The Transforming Growth Factor- Pathway Is a Common
... committee of the Schepens Eye Research Institute. Male Sprague-Dawley rats (5 weeks of age; Taconic Farms, Hudson, NY) were randomly assigned to one of the following groups: control, diabetic, diabetic treated with sorbinil (65 mg 䡠 kg⫺1 䡠 day⫺1; gift of Pfizer, Groton, CT), and diabetic treated wit ...
... committee of the Schepens Eye Research Institute. Male Sprague-Dawley rats (5 weeks of age; Taconic Farms, Hudson, NY) were randomly assigned to one of the following groups: control, diabetic, diabetic treated with sorbinil (65 mg 䡠 kg⫺1 䡠 day⫺1; gift of Pfizer, Groton, CT), and diabetic treated wit ...
Relative Reinforcing Effects of Cocaine, Remifentanil, and Their
... heroin in combination. The isobolographic analysis demonstrated that two of the drug combinations produced less reinforcing effect than would be expected by a simple addition of drug effects. One combination ratio (3.2 cocaine:1.0 heroin) produced the same reinforcing effect as would be anticipated ...
... heroin in combination. The isobolographic analysis demonstrated that two of the drug combinations produced less reinforcing effect than would be expected by a simple addition of drug effects. One combination ratio (3.2 cocaine:1.0 heroin) produced the same reinforcing effect as would be anticipated ...
View PDF - UCLA.edu
... three ubiquitinated proteins of 29, 55, and 200 kDa accumulated in not1 and not2 extracts of third instar larval tissue, as assessed on Western blots probed with an anti-Ubiquitin antibody (Figure 2F). Second, both the nonstop targeting defect and prepupal lethality were dominantly enhanced by loss ...
... three ubiquitinated proteins of 29, 55, and 200 kDa accumulated in not1 and not2 extracts of third instar larval tissue, as assessed on Western blots probed with an anti-Ubiquitin antibody (Figure 2F). Second, both the nonstop targeting defect and prepupal lethality were dominantly enhanced by loss ...
Liver X Receptor Agonists as Potential Therapeutic Agents for
... of LXR antagonists in humans. It has recently been demonstrated that n-3 fatty acids, the major constituents of fish oil, are LXR antagonists35,36 (Figure 1). Dietary n-3 fatty acids have long been known to decrease serum triglyceride in humans,37 an effect consistent with the triglyceride-raising e ...
... of LXR antagonists in humans. It has recently been demonstrated that n-3 fatty acids, the major constituents of fish oil, are LXR antagonists35,36 (Figure 1). Dietary n-3 fatty acids have long been known to decrease serum triglyceride in humans,37 an effect consistent with the triglyceride-raising e ...
Comer, Abnormal Psychology, 8th edition
... Copyright © 2015 by Worth Publishers. All rights reserved ...
... Copyright © 2015 by Worth Publishers. All rights reserved ...
Figure 1 - Journal of Neuroscience
... the head held in the natural orientation. Recordings were conducted in low light levels or in darkness. Stimulus presentation, animal monitoring via infrared video camera, and electrode advancement were controlled from outside a double-walled soundproof booth. For single electrodes, spikes were isol ...
... the head held in the natural orientation. Recordings were conducted in low light levels or in darkness. Stimulus presentation, animal monitoring via infrared video camera, and electrode advancement were controlled from outside a double-walled soundproof booth. For single electrodes, spikes were isol ...
Human Physiology - Maryville University
... Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. ...
... Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. ...
Genetically modified yeasts as a new oral drug delivery system: from
... The aim is to increase the body’s protection against environmental xenobiotics, mainly those present in food (such as pesticides or chemical additives) by ingesting microorganisms expressing phase I (cytochrome P450) or phase II (e.g. glutathione S-transferase -GST-) xenobiotic metabolizing enzymes. ...
... The aim is to increase the body’s protection against environmental xenobiotics, mainly those present in food (such as pesticides or chemical additives) by ingesting microorganisms expressing phase I (cytochrome P450) or phase II (e.g. glutathione S-transferase -GST-) xenobiotic metabolizing enzymes. ...
Programme and book of abstracts
... Chair: Annette Sprong, Netherlands Forensic Institute, The Hague, The Netherlands O10 – A Metabolomics Study of Retrospective Forensic Data from Whole Blood Samples of Humans Exposed to 3,4-Methylenedioxymethamphetamine: A New Approach for Identifying Drug Metabolites and Changes in Metabolism Relat ...
... Chair: Annette Sprong, Netherlands Forensic Institute, The Hague, The Netherlands O10 – A Metabolomics Study of Retrospective Forensic Data from Whole Blood Samples of Humans Exposed to 3,4-Methylenedioxymethamphetamine: A New Approach for Identifying Drug Metabolites and Changes in Metabolism Relat ...
