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1 The Neuromuscular Junction: Pharmacology
1 The Neuromuscular Junction: Pharmacology

... b. Enhancers (agonists). Cholinergic agonists that act at NMJ’s include carbachol and decamethonium. They maintain the open state of the ligand-gated channels that are integral to the ACh receptor. Acetylcholine itself is also, of course, an agonist of the ACh receptor but molecules like ACh and dec ...
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No Slide Title

... • More synapses a neuron has the greater its information-processing capability – cells in cerebral cortex with 40,000 synapses – cerebral cortex estimated to contain 100 trillion synapses ...
The Nervous System
The Nervous System

... • As the action potential passes, gates in the potassium channels open, allowing potassium (K+) ions to flow OUT of the cell • This restores the negative potential in the axon. ...
Myers Module Six
Myers Module Six

... specialized areas that enable us to perceive, think, and speak. Some of these areas are only 50,000 years old; that is practically brand new in terms of evolution. This brain area requires a lot of fuel (glucose, or bloodsugar), and myeline sheathing. This is supplied by the glial cells. They suppor ...
Giuseppe Minniti, MSc, City University of New York – College of
Giuseppe Minniti, MSc, City University of New York – College of

... Chronic alcohol drinking causes profound physiological adaptations, which lead to physical dependence and tolerance. Some of these adaptations result from a complex chain of events that occur in the brain, long before a state of alcohol dependence is reached. Studies performed in animal models demon ...
Downregulation of VEGF-C expression in lung and colon cancer
Downregulation of VEGF-C expression in lung and colon cancer

... Vascular endothelial growth factor C (VEGF-C) plays an important role in lymphangiogenesis. VEGF-C binds to Flt4/VEGF receptor 3 (VEGFR3), a receptor tyrosine kinase that is expressed in the progression of several malignant tumors, including non-small cell lung cancer, colorectal cancer, and breast ...
Opiates
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... Binge/Crash pattern, continual use HUGE rush, longer (2-8 hours, compared to 5-10 minutes for crack) – binds to more dopamine receptors, causes greater release, longer time Listlessness in withdrawal Pockmarks on face, loss of teeth due to chemicals in the meth ...
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Anti-seizure_and_Anti

... Poor control of seizures—look at compliance, incorrect diagnosis of type of seizure, use of wrong drug for type of seizure, inadequate drug ...
Medicinal Chemistry-1 - Al
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... Course outlines First Semester 2012-2013 Lecturer: Dr. Izzeddin M. Alsalahat E-mail: [email protected] Topics: ...
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... The activity of functionally distinct parietal motor neurons varies with the purpose of a grasping action. (Modified, with permission, from Fogassi et al. ...
Anti-seizure and Anti
Anti-seizure and Anti

... Poor control of seizures—look at compliance, incorrect diagnosis of type of seizure, use of wrong drug for type of seizure, inadequate drug ...
Biological Basis of Behavior
Biological Basis of Behavior

... Neurons are specialized cells that transmit information from one part of the body to another. Nerves are bundles of neurons. The function of most neurons is to receive information from other neurons and to pass this information on. Structural features of neurons: Soma – The cell body of the neuron. ...
Nervous System:
Nervous System:

... • Central Nervous System – made up of brain and spinal cord; functions as the command center of the nervous system • Peripheral Nervous System – made up of any nerve which is not the brain or the spinal cord. ...
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... • Uses chemically, mechanically or light gated ion channels • Graded Potentials are small deviations from the resting membrane potential caused by an appropriate stimulus • These potentials are “graded,” which means that it can vary in amplitude • Useful only for short distance communication ...
Answer Key of MCQ of AMO Exam
Answer Key of MCQ of AMO Exam

... B. Glucose coupled Na+ absorption C. Bicarbonate coupled Na+ absorption D. Passive Na+ diffusion secondary to nutrient absorption 63. What does the term “antibiotics” mean: A. Non-organic or synthetic substances that selectively kill or inhibit the growth of other microorganisms B. Substances produc ...
Neural coding in the primary olfactory cortex
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... The primary olfactory (piriform) cortex is a phylogenetically-ancient three-layered structure that is the first cortical destination of olfactory information. The comparatively simple architecture of the piriform cortex (PC) suggests that it may be a valuable model system for the study of cortical s ...
Brain - Cloudfront.net
Brain - Cloudfront.net

... the receiving neuron. This tiny gap is called the synaptic gap or cleft. ...
Sensory Receptors
Sensory Receptors

... • Altering the permeability of sodium ions creates a nerve impulse. • When sodium channels open, sodium ions flow down the concentration gradient from high to low, flowing back into the cell (These were the first proteins we talked about). ...
Parkinson`s disease - Computation & Neural Systems
Parkinson`s disease - Computation & Neural Systems

... Constipation. Detailed surveys show that most PD patients have constipation long before the clinical symptoms. Constipation does not predict PD. Intestinal biopsies show Lewy bodies in the neurons of the intestinal wall. ...
Gene Therapy Clinical Trial Yields Promising Results For Batten
Gene Therapy Clinical Trial Yields Promising Results For Batten

... procedure. Six tiny holes were made in the skull of each subject, and then a liquid containing the healthy CLN2 gene, within the harmless adeno-associated virus (AAV), was injected into the brain. "Before now, we had no hope of a therapy for Batten disease, but today we can say that there is some ho ...
Chapter 4
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semicircular canals
semicircular canals

... against the oval window causing fluid to move within the cochlea. The movement of the fluids is eventually detected by sensory cells within the cochlea. ...
MIGRAINE
MIGRAINE

... Metabolized in liver to active metabolites which have a higher affinity to 5HT1B & 1D receptors than the parent drug. Half- life for both 2-3hrs. Plasma protein binding 14%. ...
Leaving Certificate Biology Topic iQuiz
Leaving Certificate Biology Topic iQuiz

... A synapse ...
Martin 2009 - University of Colorado Denver
Martin 2009 - University of Colorado Denver

... Jumping genes, which make DNA copies of themselves through an RNA middleman, provide a stochastic process for generating brain diversity among humans. The effect of their random insertion, however, is a bit of a gamble. The enormous complexity of the human nervous system is generated by the combined ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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