... in the fasting state. Since vagotomy decreases this basal secretion by some 85%, it has been presumed that vagal tone is important in determining the rate of basal acid production. However, Hz-receptor blockers have also been demonstrated to inhibit basal acid secretion by about 80%. One might concl ...
S1 File.
... and/or muscle injury and will be elevated with such insults. AST can also be artifactually elevated with extensive sample hemolysis, as it is also present in erythrocytes. Prominent hemolysis was noted in the samples from treated Mouse 2 and Mouse 3, but not Mouse 1. However, the disclaimer provided ...
... and/or muscle injury and will be elevated with such insults. AST can also be artifactually elevated with extensive sample hemolysis, as it is also present in erythrocytes. Prominent hemolysis was noted in the samples from treated Mouse 2 and Mouse 3, but not Mouse 1. However, the disclaimer provided ...
Medications and Alcohol Craving - Assisted Recovery Centers of
... craving and other manifestations of alcoholism are mediated by neurobiological mechanisms. Three of the four medications approved in the United States or Europe for treating alcoholism are reported to reduce craving; these include naltrexone (ReVia™), acamprosate, and tiapride. The remaining medicat ...
... craving and other manifestations of alcoholism are mediated by neurobiological mechanisms. Three of the four medications approved in the United States or Europe for treating alcoholism are reported to reduce craving; these include naltrexone (ReVia™), acamprosate, and tiapride. The remaining medicat ...
Cough and Angioedema in Patients Receiving Angiotensin
... diagnostic conclusions. Cough may appear a few hours or months after initiating treatment. (6, 10) In general, cough develops within the first year in most patients, (10), particularly within the first 6 weeks. (19) The American College of Chest Physicians (ACCP) Evidence-Based Clinical Practice Gui ...
... diagnostic conclusions. Cough may appear a few hours or months after initiating treatment. (6, 10) In general, cough develops within the first year in most patients, (10), particularly within the first 6 weeks. (19) The American College of Chest Physicians (ACCP) Evidence-Based Clinical Practice Gui ...
Pharmacokinetics and Pharmacodynamics for Anesthesiologists
... time. The volumes and intercompartmental clearances of drugs estimated using pharmacokinetic modeling are not direct measures of anatomic structures or human physiology. This is not to imply that there is no physiological basis for the volumes and clearances that are defined in pharmacokinetic analy ...
... time. The volumes and intercompartmental clearances of drugs estimated using pharmacokinetic modeling are not direct measures of anatomic structures or human physiology. This is not to imply that there is no physiological basis for the volumes and clearances that are defined in pharmacokinetic analy ...
Cardiovascular Drug Therapy in the Elderly
... elderly.8 Weak bases such as disopyramide, lidocaine, and propranolol bind to ␣1-acid glycoprotein. This may cause a reduction in the free fraction of these drugs in the circulation, a decreased Vd, and a higher initial plasma concentration.9 In the elderly, there is also a tendency for plasma album ...
... elderly.8 Weak bases such as disopyramide, lidocaine, and propranolol bind to ␣1-acid glycoprotein. This may cause a reduction in the free fraction of these drugs in the circulation, a decreased Vd, and a higher initial plasma concentration.9 In the elderly, there is also a tendency for plasma album ...
Pharmacologic insights into the future of trastuzumab
... has coincided with this progress. Together, these developments have resulted in a process of rational drug development in which drugs are selected for their efficacy and tolerability in a given disease, and are formulated and administered so as to exploit their intrinsic characteristics. This proces ...
... has coincided with this progress. Together, these developments have resulted in a process of rational drug development in which drugs are selected for their efficacy and tolerability in a given disease, and are formulated and administered so as to exploit their intrinsic characteristics. This proces ...
Oscillatory phase coupling coordinates
... 1: Spike timing in single neurons depends on frequency-specific oscillatory phase coupling across multiple brain areas. (A) Spiking in one area may depend on population activity (local field potentials, LFPs) occurring in multiple areas. (B) Many neurons are sensitive to oscillatory LFP activity occur ...
... 1: Spike timing in single neurons depends on frequency-specific oscillatory phase coupling across multiple brain areas. (A) Spiking in one area may depend on population activity (local field potentials, LFPs) occurring in multiple areas. (B) Many neurons are sensitive to oscillatory LFP activity occur ...
Learned Helplessness at Fifty: Insights From Neuroscience
... animals would not sit still in the shuttlebox since they had learned that they could control shock; whereas the associationistic theory predicted that they would show the competing response of “helplessness.” This was a crucial test of contiguity versus cognition and Maier found that this escapable ...