The role of eyes in early face processing: A rapid adaptation study of
... According to the OSH, larger adaptation effects should be found for inverted than upright adaptors regardless of the category. Thus, in response to S2, a decreased activation should be found for inverted compared to upright adaptors, for each adaptor category tested: houses, mouths, eyes, faces, eye ...
... According to the OSH, larger adaptation effects should be found for inverted than upright adaptors regardless of the category. Thus, in response to S2, a decreased activation should be found for inverted compared to upright adaptors, for each adaptor category tested: houses, mouths, eyes, faces, eye ...
Anabolic–androgenic steroid dependence? Insights from animals and humans Ruth I. Wood Review
... 62 elite Finnish powerlifters who used AAS during their competitive years reported a significantly increased death rate during the 12-year follow-up [127]. Premature deaths also occur in mice treated chronically with AAS [21]. Recent evidence suggests that steroid use is increasing [86], both in term ...
... 62 elite Finnish powerlifters who used AAS during their competitive years reported a significantly increased death rate during the 12-year follow-up [127]. Premature deaths also occur in mice treated chronically with AAS [21]. Recent evidence suggests that steroid use is increasing [86], both in term ...
The Role of Ligand Efficiency Measures in Drug Discovery
... due to less favorable binding entropies for larger, more flexible ligands.40 However, in an analysis of the number of energetically accessible conformations for several thousand ligands of varying sizes and affinities no trend could be found for increased conformational entropies as ligand size incr ...
... due to less favorable binding entropies for larger, more flexible ligands.40 However, in an analysis of the number of energetically accessible conformations for several thousand ligands of varying sizes and affinities no trend could be found for increased conformational entropies as ligand size incr ...
Dynamic Computation of Incentive Salience: “Wanting” What Was
... CS⫺) to rule out gradual drift in neural firing over the trial. Testing and recording. Neural activity was recorded in two sessions spaced 24 h apart. On day 1, rats were in normal homeostasis; on day 2, rats were in sodium appetite. A syringe containing sucrose or NaCl solution was connected to the ...
... CS⫺) to rule out gradual drift in neural firing over the trial. Testing and recording. Neural activity was recorded in two sessions spaced 24 h apart. On day 1, rats were in normal homeostasis; on day 2, rats were in sodium appetite. A syringe containing sucrose or NaCl solution was connected to the ...
Prediction of Subjective Affective State From Brain Activations
... state or prospective rating in the stimulus-dependent crosscorrelations between the voxels, i.e., in the higher-order statistics. An example of the latter might be that independently of the mean level of activation of a set of voxels, if some voxels varied together for one event, but not for another ...
... state or prospective rating in the stimulus-dependent crosscorrelations between the voxels, i.e., in the higher-order statistics. An example of the latter might be that independently of the mean level of activation of a set of voxels, if some voxels varied together for one event, but not for another ...
Theory-theory and the direct perception of mental
... Lavelle, J.S. (2012). ‘Theory-theory and the direct perception of mental states’. Review of Philosophy and Psychology, 3, 213 – 230. Reddy, 2008). Thus direct perception approaches stand in opposition to both Theory-theory and Simulation theory. This paper examines the challenges that the direct pe ...
... Lavelle, J.S. (2012). ‘Theory-theory and the direct perception of mental states’. Review of Philosophy and Psychology, 3, 213 – 230. Reddy, 2008). Thus direct perception approaches stand in opposition to both Theory-theory and Simulation theory. This paper examines the challenges that the direct pe ...
Nausea and Vomiting Side Effects with Opioid
... opioid analgesia and represent a significant cause of patient discomfort and treatment dissatisfaction. This review examines the mechanisms that produce these side effects, their impact on treatment outcomes in chronic pain patients, and counteractive strategies. Results. A number of mechanisms by wh ...
... opioid analgesia and represent a significant cause of patient discomfort and treatment dissatisfaction. This review examines the mechanisms that produce these side effects, their impact on treatment outcomes in chronic pain patients, and counteractive strategies. Results. A number of mechanisms by wh ...
Opiate Assay - Beckman Coulter
... System using the Emit® II Plus Opiate assay. Positive specimens were confirmed by GC/MS. Refer to the Application Sheets for other AU Clinical Chemistry Systems and for additional information. Results may vary due to analyzer-to-analyzer differences. The following performance characteristics represe ...
... System using the Emit® II Plus Opiate assay. Positive specimens were confirmed by GC/MS. Refer to the Application Sheets for other AU Clinical Chemistry Systems and for additional information. Results may vary due to analyzer-to-analyzer differences. The following performance characteristics represe ...
