networks Of Spiking
Learning Beyond Finite Memory in Recurrent Networks Of Spiking

... though most of experimental research focuses on characterizations of potential information processing states using temporal statistics of rate properties in spike trains (e.g. (Abeles et al., 1995; Martignon et al., 2000)) there is some experimental evidence that in certain situations the temporal i ...
efficacy of Donepezil and Galantamine on retrograde amnesia
efficacy of Donepezil and Galantamine on retrograde amnesia

... remarkable  dysfunction  of  the  cholinergic  system  was  seen  in  several brain regions of patients suffering from Alzheimer’s disease  and  was  shown  to  be  correlated  with  the  severity  of  cognitive  impairment11. Dementia is one  of  the  characteristics of Alzheimer’s  disease,  Donep ...
novel Biological treatments for systemic lupus erythematosus: current and Future modalities reviews
novel Biological treatments for systemic lupus erythematosus: current and Future modalities reviews

... leukocytes, lymphocytes and monocytes, stimulates protease release by tissue macrophages, and enhances infiltration of these molecules into inflamed tissue. IL-1Ra, discovered in 1980, is an endogenous specific receptor antagonist that inhibits the pro-inflammatory effects of IL-1 by binding IL-1, t ...
Robust path integration in the entorhinal grid cell - cneuro
Robust path integration in the entorhinal grid cell - cneuro

... The exact mechanism of how grid cells and place cells interact with each other to form a robust representation of the environment is still to be elucidated. Building on experimental observations several components of the underlying neural structures have been studied by theoretical tools. The first ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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