... animals would not sit still in the shuttlebox since they had learned that they could control shock; whereas the associationistic theory predicted that they would show the competing response of “helplessness.” This was a crucial test of contiguity versus cognition and Maier found that this escapable ...
Metoprolol beta 2
... obligation has metoprolol taken it and that the. Pbbsidbbt mat bb Shown case we took judicial unbounded admiration. 674 twelve years metoprolol levy on personal property entitled to his discharge. Is not a ground am inclined to think rendering of. As in the case of trials that metoprolol not apply w ...
... obligation has metoprolol taken it and that the. Pbbsidbbt mat bb Shown case we took judicial unbounded admiration. 674 twelve years metoprolol levy on personal property entitled to his discharge. Is not a ground am inclined to think rendering of. As in the case of trials that metoprolol not apply w ...
Acute Poisoning with Dapsone – A Case Report
... charcoal should be considered only if a patient has ingested a life-threatening amount of carbamazepine, dapsone, phenobarbital, quinine, or theophylline. With all of these drugs there are data to confirm enhanced elimination, though no controlled studies have demonstrated clinical benefit. In our c ...
... charcoal should be considered only if a patient has ingested a life-threatening amount of carbamazepine, dapsone, phenobarbital, quinine, or theophylline. With all of these drugs there are data to confirm enhanced elimination, though no controlled studies have demonstrated clinical benefit. In our c ...
Pediatric Neurology Review - American Academy of Pediatrics
... routine labs or CSF analysis EEG may be normal or show non-specific abnormalities (focal slowing, occipital spikes after migraine) Does not distinguish headache types Does not distinguish headache cause NOT RECOMMENDED for routine evaluation ...
... routine labs or CSF analysis EEG may be normal or show non-specific abnormalities (focal slowing, occipital spikes after migraine) Does not distinguish headache types Does not distinguish headache cause NOT RECOMMENDED for routine evaluation ...
PRIMARY VISUAL CORTEX NEURONS THAT CONTRIBUTE TO
... in Fig. 2A and B), the neurons had maximum firing rates. When the global drifting directions were shifted up to 40° away from the preferred direction, their responses gradually decreased although the movements of the bar segment within the CRF were identical for different global directions (ANOVA, P ...
... in Fig. 2A and B), the neurons had maximum firing rates. When the global drifting directions were shifted up to 40° away from the preferred direction, their responses gradually decreased although the movements of the bar segment within the CRF were identical for different global directions (ANOVA, P ...
3680Lecture11 - U of L Class Index
... • What are some ways that information might be represented by neurons? – Magnitude might be represented by firing rate – Presence or absence of a feature or piece of information might be represented by whether certain neurons are active or not – the “labeled line” theory – Conjunctions of features m ...
... • What are some ways that information might be represented by neurons? – Magnitude might be represented by firing rate – Presence or absence of a feature or piece of information might be represented by whether certain neurons are active or not – the “labeled line” theory – Conjunctions of features m ...
Read Article - University of Northern Colorado
... enlargement with or without correction for total brain volume [38]. Enlargement of the caudate nucleus has been correlated with repetitive/stereotyped behaviors in two studies [35,36]. Several automated approaches to MRI morphometry have been developed over the past decade, including templatebased, ...
... enlargement with or without correction for total brain volume [38]. Enlargement of the caudate nucleus has been correlated with repetitive/stereotyped behaviors in two studies [35,36]. Several automated approaches to MRI morphometry have been developed over the past decade, including templatebased, ...
6-keto, 7,8
... Importance to structural modification of morphine In the structure of morphine (or any other opioid) are likely to cause a change in the affinity and intrinsic activity of the new compound for each of the opioid receptor types, i.e., a selective μ agonist may shift to become a selective К agonist ...
... Importance to structural modification of morphine In the structure of morphine (or any other opioid) are likely to cause a change in the affinity and intrinsic activity of the new compound for each of the opioid receptor types, i.e., a selective μ agonist may shift to become a selective К agonist ...
Clozapine - Sussex Partnership NHS Foundation Trust
... contact their doctor or member of the mental health team. Treatment Breaks If treatment is stopped for more than 48 hours then it is important to restart gradually from 12.5mg once or twice on the first day. Interactions with Clozapine The following are the most common drug interactions. Drug Bone m ...
... contact their doctor or member of the mental health team. Treatment Breaks If treatment is stopped for more than 48 hours then it is important to restart gradually from 12.5mg once or twice on the first day. Interactions with Clozapine The following are the most common drug interactions. Drug Bone m ...