Meaningful auditory information enhances perception of visual
... uncorrelated) auditory information is provided to subjects performing a visual search task. This confirms that synchrony between auditory and visual events cannot only improve visual performance (Dalton & Spence, 2007; Vroomen & de Gelder, 2000) but also affect visual perception phenomenologically. ...
... uncorrelated) auditory information is provided to subjects performing a visual search task. This confirms that synchrony between auditory and visual events cannot only improve visual performance (Dalton & Spence, 2007; Vroomen & de Gelder, 2000) but also affect visual perception phenomenologically. ...
EFFECT OF RESVERATROL AND ENVIRONMENTAL
... young healthy animals (Muhammad et al. 2014). The physiological effects of resveratrol on antioxidant system have been extensively studied in animal models of various disease conditions such as obesity, diabetes and neurodegenerative disorders. The role of resveratrol in modulating the antioxidant s ...
... young healthy animals (Muhammad et al. 2014). The physiological effects of resveratrol on antioxidant system have been extensively studied in animal models of various disease conditions such as obesity, diabetes and neurodegenerative disorders. The role of resveratrol in modulating the antioxidant s ...
Assessment of Antimicrobial Combinations for Klebsiella
... aztreonam, in addition to most β-lactam agents [8–10]. In general, susceptibility to a few antimicrobials, such as polymyxins and tigecycline, may only be retained [11]. As a result of broad antimicrobial resistance, treatment options are very limited. Further compounding the severity of the proble ...
... aztreonam, in addition to most β-lactam agents [8–10]. In general, susceptibility to a few antimicrobials, such as polymyxins and tigecycline, may only be retained [11]. As a result of broad antimicrobial resistance, treatment options are very limited. Further compounding the severity of the proble ...
Fig. - Development - The Company of Biologists
... number of mandibular neurons than in wild type, whereas Hmx1+ and OC1 + cells were concomitantly reduced (Fig. 2F-H). This was further confirmed with Hmx1/Tbx3 double fluorescent in situ hybridisation (FISH) and quantified (Fig. 2I-K). This effect was not a result of increased cell death in the mand ...
... number of mandibular neurons than in wild type, whereas Hmx1+ and OC1 + cells were concomitantly reduced (Fig. 2F-H). This was further confirmed with Hmx1/Tbx3 double fluorescent in situ hybridisation (FISH) and quantified (Fig. 2I-K). This effect was not a result of increased cell death in the mand ...
Facial whisker pattern is not sufficient to instruct a
... number of mandibular neurons than in wild type, whereas Hmx1+ and OC1 + cells were concomitantly reduced (Fig. 2F-H). This was further confirmed with Hmx1/Tbx3 double fluorescent in situ hybridisation (FISH) and quantified (Fig. 2I-K). This effect was not a result of increased cell death in the mand ...
... number of mandibular neurons than in wild type, whereas Hmx1+ and OC1 + cells were concomitantly reduced (Fig. 2F-H). This was further confirmed with Hmx1/Tbx3 double fluorescent in situ hybridisation (FISH) and quantified (Fig. 2I-K). This effect was not a result of increased cell death in the mand ...
Examination of Thyrotropin-Releasing Hormone (TRH)
... considered a thyroid hormone inactivating enzyme in euthyroid conditions by producing inactive rT3 or T2 [14]. The liver and kidney, where D1 participates in the clearance of TH derivatives, contains a relatively large concentration of this enzyme, but D1 is also present in the anterior pituitary, i ...
... considered a thyroid hormone inactivating enzyme in euthyroid conditions by producing inactive rT3 or T2 [14]. The liver and kidney, where D1 participates in the clearance of TH derivatives, contains a relatively large concentration of this enzyme, but D1 is also present in the anterior pituitary, i ...
FABRICATION, EVALUATION AND PRELIMINARY CLINICAL STUDY OF BI-LAYER OROBUCCAL
... Objective: Formulation and Evaluation of Ketorolac Tromethamine and Chlorhexidine hydrochloride Orobuccal Devices and preliminary clinical study of selected ketorolac tromethamine and chlorhexidine hydrochloride orobuccal devices. Methods: Ketorolac tromethamine [KT] is a well known non-steroidal an ...
... Objective: Formulation and Evaluation of Ketorolac Tromethamine and Chlorhexidine hydrochloride Orobuccal Devices and preliminary clinical study of selected ketorolac tromethamine and chlorhexidine hydrochloride orobuccal devices. Methods: Ketorolac tromethamine [KT] is a well known non-steroidal an ...