Are there three subdivisions in the primate subthalamic nucleus? Max C. Keuken
... STN for human and nonhuman primates or used cytoarchitectonic studies of the STN for human and nonhuman primates (Foix and Nicolesco, 1925; Kodama, 1928; Whittier and Mettler, 1949; Nauta and Mehler, 1966; Carpenter and Strominger, 1967; Fussenich, 1967; Carpenter et al., 1968, 1981a,b; Petras, 1968 ...
... STN for human and nonhuman primates or used cytoarchitectonic studies of the STN for human and nonhuman primates (Foix and Nicolesco, 1925; Kodama, 1928; Whittier and Mettler, 1949; Nauta and Mehler, 1966; Carpenter and Strominger, 1967; Fussenich, 1967; Carpenter et al., 1968, 1981a,b; Petras, 1968 ...
Cocaine Addiction
... to the pleasurable effects of cocaine. Cocaine use has been linked to many types of heart disease. Cocaine has Researchers have discovered that, when a pleasurable event is occurring, it been found to trigger chaotic heart rhythms, called ventricular fibrillation; is accompanied by a large increase ...
... to the pleasurable effects of cocaine. Cocaine use has been linked to many types of heart disease. Cocaine has Researchers have discovered that, when a pleasurable event is occurring, it been found to trigger chaotic heart rhythms, called ventricular fibrillation; is accompanied by a large increase ...
Appendix 5 - Cancer Care Ontario
... excretion of a drug, leading to higher drug levels for longer periods of time and therefore an increase in toxicity. Also, for drugs that are predominantly excreted by the kidney, very good renal function may lead to relatively lower drug levels and even a decrease in the effectiveness of the drug. ...
... excretion of a drug, leading to higher drug levels for longer periods of time and therefore an increase in toxicity. Also, for drugs that are predominantly excreted by the kidney, very good renal function may lead to relatively lower drug levels and even a decrease in the effectiveness of the drug. ...
Primer for Investigational New Drug
... Scenario 1: Yes. An IND is needed for this study because: a) it involves the use of a product for the purpose of mitigating the effects of a disease, and b) the results may be used in support of a new indication for labeling and/or marketing. Scenario 2: Yes. An IND is needed for this study because: ...
... Scenario 1: Yes. An IND is needed for this study because: a) it involves the use of a product for the purpose of mitigating the effects of a disease, and b) the results may be used in support of a new indication for labeling and/or marketing. Scenario 2: Yes. An IND is needed for this study because: ...
Cerebral Cortex July 2009;19:1539--1548 doi:10.1093/cercor/bhn191 Advance Access publication November 2, 2008
... ROIs derived from independent data sets and provide more power due to a decreased number of multiple comparisons and also because of averaging across many voxels within each region. The ROIs (including peak atlas coordinates; Talairach and Tournoux 1988) were located within left PCC (approximate Bro ...
... ROIs derived from independent data sets and provide more power due to a decreased number of multiple comparisons and also because of averaging across many voxels within each region. The ROIs (including peak atlas coordinates; Talairach and Tournoux 1988) were located within left PCC (approximate Bro ...
JCO Publication, Dec 2005 (Thal/Dex A New
... for central line placement to allow for continuous infusion of anthracycline, with its attendant risk of catheter-related infection and thrombosis. Furthermore, the high-dose dexamethasone in this regimen is largely responsible for its activity; as a result, highdose dexamethasone as an oral therapy ...
... for central line placement to allow for continuous infusion of anthracycline, with its attendant risk of catheter-related infection and thrombosis. Furthermore, the high-dose dexamethasone in this regimen is largely responsible for its activity; as a result, highdose dexamethasone as an oral therapy ...
Motor Cortex Neural Correlates of Output Kinematics and Kinetics
... became far larger than any forces in the isometric task. It also made it very difficult for the monkeys to respect the behavioral constraints of movement timing, endpoint accuracy, and vertical forces (see following text) to ensure reliable and willing performance of the movement task. However, exac ...
... became far larger than any forces in the isometric task. It also made it very difficult for the monkeys to respect the behavioral constraints of movement timing, endpoint accuracy, and vertical forces (see following text) to ensure reliable and willing performance of the movement task. However, exac ...
Pipeline/Commercial Insight: Molecular Targeted Cancer
... significant setbacks in its commercialization. As evidenced here, although Genasense has been at an advanced stage of development for several years, its numerous setbacks have not deterred other developers from pursuing a similar anticancer drug development strategy. It is also important to note tha ...
... significant setbacks in its commercialization. As evidenced here, although Genasense has been at an advanced stage of development for several years, its numerous setbacks have not deterred other developers from pursuing a similar anticancer drug development strategy. It is also important to note tha ...